AU2017214134B2 - Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof - Google Patents

Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof Download PDF

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Publication number
AU2017214134B2
AU2017214134B2 AU2017214134A AU2017214134A AU2017214134B2 AU 2017214134 B2 AU2017214134 B2 AU 2017214134B2 AU 2017214134 A AU2017214134 A AU 2017214134A AU 2017214134 A AU2017214134 A AU 2017214134A AU 2017214134 B2 AU2017214134 B2 AU 2017214134B2
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compound
formula
acid
process according
sodium
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AU2017214134A1 (en
Inventor
Zhaozhong DING
Yinghu HU
Fei Sun
Ling Yang
Rui Zhao
Yilong ZHOU
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AU2017214134A 2016-02-05 2017-02-04 Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof Active AU2017214134B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610082028.3A CN107043378A (zh) 2016-02-05 2016-02-05 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体
CN201610082028.3 2016-02-05
PCT/CN2017/072893 WO2017133686A1 (zh) 2016-02-05 2017-02-04 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体

Publications (2)

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AU2017214134A1 AU2017214134A1 (en) 2018-08-23
AU2017214134B2 true AU2017214134B2 (en) 2020-08-27

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AU2017214134A Active AU2017214134B2 (en) 2016-02-05 2017-02-04 Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof

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EP (1) EP3412673B1 (enExample)
JP (1) JP6877449B2 (enExample)
KR (1) KR102371500B1 (enExample)
CN (2) CN107043378A (enExample)
AR (1) AR107549A1 (enExample)
AU (1) AU2017214134B2 (enExample)
BR (1) BR112018015879B1 (enExample)
CA (1) CA3013520C (enExample)
CL (1) CL2018002094A1 (enExample)
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EA (1) EA034581B1 (enExample)
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HU (1) HUE053455T2 (enExample)
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LT (1) LT3412673T (enExample)
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PT (1) PT3412673T (enExample)
SG (1) SG11201806685VA (enExample)
SI (1) SI3412673T1 (enExample)
TW (1) TW201728590A (enExample)
UA (1) UA124100C2 (enExample)
WO (1) WO2017133686A1 (enExample)

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EA201891620A1 (ru) 2016-02-05 2019-02-28 Денали Терапьютикс Инк. Ингибиторы взаимодействующей с рецептором протеинкиназы 1
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
MX2021009496A (es) 2019-02-08 2021-09-08 Progeneer Inc Complejo de colesterol-agonista del receptor 7 u 8 tipo larga distancia, y uso del mismo.
WO2021177679A1 (ko) 2020-03-02 2021-09-10 성균관대학교산학협력단 병원균 외벽 성분 기반 생병원체 모방 나노 입자 및 그 제조 방법
EP4194006A4 (en) 2020-08-04 2024-12-04 Progeneer Inc. mRNA VACCINE WITH AN ADJUVANT CAPABLE OF KINETIC CONTROL
JP2023536954A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途
US20230355750A1 (en) 2020-08-04 2023-11-09 Progeneer Inc. Kinetically acting adjuvant ensemble
MX2024008648A (es) 2022-01-12 2024-09-23 Denali Therapeutics Inc Formas cristalinas de (s)-5-bencil-n-(5-metil-4-oxo-2,3,4,5-tetrah idropirido [3,2- b][1,4]oxacepin-3-il)-4h-1,2,4-triazol-3-carboxam ida.

Citations (1)

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WO2014081644A1 (en) * 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds

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WO2009082247A1 (en) 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
NZ593110A (en) 2008-12-09 2013-06-28 Gilead Sciences Inc pteridinone derivatives as MODULATORS OF TOLL-LIKE RECEPTORS
MX365114B (es) * 2012-10-10 2019-05-23 Janssen Sciences Ireland Uc Derivados pirrolo[3,2-d]pirimidinicos para el tratamiento de infecciones viricas y otras enfermedades.
JP6228223B2 (ja) * 2012-11-20 2017-11-08 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ 新規化合物
PL3137470T3 (pl) * 2014-05-01 2021-10-11 Novartis Ag Związki i kompozycje jako agonisty receptora toll-like 7
PL3190113T3 (pl) * 2014-08-15 2021-10-25 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Związki pirolopirymidynowe stosowane jako agonista TLR7
CN105367576A (zh) 2014-08-15 2016-03-02 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
BR112018008880B1 (pt) 2015-11-05 2023-01-17 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 7-(tiazol-5-il) pirrolopirimidina, seu uso, e composição farmacêutica
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043377A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途

Patent Citations (1)

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WO2014081644A1 (en) * 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds

Also Published As

Publication number Publication date
CN108602832A (zh) 2018-09-28
EP3412673B1 (en) 2020-11-25
UA124100C2 (uk) 2021-07-21
PH12018501642B1 (en) 2019-06-03
MY190551A (en) 2022-04-27
JP6877449B2 (ja) 2021-05-26
CN107043378A (zh) 2017-08-15
CA3013520A1 (en) 2017-08-10
US20190040072A1 (en) 2019-02-07
NZ744885A (en) 2022-07-01
LT3412673T (lt) 2021-03-10
KR20180104724A (ko) 2018-09-21
CL2018002094A1 (es) 2018-12-07
SG11201806685VA (en) 2018-09-27
CN108602832B (zh) 2020-10-09
IL260999B (en) 2021-02-28
SI3412673T1 (sl) 2021-04-30
US20200239484A1 (en) 2020-07-30
AU2017214134A1 (en) 2018-08-23
AR107549A1 (es) 2018-05-09
EA034581B1 (ru) 2020-02-21
MX374298B (es) 2025-03-06
PL3412673T3 (pl) 2021-07-26
DK3412673T3 (da) 2021-01-18
WO2017133686A1 (zh) 2017-08-10
KR102371500B1 (ko) 2022-03-07
CA3013520C (en) 2022-07-19
EP3412673A1 (en) 2018-12-12
HUE053455T2 (hu) 2021-06-28
EA201891769A1 (ru) 2019-04-30
JP2019505531A (ja) 2019-02-28
TW201728590A (zh) 2017-08-16
US10654856B2 (en) 2020-05-19
BR112018015879B1 (pt) 2024-02-15
HRP20210103T1 (hr) 2021-03-05
ES2852323T3 (es) 2021-09-13
PT3412673T (pt) 2021-02-15
BR112018015879A2 (pt) 2018-12-26
PH12018501642A1 (en) 2019-06-03
MX2018009502A (es) 2018-12-11
HK1259183A1 (zh) 2019-11-29
EP3412673A4 (en) 2019-07-03

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