AU2015230933B2 - Antagonist antibodies directed against calcitonin gene-related peptide and methods using same - Google Patents

Antagonist antibodies directed against calcitonin gene-related peptide and methods using same Download PDF

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Publication number
AU2015230933B2
AU2015230933B2 AU2015230933A AU2015230933A AU2015230933B2 AU 2015230933 B2 AU2015230933 B2 AU 2015230933B2 AU 2015230933 A AU2015230933 A AU 2015230933A AU 2015230933 A AU2015230933 A AU 2015230933A AU 2015230933 B2 AU2015230933 B2 AU 2015230933B2
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AU
Australia
Prior art keywords
antibody
cdr
seq
subject
headache
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AU2015230933A1 (en
Inventor
Marcelo BIGAL
Michael Chang
Henry STERN
Sarah Walter
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Teva Pharmaceuticals International GmbH
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Teva Pharmaceuticals International GmbH
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
AU2015230933A 2014-03-21 2015-03-20 Antagonist antibodies directed against calcitonin gene-related peptide and methods using same Active AU2015230933B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461968897P 2014-03-21 2014-03-21
US61/968,897 2014-03-21
US201462083809P 2014-11-24 2014-11-24
US62/083,809 2014-11-24
US201562119778P 2015-02-23 2015-02-23
US62/119,778 2015-02-23
PCT/US2015/021887 WO2015143409A1 (en) 2014-03-21 2015-03-20 Antagonist antibodies directed against calcitonin gene-related peptide and methods using same

Publications (2)

Publication Number Publication Date
AU2015230933A1 AU2015230933A1 (en) 2016-11-03
AU2015230933B2 true AU2015230933B2 (en) 2020-08-13

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AU2015230933A Active AU2015230933B2 (en) 2014-03-21 2015-03-20 Antagonist antibodies directed against calcitonin gene-related peptide and methods using same

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US (3) US9896502B2 (enExample)
EP (2) EP4324481A3 (enExample)
JP (5) JP6568099B2 (enExample)
KR (4) KR20200126018A (enExample)
CN (3) CN113244387A (enExample)
AU (1) AU2015230933B2 (enExample)
BR (1) BR112016021423A2 (enExample)
CA (1) CA2943551A1 (enExample)
CL (1) CL2016002375A1 (enExample)
DK (1) DK3119431T3 (enExample)
EA (1) EA201691787A1 (enExample)
ES (1) ES2974803T3 (enExample)
FI (1) FI3119431T3 (enExample)
HR (1) HRP20240159T1 (enExample)
HU (1) HUE065397T2 (enExample)
IL (2) IL247853B (enExample)
LT (1) LT3119431T (enExample)
MX (2) MX378344B (enExample)
PE (2) PE20161439A1 (enExample)
PL (1) PL3119431T3 (enExample)
PT (1) PT3119431T (enExample)
RS (1) RS65360B1 (enExample)
SI (1) SI3119431T1 (enExample)
SM (1) SMT202400131T1 (enExample)
UA (1) UA123759C2 (enExample)
WO (1) WO2015143409A1 (enExample)
ZA (1) ZA201606745B (enExample)

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US20100266638A1 (en) 2004-02-26 2010-10-21 Allergan, Inc. Headache treatment method
EP3045182B1 (en) 2005-11-14 2018-03-07 Teva Pharmaceuticals International GmbH Antagonist antibodies directed against calcitonin gene-related peptide for treating cluster headache
RU2522493C2 (ru) 2008-03-04 2014-07-20 Пфайзер Лимитед Способы лечения хронической боли
US20170114122A1 (en) 2015-10-23 2017-04-27 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
US10556945B2 (en) 2014-03-21 2020-02-11 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
FI3119431T3 (fi) 2014-03-21 2024-03-20 Teva Pharmaceuticals Int Gmbh Kalsitoniinigeeniin liittyvää peptidiä vastaan suunnattuja antagonisti-vasta-aineita ja menetelmiä niiden käyttämiseksi
JOP20200116A1 (ar) * 2015-04-24 2017-06-16 Amgen Inc طرق لعلاج أو الوقاية من الصداع النصفي
AR104847A1 (es) * 2015-06-17 2017-08-16 Lilly Co Eli Formulación de anticuerpo anti-cgrp
TW201725212A (zh) * 2015-12-10 2017-07-16 第一三共股份有限公司 特異性於降鈣素基因相關胜肽的新穎蛋白
KR20190066607A (ko) 2016-09-23 2019-06-13 테바 파마슈티컬스 인터내셔널 게엠베하 불응성 편두통의 치료
RU2770066C2 (ru) 2017-03-02 2022-04-14 Бет Изрейэл Диконисс Медикал Сентер, Инк. Отбор пациентов с головной болью, восприимчивых к антителам, направленным против кальцитонин ген-родственного пептида
AR114722A1 (es) 2018-04-02 2020-10-07 Amgen Inc Composiciones de erenumab y usos de las mismas
US10899826B1 (en) 2018-09-13 2021-01-26 Teva Pharmaceuticals International Gmbh Pharmaceutical compositions for an anti-CGRP antagonist antibody
MX2021008267A (es) 2019-01-08 2021-08-05 H Lundbeck As Tratamiento agudo y tratamiento rapido de la cefalea usando anticuerpos anti-cgrp.
EP3920904A4 (en) * 2019-02-08 2022-11-09 Schedule 1 Therapeutics, Inc. COMPOSITIONS CONTAINING CANNABINOIDS AND METHODS OF USE THEREOF
GEP20257803B (en) * 2019-05-02 2025-10-10 H Lundbeck As Treatment of headache using anti-cgrp antibodies
WO2020239014A1 (zh) * 2019-05-30 2020-12-03 山东博安生物技术有限公司 抗cgrp抗体及其应用
BR102020007149A8 (pt) * 2020-04-06 2023-09-26 H Lundbeck As Usos de um anticorpo anti-cgrp ou anti-cgrp-r ou um fragmento dos mesmos para melhorar o sintoma mais incômodo (mbs) e a impressão global de mudança (pgic) associados com enxaqueca
WO2021243284A1 (en) * 2020-05-29 2021-12-02 Amgen Inc. Antibody formulations and uses thereof

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