JP6568099B2 - カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法 - Google Patents

カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法 Download PDF

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JP6568099B2
JP6568099B2 JP2016558395A JP2016558395A JP6568099B2 JP 6568099 B2 JP6568099 B2 JP 6568099B2 JP 2016558395 A JP2016558395 A JP 2016558395A JP 2016558395 A JP2016558395 A JP 2016558395A JP 6568099 B2 JP6568099 B2 JP 6568099B2
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antibody
cgrp
headache
subject
antibodies
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JP2017510579A5 (enExample
JP2017510579A (ja
Inventor
マルセロ ビガル，
マルセロ ビガル，
サラ ウォルター，
サラ ウォルター，
ヘンリー スターン，
ヘンリー スターン，
マイケル チャン，
マイケル チャン，
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Teva Pharmaceuticals International GmbH
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Teva Pharmaceuticals International GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
JP2016558395A 2014-03-21 2015-03-20 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法 Active JP6568099B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019085486A JP6892891B2 (ja) 2014-03-21 2019-04-26 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461968897P 2014-03-21 2014-03-21
US61/968,897 2014-03-21
US201462083809P 2014-11-24 2014-11-24
US62/083,809 2014-11-24
US201562119778P 2015-02-23 2015-02-23
US62/119,778 2015-02-23
PCT/US2015/021887 WO2015143409A1 (en) 2014-03-21 2015-03-20 Antagonist antibodies directed against calcitonin gene-related peptide and methods using same

Related Child Applications (1)

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JP2019085486A Division JP6892891B2 (ja) 2014-03-21 2019-04-26 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法

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JP2017510579A JP2017510579A (ja) 2017-04-13
JP2017510579A5 JP2017510579A5 (enExample) 2018-05-31
JP6568099B2 true JP6568099B2 (ja) 2019-08-28

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JP2016558395A Active JP6568099B2 (ja) 2014-03-21 2015-03-20 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法
JP2019085486A Active JP6892891B2 (ja) 2014-03-21 2019-04-26 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法
JP2020185826A Pending JP2021014464A (ja) 2014-03-21 2020-11-06 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法
JP2021090623A Pending JP2021121637A (ja) 2014-03-21 2021-05-28 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法
JP2024014955A Pending JP2024040245A (ja) 2014-03-21 2024-02-02 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法

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JP2019085486A Active JP6892891B2 (ja) 2014-03-21 2019-04-26 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法
JP2020185826A Pending JP2021014464A (ja) 2014-03-21 2020-11-06 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法
JP2021090623A Pending JP2021121637A (ja) 2014-03-21 2021-05-28 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法
JP2024014955A Pending JP2024040245A (ja) 2014-03-21 2024-02-02 カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法

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US (3) US9896502B2 (enExample)
EP (2) EP3119431B1 (enExample)
JP (5) JP6568099B2 (enExample)
KR (4) KR20200126018A (enExample)
CN (3) CN111973740A (enExample)
AU (1) AU2015230933B2 (enExample)
BR (1) BR112016021423A2 (enExample)
CA (1) CA2943551A1 (enExample)
CL (1) CL2016002375A1 (enExample)
DK (1) DK3119431T3 (enExample)
EA (1) EA201691787A1 (enExample)
ES (1) ES2974803T3 (enExample)
FI (1) FI3119431T3 (enExample)
HR (1) HRP20240159T1 (enExample)
HU (1) HUE065397T2 (enExample)
IL (2) IL247853B (enExample)
LT (1) LT3119431T (enExample)
MX (2) MX378344B (enExample)
PE (2) PE20161439A1 (enExample)
PL (1) PL3119431T3 (enExample)
PT (1) PT3119431T (enExample)
RS (1) RS65360B1 (enExample)
SI (1) SI3119431T1 (enExample)
SM (1) SMT202400131T1 (enExample)
UA (1) UA123759C2 (enExample)
WO (1) WO2015143409A1 (enExample)
ZA (1) ZA201606745B (enExample)

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ES2433251T5 (es) 2005-11-14 2020-03-13 Teva Pharmaceuticals Int Gmbh Anticuerpos antagonistas dirigidos contra un péptido relacionado con el gen de la calcitonina y procedimientos que utilizan los mismos
WO2009109911A1 (en) 2008-03-04 2009-09-11 Pfizer Limited Methods of treating chronic pain
US20170114122A1 (en) 2015-10-23 2017-04-27 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
US10556945B2 (en) 2014-03-21 2020-02-11 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
MX378344B (es) 2014-03-21 2025-03-10 Teva Pharmaceuticals Int Gmbh Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos.
TWI728953B (zh) 2015-04-24 2021-06-01 美商安美基公司 治療或預防偏頭痛之方法
AR104847A1 (es) * 2015-06-17 2017-08-16 Lilly Co Eli Formulación de anticuerpo anti-cgrp
TW201725212A (zh) * 2015-12-10 2017-07-16 第一三共股份有限公司 特異性於降鈣素基因相關胜肽的新穎蛋白
AU2017331593B2 (en) 2016-09-23 2022-04-28 Teva Pharmaceuticals International Gmbh Treating refractory migraine
CN110621343A (zh) 2017-03-02 2019-12-27 贝丝以色列女执事医疗中心 选择对针对降钙素基因相关肽的抗体有反应的头痛患者
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US10899826B1 (en) 2018-09-13 2021-01-26 Teva Pharmaceuticals International Gmbh Pharmaceutical compositions for an anti-CGRP antagonist antibody
PE20211707A1 (es) * 2019-01-08 2021-09-01 H Lundbeck As Tratamiento agudo y tratamiento rapido de la cefalea usando anticuerpos anticgrp
US20220110887A1 (en) * 2019-02-08 2022-04-14 Schedule 1 Therapeutics, Inc. Compositions comprising cannabinoids and methods of use thereof
GEP20257803B (en) * 2019-05-02 2025-10-10 H Lundbeck As Treatment of headache using anti-cgrp antibodies
CN114127110B (zh) * 2019-05-30 2022-07-01 山东博安生物技术股份有限公司 抗cgrp抗体及其应用
KR20210124867A (ko) 2020-04-06 2021-10-15 하. 룬드벡 아크티에셀스카브 항-cgrp 항체를 사용하는 편두통 관련 성가심 증상 (mbs) 의 치료
KR20230019145A (ko) * 2020-05-29 2023-02-07 암젠 인크 항체 제형 및 이의 용도

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