|
US3547119A
(en)
|
1967-12-08 |
1970-12-15 |
Baxter Laboratories Inc |
Catheter assembly
|
|
US4360019A
(en)
|
1979-02-28 |
1982-11-23 |
Andros Incorporated |
Implantable infusion device
|
|
US4692147A
(en)
|
1980-04-02 |
1987-09-08 |
Medtronic, Inc. |
Drug administration device
|
|
US4311137A
(en)
|
1980-04-30 |
1982-01-19 |
Sherwood Medical Industries Inc. |
Infusion device
|
|
JPS57106673A
(en)
|
1980-12-24 |
1982-07-02 |
Chugai Pharmaceut Co Ltd |
Dibenzo(b,f)(1,4)oxazepin derivative
|
|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
US4531937A
(en)
|
1983-01-24 |
1985-07-30 |
Pacesetter Systems, Inc. |
Introducer catheter apparatus and method of use
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4725852A
(en)
|
1985-05-09 |
1988-02-16 |
Burlington Industries, Inc. |
Random artificially perturbed liquid apparatus and method
|
|
US4755173A
(en)
|
1986-02-25 |
1988-07-05 |
Pacesetter Infusion, Ltd. |
Soft cannula subcutaneous injection set
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US4843155A
(en)
|
1987-11-19 |
1989-06-27 |
Piotr Chomczynski |
Product and process for isolating RNA
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
JPH01167840A
(ja)
|
1987-12-24 |
1989-07-03 |
Konica Corp |
新規な写真用シアンカプラー
|
|
US5744101A
(en)
|
1989-06-07 |
1998-04-28 |
Affymax Technologies N.V. |
Photolabile nucleoside protecting groups
|
|
US5800992A
(en)
|
1989-06-07 |
1998-09-01 |
Fodor; Stephen P.A. |
Method of detecting nucleic acids
|
|
US6040138A
(en)
|
1995-09-15 |
2000-03-21 |
Affymetrix, Inc. |
Expression monitoring by hybridization to high density oligonucleotide arrays
|
|
US5143854A
(en)
|
1989-06-07 |
1992-09-01 |
Affymax Technologies N.V. |
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
|
|
ES2097925T3
(es)
|
1991-09-18 |
1997-04-16 |
Affymax Tech Nv |
Metodo para sintetizar diversas colecciones de oligomeros.
|
|
WO1993009668A1
(en)
|
1991-11-22 |
1993-05-27 |
Affymax Technology N.V. |
Combinatorial strategies for polymer synthesis
|
|
US5384261A
(en)
|
1991-11-22 |
1995-01-24 |
Affymax Technologies N.V. |
Very large scale immobilized polymer synthesis using mechanically directed flow paths
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
GB9226855D0
(en)
|
1992-12-23 |
1993-02-17 |
Erba Carlo Spa |
Vinylene-azaindole derivatives and process for their preparation
|
|
EP1090914B1
(en)
|
1992-12-29 |
2003-01-02 |
Abbott Laboratories |
Retroviral protease inhibiting compounds
|
|
US5545143A
(en)
|
1993-01-21 |
1996-08-13 |
T. S. I. Medical |
Device for subcutaneous medication delivery
|
|
US5702890A
(en)
|
1993-07-26 |
1997-12-30 |
K.O. Technology, Inc. |
Inhibitors of alternative alleles of genes as a basis for cancer therapeutic agents
|
|
US6326469B1
(en)
|
1994-04-22 |
2001-12-04 |
Sugen, Inc. |
Megakaryocytic protein tyrosine kinases
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US5556752A
(en)
|
1994-10-24 |
1996-09-17 |
Affymetrix, Inc. |
Surface-bound, unimolecular, double-stranded DNA
|
|
US5530012A
(en)
|
1994-12-22 |
1996-06-25 |
Bristol-Myers Squibb Co. |
3-alkoxybenzylpiperidine derivatives as melatonergic agents
|
|
US5643207A
(en)
|
1995-04-28 |
1997-07-01 |
Medtronic, Inc. |
Implantable techniques for infusing a therapeutic agent with endogenous bodily fluid
|
|
US5593997A
(en)
|
1995-05-23 |
1997-01-14 |
Pfizer Inc. |
4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
|
|
US5994348A
(en)
|
1995-06-07 |
1999-11-30 |
Sanofi |
Pharmaceutical compositions containing irbesartan
|
|
US5545531A
(en)
|
1995-06-07 |
1996-08-13 |
Affymax Technologies N.V. |
Methods for making a device for concurrently processing multiple biological chip assays
|
|
US6113898A
(en)
|
1995-06-07 |
2000-09-05 |
Idec Pharmaceuticals Corporation |
Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
|
|
US5856174A
(en)
|
1995-06-29 |
1999-01-05 |
Affymetrix, Inc. |
Integrated nucleic acid diagnostic device
|
|
US5854033A
(en)
|
1995-11-21 |
1998-12-29 |
Yale University |
Rolling circle replication reporter systems
|
|
EP1240899A3
(en)
|
1996-01-23 |
2004-05-19 |
Ribapharm, Inc. |
Modulation of Th1/Th2 Cytokine expression by Ribavirin and Ribavirin analogs in actived T-Lymphocytes for treating HCV infections
|
|
EP0880598A4
(en)
|
1996-01-23 |
2005-02-23 |
Affymetrix Inc |
RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
|
|
CH690773A5
(de)
|
1996-02-01 |
2001-01-15 |
Novartis Ag |
Pyrrolo(2,3-d)pyrimide und ihre Verwendung.
|
|
US6054472A
(en)
|
1996-04-23 |
2000-04-25 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of IMPDH enzyme
|
|
US5807876A
(en)
|
1996-04-23 |
1998-09-15 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
|
WO1997040028A1
(en)
|
1996-04-23 |
1997-10-30 |
Vertex Pharmaceuticals Incorporated |
Urea derivatives as inhibitors of impdh enzyme
|
|
US5820589A
(en)
|
1996-04-30 |
1998-10-13 |
Medtronic, Inc. |
Implantable non-invasive rate-adjustable pump
|
|
WO1997049706A1
(en)
|
1996-06-25 |
1997-12-31 |
Novartis Ag |
SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF
|
|
EP1302474A1
(en)
|
1996-10-16 |
2003-04-16 |
Ribapharm, Inc. |
Monocyclic L-nucleosides, analogs and uses thereof
|
|
EP0851513B1
(en)
|
1996-12-27 |
2007-11-21 |
Canon Kabushiki Kaisha |
Method of producing semiconductor member and method of producing solar cell
|
|
US6756289B1
(en)
|
1996-12-27 |
2004-06-29 |
Canon Kabushiki Kaisha |
Method of producing semiconductor member and method of producing solar cell
|
|
CA2282398A1
(en)
|
1997-03-14 |
1998-09-17 |
Steven M. Ronkin |
Inhibitors of impdh enzyme
|
|
JP2001516353A
(ja)
|
1997-03-19 |
2001-09-25 |
ビーエーエスエフ アクチェンゲゼルシャフト |
ピロロ[2,3d]ピリミジンおよびチロシンキナーゼ阻害剤としてのこれらの使用
|
|
WO1999023254A1
(en)
|
1997-10-31 |
1999-05-14 |
Affymetrix, Inc. |
Expression profiles in adult and fetal organs
|
|
GB2332325A
(en)
|
1997-12-10 |
1999-06-16 |
Snell & Wilcox Ltd |
Video signal spatial interpolation for de-interlacing processing
|
|
US7390619B1
(en)
|
1998-02-11 |
2008-06-24 |
Maxygen, Inc. |
Optimization of immunomodulatory properties of genetic vaccines
|
|
US6200754B1
(en)
|
1998-03-19 |
2001-03-13 |
Variagenics, Inc. |
Inhibitors of alternative alleles of genes encoding products that mediate cell response to environmental changes
|
|
US6020135A
(en)
|
1998-03-27 |
2000-02-01 |
Affymetrix, Inc. |
P53-regulated genes
|
|
ATE269295T1
(de)
|
1998-04-17 |
2004-07-15 |
Parker Hughes Inst |
Btk inhibitoren und verfahren zur identifizierung und verwendung
|
|
US6303652B1
(en)
|
1998-08-21 |
2001-10-16 |
Hughes Institute |
BTK inhibitors and methods for their identification and use
|
|
SE9801799D0
(sv)
|
1998-05-20 |
1998-05-20 |
Sten Eric Lindquist |
Färgämnessensiterad nanostrukturerad fotovoltaisk tandemcell
|
|
DE69942453D1
(de)
|
1998-05-29 |
2010-07-15 |
Jgc Catalysts & Chemicals Ltd |
Verfahren zur herstellung photoelektrischer zellen
|
|
US6335155B1
(en)
|
1998-06-26 |
2002-01-01 |
Sunesis Pharmaceuticals, Inc. |
Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
|
|
US6998233B2
(en)
|
1998-06-26 |
2006-02-14 |
Sunesis Pharmaceuticals, Inc. |
Methods for ligand discovery
|
|
US20050287596A9
(en)
|
1998-06-26 |
2005-12-29 |
Braisted Andrew C |
Novel ligands and libraries of ligands
|
|
US7087236B1
(en)
|
1998-09-01 |
2006-08-08 |
Merrion Research I Limited |
Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
|
|
CA2345722A1
(en)
|
1998-09-28 |
2000-04-06 |
Albert Edge |
Determining resistance to treatment for hepatitis c virus
|
|
US6824768B2
(en)
|
1998-12-18 |
2004-11-30 |
Schering Corporation |
Ribavirin-pegylated interferon alfa induction HCV combination therapy
|
|
US6198966B1
(en)
|
1999-02-26 |
2001-03-06 |
Medtronic, Inc. |
Recirculating implantable drug delivery system
|
|
WO2000056331A1
(en)
|
1999-03-19 |
2000-09-28 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of impdh enzyme
|
|
US6306897B1
(en)
|
1999-03-19 |
2001-10-23 |
Parker Hughes Institute |
Calanolides for inhibiting BTK
|
|
AU4463300A
(en)
|
1999-04-19 |
2000-11-02 |
Schering Corporation |
Hcv combination therapy, containing ribavirin in association with antioxidants
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
DE60004685T2
(de)
|
1999-09-17 |
2004-07-29 |
Abbott Gmbh & Co. Kg |
Pyrazolopyrimidine als arzneimittel
|
|
EP1222187B1
(en)
|
1999-10-06 |
2004-09-22 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Heterocyclic compounds useful as inhibitors of tyrosine kinases
|
|
US6506769B2
(en)
|
1999-10-06 |
2003-01-14 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Heterocyclic compounds useful as inhibitors of tyrosine kinases
|
|
WO2001029058A1
(en)
|
1999-10-15 |
2001-04-26 |
University Of Massachusetts |
Rna interference pathway genes as tools for targeted genetic interference
|
|
WO2001032210A2
(en)
|
1999-10-29 |
2001-05-10 |
Pharmacyclics, Inc. |
Compositions for treating atheroma and neoplastic tissue
|
|
CA2390857A1
(en)
|
1999-11-30 |
2001-06-14 |
Fatih M. Uckun |
Inhibitors of collagen-induced platelet aggregation
|
|
CA2394650A1
(en)
|
1999-12-17 |
2001-06-21 |
Chi B. Vu |
Novel heterocycles
|
|
US6602767B2
(en)
|
2000-01-27 |
2003-08-05 |
Canon Kabushiki Kaisha |
Method for transferring porous layer, method for making semiconductor devices, and method for making solar battery
|
|
US7835970B1
(en)
|
2000-02-02 |
2010-11-16 |
Cmvt, Llc |
Method and system for automated auction and tender of complex multi-variable commodities
|
|
GB0005345D0
(en)
|
2000-03-06 |
2000-04-26 |
Mathilda & Terence Kennedy Ins |
Methods of treating sepsis septic shock and inflammation
|
|
JP2003525907A
(ja)
|
2000-03-09 |
2003-09-02 |
シェーリング コーポレイション |
Hiv免疫アジュバント治療
|
|
WO2001077384A2
(de)
|
2000-04-07 |
2001-10-18 |
Epigenomics Ag |
DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN
|
|
CN1152778C
(zh)
|
2000-05-19 |
2004-06-09 |
Tdk株式会社 |
具有功能性层的功能性薄膜及带有该功能性层的物体
|
|
JP2004518615A
(ja)
|
2000-08-09 |
2004-06-24 |
ザ・リージェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア |
癌の処置に有用なインドール化合物
|
|
CN1516599A
(zh)
|
2000-10-18 |
2004-07-28 |
���鹫˾ |
病毒唑-聚乙二醇化干扰素α联合治疗慢性传染性丙型肝炎的方法
|
|
US20030040461A1
(en)
|
2000-10-23 |
2003-02-27 |
Mcatee C. Patrick |
Modulators of Bruton'sTyrosine Kinase and Bruton's Tyrosine Kinase intermediates and methods for their identification and use in the treatment and prevention of osteoporosis and related diseases states
|
|
US20020094545A1
(en)
|
2000-11-30 |
2002-07-18 |
Harris Paul E. |
Growth of human dendritic cells for cancer immunotherapy in closed system using microcarrier beads
|
|
AU2002232492A1
(en)
|
2000-12-06 |
2002-06-18 |
Pharmacia Corporation |
Rapidly dispersing pharmaceutical composition comprising effervescent agents
|
|
DK1355919T3
(da)
|
2000-12-12 |
2011-03-14 |
Medimmune Llc |
Molekyler med længere halveringstider, sammensætninger og anvendelser deraf
|
|
MXPA03008560A
(es)
|
2001-03-22 |
2004-06-30 |
Abbot Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos.
|
|
AR036993A1
(es)
|
2001-04-02 |
2004-10-20 |
Wyeth Corp |
Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
|
|
US8306897B2
(en)
|
2001-05-04 |
2012-11-06 |
Stockshield, Inc. |
Method and system for insuring against investment loss
|
|
US20030103938A1
(en)
|
2001-05-09 |
2003-06-05 |
Alk-Abello A/S |
Pharmaceutical compositions for preventing or treating Th1 and Th2 cell related diseases by modulating the Th1/Th2 ratio
|
|
US20030114467A1
(en)
|
2001-06-21 |
2003-06-19 |
Shakespeare William C. |
Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof
|
|
GB0116249D0
(en)
|
2001-07-05 |
2001-08-29 |
Imp College Innovations Ltd |
Methods
|
|
EP1418917A1
(en)
|
2001-08-10 |
2004-05-19 |
Novartis AG |
Use of c-src inhibitors alone or in combination with sti571 for the treatment of leukaemia
|
|
US20030119060A1
(en)
|
2001-08-10 |
2003-06-26 |
Desrosiers Peter J. |
Apparatuses and methods for creating and testing pre-formulations and systems for same
|
|
WO2003016338A1
(en)
|
2001-08-15 |
2003-02-27 |
Parker Hughes Institute |
Crystal structure of the btk kinase domain
|
|
US7622260B2
(en)
|
2001-09-05 |
2009-11-24 |
The Brigham And Women's Hospital, Inc. |
Diagnostic and prognostic tests
|
|
NZ532579A
(en)
|
2001-11-21 |
2006-11-30 |
Sunesis Pharmaceuticals Inc |
Methods for ligand discovery based on tethering process
|
|
US20030175761A1
(en)
|
2001-12-07 |
2003-09-18 |
Sabath Daniel E. |
Identification of genes whose expression patterns distinguish benign lymphoid tissue and mantle cell, follicular, and small lymphocytic lymphoma
|
|
WO2003081210A2
(en)
|
2002-03-21 |
2003-10-02 |
Sunesis Pharmaceuticals, Inc. |
Identification of kinase inhibitors
|
|
US20050084905A1
(en)
|
2002-03-21 |
2005-04-21 |
Prescott John C. |
Identification of kinase inhibitors
|
|
CA2478395A1
(en)
|
2002-04-08 |
2003-10-23 |
Sunesis Pharmaceuticals, Inc. |
Methods for identifying allosteric sites
|
|
JP3764402B2
(ja)
|
2002-05-02 |
2006-04-05 |
パイロットインキ株式会社 |
移動玩具セット
|
|
GB2388594A
(en)
|
2002-05-16 |
2003-11-19 |
Bayer Ag |
Imidazo-triazine PDE 4 inhibitors
|
|
EP1553982A4
(en)
|
2002-07-15 |
2008-03-26 |
Wyeth Corp |
METHOD AND COMPOSITIONS FOR MODULATING THE DEVELOPMENT AND FUNCTION OF T-HELPER CELLS (T sb H / sb)
|
|
WO2004014905A1
(en)
|
2002-08-08 |
2004-02-19 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Substituted benzimidazole compounds
|
|
EP2572714A1
(en)
|
2002-12-30 |
2013-03-27 |
3M Innovative Properties Company |
Immunostimulatory Combinations
|
|
GB0303910D0
(en)
|
2003-02-20 |
2003-03-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
EP1463073A1
(en)
|
2003-03-24 |
2004-09-29 |
Sony International (Europe) GmbH |
Porous film having a gradient of light scattering strength
|
|
US7687506B2
(en)
|
2003-04-11 |
2010-03-30 |
The Regents Of The University Of California |
Selective serine/threonine kinase inhibitors
|
|
WO2004100868A2
(en)
|
2003-04-23 |
2004-11-25 |
Abbott Laboratories |
Method of treating transplant rejection
|
|
EP1473039A1
(en)
|
2003-05-02 |
2004-11-03 |
Centre National De La Recherche Scientifique (Cnrs) |
Use of inhibitors and antisense oligonucleotides of BTK for the treatment of proliferative mastocytosis
|
|
WO2004110245A2
(en)
|
2003-05-16 |
2004-12-23 |
Intermune, Inc. |
Combination therapy for cancer treatment
|
|
WO2005014599A1
(en)
|
2003-06-04 |
2005-02-17 |
Cellular Genomics, Inc. |
Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds
|
|
WO2005005429A1
(en)
|
2003-06-30 |
2005-01-20 |
Cellular Genomics, Inc. |
Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
|
|
US8131475B2
(en)
|
2003-09-03 |
2012-03-06 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Methods for identifying, diagnosing, and predicting survival of lymphomas
|
|
JP2005089352A
(ja)
|
2003-09-16 |
2005-04-07 |
Kissei Pharmaceut Co Ltd |
新規なイミダゾ[1,5−a]ピラジン誘導体、それを含有する医薬組成物およびそれらの用途
|
|
CA2539702A1
(en)
|
2003-09-30 |
2005-04-07 |
Telethon Institute For Child Health Research |
Immunotherapy method
|
|
CN1897950A
(zh)
|
2003-10-14 |
2007-01-17 |
惠氏公司 |
稠合芳基和杂芳基衍生物及其使用方法
|
|
BRPI0415395A
(pt)
|
2003-10-15 |
2006-12-12 |
Osi Pharm Inc |
composto, métodos para inibir a atividade da proteìna quinase e para tratar um paciente que tenha uma condição que seja mediada pela atividade da proteìna quinase, e, composição
|
|
WO2005047290A2
(en)
|
2003-11-11 |
2005-05-26 |
Cellular Genomics Inc. |
Imidazo[1,2-a] pyrazin-8-ylamines as kinase inhibitors
|
|
WO2005060956A1
(en)
|
2003-12-12 |
2005-07-07 |
University Of Maryland, Baltimore |
IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE pY+3 BINDING SITE OF TYROSENE KINASE p56 LCK SH2 DOMAIN
|
|
BRPI0418031A
(pt)
|
2003-12-22 |
2007-04-17 |
Gilead Sciences Inc |
inibidores de quinase fosfonato-substituìdos
|
|
US20050153990A1
(en)
|
2003-12-22 |
2005-07-14 |
Watkins William J. |
Phosphonate substituted kinase inhibitors
|
|
ES2298861T3
(es)
|
2004-01-08 |
2008-05-16 |
Wyeth |
Composicion farmaceutica que puede obtenerse mediante compresion directa para la administracion oral de cci-779.
|
|
KR101164541B1
(ko)
|
2004-01-12 |
2012-07-10 |
와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 |
선택적 키나제 저해제
|
|
EP1716151A1
(en)
|
2004-01-26 |
2006-11-02 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of protein kinases
|
|
EP1730148A4
(en)
|
2004-02-03 |
2009-08-19 |
Abbott Lab |
USE OF AMINOBENZOXAZOLES AS THERAPEUTIC AGENTS
|
|
EP2027853A3
(en)
|
2004-06-18 |
2011-01-05 |
Agennix USA Inc. |
Kinase inhibitors for treating cancers
|
|
ITMI20041314A1
(it)
|
2004-06-30 |
2004-09-30 |
Nuvera Fuel Cells Europ Srl |
Dispositivo di raffreddamento per celle a combustibili a membrana
|
|
AR053090A1
(es)
|
2004-07-20 |
2007-04-25 |
Osi Pharm Inc |
Imidazotriazinas como inhibidores de proteina quinasas y su uso para la preparacion de medicamentos
|
|
AU2005289728B2
(en)
|
2004-09-22 |
2011-11-24 |
Tripath Imaging, Inc. |
Methods and compositions for evaluating breast cancer prognosis
|
|
JP2008514635A
(ja)
|
2004-09-27 |
2008-05-08 |
コーザン バイオサイエンシス インコーポレイテッド |
特異的キナーゼ阻害剤
|
|
EP1802602A1
(en)
|
2004-09-28 |
2007-07-04 |
Janssen Pharmaceutica N.V. |
Substituted dipiperdine ccr2 antagonists
|
|
MX2007003533A
(es)
|
2004-10-01 |
2007-05-23 |
Medarex Inc |
Metodos de tratar linfomas cd30 positivas.
|
|
SG159549A1
(en)
|
2004-11-10 |
2010-03-30 |
Cgi Pharmaceuticals Inc |
Imidazo[1,2-a] pyrazin-8-ylamines useful as modulators of kinase activity
|
|
GB0425035D0
(en)
|
2004-11-12 |
2004-12-15 |
Novartis Ag |
Organic compounds
|
|
RU2423351C2
(ru)
|
2004-12-16 |
2011-07-10 |
Вертекс Фармасьютикалз Инкорпорейтед |
Пирид-2-оны, применимые как ингибиторы протеинкиназ семейства тес для лечения воспалительных, пролиферативных и иммунологически-опосредованных заболеваний
|
|
KR100735639B1
(ko)
|
2004-12-29 |
2007-07-04 |
한미약품 주식회사 |
암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법
|
|
DK1848414T3
(da)
|
2005-02-03 |
2011-07-25 |
Gen Hospital Corp |
Fremgangsmåde til behandling af gefitinib-resistent cancer
|
|
BRPI0608252A2
(pt)
|
2005-03-10 |
2010-04-06 |
Cgi Pharmaceuticals Inc |
entidades quìmicas, composições farmacêuticas compreendendo as mesmas, métodos utilizando as referidas entidades quìmicas e uso das referidas entidades quìmicas
|
|
WO2006101692A1
(en)
|
2005-03-23 |
2006-09-28 |
Pfizer Products Inc. |
Anti-ctla4 antibody and indolinone combination therapy for treatment of cancer
|
|
EP1891066B1
(en)
|
2005-05-13 |
2010-12-22 |
Irm, Llc |
Compounds and compositions as protein kinase inhibitors
|
|
NZ563444A
(en)
|
2005-05-17 |
2011-04-29 |
Plexxikon Inc |
Pyrrolo(2,3-b)pyridine derivatives as protein kinase inhibitors
|
|
UA95244C2
(ru)
|
2005-06-22 |
2011-07-25 |
Плексикон, Инк. |
Соединения и способ модулирования активности киназ, и показания для их применения
|
|
KR101607288B1
(ko)
|
2005-07-01 |
2016-04-05 |
이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
|
|
JP2009507792A
(ja)
|
2005-08-29 |
2009-02-26 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
非受容体型チロシンキナーゼのtecファミリーの阻害剤として有用な3,5−二置換ピリド−2−オン
|
|
US20070065449A1
(en)
|
2005-09-16 |
2007-03-22 |
Claire Verschraegen |
Method of treating cancer, especially soft tissue sarcoma utilizing gemcitabine in combination with docetaxel and anti-VEGF therapy (bevacizumab)
|
|
PT1951300E
(pt)
|
2005-11-04 |
2011-09-05 |
Novartis Vaccines & Diagnostic |
Modificação do equilíbrio de th1/th2 em vacinas da influenza fragmentadas com adjuvantes
|
|
CA2629314A1
(en)
|
2005-11-12 |
2007-05-24 |
Boehringer Ingelheim International Gmbh |
Tec kinase inhibitors
|
|
WO2007059329A2
(en)
|
2005-11-16 |
2007-05-24 |
Pharmacyclics, Inc. |
Methods and compositions for treating cancer
|
|
CN101421269A
(zh)
|
2006-01-13 |
2009-04-29 |
环状药物公司 |
酪氨酸激酶抑制剂及其用途
|
|
US20090317836A1
(en)
|
2006-01-30 |
2009-12-24 |
The Scripps Research Institute |
Methods for Detection of Circulating Tumor Cells and Methods of Diagnosis of Cancer in Mammalian Subject
|
|
US7908091B2
(en)
|
2006-03-17 |
2011-03-15 |
Prometheus Laboratories Inc. |
Methods of predicting and monitoring tyrosine kinase inhibitor therapy
|
|
GB0605521D0
(en)
|
2006-03-18 |
2006-04-26 |
Isis Innovation |
Adjuvant
|
|
AU2007347115A1
(en)
|
2006-04-04 |
2008-10-23 |
The Regents Of The University Of California |
PI3 kinase antagonists
|
|
EP2591775A1
(en)
|
2006-04-05 |
2013-05-15 |
Novartis AG |
Combinations comprising mtor inhibitors for treating cancer
|
|
MX2008012903A
(es)
|
2006-04-07 |
2008-10-13 |
Novartis Ag |
Uso de inhibidores de c-src en combinacion con un compuesto de pirimidilaminobenzamida para el tratamiento de la leucemia.
|
|
US8604031B2
(en)
|
2006-05-18 |
2013-12-10 |
Mannkind Corporation |
Intracellular kinase inhibitors
|
|
CA2666814A1
(en)
|
2006-08-21 |
2008-05-29 |
United Therapeutics Corporation |
Combination therapy for treatment of viral infections
|
|
PE20081370A1
(es)
|
2006-09-11 |
2008-11-28 |
Cgi Pharmaceuticals Inc |
Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas
|
|
AR063946A1
(es)
|
2006-09-11 |
2009-03-04 |
Cgi Pharmaceuticals Inc |
Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
|
|
JP2010502751A
(ja)
|
2006-09-11 |
2010-01-28 |
シージーアイ ファーマシューティカルズ,インコーポレイティド |
キナーゼ阻害物質、およびキナーゼ阻害物質の使用および同定方法
|
|
PT2201840E
(pt)
|
2006-09-22 |
2012-02-14 |
Pharmacyclics Inc |
Inibidores da tirosina quinase de bruton
|
|
EP2083852B1
(en)
|
2006-10-04 |
2014-12-10 |
Dana-Farber Cancer Institute, Inc. |
Tumor immunity
|
|
NZ589053A
(en)
|
2006-10-27 |
2012-03-30 |
Signal Pharm Llc |
Process of preparing 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol compounds
|
|
AU2007328427A1
(en)
|
2006-11-06 |
2008-06-12 |
Source Precision Medicine, Inc. |
Gene expression profiling for identification, monitoring and treatment of melanoma
|
|
EP2626067A1
(en)
|
2006-12-26 |
2013-08-14 |
Pharmacyclics, Inc. |
Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
|
|
AU2008210266B2
(en)
|
2007-01-31 |
2013-09-05 |
Ym Biosciences Australia Pty Ltd |
Thiopyrimidine-based compounds and uses thereof
|
|
EP2491923A3
(en)
|
2007-02-15 |
2012-12-26 |
Novartis AG |
Combinations of therapeutic agents for treating cancer
|
|
NL2000640C2
(nl)
|
2007-03-05 |
2008-09-08 |
Stichting Wetsus Ct Of Excelle |
Werkwijze en systeem voor het zuiveren van een vloeistof.
|
|
WO2008110624A2
(en)
|
2007-03-14 |
2008-09-18 |
Universita' Degli Studi Di Milano-Bicocca |
Sirna-mediated silencing of genes for treating chemotherapeutic drug-resistant epithelial tumors
|
|
EA017865B1
(ru)
|
2007-03-28 |
2013-03-29 |
Фармасайкликс, Инк. |
Ингибиторы тирозинкиназы брутона
|
|
US8809273B2
(en)
|
2007-03-28 |
2014-08-19 |
Pharmacyclics, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
|
US20120065201A1
(en)
|
2007-03-28 |
2012-03-15 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
ES2808569T3
(es)
|
2007-04-05 |
2021-03-01 |
Fund D Anna Sommer Champalimaud E Dr Carlos Montez Champalimaud |
Sistema y método para manejar, diagnosticar y predecir la aparición de una afección médica
|
|
US20090010911A1
(en)
|
2007-04-06 |
2009-01-08 |
Iowa State University Research Foundation, Inc. |
Methods and compositions for affecting cyclophilin a regulation of kinases in modulating cellular activities
|
|
WO2008127659A2
(en)
|
2007-04-13 |
2008-10-23 |
University Of Texas Southwestern Medical Center |
Combination therapy for cancer
|
|
UY31050A1
(es)
|
2007-04-27 |
2008-07-03 |
Shionogi & Co |
Antagonistas de trpv1 y usos de los mismos
|
|
WO2008138578A2
(en)
|
2007-05-11 |
2008-11-20 |
Medical Prognosis Institute |
Methods, kits, and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
|
|
ES2547229T3
(es)
|
2007-08-07 |
2015-10-02 |
Purdue Research Foundation |
Inhibidores de cinasa y usos de los mismos
|
|
JP5376780B2
(ja)
|
2007-08-08 |
2013-12-25 |
株式会社東芝 |
圧電モータおよびカメラ装置
|
|
WO2009048307A2
(en)
|
2007-10-12 |
2009-04-16 |
Electronics And Telecommunications Research Institute |
Mobile rfid reader and rfid communication method using shared system clock
|
|
US7989465B2
(en)
|
2007-10-19 |
2011-08-02 |
Avila Therapeutics, Inc. |
4,6-disubstituted pyrimidines useful as kinase inhibitors
|
|
CA2702674C
(en)
|
2007-10-19 |
2016-05-03 |
Avila Therapeutics, Inc. |
Heteroaryl compounds and uses thereof
|
|
CA2701275C
(en)
|
2007-10-23 |
2016-06-21 |
F. Hoffmann-La Roche Ag |
Kinase inhibitors
|
|
AU2008321016B2
(en)
|
2007-11-12 |
2013-03-28 |
Theraclone Sciences, Inc. |
Compositions and methods for the therapy and diagnosis of influenza
|
|
US8426441B2
(en)
|
2007-12-14 |
2013-04-23 |
Roche Palo Alto Llc |
Inhibitors of bruton's tyrosine kinase
|
|
US20150152115A1
(en)
|
2007-12-27 |
2015-06-04 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
CN101475632B
(zh)
|
2008-01-03 |
2012-01-04 |
张喜田 |
具有抗肿瘤作用的重组灵芝免疫调节蛋白及其药物制剂
|
|
WO2009089399A2
(en)
|
2008-01-10 |
2009-07-16 |
Bausch & Lomb Incorporated |
Compositions comprising toll-like receptor or coreceptor antagonists and methods for ocular neuroprotection
|
|
MX2010009647A
(es)
|
2008-03-25 |
2010-09-28 |
Roche Glycart Ag |
Uso de un anticuerpo anti-cd20 de tipo ii con citotoxicidad celular dependiente del anticuerpo aumentada en combinacion con ciclofosfamida, vincristina y doxorubicina para el tratamiento de linfoma no hodgkiniano.
|
|
GB0805356D0
(en)
|
2008-03-25 |
2008-04-30 |
Isis Innovation |
Vaccine adjuvant composition
|
|
AU2009244291B2
(en)
|
2008-05-06 |
2014-02-13 |
Genentech, Inc. |
Substituted amides, method of making, and use as Btk inhibitors
|
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
|
CN105363034A
(zh)
|
2008-05-23 |
2016-03-02 |
香港大学 |
治疗流感的联合疗法
|
|
EP2318031A4
(en)
|
2008-06-03 |
2012-09-12 |
Aethlon Medical Inc |
IMPROVED METHODS AND DEVICES FOR ANTIVIRAL THERAPY
|
|
JP5502077B2
(ja)
|
2008-06-05 |
2014-05-28 |
グラクソ グループ リミテッド |
新規な化合物
|
|
CN103709148B
(zh)
|
2008-06-24 |
2015-10-21 |
霍夫曼-拉罗奇有限公司 |
取代的吡啶-2-酮和哒嗪-3-酮
|
|
TWI458721B
(zh)
|
2008-06-27 |
2014-11-01 |
Celgene Avilomics Res Inc |
雜芳基化合物及其用途
|
|
AU2009270856B2
(en)
|
2008-07-16 |
2013-07-25 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
|
|
ES2620442T3
(es)
|
2008-07-29 |
2017-06-28 |
Frontier Scientific, Inc. |
Uso de derivados de tetraquis(N-alquilpiridinio)-porfirina para la destrucción de microbios o la prevención de su crecimiento
|
|
CN102405284B
(zh)
|
2008-09-05 |
2016-01-20 |
新基阿维罗米克斯研究公司 |
设计不可逆抑制剂的算法
|
|
WO2010034670A2
(en)
|
2008-09-26 |
2010-04-01 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Host cell kinases as targets for antiviral therapies against hcv infection
|
|
WO2010056875A1
(en)
|
2008-11-12 |
2010-05-20 |
Cgi Pharmaceuticals, Inc. |
Pyridazinones and their use as btk inhibitors
|
|
ES2674719T3
(es)
|
2008-11-13 |
2018-07-03 |
Gilead Calistoga Llc |
Terapias para neoplasias hematológicas
|
|
US20100160322A1
(en)
|
2008-12-04 |
2010-06-24 |
Abbott Laboratories |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
UA108193C2
(uk)
|
2008-12-04 |
2015-04-10 |
|
Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
|
|
US8426428B2
(en)
|
2008-12-05 |
2013-04-23 |
Principia Biopharma, Inc. |
EGFR kinase knockdown via electrophilically enhanced inhibitors
|
|
TW201639852A
(zh)
|
2008-12-09 |
2016-11-16 |
吉李德科學股份有限公司 |
用於製備可用作類鐸受體調節劑之化合物的中間體化合物
|
|
TWI729512B
(zh)
|
2008-12-09 |
2021-06-01 |
美商建南德克公司 |
抗pd-l1抗體及其於增進t細胞功能之用途
|
|
WO2010068806A1
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer
|
|
WO2010068788A1
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Heterocyclic amides as btk inhibitors
|
|
WO2010068810A2
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Certain substituted amides, method of making, and method of use thereof
|
|
EP2376081A2
(en)
|
2008-12-15 |
2011-10-19 |
Eli Lilly and Company |
Enzastaurin for the treatment of cancer
|
|
EP2379745A1
(en)
|
2008-12-18 |
2011-10-26 |
F. Hoffmann-La Roche AG |
Biomarkers for hcv treatment response
|
|
SG171815A1
(en)
|
2008-12-19 |
2011-07-28 |
Bristol Myers Squibb Co |
Carbazole carboxamide compounds useful as kinase inhibitors
|
|
WO2010093843A2
(en)
|
2009-02-12 |
2010-08-19 |
Vertex Pharmaceuticals Incorporated |
Hcv combination therapies
|
|
US8299077B2
(en)
|
2009-03-02 |
2012-10-30 |
Roche Palo Alto Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
SG175289A1
(en)
|
2009-04-20 |
2011-11-28 |
Genentech Inc |
Adjuvant cancer therapy
|
|
EP2424368B1
(en)
|
2009-04-29 |
2014-12-31 |
Locus Pharmaceuticals, Inc. |
Pyrrolotriazine compounds
|
|
BR122019016429B1
(pt)
|
2009-05-26 |
2020-03-24 |
Abbvie Ireland Unlimited Company |
Compostos inibidores da atividade de proteínas bcl-2 antiapoptótica e composição farmacêutica compreendendo ditos compostos
|
|
ES2444777T3
(es)
|
2009-06-12 |
2014-02-26 |
Bristol-Myers Squibb Company |
Compuestos de nicotinamida útiles como moduladores de quinasas
|
|
LU91583B1
(en)
|
2009-07-03 |
2011-01-04 |
Wurth Paul Sa |
Sealing valve arrangement for a shaft furnace charging installation
|
|
PL2473049T3
(pl)
|
2009-09-04 |
2019-07-31 |
Biogen Ma Inc. |
Inhibitory kinazy tyrozynowej brutona
|
|
EP2478361A4
(en)
|
2009-09-16 |
2014-05-21 |
Celgene Avilomics Res Inc |
CONJUGATES AND INHIBITORS OF PROTEIN KINASE
|
|
GB2474748B
(en)
|
2009-10-01 |
2011-10-12 |
Amira Pharmaceuticals Inc |
Polycyclic compounds as lysophosphatidic acid receptor antagonists
|
|
US7741330B1
(en)
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
|
UA109417C2
(uk)
|
2009-10-14 |
2015-08-25 |
Мерк Шарп Енд Доме Корп. |
ЗАМІЩЕНІ ПІПЕРИДИНИ, ЯКІ ПІДВИЩУЮТЬ АКТИВНІСТЬ p53, І ЇХ ЗАСТОСУВАННЯ
|
|
US8299070B2
(en)
|
2009-11-25 |
2012-10-30 |
Japan Tobacco Inc. |
Indole compounds and pharmaceutical use thereof
|
|
US8575177B2
(en)
|
2009-12-04 |
2013-11-05 |
Senhwa Biosciences, Inc. |
Pyrazolopyrimidines and related heterocycles as CK2 inhibitors
|
|
WO2011133609A2
(en)
*
|
2010-04-19 |
2011-10-27 |
The Translational Genomics Research Institute |
Methods and kits to predict therapeutic outcome of btk inhibitors
|
|
ES2573716T3
(es)
|
2010-05-07 |
2016-06-09 |
Gilead Connecticut, Inc. |
Compuestos de piridona y aza-piridona y métodos de utilización
|
|
CN107674073B
(zh)
|
2010-05-17 |
2021-09-10 |
印蔻真治疗公司 |
作为蛋白激酶调节剂的3,5-二取代-3h-咪唑(或[1,2,3]三唑)并[4,5-b] 吡啶化合物
|
|
CA2799944A1
(en)
|
2010-05-20 |
2011-11-24 |
University Of Rochester |
Methods and compositions related to modulating autophagy
|
|
MY169745A
(en)
|
2010-05-31 |
2019-05-14 |
Ono Pharmaceutical Co |
Purinone derivative
|
|
EA201890869A3
(ru)
|
2010-06-03 |
2019-03-29 |
Фармасайкликс, Инк. |
Применение ингибиторов тирозинкиназы брутона (btk)
|
|
US20120071497A1
(en)
|
2010-06-03 |
2012-03-22 |
Pharmacyclics, Inc. |
Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase
|
|
LT2585470T
(lt)
|
2010-06-23 |
2017-04-10 |
Hanmi Science Co., Ltd. |
Nauji kondensuoti pirimidino dariniai tirozino kinazės aktyvumo slopinimui
|
|
WO2011160206A1
(en)
|
2010-06-23 |
2011-12-29 |
Morin Ryan D |
Biomarkers for non-hodgkin lymphomas and uses thereof
|
|
GB2481611A
(en)
|
2010-06-30 |
2012-01-04 |
Statoil Asa |
Test cell for well fluid assessment
|
|
RU2013109393A
(ru)
|
2010-08-10 |
2014-09-20 |
Сэлджин Авиаломикс Ресеарч, Инк. |
Безилатная соль ингибитора втк
|
|
AR082590A1
(es)
|
2010-08-12 |
2012-12-19 |
Hoffmann La Roche |
Inhibidores de la tirosina-quinasa de bruton
|
|
EA201300282A1
(ru)
|
2010-08-27 |
2013-08-30 |
Мерк Патент Гмбх |
Производные триазолопиразина
|
|
CN103189369B
(zh)
|
2010-09-01 |
2016-08-24 |
吉利德康涅狄格有限公司 |
吡啶酮/吡嗪酮、其制备方法及使用方法
|
|
EP2611798B1
(en)
|
2010-09-01 |
2015-04-08 |
Gilead Connecticut, Inc. |
Pyridazinones, method of making, and method of use thereof
|
|
NZ708508A
(en)
|
2010-11-23 |
2016-06-24 |
Abbvie Bahamas Ltd |
Methods of treatment using selective bcl-2 inhibitors
|
|
EP2680886B1
(en)
|
2011-02-28 |
2016-08-10 |
Calitor Sciences, LLC |
Substituted quinoline compounds
|
|
WO2012135801A1
(en)
|
2011-04-01 |
2012-10-04 |
University Of Utah Research Foundation |
Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors
|
|
PL2710005T3
(pl)
|
2011-05-17 |
2017-07-31 |
Principia Biopharma Inc. |
Inhibitory kinazy tyrozynowej
|
|
US9376438B2
(en)
|
2011-05-17 |
2016-06-28 |
Principia Biopharma, Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
|
US20140107151A1
(en)
|
2011-05-17 |
2014-04-17 |
Principia Biophama Inc. |
Tyrosine kinase inhibitors
|
|
MX2013013331A
(es)
|
2011-05-17 |
2014-10-17 |
Principia Biopharma Inc |
Derivados de azaindol como inhibidores de tirosina-cinasas.
|
|
BR112013029620A2
(pt)
|
2011-05-17 |
2016-09-06 |
Hoffmann La Roche |
inibidores de tirosina quinase de bruton
|
|
PL2718290T3
(pl)
|
2011-06-07 |
2016-11-30 |
|
Kompozycje i sposoby modulowania kinazy
|
|
WO2013003112A1
(en)
|
2011-06-27 |
2013-01-03 |
The Jackson Laboratory |
Methods and compositions for treatment of cancer and autoimmune disease
|
|
ES2548414T3
(es)
|
2011-07-08 |
2015-10-16 |
Novartis Ag |
Novedosos derivados de pirrolo pirimidina
|
|
WO2013012918A1
(en)
|
2011-07-19 |
2013-01-24 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
|
EP2548877A1
(en)
|
2011-07-19 |
2013-01-23 |
MSD Oss B.V. |
4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
|
|
WO2013010869A1
(en)
|
2011-07-19 |
2013-01-24 |
Msd Oss B.V. |
4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides btk-inhibitors
|
|
JP5826931B2
(ja)
|
2011-07-19 |
2015-12-02 |
メルク・シャープ・エンド・ドーム・ベー・フェー |
Btk阻害剤としての4−イミダゾピリダジン−1−イル−ベンズアミドおよび4−イミダゾトリアジン−1−イル−ベンズアミド
|
|
AU2012296888A1
(en)
|
2011-08-17 |
2014-01-23 |
F. Hoffmann-La Roche Ag |
Inhibitors of Bruton's Tyrosine Kinase
|
|
WO2013036994A1
(en)
|
2011-09-16 |
2013-03-21 |
Biota Scientific Management Pty Ltd |
Compounds for the treatment of hcv
|
|
KR102054468B1
(ko)
|
2011-10-19 |
2019-12-11 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 인산화효소(btk)의 억제제의 용도
|
|
CN103073508B
(zh)
|
2011-10-25 |
2016-06-01 |
北京大学深圳研究生院 |
激酶抑制剂及治疗相关疾病的方法
|
|
EP2788020A4
(en)
|
2011-12-05 |
2015-04-29 |
Immunomedics Inc |
THERAPEUTIC USE OF ANTI-CD22 ANTIBODIES FOR THE INDUCTION OF TROGO CYTOSIS
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
BR112014017021A8
(pt)
|
2012-01-10 |
2017-07-04 |
Nimbus Iris Inc |
inibidores de irak e usos dos mesmos
|
|
US8501724B1
(en)
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
US20150072988A1
(en)
|
2012-03-30 |
2015-03-12 |
The Johns Hopkins University |
Use of n-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine in combination with histone deacetylase inhibitors for treatment of cancer
|
|
GB201207305D0
(en)
|
2012-04-26 |
2012-06-13 |
E Therapeutics Plc |
Therapy
|
|
JP5514256B2
(ja)
|
2012-05-18 |
2014-06-04 |
株式会社東芝 |
磁気記憶素子及びその製造方法
|
|
CA3218491A1
(en)
|
2012-06-04 |
2013-12-12 |
Pharmacyclics Llc |
Crystalline forms of a bruton's tyrosine kinase inhibitor
|
|
JP6280546B2
(ja)
|
2012-06-26 |
2018-02-14 |
デル マー ファーマシューティカルズ |
ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はahi1の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
|
|
US20150140085A1
(en)
|
2012-06-29 |
2015-05-21 |
Principia Biopharma Inc. |
Formulations comprising ibrutinib
|
|
CA2878686A1
(en)
|
2012-07-10 |
2014-01-16 |
The Regents Of The University Of California |
Methods of inducing anesthesia
|
|
US8684552B2
(en)
|
2012-07-11 |
2014-04-01 |
Agio International Company, Ltd |
Lighted furniture assembly
|
|
WO2014018567A1
(en)
|
2012-07-24 |
2014-01-30 |
Pharmacyclics, Inc. |
Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
|
|
CN111481552A
(zh)
|
2012-09-07 |
2020-08-04 |
吉宁特有限公司 |
II型抗CD20抗体与选择性Bcl-2抑制剂的组合治疗
|
|
CA2890111A1
(en)
|
2012-11-02 |
2014-05-08 |
Pharmacyclics, Inc. |
Tec family kinase inhibitor adjuvant therapy
|
|
US9944991B2
(en)
|
2012-11-02 |
2018-04-17 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies
|
|
JP2015537033A
(ja)
|
2012-11-15 |
2015-12-24 |
ファーマサイクリックス,インク. |
キナーゼ阻害剤としてのピロロピリミジン化合物
|
|
BR112015014034A2
(pt)
|
2013-01-10 |
2017-07-11 |
Nimbus Iris Inc |
inibidores de irak e usos dos mesmos
|
|
US20140206681A1
(en)
|
2013-01-23 |
2014-07-24 |
Ronald M. Kim |
Btk inhibitors
|
|
CN105209068A
(zh)
|
2013-02-07 |
2015-12-30 |
免疫医疗公司 |
用于靶向癌症治疗的缀合至抗体的高效2-吡咯啉多柔比星的前药形式(p2pdox)
|
|
FR3002733B1
(fr)
|
2013-03-04 |
2015-08-14 |
Servier Lab |
Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
CA2902099C
(en)
|
2013-03-08 |
2020-06-02 |
F. Hoffmann-La Roche Ag |
Egfr mutation blood testing
|
|
US20160022683A1
(en)
|
2013-03-14 |
2016-01-28 |
Pharmacyclics Llc |
Combinations of bruton's tyrosine kinase inhibitors and cyp3a4 inhibitors
|
|
BR112015025711A8
(pt)
|
2013-04-08 |
2019-12-17 |
Janssen Pharmaceutica Nv |
uso de ibrutinibe e coposição farmacêutica compreendendo ibrutinibe e um agente anticâncer
|
|
EP3003309B1
(en)
|
2013-05-30 |
2020-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using pi3 kinase isoform modulators
|
|
SG11201509992RA
(en)
|
2013-06-07 |
2016-01-28 |
Rhizen Pharmaceuticals Sa |
Dual selective pi3 delta and gamma kinase inhibitors
|
|
KR20160099081A
(ko)
|
2013-07-26 |
2016-08-19 |
업데이트 파마 인코포레이트 |
비산트렌의 치료 효과 개선용 조합 방법
|
|
AR097204A1
(es)
|
2013-08-02 |
2016-02-24 |
Pharmacyclics Inc |
Métodos de tratamiento de tumores sólidos
|
|
WO2015018522A1
(en)
|
2013-08-06 |
2015-02-12 |
Oncoethix Sa |
Bet-bromodomain inhibitor shows synergism with several anti-cancer agents in pre-clinical models of diffuse large b-cell lymphoma (dlbcl)
|
|
EP3033079B1
(en)
|
2013-08-12 |
2018-10-31 |
Pharmacyclics LLC |
Methods for the treatment of her2 amplified cancer
|
|
US9624224B2
(en)
|
2013-09-30 |
2017-04-18 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
JP2016536354A
(ja)
|
2013-10-10 |
2016-11-24 |
アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. |
非ホジキンリンパ腫を治療するための、hdac阻害剤単独またはbtk阻害剤との組み合わせ
|
|
TWI660739B
(zh)
|
2013-10-25 |
2019-06-01 |
製藥公司 |
使用布魯頓氏酪胺酸激酶抑制劑之治療及免疫療法
|
|
MX392373B
(es)
|
2013-10-25 |
2025-03-24 |
Pharmacyclics Llc |
Uso de ibrutinib en el tratamiento de enfermedad injerto contra huesped cronica
|
|
US20150140036A1
(en)
|
2013-11-13 |
2015-05-21 |
Novartis Institutes For Biomedical Research, Inc. |
Low, immune enhancing, dose mtor inhibitors and uses thereof
|
|
US10314842B2
(en)
|
2013-12-02 |
2019-06-11 |
Cornell University |
Methods for treating B cell proliferative disorders
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
CN103923084B
(zh)
|
2014-01-29 |
2016-08-17 |
苏州晶云药物科技有限公司 |
几种晶型及其制备方法
|
|
WO2015127234A1
(en)
|
2014-02-20 |
2015-08-27 |
Board Of Regents, The University Of Texas System |
Use of ibrutinib to treat egfr mutant cancer
|
|
WO2015127261A1
(en)
|
2014-02-21 |
2015-08-27 |
Pharmacyclics, Inc. |
Biomarkers for predicting response of dlbcl to treatment with ibrutinib
|
|
CA2942528A1
(en)
|
2014-03-20 |
2015-09-24 |
Pharmacyclics Inc. |
Phospholipase c gamma 2 and resistance associated mutations
|
|
NZ724796A
(en)
|
2014-04-04 |
2019-04-26 |
Bionomics Ltd |
Method for treating chronic lymphocytic leukemia
|
|
PL3149001T3
(pl)
|
2014-05-28 |
2019-10-31 |
Novartis Ag |
Nowe pochodne pirazolopirymidyny i ich zastosowanie jako inhibitory MALT1
|
|
US20150361504A1
(en)
|
2014-06-13 |
2015-12-17 |
Pharmacyclics Llc |
Biomarker for predicting response of cll to treatment with a btk inhibitor
|
|
US9580418B2
(en)
|
2014-07-14 |
2017-02-28 |
Incyte Corporation |
Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
|
|
US20160022684A1
(en)
|
2014-07-25 |
2016-01-28 |
Pharmacyclics Llc |
Bet inhibitor and bruton's tyrosine kinase inhibitor combinations
|
|
BR112017001677A2
(pt)
|
2014-08-01 |
2018-07-17 |
Pharmacyclics Llc |
biomarcadores para predizer resposta de dlbcl ao tratamento com um inibidor de btk
|
|
MX2017001671A
(es)
|
2014-08-07 |
2017-07-04 |
Pharmacyclics Llc |
Formulaciones novedosas de un inhibidor de la tirosina cinasa de bruton.
|
|
US9730938B2
(en)
|
2014-08-08 |
2017-08-15 |
Pharmacyclics Llc |
Bruton's tyrosine kinase inhibitor combinations and uses thereof
|
|
US20170231995A1
(en)
|
2014-08-11 |
2017-08-17 |
Acerta Pharma B.V. |
BTK Inhibitors to Treat Solid Tumors Through Modulation of the Tumor Microenvironment
|
|
UY36298A
(es)
|
2014-09-16 |
2016-04-29 |
Gilead Science Inc |
Formas sólidas de un modulador del receptor tipo toll
|
|
WO2016044774A1
(en)
|
2014-09-18 |
2016-03-24 |
Pharmacyclics Llc |
Dendritic cell based vaccine with bruton's tyrosine kinase inhibitor
|
|
US20170298446A1
(en)
|
2014-10-03 |
2017-10-19 |
Ohio State Innovation Foundation |
Biomarkers of bruton tyrosine kinase inhibitor resistance
|
|
US20170209574A1
(en)
|
2014-10-03 |
2017-07-27 |
Novartis Ag |
Combination therapies
|
|
IL251669B2
(en)
|
2014-10-10 |
2023-02-01 |
Idera Pharmaceuticals Inc |
Cancer treatment using a tlr9 agonist with checkpoint inhibitors
|
|
CN114920840A
(zh)
|
2014-10-14 |
2022-08-19 |
诺华股份有限公司 |
针对pd-l1的抗体分子及其用途
|
|
TW201628622A
(zh)
|
2014-11-17 |
2016-08-16 |
製藥公司 |
Tlr抑制劑與布魯頓氏(bruton's)酪胺酸激酶抑制劑之組合
|
|
TWI595006B
(zh)
|
2014-12-09 |
2017-08-11 |
禮納特神經系統科學公司 |
抗pd-1抗體類和使用彼等之方法
|
|
US20170360796A1
(en)
|
2014-12-23 |
2017-12-21 |
Pharmacyclics Llc |
Btk inhibitor combinations and dosing regimen
|
|
WO2016123504A1
(en)
|
2015-01-30 |
2016-08-04 |
Pharmacyclics Llc |
Btk inhibitor combinations and multidrug-resistance
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
EP3722297A1
(en)
|
2015-03-04 |
2020-10-14 |
Gilead Sciences, Inc. |
Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
|
|
WO2016161347A1
(en)
|
2015-04-03 |
2016-10-06 |
Pharmacyclics Llc |
Combinations for generating tumor-specific immunological memory
|
|
CN106336413B
(zh)
|
2015-07-09 |
2021-04-20 |
广东东阳光药业有限公司 |
作为jak抑制剂的化合物及其用途
|
|
WO2017011314A1
(en)
|
2015-07-10 |
2017-01-19 |
Paharmacyclics Llc |
Btk and hdac combinations
|
|
CN106474143A
(zh)
|
2015-08-26 |
2017-03-08 |
长春华普生物技术有限公司 |
Toll样受体TLR7和TLR9抑制性寡核苷酸在制备用于治疗B细胞淋巴瘤的药物方面的应用
|
|
CN108135904A
(zh)
|
2015-08-31 |
2018-06-08 |
药品循环有限责任公司 |
用于治疗多发性骨髓瘤的btk抑制剂组合
|
|
US20170071962A1
(en)
|
2015-09-11 |
2017-03-16 |
Acerta Pharma B.V. |
Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor
|
|
WO2017087947A2
(en)
|
2015-11-19 |
2017-05-26 |
Pharmacyclics Llc |
Method of treatment of follicular lymphoma with a btk inhibitor
|