AU2013234496B2 - Compositions of GLP-1 peptides and preparation thereof - Google Patents

Compositions of GLP-1 peptides and preparation thereof Download PDF

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Publication number
AU2013234496B2
AU2013234496B2 AU2013234496A AU2013234496A AU2013234496B2 AU 2013234496 B2 AU2013234496 B2 AU 2013234496B2 AU 2013234496 A AU2013234496 A AU 2013234496A AU 2013234496 A AU2013234496 A AU 2013234496A AU 2013234496 B2 AU2013234496 B2 AU 2013234496B2
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Prior art keywords
ethoxy
glp
amino
peptide
hydroxybenzoyl
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AU2013234496A
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AU2013234496A1 (en
Inventor
Helle Eliasen
Tue Hansen
Thomas Vilhelmsen
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Novo Nordisk AS
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Novo Nordisk AS
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2013234496A 2012-03-22 2013-03-15 Compositions of GLP-1 peptides and preparation thereof Active 2037-02-07 AU2013234496B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017251814A AU2017251814B2 (en) 2012-03-22 2017-10-27 Compositions of GLP-1 peptides and preparation thereof

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP12160743 2012-03-22
EP12160743.6 2012-03-22
US201361748840P 2013-01-04 2013-01-04
US61/748,840 2013-01-04
EP13153459.6 2013-01-31
EP13153459 2013-01-31
PCT/EP2013/055362 WO2013139694A1 (en) 2012-03-22 2013-03-15 Compositions of glp-1 peptides and preparation thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017251814A Division AU2017251814B2 (en) 2012-03-22 2017-10-27 Compositions of GLP-1 peptides and preparation thereof

Publications (2)

Publication Number Publication Date
AU2013234496A1 AU2013234496A1 (en) 2014-09-11
AU2013234496B2 true AU2013234496B2 (en) 2017-07-27

Family

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Family Applications (2)

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AU2013234496A Active 2037-02-07 AU2013234496B2 (en) 2012-03-22 2013-03-15 Compositions of GLP-1 peptides and preparation thereof
AU2017251814A Active 2037-02-07 AU2017251814B2 (en) 2012-03-22 2017-10-27 Compositions of GLP-1 peptides and preparation thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017251814A Active 2037-02-07 AU2017251814B2 (en) 2012-03-22 2017-10-27 Compositions of GLP-1 peptides and preparation thereof

Country Status (22)

Country Link
US (6) US10933120B2 (enExample)
EP (3) EP4324475A1 (enExample)
JP (1) JP6001158B2 (enExample)
KR (1) KR102072202B1 (enExample)
CN (2) CN107812181B (enExample)
AU (2) AU2013234496B2 (enExample)
BR (1) BR112014023374B1 (enExample)
CA (1) CA2868188A1 (enExample)
DK (1) DK2827885T3 (enExample)
ES (2) ES2690553T3 (enExample)
HR (2) HRP20231060T1 (enExample)
HU (2) HUE062740T2 (enExample)
LT (1) LT2827885T (enExample)
MX (1) MX353067B (enExample)
MY (1) MY171146A (enExample)
PL (2) PL2827885T3 (enExample)
RS (2) RS57727B1 (enExample)
RU (1) RU2641198C3 (enExample)
SI (1) SI2827885T1 (enExample)
SM (1) SMT201800491T1 (enExample)
WO (1) WO2013139694A1 (enExample)
ZA (1) ZA201406250B (enExample)

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CN104203266B (zh) 2017-12-26
CA2868188A1 (en) 2013-09-26
CN107812181A (zh) 2018-03-20

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