BR112014023374A2 - composições de peptídeos de glp-1 e preparação das mesmas - Google Patents

composições de peptídeos de glp-1 e preparação das mesmas

Info

Publication number
BR112014023374A2
BR112014023374A2 BR112014023374A BR112014023374A BR112014023374A2 BR 112014023374 A2 BR112014023374 A2 BR 112014023374A2 BR 112014023374 A BR112014023374 A BR 112014023374A BR 112014023374 A BR112014023374 A BR 112014023374A BR 112014023374 A2 BR112014023374 A2 BR 112014023374A2
Authority
BR
Brazil
Prior art keywords
glp
granules
preparation
type
peptide
Prior art date
Application number
BR112014023374A
Other languages
English (en)
Other versions
BR112014023374B1 (pt
BR112014023374A8 (pt
Inventor
Eliasen Helle
Villhelmsen Thomas
Hansen Tue
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49221868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014023374(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of BR112014023374A2 publication Critical patent/BR112014023374A2/pt
Publication of BR112014023374A8 publication Critical patent/BR112014023374A8/pt
Publication of BR112014023374B1 publication Critical patent/BR112014023374B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

resumo patente de invenção: "composições de peptídeos de glp-1 e preparação das mesmas". a presente invenção refere-se às composições farmacêuticas compreendendo um primeiro tipo de grânulos e um segundo tipo de grânulos, em que o referido primeiro tipo de grânulos compreende um sal de ácido n-(8-(2-hidroxibenzoil)amino)caprílico e nenhum peptídeo glp-1, e em que o referido segundo tipo de grânulos compreende um peptídeo glp-1 e nenhum sal de ácido n-(8-(2-hidroxibenzoil) amino)caprílico, bem como os grânulos intermediários, processos para a preparação dos grânulos e composições, e uso dos mesmos no medicamento.
BR112014023374-8A 2012-03-22 2013-03-15 Composições de peptídeos de glp-1, seu processo de preparação e seu uso para o tratamento de diabetes e obesidade BR112014023374B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP12160743.6 2012-03-22
EP12160743 2012-03-22
US201361748840P 2013-01-04 2013-01-04
US61/748,840 2013-01-04
EP13153459.6 2013-01-31
EP13153459 2013-01-31
PCT/EP2013/055362 WO2013139694A1 (en) 2012-03-22 2013-03-15 Compositions of glp-1 peptides and preparation thereof

Publications (3)

Publication Number Publication Date
BR112014023374A2 true BR112014023374A2 (pt) 2017-07-11
BR112014023374A8 BR112014023374A8 (pt) 2018-01-16
BR112014023374B1 BR112014023374B1 (pt) 2021-09-21

Family

ID=49221868

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014023374-8A BR112014023374B1 (pt) 2012-03-22 2013-03-15 Composições de peptídeos de glp-1, seu processo de preparação e seu uso para o tratamento de diabetes e obesidade

Country Status (21)

Country Link
US (5) US10933120B2 (pt)
EP (3) EP3488857B9 (pt)
JP (1) JP6001158B2 (pt)
KR (1) KR102072202B1 (pt)
CN (2) CN104203266B (pt)
AU (2) AU2013234496B2 (pt)
BR (1) BR112014023374B1 (pt)
CA (1) CA2868188A1 (pt)
DK (1) DK2827885T3 (pt)
ES (2) ES2952874T3 (pt)
HR (2) HRP20231060T1 (pt)
HU (2) HUE039406T2 (pt)
LT (1) LT2827885T (pt)
MX (1) MX353067B (pt)
MY (1) MY171146A (pt)
PL (2) PL2827885T3 (pt)
RS (2) RS64460B1 (pt)
RU (1) RU2641198C3 (pt)
SI (1) SI2827885T1 (pt)
WO (1) WO2013139694A1 (pt)
ZA (1) ZA201406250B (pt)

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