AU2012245455A1 - Insulin-Like Growth Factor-1 Receptor inhibitors - Google Patents

Insulin-Like Growth Factor-1 Receptor inhibitors Download PDF

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Publication number
AU2012245455A1
AU2012245455A1 AU2012245455A AU2012245455A AU2012245455A1 AU 2012245455 A1 AU2012245455 A1 AU 2012245455A1 AU 2012245455 A AU2012245455 A AU 2012245455A AU 2012245455 A AU2012245455 A AU 2012245455A AU 2012245455 A1 AU2012245455 A1 AU 2012245455A1
Authority
AU
Australia
Prior art keywords
alkyl
group
phenoxymethyl
chloro
morpholinosulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2012245455A
Other languages
English (en)
Other versions
AU2012245455A8 (en
Inventor
Sarala Balachandran
Christopher J. Dinsmore
Abhijit Roychowdhury
Rajiv Sharma
Ram Asrey Vishwakarma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Piramal Enterprises Ltd
Merck Sharp & Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp & Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp & Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Publication of AU2012245455A1 publication Critical patent/AU2012245455A1/en
Publication of AU2012245455A8 publication Critical patent/AU2012245455A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2012245455A 2011-04-21 2012-04-19 Insulin-Like Growth Factor-1 Receptor inhibitors Abandoned AU2012245455A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477937P 2011-04-21 2011-04-21
US61/477,937 2011-04-21
PCT/US2012/034188 WO2012145471A1 (en) 2011-04-21 2012-04-19 Insulin-like growth factor-1 receptor inhibitors

Publications (2)

Publication Number Publication Date
AU2012245455A1 true AU2012245455A1 (en) 2013-10-31
AU2012245455A8 AU2012245455A8 (en) 2013-11-07

Family

ID=46026953

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2012245455A Abandoned AU2012245455A1 (en) 2011-04-21 2012-04-19 Insulin-Like Growth Factor-1 Receptor inhibitors
AU2012245971A Abandoned AU2012245971A1 (en) 2011-04-21 2012-04-19 A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2012245971A Abandoned AU2012245971A1 (en) 2011-04-21 2012-04-19 A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation

Country Status (9)

Country Link
US (3) US20140045832A1 (enExample)
EP (2) EP2699567A1 (enExample)
JP (1) JP2014514321A (enExample)
CN (1) CN103732592A (enExample)
AU (2) AU2012245455A1 (enExample)
CA (2) CA2831730A1 (enExample)
IL (1) IL228810A0 (enExample)
IN (1) IN2013MN02170A (enExample)
WO (3) WO2012143879A1 (enExample)

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WO2014002007A1 (en) * 2012-06-26 2014-01-03 Piramal Enterprises Limited Method of predicting or monitoring response to igf-1r and ir inhibitors using biomarkers
AU2013352304C1 (en) 2012-11-29 2018-03-22 Chemocentryx, Inc. CXCR7 antagonists
WO2014177915A1 (en) 2013-05-01 2014-11-06 Piramal Enterprises Limited Cancer combination therapy using imidazo[4,5-c]quinoline derivatives
CN104098498A (zh) * 2014-07-30 2014-10-15 天津市斯芬克司药物研发有限公司 一种吲唑类化合物及其制备方法
CN107003600A (zh) 2014-09-15 2017-08-01 德米特里·戈里洛夫斯基 包括观察大场景的多个数字照相机的系统
CN105218475A (zh) * 2015-10-15 2016-01-06 湖南华腾制药有限公司 1,2-吗啉盐酸盐的合成方法
EP3724178B1 (en) 2017-12-15 2024-05-01 Inthera Bioscience AG 1-(piperidinocarbonylmethyl)-2-oxopiperazine derivatives for treating cancer
SG11202105889YA (en) 2018-12-12 2021-07-29 Chemocentryx Inc Cxcr7 inhibitors for the treatment of cancer
JP2022545835A (ja) 2019-08-28 2022-10-31 ホライゾン セラピューティクス アイルランド デジグネイテッド アクティビティ カンパニー 甲状腺眼症の治療方法
CN113149941A (zh) * 2020-01-22 2021-07-23 中国科学院上海药物研究所 醚类化合物及其在防治糖尿病及代谢综合征中的药学用途
US12611406B2 (en) 2020-06-19 2026-04-28 Inthera Bioscience AG Oxopiperazine derivatives for the treatment of cancer
CN122003247A (zh) 2023-07-07 2026-05-08 维里迪安治疗公司 治疗活动性和慢性甲状腺眼病的方法

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CN103732592A (zh) 2014-04-16
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US20140045847A1 (en) 2014-02-13
US20140046059A1 (en) 2014-02-13
IL228810A0 (en) 2013-12-31
AU2012245971A1 (en) 2013-10-17
EP2699568A1 (en) 2014-02-26
WO2012145471A1 (en) 2012-10-26
AU2012245455A8 (en) 2013-11-07
CA2833009A1 (en) 2012-10-26
AU2012245971A8 (en) 2013-11-07
WO2012143874A1 (en) 2012-10-26
JP2014514321A (ja) 2014-06-19
IN2013MN02170A (enExample) 2015-06-12
US20140045832A1 (en) 2014-02-13
CA2831730A1 (en) 2012-10-26

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