AU2012212196B2 - Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels - Google Patents

Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels Download PDF

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Publication number
AU2012212196B2
AU2012212196B2 AU2012212196A AU2012212196A AU2012212196B2 AU 2012212196 B2 AU2012212196 B2 AU 2012212196B2 AU 2012212196 A AU2012212196 A AU 2012212196A AU 2012212196 A AU2012212196 A AU 2012212196A AU 2012212196 B2 AU2012212196 B2 AU 2012212196B2
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pain
compound
mmol
alkyl
methyl
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AU2012212196A1 (en
Inventor
Corey Anderson
Vijayalaksmi Arumugam
Peter Diederik Jan Grootenhuis
Sara S. Hadida Ruah
Licong JIANG
Edward Adam Kallel
Jason Mccartney
Mark Thomas Miller
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2012212196A 2011-02-02 2012-02-02 Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels Ceased AU2012212196B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161438685P 2011-02-02 2011-02-02
US61/438,685 2011-02-02
US201161440987P 2011-02-09 2011-02-09
US61/440,987 2011-02-09
US201161495538P 2011-06-10 2011-06-10
US61/495,538 2011-06-10
PCT/US2012/023593 WO2012106499A1 (en) 2011-02-02 2012-02-02 Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels

Publications (2)

Publication Number Publication Date
AU2012212196A1 AU2012212196A1 (en) 2013-07-25
AU2012212196B2 true AU2012212196B2 (en) 2016-10-13

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AU2012212196A Ceased AU2012212196B2 (en) 2011-02-02 2012-02-02 Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels

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US (3) US8916565B2 (https=)
EP (2) EP2670752B1 (https=)
JP (2) JP6021824B2 (https=)
KR (1) KR101923367B1 (https=)
CN (2) CN103403004B (https=)
AR (1) AR085893A1 (https=)
AU (1) AU2012212196B2 (https=)
BR (1) BR112013019211A2 (https=)
CA (1) CA2825204C (https=)
CY (1) CY1117471T1 (https=)
DK (1) DK2670752T3 (https=)
ES (1) ES2573497T3 (https=)
HR (1) HRP20160382T8 (https=)
HU (1) HUE028789T2 (https=)
IL (1) IL227815B (https=)
MX (1) MX355907B (https=)
NZ (1) NZ613028A (https=)
PL (1) PL2670752T3 (https=)
PT (1) PT2670752E (https=)
RS (1) RS54785B1 (https=)
RU (1) RU2634900C2 (https=)
SG (1) SG192248A1 (https=)
SI (1) SI2670752T1 (https=)
SM (1) SMT201600162B (https=)
TW (2) TW201604196A (https=)
WO (1) WO2012106499A1 (https=)
ZA (1) ZA201305152B (https=)

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JP5389030B2 (ja) 2007-08-24 2014-01-15 バーテックス ファーマシューティカルズ インコーポレイテッド （特に）嚢胞性線維症の処置に有用なイソチアゾロピリジノン
US8598164B2 (en) 2010-05-06 2013-12-03 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
MX355907B (es) * 2011-02-02 2018-05-04 Vertex Pharma Pirrolopirazina-piperidina espirociclica-amidas como moduladores de canales de ionicos.
JP5940562B2 (ja) 2011-02-18 2016-06-29 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ イオンチャネルのモジュレーターとしてのクロマン−スピロ環式ピペリジンアミド
MX347982B (es) 2011-03-14 2017-05-22 Vertex Pharma Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos.
JP6014155B2 (ja) 2011-10-31 2016-10-25 ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用
RU2014121984A (ru) 2011-10-31 2015-12-10 Ксенон Фармасьютикалз Инк. Бензолсульфонамидные соединения и их применение в качестве терапевтических средств
CN104718188B (zh) 2012-05-22 2018-08-21 基因泰克公司 N-取代的苯甲酰胺类及其在治疗疼痛中的用途
KR101663436B1 (ko) 2012-07-06 2016-10-06 제넨테크, 인크. N-치환된 벤즈아미드 및 이의 사용 방법
WO2014022639A1 (en) * 2012-08-01 2014-02-06 Vertex Pharmaceuticals Incorporated Solid forms of (4-isopropoxy-3-methoxyphenyl)(2'-methyl-6'-(trifluoromethyl)-3',4'-dihydro-2'h-spiro[piperidine-4,1'-pyrrolo[1,2-a]pyrazine]-1-yl)methanone
CN105073738B (zh) 2013-01-31 2018-01-05 沃泰克斯药物股份有限公司 作为钠通道调节剂的喹啉及喹喔啉酰胺类
KR102295748B1 (ko) 2013-01-31 2021-09-01 버텍스 파마슈티칼스 인코포레이티드 나트륨 채널의 조절제로서의 피리돈 아미드
WO2014134391A1 (en) 2013-02-28 2014-09-04 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
RU2015143906A (ru) 2013-03-14 2017-04-18 Дженентек, Инк. Замещенные триазолопиридины и способы их применения
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