AR085893A1 - Pirrolopirazina-amidas de piperidina espirociclica como moduladores de los canales ionicos - Google Patents

Pirrolopirazina-amidas de piperidina espirociclica como moduladores de los canales ionicos

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Publication number
AR085893A1
AR085893A1 ARP120100346A ARP120100346A AR085893A1 AR 085893 A1 AR085893 A1 AR 085893A1 AR P120100346 A ARP120100346 A AR P120100346A AR P120100346 A ARP120100346 A AR P120100346A AR 085893 A1 AR085893 A1 AR 085893A1
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Argentina
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cycloalkyl
alkyl
replaced
units
halo
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ARP120100346A
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English (en)
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Corey Anderson
Peter Diederik Jan Grootenhuis
Ruah Sara S Hadida
Edward Adam Kallel
Mark Thomas Miller
Vijayalaksmi Arumugam
Jason Mcartney
Licong Jiang
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Vertex Pharma
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Publication of AR085893A1 publication Critical patent/AR085893A1/es

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Abstract

La presente se refiere a compuestos de pirrolopirazina-amida de piperidina espirocíclica útiles como inhibidores de los canales iónicos. La presente también provee composiciones farmacéuticamente aceptables que comprenden los compuestos de la presente y métodos para utilizar las composiciones para el tratamiento de varios trastornos.Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1) o una sal farmacéuticamente aceptable del mismo, donde, independientemente de cada aparición: R1 es H, alquilo C1-8, cicloalquilo C3-8, halo, CN, NR8SO2R8, SO2R8, SR8, SOR8, NR8COR8, NR8CO2R8, CON(R8)2, SO2N(R8)2, CF3, heterocicloalquilo, o un C1-8-R9 de cadena recta, ramificada o cíclico donde hasta dos unidades CH2 pueden ser reemplazadas por O, CO, S, SO, SO2 o NR8, o dos R1 tomados juntos forman un grupo oxo, o un anillo cicloalquilo fusionado de 3 a 7 miembros, o un anillo espirocíclico de 3 a 7 miembros; R2 es H, alquilo C1-8, halo, haloalquilo C1-8, CN, OH, SO2R8, SR8, SOR8, COR8, CO2R8, CON(R8)2, SO2N(R8)2, CF3, CHF2, o un C1-8-R9 de cadena recta, ramificado o cíclico donde hasta dos unidades CH2 pueden ser reemplazadas por O, CO, S, SO, SO2, CF2, o NR8; R3 es H, alquilo C1-8, cicloalquilo C3-8, CO2R8, COR8, COH, CON(R8)2, CF3, CH2CF3, CH2CHF2, o un C1-8-R9 de cadena recta, ramificada o cíclico donde hasta dos unidades CH2 pueden ser reemplazadas por O, CO, S, SO, SO2 o NR8; R4 es H, alquilo C1-8, halo, cicloalquilo C3-8, donde hasta dos unidades CH2 pueden ser reemplazadas por O, CO, S, SO, SO2, o NR8, o 2 R4 tomados juntos pueden formar un anillo cicloalquilo de 3 a 7 miembros; R8 es H, alquilo C1-8, CF3, cicloalquilo C3-8, fluoroalquilo, arilo, heteroarilo, o un C1-8-R9 de cadena recta, ramificada o cíclico donde hasta dos unidades CH2 pueden ser reemplazadas por O, CO, S, SO, SO2 o NR, o 2 R8 tomados junto con los átomos a los que están ligados, forman un anillo; R9 es H, CF3, CO2R, OH, arilo, heteroarilo, cicloalquilo C3-8, heterocicloalquilo, N(R)2, NRCOR, CON(R)2, CN, halo, o SO2R; R es H, alquilo C1-8, arilo, heteroarilo, cicloalquilo C3-8, o heterocicloalquilo; A es un arilo, heteroarilo o heterocíclico opcionalmente sustituido; m es un entero entre 0 y 4 inclusive; n es un entero entre 0 y 3 inclusive; y o es un entero entre 0 y 4 inclusive.
ARP120100346A 2011-02-02 2012-02-02 Pirrolopirazina-amidas de piperidina espirociclica como moduladores de los canales ionicos AR085893A1 (es)

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US201161438685P 2011-02-02 2011-02-02
US201161440987P 2011-02-09 2011-02-09
US201161495538P 2011-06-10 2011-06-10

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AR085893A1 true AR085893A1 (es) 2013-11-06

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KR (1) KR101923367B1 (es)
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AR (1) AR085893A1 (es)
AU (1) AU2012212196B2 (es)
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MX2013009393A (es) 2011-02-18 2013-08-29 Vertex Pharma Piperidinamidas cromano-espirociclicas como moduladores de canales de iones.
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