AU2011213568B2 - Methods and apparatus for synthesizing imaging agents, and intermediates thereof - Google Patents

Methods and apparatus for synthesizing imaging agents, and intermediates thereof Download PDF

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Publication number
AU2011213568B2
AU2011213568B2 AU2011213568A AU2011213568A AU2011213568B2 AU 2011213568 B2 AU2011213568 B2 AU 2011213568B2 AU 2011213568 A AU2011213568 A AU 2011213568A AU 2011213568 A AU2011213568 A AU 2011213568A AU 2011213568 B2 AU2011213568 B2 AU 2011213568B2
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imaging
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imaging agent
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AU2011213568A1 (en
Inventor
James F. Castner
Richard R. Cesati
Edward H. Cheesman
Marybeth Devine
Joel Lazewatsky
Enrico Mongeau
Heike S. Radeke
Robert Wilburn Siegler
Dianne D. Zdankiewicz
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Lantheus Medical Imaging Inc
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Lantheus Medical Imaging Inc
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Priority to AU2016213781A priority Critical patent/AU2016213781A1/en
Priority to AU2018201916A priority patent/AU2018201916C1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cameras In General (AREA)
AU2011213568A 2010-02-08 2011-02-08 Methods and apparatus for synthesizing imaging agents, and intermediates thereof Active AU2011213568B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2016213781A AU2016213781A1 (en) 2010-02-08 2016-08-11 Methods and apparatus for synthesizing imaging agents, and intermediates thereof
AU2018201916A AU2018201916C1 (en) 2010-02-08 2018-03-16 Methods and apparatus for synthesizing imaging agents, and intermediates thereof

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US30247710P 2010-02-08 2010-02-08
US61/302,477 2010-02-08
US31537610P 2010-03-18 2010-03-18
US61/315,376 2010-03-18
US33369310P 2010-05-11 2010-05-11
US61/333,693 2010-05-11
PCT/US2011/024109 WO2011097649A2 (en) 2010-02-08 2011-02-08 Methods and apparatus for synthesizing imaging agents, and intermediates thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016213781A Division AU2016213781A1 (en) 2010-02-08 2016-08-11 Methods and apparatus for synthesizing imaging agents, and intermediates thereof

Publications (2)

Publication Number Publication Date
AU2011213568A1 AU2011213568A1 (en) 2012-09-27
AU2011213568B2 true AU2011213568B2 (en) 2016-05-12

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AU2011213568A Active AU2011213568B2 (en) 2010-02-08 2011-02-08 Methods and apparatus for synthesizing imaging agents, and intermediates thereof
AU2016213781A Abandoned AU2016213781A1 (en) 2010-02-08 2016-08-11 Methods and apparatus for synthesizing imaging agents, and intermediates thereof
AU2018201916A Active AU2018201916C1 (en) 2010-02-08 2018-03-16 Methods and apparatus for synthesizing imaging agents, and intermediates thereof

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AU2016213781A Abandoned AU2016213781A1 (en) 2010-02-08 2016-08-11 Methods and apparatus for synthesizing imaging agents, and intermediates thereof
AU2018201916A Active AU2018201916C1 (en) 2010-02-08 2018-03-16 Methods and apparatus for synthesizing imaging agents, and intermediates thereof

Country Status (19)

Country Link
US (6) US8936777B2 (enExample)
EP (3) EP3323810B1 (enExample)
JP (3) JP6092628B2 (enExample)
KR (5) KR101709372B1 (enExample)
CN (3) CN109200296B (enExample)
AU (3) AU2011213568B2 (enExample)
BR (1) BR112012019789A2 (enExample)
CA (1) CA2789044C (enExample)
DK (2) DK2534136T3 (enExample)
ES (2) ES2651466T3 (enExample)
IL (2) IL221253B (enExample)
MX (2) MX348958B (enExample)
NO (1) NO2534136T3 (enExample)
NZ (1) NZ602291A (enExample)
PT (2) PT3323810T (enExample)
RU (1) RU2631500C2 (enExample)
SG (2) SG10201500929XA (enExample)
TW (4) TWI664169B (enExample)
WO (1) WO2011097649A2 (enExample)

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