AU2010307198C9 - Substituted piperidines that increase p53 activity and the uses thereof - Google Patents

Substituted piperidines that increase p53 activity and the uses thereof Download PDF

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Publication number
AU2010307198C9
AU2010307198C9 AU2010307198A AU2010307198A AU2010307198C9 AU 2010307198 C9 AU2010307198 C9 AU 2010307198C9 AU 2010307198 A AU2010307198 A AU 2010307198A AU 2010307198 A AU2010307198 A AU 2010307198A AU 2010307198 C9 AU2010307198 C9 AU 2010307198C9
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AU
Australia
Prior art keywords
alkyl
pct
compound
group
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2010307198A
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English (en)
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AU2010307198A1 (en
AU2010307198B9 (en
AU2010307198B2 (en
AU2010307198C1 (en
Inventor
Stephane L. Bogen
Ronald J. Doll
Craig R. Gibeau
Timothy J. Guzi
Danny J. Hicklin
Margarita Kirova-Snover
Bheemashankar A. Kulkarni
Brian Robert Lahue
Yuan Liu
Yao Ma
Malcolm Maccoss
Latha G. Nair
Amin Nomeir
Weidong Pan
Diane Rindgen
Giovanna Scapin
Cynthia Seidel-Dugan
Gerald W. Shipps Jr.
Manami Shizuka
Yuan Tian
Matthew Ernst Voss
Yaolin Wang
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Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
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Publication of AU2010307198A1 publication Critical patent/AU2010307198A1/en
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. Alteration of Name(s) of Applicant(s) under S113 Assignors: SCHERING CORPORATION
Publication of AU2010307198B2 publication Critical patent/AU2010307198B2/en
Application granted granted Critical
Publication of AU2010307198C1 publication Critical patent/AU2010307198C1/en
Publication of AU2010307198B9 publication Critical patent/AU2010307198B9/en
Publication of AU2010307198C9 publication Critical patent/AU2010307198C9/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AU2010307198A 2009-10-14 2010-10-05 Substituted piperidines that increase p53 activity and the uses thereof Ceased AU2010307198C9 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25160309P 2009-10-14 2009-10-14
US61/251,603 2009-10-14
US25246809P 2009-10-16 2009-10-16
US61/252,468 2009-10-16
PCT/US2010/051403 WO2011046771A1 (en) 2009-10-14 2010-10-05 SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF

Publications (5)

Publication Number Publication Date
AU2010307198A1 AU2010307198A1 (en) 2012-04-19
AU2010307198B2 AU2010307198B2 (en) 2013-10-10
AU2010307198C1 AU2010307198C1 (en) 2014-01-23
AU2010307198B9 AU2010307198B9 (en) 2014-02-13
AU2010307198C9 true AU2010307198C9 (en) 2014-02-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010307198A Ceased AU2010307198C9 (en) 2009-10-14 2010-10-05 Substituted piperidines that increase p53 activity and the uses thereof

Country Status (28)

Country Link
US (2) US8859776B2 (cg-RX-API-DMAC7.html)
EP (1) EP2488028B1 (cg-RX-API-DMAC7.html)
JP (2) JP5099731B1 (cg-RX-API-DMAC7.html)
KR (1) KR101485645B1 (cg-RX-API-DMAC7.html)
CN (2) CN102638981B (cg-RX-API-DMAC7.html)
AR (1) AR078622A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010307198C9 (cg-RX-API-DMAC7.html)
BR (1) BR112012008849A2 (cg-RX-API-DMAC7.html)
CA (1) CA2777043C (cg-RX-API-DMAC7.html)
CL (1) CL2012000949A1 (cg-RX-API-DMAC7.html)
CO (1) CO6531452A2 (cg-RX-API-DMAC7.html)
CR (1) CR20120183A (cg-RX-API-DMAC7.html)
EA (1) EA023838B1 (cg-RX-API-DMAC7.html)
GT (1) GT201200111A (cg-RX-API-DMAC7.html)
IL (1) IL219125A0 (cg-RX-API-DMAC7.html)
IN (1) IN2012DN03085A (cg-RX-API-DMAC7.html)
MA (1) MA33745B1 (cg-RX-API-DMAC7.html)
MX (1) MX2012004377A (cg-RX-API-DMAC7.html)
MY (1) MY174452A (cg-RX-API-DMAC7.html)
NI (1) NI201200059A (cg-RX-API-DMAC7.html)
NZ (1) NZ599343A (cg-RX-API-DMAC7.html)
PE (1) PE20121172A1 (cg-RX-API-DMAC7.html)
PH (1) PH12012500713A1 (cg-RX-API-DMAC7.html)
TN (1) TN2012000129A1 (cg-RX-API-DMAC7.html)
TW (1) TWI507405B (cg-RX-API-DMAC7.html)
UA (1) UA109417C2 (cg-RX-API-DMAC7.html)
WO (1) WO2011046771A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA201202667B (cg-RX-API-DMAC7.html)

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JP6575950B2 (ja) 2012-07-24 2019-09-18 ファーマサイクリックス エルエルシー Ｂｒｕｔｏｎ型チロシンキナーゼ（Ｂｔｋ）阻害剤に対する耐性を伴う変異
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JP2017520610A (ja) 2014-07-17 2017-07-27 シーエイチディーアイ ファウンデーション，インコーポレーテッド Ｈｉｖ関連障害を治療するための方法及び組成物
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WO2018227129A1 (en) * 2017-06-09 2018-12-13 Regents Of The University Of Minnesota Skin care formulations and skin cancer treatment
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