AU2010305281C1 - Siglec 15 antibodies in treating bone loss-related disease - Google Patents

Siglec 15 antibodies in treating bone loss-related disease Download PDF

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Publication number
AU2010305281C1
AU2010305281C1 AU2010305281A AU2010305281A AU2010305281C1 AU 2010305281 C1 AU2010305281 C1 AU 2010305281C1 AU 2010305281 A AU2010305281 A AU 2010305281A AU 2010305281 A AU2010305281 A AU 2010305281A AU 2010305281 C1 AU2010305281 C1 AU 2010305281C1
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Australia
Prior art keywords
seq
chain variable
variable domain
antibody
set forth
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Ceased
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AU2010305281A
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AU2010305281A1 (en
AU2010305281B2 (en
Inventor
Mario Filion
Matthew Stuible
Gilles Bernard Tremblay
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Alethia Biotherapeutics Inc
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Alethia Biotherapeutics Inc
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Application filed by Alethia Biotherapeutics Inc filed Critical Alethia Biotherapeutics Inc
Publication of AU2010305281A1 publication Critical patent/AU2010305281A1/en
Publication of AU2010305281B2 publication Critical patent/AU2010305281B2/en
Priority to AU2014224071A priority Critical patent/AU2014224071A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/57407—Specifically defined cancers
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/00—Immunoglobulins specific features
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  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Mycology (AREA)
  • Hospice & Palliative Care (AREA)
AU2010305281A 2009-10-06 2010-10-06 Siglec 15 antibodies in treating bone loss-related disease Ceased AU2010305281C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014224071A AU2014224071A1 (en) 2009-10-06 2014-09-11 Siglec 15 antibodies in treating bone loss-related disease

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24896009P 2009-10-06 2009-10-06
US61/248,960 2009-10-06
US12/580,943 2009-10-16
US12/580,943 US8168181B2 (en) 2006-02-13 2009-10-16 Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
PCT/CA2010/001586 WO2011041894A1 (en) 2009-10-06 2010-10-06 Siglec 15 antibodies in treating bone loss-related disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014224071A Division AU2014224071A1 (en) 2009-10-06 2014-09-11 Siglec 15 antibodies in treating bone loss-related disease

Publications (3)

Publication Number Publication Date
AU2010305281A1 AU2010305281A1 (en) 2012-05-03
AU2010305281B2 AU2010305281B2 (en) 2014-06-12
AU2010305281C1 true AU2010305281C1 (en) 2014-12-04

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ID=43856338

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Application Number Title Priority Date Filing Date
AU2010305281A Ceased AU2010305281C1 (en) 2009-10-06 2010-10-06 Siglec 15 antibodies in treating bone loss-related disease
AU2014224071A Abandoned AU2014224071A1 (en) 2009-10-06 2014-09-11 Siglec 15 antibodies in treating bone loss-related disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2014224071A Abandoned AU2014224071A1 (en) 2009-10-06 2014-09-11 Siglec 15 antibodies in treating bone loss-related disease

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Country Link
US (6) US8168181B2 (enExample)
EP (1) EP2486060A4 (enExample)
JP (2) JP5855569B2 (enExample)
KR (1) KR20120086297A (enExample)
CN (2) CN102803293B (enExample)
AU (2) AU2010305281C1 (enExample)
BR (1) BR112012007860A2 (enExample)
CA (2) CA2870980A1 (enExample)
IL (1) IL218985A0 (enExample)
MX (1) MX2012004084A (enExample)
NZ (1) NZ599193A (enExample)
RU (1) RU2596392C2 (enExample)
WO (1) WO2011041894A1 (enExample)

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US8168181B2 (en) * 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
DK1994155T4 (da) † 2006-02-13 2022-07-25 Daiichi Sankyo Co Ltd Polynukleotid- og polypeptidsekvenser involveret i fremgangsmåden med knogleremodellering
CN103483169A (zh) * 2007-09-28 2014-01-01 第一三共株式会社 用于制备双环γ-氨基酸衍生物的中间体
SG10201605897RA (en) * 2007-10-11 2016-09-29 Daiichi Sankyo Co Ltd ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN Siglec-15
JP5557292B2 (ja) 2009-03-26 2014-07-23 第一三共株式会社 二環性γ−アミノ酸誘導体の製造方法
MX2011007342A (es) 2009-04-09 2011-07-21 Daiichi Sankyo Co Ltd Anticuerpo anti-lectina similar a inmunoglobulina de union a acido sialico-15.
BR112013008255A2 (pt) 2010-10-05 2018-09-25 Daiichi Sankyo Co Ltd anticorpo isolado ou um fragmento funcional do mesmo, uso de um anticorpo isolado ou de um fragmento funcional do mesmo, composição farmacêutica, polinucleotídeo, vetor, célula transformada, e, método para produzir anticorpo
CA2848074A1 (en) 2011-09-09 2013-03-14 Medimmune Limited Anti-siglec-15 antibodies and uses thereof
US9003797B2 (en) * 2011-11-02 2015-04-14 E L Du Pont De Nemours And Company Use of compositions comprising 1,1,1,2,3-pentafluoropropane and optionally Z-1,1,1,4,4,4-hexafluoro-2-butene in power cycles
KR20140138215A (ko) 2012-03-30 2014-12-03 다이이찌 산쿄 가부시키가이샤 신규 항 Ｓｉｇｌｅｃ-15 항체
NZ631509A (en) * 2012-03-30 2016-09-30 Daiichi Sankyo Co Ltd Cdr-modified anti-siglec-15 antibody
US9493562B2 (en) * 2012-07-19 2016-11-15 Alethia Biotherapeutics Inc. Anti-Siglec-15 antibodies
ES2729797T3 (es) * 2013-12-20 2019-11-06 Dev Ct Biotechnology Anticuerpos específicos de la alfa-enolasa y métodos de uso en terapias contra el cáncer
US9382331B2 (en) * 2013-12-27 2016-07-05 Development Center For Biotechnology Alpha-enolase specific antibodies and methods of uses in cancer therapy
US20170129956A1 (en) * 2014-06-18 2017-05-11 Daiichi Sankyo Company, Limited Anti-siglec-15 antibodies for use in treatment of osteogenesis imperfecta
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