AU2010229490B2 - Slip chip device and methods - Google Patents

Slip chip device and methods Download PDF

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Publication number
AU2010229490B2
AU2010229490B2 AU2010229490A AU2010229490A AU2010229490B2 AU 2010229490 B2 AU2010229490 B2 AU 2010229490B2 AU 2010229490 A AU2010229490 A AU 2010229490A AU 2010229490 A AU2010229490 A AU 2010229490A AU 2010229490 B2 AU2010229490 B2 AU 2010229490B2
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Australia
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areas
area
substance
exposed
slipchip
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AU2010229490A1 (en
Inventor
Delai Chen
Wenbin Du
Rustem F. Ismagilov
Jason Eugene Kreutz
Liang Li
Kevin Paul Flood Nichols
Feng Shen
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University of Chicago
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University of Chicago
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Priority to AU2015200465A priority Critical patent/AU2015200465A1/en
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Publication of AU2010229490B2 publication Critical patent/AU2010229490B2/en
Priority to AU2017202597A priority patent/AU2017202597B2/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L23/00—Details of semiconductor or other solid state devices
    • H01L23/52—Arrangements for conducting electric current within the device in operation from one component to another, i.e. interconnections, e.g. wires, lead frames
    • H01L23/538—Arrangements for conducting electric current within the device in operation from one component to another, i.e. interconnections, e.g. wires, lead frames the interconnection structure between a plurality of semiconductor chips being formed on, or in, insulating substrates
    • H01L23/5381—Crossover interconnections, e.g. bridge stepovers
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
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    • B01F33/30—Micromixers
    • B01F33/304—Micromixers the mixing being performed in a mixing chamber where the products are brought into contact
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
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    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
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    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/0001—Technical content checked by a classifier
    • H01L2924/0002—Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00
AU2010229490A 2009-03-24 2010-03-23 Slip chip device and methods Active AU2010229490B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2015200465A AU2015200465A1 (en) 2009-03-24 2015-01-30 Slip chip device and methods
AU2017202597A AU2017202597B2 (en) 2009-03-24 2017-04-19 Slip chip device and methods

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US16292209P 2009-03-24 2009-03-24
US61/162,922 2009-03-24
US26237509P 2009-11-18 2009-11-18
US61/262,375 2009-11-18
US34087210P 2010-03-22 2010-03-22
US61/340,872 2010-03-22
PCT/US2010/028316 WO2010111265A1 (en) 2009-03-24 2010-03-23 Slip chip device and methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2015200465A Division AU2015200465A1 (en) 2009-03-24 2015-01-30 Slip chip device and methods

Publications (2)

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AU2010229490A1 AU2010229490A1 (en) 2011-10-20
AU2010229490B2 true AU2010229490B2 (en) 2015-02-12

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AU2010229490A Active AU2010229490B2 (en) 2009-03-24 2010-03-23 Slip chip device and methods

Country Status (9)

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US (3) US9415392B2 (ko)
EP (1) EP2412020B1 (ko)
JP (4) JP5766178B2 (ko)
KR (2) KR101796906B1 (ko)
CN (2) CN104722342B (ko)
AU (1) AU2010229490B2 (ko)
CA (1) CA2756463C (ko)
IL (2) IL215160A (ko)
WO (1) WO2010111265A1 (ko)

Families Citing this family (239)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005027714A2 (en) 2003-07-12 2005-03-31 Accelr8 Technology Corporation Sensitive and rapid biodetection
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US8741158B2 (en) 2010-10-08 2014-06-03 Ut-Battelle, Llc Superhydrophobic transparent glass (STG) thin film articles
KR20100135797A (ko) 2008-03-12 2010-12-27 유니버시티 오브 버지니아 페이턴트 파운데이션 중합체 분석물의 검출
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US10196700B2 (en) * 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
CN104722342B (zh) 2009-03-24 2017-01-11 芝加哥大学 滑动式芯片装置和方法
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
IT1393855B1 (it) * 2009-04-22 2012-05-11 Consiglio Nazionale Ricerche Dispensatore elettrodinamico di liquidi in quantita' micro/nano-litriche basato sull'effetto piroelettrico in materiali funzionalizzati, senza l'impiego di sorgenti elettriche esterne.
WO2011014946A1 (en) * 2009-08-02 2011-02-10 Samad Talebpour Cell concentration, capture and lysis devices and methods of use thereof
US10739358B2 (en) * 2009-12-18 2020-08-11 Entegrion, Inc. Portable coagulation monitoring devices, systems, and methods
JP5791634B2 (ja) 2010-01-29 2015-10-07 マイクロニクス， インコーポレイテッド サンプル−回答型のマイクロ流体カートリッジ
EP2543981A1 (en) * 2010-03-03 2013-01-09 Nippon Kayaku Kabushiki Kaisha Detection device
US20140297397A1 (en) * 2010-04-25 2014-10-02 Tomer Bakalash Use of neural activation in the superior temporal sulcus as a predictor for memorability of audio and/or visual content and emotional engagement
US20150359431A1 (en) * 2010-04-25 2015-12-17 Tomer Bakalash Brand-self perceptual neural model utilizing the superior temporal sulcus
US10232374B2 (en) 2010-05-05 2019-03-19 Miroculus Inc. Method of processing dried samples using digital microfluidic device
JP5893620B2 (ja) 2010-07-22 2016-03-23 ジェンセル バイオシステムズ リミテッド 合成液体セル
US9476811B2 (en) 2010-10-01 2016-10-25 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods incorporating a solid phase
JP5756611B2 (ja) * 2010-10-07 2015-07-29 株式会社 資生堂 分析方法
US11292919B2 (en) 2010-10-08 2022-04-05 Ut-Battelle, Llc Anti-fingerprint coatings
WO2012100198A2 (en) * 2011-01-20 2012-07-26 University Of Washington Through Its Center For Commercialization Methods and systems for performing digital measurements
WO2012122314A2 (en) 2011-03-07 2012-09-13 Accelr8 Technology Corporation Rapid cell purification systems
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
WO2012122628A1 (en) * 2011-03-15 2012-09-20 National Research Council Of Canada Microfluidic system having monolithic nanoplasmonic structures
US9541480B2 (en) 2011-06-29 2017-01-10 Academia Sinica Capture, purification, and release of biological substances using a surface coating
US20140349298A1 (en) * 2011-07-14 2014-11-27 William Eugene Stanchina Portable, low power instrument for the optoelectronic detection of pathogens using isothermal nucleic acid amplification protocols
JP6203721B2 (ja) 2011-08-22 2017-09-27 ウオーターズ・テクノロジーズ・コーポレイシヨン 抽出サンプルの希釈を伴うマイクロ流体システムにおける乾燥血液スポットサンプルの分析
US9481945B2 (en) * 2011-08-30 2016-11-01 The Royal Institution For The Advancement Of Learning / Mcgill University Methods and devices for multiplexed microarray microfluidic analysis of biomolecules
EP3812468A1 (en) * 2011-10-31 2021-04-28 Merck Sharp & Dohme Corp. Methods of preparing lyophilized spherical-shaped pellets of biological materials
US8824768B1 (en) * 2011-11-10 2014-09-02 Blair K. Simon Fertilization test method and apparatus
JP6057251B2 (ja) * 2011-11-11 2017-01-11 国立研究開発法人産業技術総合研究所 粒子分別装置および粒子分別方法
ES2757700T3 (es) 2011-12-21 2020-04-29 Huawei Tech Co Ltd Detección y codificación de altura tonal muy débil
DE102012100824A1 (de) * 2012-02-01 2013-09-05 Albert-Ludwigs-Universität Freiburg Gemultiplexte Digital PCR
EP3417941B1 (en) * 2012-03-16 2022-03-02 Life Technologies Corporation Systems and methods for assessing of biological samples
US9192651B2 (en) 2012-04-02 2015-11-24 Moderna Therapeutics, Inc. Modified polynucleotides for the production of secreted proteins
CA2868391A1 (en) 2012-04-02 2013-10-10 Stephane Bancel Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same
AU2013249007B2 (en) * 2012-04-20 2016-04-21 California Institute Of Technology Fluidic devices and systems for sample preparation or autonomous analysis
WO2013159116A1 (en) * 2012-04-20 2013-10-24 University Of Chicago Fluidic devices for biospecimen preservation
US9803237B2 (en) * 2012-04-24 2017-10-31 California Institute Of Technology Slip-induced compartmentalization
CA2871191A1 (en) * 2012-04-24 2013-10-31 Transfert Plus, S.E.C. Methods and apparatuses for evaluating water pollution
US9044738B2 (en) * 2012-04-30 2015-06-02 General Electric Company Methods and compositions for extraction and storage of nucleic acids
US9480966B2 (en) 2012-04-30 2016-11-01 General Electric Company Substrates and methods for collection, stabilization and elution of biomolecules
US9283559B2 (en) 2012-05-09 2016-03-15 Wisconsin Alumni Research Foundation Lid for functionalized microfluidic platform and method
US9186670B2 (en) * 2012-05-09 2015-11-17 Wisconsin Alumni Research Foundation Functionalized microfluidic device and method
US9410171B2 (en) 2012-06-20 2016-08-09 The Regents Of The University Of California Non-thermal cycling for polymerase chain reaction
JP6298048B2 (ja) 2012-06-28 2018-03-20 フルオレセントリック，インコーポレイテッド 化学的インジケータデバイス
US10079086B2 (en) 2012-06-29 2018-09-18 Koninklijke Philips N.V. Processing of bound and unbound magnetic particles
US9136099B2 (en) * 2012-07-04 2015-09-15 Sony Dadc Austria Ag Method and substrates for forming crystals
US9771656B2 (en) 2012-08-28 2017-09-26 Ut-Battelle, Llc Superhydrophobic films and methods for making superhydrophobic films
US9766166B2 (en) * 2013-01-09 2017-09-19 Wisconsin Alumni Research Foundation Device and method incorporating a slideable lid for extracting a targeted fraction from a sample
EP2904116A4 (en) * 2012-10-05 2016-05-11 California Inst Of Techn METHOD AND SYSTEMS FOR MICROFLUID RECYCLING AND ANALYSIS
WO2016154113A1 (en) * 2015-03-20 2016-09-29 The Methodist Hospital Multiplexed volumetric bar chart chip for point of care biomarker and/or analyte quantitation, including competitive control
US9097710B2 (en) * 2012-10-16 2015-08-04 The Methodist Hospital Research Institute Multiplexed volumetric bar chart chip for point of care biomarker and analyte quantitation
EP2925449A2 (en) 2012-11-27 2015-10-07 Gencell Biosystems Limited Handling liquid samples
WO2014100725A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Portable fluorescence detection system and microassay cartridge
CN107824233B (zh) 2012-12-21 2020-06-30 珀金埃尔默健康科学有限公司 用于微流体用途的低弹性膜
EP2935908B1 (en) 2012-12-21 2019-08-14 PerkinElmer Health Sciences, Inc. Fluidic circuits and related manufacturing methods
US20140206007A1 (en) * 2013-01-18 2014-07-24 The Johns Hopkins University Electromagnetically actuated droplet microfluidic chip and system
US9888283B2 (en) 2013-03-13 2018-02-06 Nagrastar Llc Systems and methods for performing transport I/O
USD758372S1 (en) * 2013-03-13 2016-06-07 Nagrastar Llc Smart card interface
EP2972244A4 (en) * 2013-03-14 2016-11-02 Diagnostics For All Inc MOLECULAR DIAGNOSTIC DEVICES WITH MAGNETIC COMPONENTS
US11029310B2 (en) * 2013-03-14 2021-06-08 Wisconsin Alumni Research Foundation Device and method for extracting a targeted fraction from a sample
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
GB201304797D0 (en) * 2013-03-15 2013-05-01 Diagnostics For The Real World Ltd Apparatus and method for automated sample preparation and adaptor for use in the apparatus
SG10201800317PA (en) * 2013-04-19 2018-02-27 California Inst Of Techn Parallelized sample handling
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
AU2014262726B2 (en) 2013-05-07 2019-09-19 Perkinelmer Health Sciences, Inc. Device for preparation and analysis of nucleic acids
JP6472788B2 (ja) 2013-05-07 2019-02-20 マイクロニクス， インコーポレイテッド 粘土鉱物およびアルカリ性溶液を使用して核酸含有試料を調製するための方法
JP6244589B2 (ja) * 2013-05-21 2017-12-13 国立大学法人名古屋大学 微粒子分離用マイクロ流路チップ、移流集積ユニット、微粒子分離用システム及び微粒子分離方法
GB201311679D0 (en) 2013-06-28 2013-08-14 Ibm Microfluidic chip with dielectrophoretic electrodes extending in hydrophilic flow path
WO2015009967A1 (en) * 2013-07-19 2015-01-22 California Institute Of Technology Digital assay for quantifying and concentrating analytes
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
AU2014315287A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Chimeric polynucleotides
CN105939779A (zh) * 2013-09-18 2016-09-14 加州理工学院 用于移动和定时控制的系统和方法
JP2015068708A (ja) * 2013-09-27 2015-04-13 株式会社東芝 表面状態評価装置及び表面状態評価方法
TWI581861B (zh) * 2013-09-30 2017-05-11 新加坡科技研究局 微流體裝置、用於檢測之系統、使用該系統之檢測方法及該系統之用途
CN105848783B (zh) * 2013-09-30 2017-12-01 卡皮坦内尔公司 微流体装置、使用和方法
CA2926218A1 (en) 2013-10-03 2015-04-09 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
WO2015058008A2 (en) 2013-10-18 2015-04-23 California Institute Of Technology Enhanced nucleic acid identification and detection
US10823743B1 (en) 2013-10-28 2020-11-03 Ifirst Medical Technologies, Inc. Methods of measuring coagulation of a biological sample
US10168271B2 (en) 2013-11-01 2019-01-01 The General Hospital Corporation Microparticles having reference markers arranged in different concentrations
WO2015160419A2 (en) 2014-02-05 2015-10-22 Slipchip Corporation Sample preparation module with stepwise pressurization mechanism
CN106029885A (zh) 2014-02-10 2016-10-12 基因细胞生物系统有限公司 复合液体池(clc)介导的核酸文库制备装置及其使用方法
US20150239773A1 (en) 2014-02-21 2015-08-27 Ut-Battelle, Llc Transparent omniphobic thin film articles
CN105473996B (zh) 2014-03-07 2019-11-12 生物辐射实验室股份有限公司 使用滑动装置的自动印迹
US10195610B2 (en) * 2014-03-10 2019-02-05 Click Diagnostics, Inc. Cartridge-based thermocycler
WO2015148609A2 (en) * 2014-03-26 2015-10-01 Li-Cor, Inc. Immunoassays using colloidal crystals
EP3126814B1 (en) 2014-04-01 2019-06-12 Academia Sinica Methods and systems for cancer diagnosis and prognosis
US10619192B2 (en) 2014-04-08 2020-04-14 University Of Washington Through Its Center For Commercialization Methods and apparatus for performing digital assays using polydisperse droplets
WO2015164770A1 (en) 2014-04-24 2015-10-29 Diassess Inc. Colorimetric detection of nucleic acid amplification
KR101596131B1 (ko) * 2014-04-25 2016-02-22 한국과학기술원 소수성 표면을 이용한 칩 패키징 방법 및 칩 패키지
EP3169693B1 (en) 2014-07-16 2022-03-09 ModernaTX, Inc. Chimeric polynucleotides
US20170210788A1 (en) 2014-07-23 2017-07-27 Modernatx, Inc. Modified polynucleotides for the production of intrabodies
US10073091B2 (en) 2014-08-08 2018-09-11 Ortho-Clinical Diagnostics, Inc. Lateral flow assay device
CN105381824B (zh) 2014-08-26 2019-04-23 中央研究院 收集器架构布局设计
WO2016044578A1 (en) * 2014-09-18 2016-03-24 Cedars-Sinai Medical Center Antifungal therapy for the treatment of hirschsprung-associated enterocolitis
US10094767B2 (en) * 2014-09-19 2018-10-09 Konica Minolta, Inc. Image processor, image processing method, and program
US10446728B2 (en) * 2014-10-31 2019-10-15 eLux, Inc. Pick-and remove system and method for emissive display repair
US10418527B2 (en) * 2014-10-31 2019-09-17 eLux, Inc. System and method for the fluidic assembly of emissive displays
EP3212315A4 (en) 2014-10-31 2018-07-11 Massachusetts Institute of Technology Compositions and methods for forming emulsions
CN107636173A (zh) 2014-11-05 2018-01-26 加州理工学院 生物体对药物的响应的微流体测量
FR3028318A1 (fr) * 2014-11-12 2016-05-13 Phuong Lan Tran Procede et dispositif de tri selectif, specifique et simultane de cellules rares cibles dans un echantillon biologique
EP3240906B1 (en) 2014-12-31 2021-08-25 Visby Medical, Inc. Devices for molecular diagnostic testing
US10233505B2 (en) * 2015-01-16 2019-03-19 Kansas State University Research Foundation Co-detection and association of multiple genes from the same genome in a sample
GB2536650A (en) 2015-03-24 2016-09-28 Augmedics Ltd Method and system for combining video-based and optic-based augmented reality in a near eye display
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
KR101656181B1 (ko) 2015-03-30 2016-09-08 경희대학교 산학협력단 마이크로 패드 플랫폼
EP3278115A2 (en) 2015-03-30 2018-02-07 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
CN104774747B (zh) * 2015-04-14 2017-03-01 浙江大学 用于细胞迁移分析实验的微流控液滴芯片装置及方法
WO2016172388A2 (en) * 2015-04-21 2016-10-27 Joseph Paul Robinson Culture detection and measurement over time
EP3250919A4 (en) * 2015-04-29 2019-03-06 Ixcela, Inc. METHOD AND DEVICE FOR QUANTIZING BLOOD SAMPLES
USD864968S1 (en) 2015-04-30 2019-10-29 Echostar Technologies L.L.C. Smart card interface
CN106268392B (zh) * 2015-05-27 2019-12-13 艾博生物医药(杭州)有限公司 一种混合至少两种物质的方法
WO2016197103A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
CN208562324U (zh) 2015-06-05 2019-03-01 米罗库鲁斯公司 空气基质数字微流控(dmf)装置
GB201511342D0 (en) * 2015-06-29 2015-08-12 Rolls Royce Plc Vortex identification methods and tools
EP3120928A1 (en) 2015-07-24 2017-01-25 Centre National De La Recherche Scientifique Fluidic devices with at least one actionnable fiber
EP3341465B1 (en) * 2015-08-26 2023-10-04 Emulate, Inc. Perfusion manifold assembly
US20170058277A1 (en) * 2015-08-26 2017-03-02 Gencell Biosystems Ltd. Composite liquid cell (clc) supports, and methods of making and using the same
CN115161178A (zh) 2015-09-09 2022-10-11 集联健康有限公司 用于样品收集、稳定化和保存的系统、方法和装置
US10300485B2 (en) 2015-10-23 2019-05-28 The Royal Institution For The Advancement Of Learning/Mcgill University Nanoarray-in-microarray multiplexed analysis methods and systems
FR3044685B1 (fr) * 2015-12-02 2020-11-27 Univ Grenoble 1 Puce microfluidique pour la cristallisation de molecules, procede de preparation, dispositif la comprenant et procede de cristallisation de molecules
TWI579030B (zh) * 2015-12-15 2017-04-21 Ｃｇ生物技術有限公司 分離細胞之容器、系統及方法
CN105400693B (zh) * 2015-12-15 2017-06-06 上海海洋大学 平板等温核酸扩增芯片
CN105400692B (zh) * 2015-12-15 2017-06-27 上海海洋大学 等温核酸扩增装置及等温核酸扩增实验方法
EP3402595A4 (en) * 2016-01-11 2019-10-02 Fluoresentric, Inc. SYSTEMS, APPARATUS AND METHODS FOR PREPARING CONTINUOUS SAMPLES
KR20170099737A (ko) * 2016-02-23 2017-09-01 노을 주식회사 접촉식 염색 패치 및 이를 이용하는 염색 방법
JP7064665B2 (ja) 2016-03-07 2022-05-11 ファーザー フラナガンズ ボーイズ ホーム ドゥーイング ビジネス アズ ボーイズ タウン ナショナル リサーチ ホスピタル 非侵襲的分子対照
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
CN105861309B (zh) * 2016-04-14 2018-05-11 清华大学 一种超疏水微坑阵列芯片及其制备方法与应用
WO2017185067A1 (en) 2016-04-22 2017-10-26 Click Diagnostics, Inc. Printed circuit board heater for an amplification module
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
CN106031889B (zh) * 2016-05-17 2018-04-17 西安交通大学 一种基于离心平台的蛋白质快速检测系统
CN106513062B (zh) * 2016-05-30 2019-02-22 苏州汶颢芯片科技有限公司 酶联免疫快速检测的微流控芯片及其预处理和检测方法
US10255524B2 (en) 2016-06-03 2019-04-09 Becton Dickinson Rowa Germany Gmbh Method for providing a singling device of a storage and dispensing container
US10150115B2 (en) * 2016-07-21 2018-12-11 Spacepharma SA System and method for rehydrating powder and delivering the rehydrated powder to a reactor
CN106268990B (zh) * 2016-07-26 2018-07-24 林捷琳 一种基于点阵热压法的纸微流控芯片制备方法
CA3034064A1 (en) 2016-08-22 2018-03-01 Miroculus Inc. Feedback system for parallel droplet control in a digital microfluidic device
US11168347B2 (en) 2016-09-23 2021-11-09 California Institute Of Technology Digital quantification of DNA replication and/or chromosome segregation based determination of antimicrobial susceptibility
EP3532821A4 (en) * 2016-10-26 2020-06-24 Integrated Nano-Technologies, Inc. SYSTEMS AND METHODS FOR OPTICAL DETECTION OF BIOMOLECULAR TARGETS
CN106370832B (zh) * 2016-11-09 2024-02-27 苏州一呼医疗科技有限公司 智能呼气分子诊断系统
CN106754335B (zh) * 2016-11-22 2019-05-17 上海海洋大学 一种等温核酸扩增芯片
CA3049416A1 (en) 2016-12-28 2018-07-05 Miroculus Inc. Digital microfluidic devices and methods
TWI786079B (zh) 2017-01-10 2022-12-11 美商集聯健康有限公司 用於收集及儲存血液的裝置
US10470841B2 (en) * 2017-03-28 2019-11-12 Steris Inc. Robot-based rack processing system
WO2018187476A1 (en) 2017-04-04 2018-10-11 Miroculus Inc. Digital microfluidic apparatuses and methods for manipulating and processing encapsulated droplets
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
CN106916728B (zh) * 2017-04-18 2023-10-27 朱红 一种磁力搅拌式药敏分析仪器以及配套试剂盒
US10787695B2 (en) * 2017-06-01 2020-09-29 General Electric Company Systems and methods for rapidly sensing microbial metabolism
US11413617B2 (en) 2017-07-24 2022-08-16 Miroculus Inc. Digital microfluidics systems and methods with integrated plasma collection device
JP2019024366A (ja) * 2017-07-27 2019-02-21 キヤノン株式会社 分析システム、分析方法、プログラム、および記憶媒体
CN107287112A (zh) * 2017-08-03 2017-10-24 甘肃出入境检验检疫局检验检疫综合技术中心 一种阵列式数字pcr芯片及其使用方法
CN107365685A (zh) * 2017-08-03 2017-11-21 甘肃出入境检验检疫局检验检疫综合技术中心 数字pcr扩增仪及其工作方法
JP2019030273A (ja) * 2017-08-09 2019-02-28 キヤノン株式会社 分析システム、分析方法、プログラム、および記憶媒体
EP3669180A4 (en) 2017-08-18 2021-06-09 Somadetect Inc. METHODS AND SYSTEMS FOR EVALUATING THE HEALTH CONDITION OF A LACTATING MAMMAL
KR102192651B1 (ko) * 2017-08-23 2020-12-17 노을 주식회사 시약을 저장하는 저장 매체 및 이를 이용한 검사 방법 및 검사 모듈
EP3676009A4 (en) 2017-09-01 2021-06-16 Miroculus Inc. DIGITAL MICROFLUIDIC DEVICES AND THEIR METHODS OF USE
EP3679140B1 (en) 2017-09-08 2022-11-16 MiNA Therapeutics Limited Stabilized cebpa sarna compositions and methods of use
KR101977963B1 (ko) * 2017-09-13 2019-08-28 건국대학교 산학협력단 미세 유체 제어 장치 및 이를 이용하는 미세 유체의 제어 방법
WO2019135800A2 (en) 2017-09-14 2019-07-11 California Institute Of Technology Purification and detection of analytes
WO2019060900A1 (en) * 2017-09-25 2019-03-28 California Institute Of Technology DEVICE FOR ADDITIVE REAGENT DISTRIBUTION AND ASSOCIATED METHODS AND SYSTEMS
CN107886496A (zh) * 2017-09-30 2018-04-06 北京得华机器人技术研究院有限公司 一种基于形状匹配的汽车零配件的质量检测方法
US11827944B2 (en) 2017-10-11 2023-11-28 California Institute Of Technology Antibiotic susceptibility of microorganisms and related compositions, methods and systems
WO2019075321A1 (en) 2017-10-13 2019-04-18 The Charles Stark Draper Laboratory, Inc. MINIATURIZED DNA MICROARRAY FOR SMALL VOLUME SAMPLE PROCESSING
CN108004129A (zh) * 2017-10-28 2018-05-08 深圳职业技术学院 一种核酸一体化多重检测盒体及检测方法
JP7098096B2 (ja) * 2017-11-07 2022-07-11 株式会社リコー 検出精度特定方法、検出精度特定装置、及び検出精度特定プログラム
AU2018364741B2 (en) 2017-11-09 2021-03-25 Visby Medical, Inc. Portable molecular diagnostic device and methods for the detection of target viruses
US11162192B2 (en) 2017-12-01 2021-11-02 Arizona Board Of Regents On Behalf Of Arizona State University Materials and methods relating to single molecule arrays
EP3495865A1 (en) * 2017-12-07 2019-06-12 European Molecular Biology Laboratory A sample holder for imaging a plurality of samples
CA3082938C (en) * 2017-12-08 2024-01-02 Enuvio Inc. Microfluidic chip and method for making the same
CN116121340A (zh) * 2017-12-19 2023-05-16 生物动力学公司 用于从生物样品中检测多种分析物的方法和装置
CN108153955A (zh) * 2017-12-20 2018-06-12 湖州师范学院 基于遗传算法的柴油机硅油减振器多目标动态匹配方法
WO2019155488A1 (en) * 2018-02-07 2019-08-15 Jaydeep Bhattacharya A low cost microfluidic device for dna/rna isolation, purification and amplification using chip based pcr/ rt- pcr for biosensing applications
CN108660068B (zh) * 2018-02-13 2022-04-05 臻准生物工程(山西)有限公司 生物反应芯片及其制备方法
WO2019165363A1 (en) * 2018-02-23 2019-08-29 University Of Virginia Patent Foundation Slipchip device for on-chip dilution and size-based extraction of protein labeling reagents
CN108121981A (zh) * 2018-02-26 2018-06-05 深圳市生强科技有限公司 指纹检测装置
JP2021520218A (ja) 2018-04-02 2021-08-19 バイオロジカル ダイナミクス，インク． 誘電体材料
EP4242307A3 (en) 2018-04-12 2023-12-27 MiNA Therapeutics Limited Sirt1-sarna compositions and methods of use
CN114345261B (zh) * 2018-04-17 2023-03-14 上海交通大学 一种制备微颗粒的方法
EP3787543A4 (en) 2018-05-02 2022-01-19 Augmedics Ltd. REGISTRATION OF A REFERENCE MARK FOR AN AUGMENTED REALITY SYSTEM
CA3100580A1 (en) * 2018-05-18 2019-11-21 Enersoft Inc. Geological analysis system and methods using x-ray flurescence and spectroscopy
CN108837718A (zh) * 2018-06-11 2018-11-20 上海交通大学 一种高通量微液滴梯度稀释装置和方法
CN108896754A (zh) * 2018-07-05 2018-11-27 南京优芯生物科技有限公司 一种快速检测生物标志物的滑动微流控芯片
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
WO2020028729A1 (en) * 2018-08-01 2020-02-06 Mammoth Biosciences, Inc. Programmable nuclease compositions and methods of use thereof
JP2020034496A (ja) * 2018-08-31 2020-03-05 シスメックス株式会社 試料処理方法、試料処理装置、プログラムおよび試料処理カートリッジ
JP2020031606A (ja) * 2018-08-31 2020-03-05 シスメックス株式会社 核酸検出装置および核酸検出方法
CN109046484B (zh) * 2018-09-12 2021-03-30 上海交通大学 一种位移式微流控芯片由表面张力生成液滴的方法
CA3114215A1 (en) * 2018-10-09 2020-04-16 Lucira Health, Inc. Consumer-based disease diagnostics
WO2020086674A1 (en) * 2018-10-23 2020-04-30 Myriad Applied Technologies, Inc. Kits and methods for real-time multiplex detection and identification of pathogens
CN109092022B (zh) * 2018-11-06 2023-11-24 王东杰 一种内外循环风道切换结构及其控湿装置
CN109612853B (zh) * 2018-11-26 2021-08-03 Tcl华星光电技术有限公司 抗压测试装置及其测试方法
US11766296B2 (en) 2018-11-26 2023-09-26 Augmedics Ltd. Tracking system for image-guided surgery
US20220120671A1 (en) * 2019-01-14 2022-04-21 Infiniplex Ltd. Multi-test kit
AU2020215103A1 (en) * 2019-01-31 2021-07-29 Samplix Aps A microfluidic device and a method for provision of emulsion droplets
CN109540860B (zh) * 2019-02-19 2021-03-02 济南大学 一种检测卡那霉素的荧光生物传感器及其制备方法和应用
CN112563226B (zh) * 2019-02-22 2022-07-19 西安航思半导体有限公司 便于散热的dfn封装器件
WO2020190454A1 (en) * 2019-03-18 2020-09-24 Cellular Research, Inc. Precise delivery of components into fluids
CN113661235A (zh) 2019-04-03 2021-11-16 格瑞丁泰克公司 盒组件
CA3133124A1 (en) 2019-04-08 2020-10-15 Miroculus Inc. Multi-cartridge digital microfluidics apparatuses and methods of use
WO2020208361A1 (en) 2019-04-12 2020-10-15 Mina Therapeutics Limited Sirt1-sarna compositions and methods of use
CN110071031B (zh) * 2019-05-05 2020-05-05 东北大学 一种蛇形线式质谱仪连续性变压取样装置及方法
CN110082346B (zh) * 2019-05-12 2020-11-03 武汉生之源生物科技股份有限公司 一种载脂蛋白e检测试剂盒
EP3976821A1 (en) * 2019-05-27 2022-04-06 Centre National De La Recherche Scientifique (Cnrs) Digital biomolecules detection and/or quantification using isothermal amplification
CN110272822B (zh) * 2019-06-06 2021-10-26 上海交通大学 一种基因扩增实时荧光定量检测装置及检测方法
US11524298B2 (en) 2019-07-25 2022-12-13 Miroculus Inc. Digital microfluidics devices and methods of use thereof
US20220268754A1 (en) * 2019-07-29 2022-08-25 The Regents Of The University Of California Early detection of e. coli and total coliform using an automated, colorimetric and fluorometric fiber optics-based device
CN110643483B (zh) * 2019-09-06 2023-04-14 上海交通大学 一种在微流控芯片上生成液滴阵列的方法
US20210116338A1 (en) * 2019-10-19 2021-04-22 Cfd Research Corporation Fluidic bead trap and methods of use
US11382712B2 (en) 2019-12-22 2022-07-12 Augmedics Ltd. Mirroring in image guided surgery
US11866695B2 (en) 2019-12-23 2024-01-09 California Institute Of Technology Methods and systems and related compositions for mixtures separation with a solid matrix
EP4085149A4 (en) 2020-01-03 2024-03-06 Visby Medical Inc ANTIBIOTIC SUSCEPTIBILITY TESTING DEVICES AND METHODS
US20230051263A1 (en) * 2020-01-09 2023-02-16 The Regents Of The University Of Michigan Device for rapid and quantitative detection of drugs of abuse in sweat
CN111250182B (zh) * 2020-02-11 2021-03-19 北京理工大学 一种高通量微流控电泳筛分芯片及其制备方法、应用方法
KR102375816B1 (ko) * 2020-02-14 2022-03-18 주식회사 디앤에이보이 검체 분석 디바이스 및 이의 제조 방법
CN111676131A (zh) * 2020-06-17 2020-09-18 清华大学 用于活体单细胞局部微区原位自由基刺激的微流控装置
EP4228815A1 (en) * 2020-10-19 2023-08-23 Bio-Rad Laboratories, Inc. System and method for rapid multiplexed sample processing with applications for nucleic acid amplification assays
TWI776559B (zh) * 2020-11-12 2022-09-01 邑流微測股份有限公司 顯微鏡觀測載台
GB2603454A (en) 2020-12-09 2022-08-10 Ucl Business Ltd Novel therapeutics for the treatment of neurodegenerative disorders
JP2022102386A (ja) * 2020-12-25 2022-07-07 国立大学法人旭川医科大学 遺伝子解析用サンプルの製造方法
CN114798013A (zh) * 2021-01-29 2022-07-29 中国科学院长春光学精密机械与物理研究所 一种微流控芯片及其制造方法
CN114836291A (zh) * 2021-02-01 2022-08-02 深圳拜尔洛克生物技术有限公司 生物材料解冻复苏的系统及其方法
CA3214137A1 (en) 2021-03-26 2022-09-29 Mina Therapeutics Limited Tmem173 sarna compositions and methods of use
KR102577768B1 (ko) * 2021-04-06 2023-09-12 연세대학교 산학협력단 세포포획이 가능한 미세유체 디바이스
US11896445B2 (en) 2021-07-07 2024-02-13 Augmedics Ltd. Iliac pin and adapter
CN113699033A (zh) * 2021-08-10 2021-11-26 上海交通大学 一种基于熔解曲线的多重数字核酸分析装置和分析方法
RU209656U1 (ru) * 2021-09-22 2022-03-17 Федеральное государственное бюджетное образовательное учреждение высшего образования "Брянский государственный аграрный университет" Цилиндрический триер
CA3233168A1 (en) * 2021-09-27 2023-03-30 Richard D. Oleschuk Method and apparatus for rapid mass spectrometric calibration
CN114062632B (zh) * 2021-11-17 2023-12-29 扬州大学 一种基于纳米颗粒酶联增敏的镉离子微流控检测方法
WO2023099884A1 (en) 2021-12-01 2023-06-08 Mina Therapeutics Limited Pax6 sarna compositions and methods of use
GB202117758D0 (en) 2021-12-09 2022-01-26 Ucl Business Ltd Therapeutics for the treatment of neurodegenerative disorders
CN114113023B (zh) * 2021-12-16 2024-04-26 郑州轻工业大学 基于单核增生李斯特菌来源的氮掺杂碳点的制备方法和应用
US11772093B2 (en) 2022-01-12 2023-10-03 Miroculus Inc. Methods of mechanical microfluidic manipulation
WO2023170435A1 (en) 2022-03-07 2023-09-14 Mina Therapeutics Limited Il10 sarna compositions and methods of use
CN114591812B (zh) * 2022-05-10 2022-07-22 博奥生物集团有限公司 生物反应芯片及离心式微流控系统
CN114608891B (zh) * 2022-05-12 2022-07-15 潍坊优特检测服务有限公司 一种全自动水质检测仪器
CN115178199B (zh) * 2022-05-31 2024-04-30 清华大学 无源微流控微反应器以及微流控芯片
CN116606727B (zh) * 2023-04-17 2024-03-12 长庚大学 核酸检测装置及核酸检测方法
CN117168612B (zh) * 2023-09-27 2024-01-02 华安钢宝利高新汽车板加工(常熟)有限公司 一种激光器发光功率监测装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020125197A1 (en) * 2001-03-08 2002-09-12 Hager David C. Multi-well apparatus
US20040119070A1 (en) * 2002-08-02 2004-06-24 Roach David John Integrated microchip design
US20070026439A1 (en) * 2005-07-15 2007-02-01 Applera Corporation Fluid processing device and method
US20090021728A1 (en) * 2007-06-21 2009-01-22 Gen-Probe Incorporated Multi-Channel Optical Measurement Instrument

Family Cites Families (278)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2541413A (en) 1947-04-01 1951-02-13 Graflex Inc Photographic camera and shutter therefor
US3787290A (en) 1972-04-10 1974-01-22 S Kaye Method and means for assaying biological factors demonstrating quantal response
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4071409A (en) 1976-05-20 1978-01-31 Corning Glass Works Immobilization of proteins on inorganic support materials
GB2097692B (en) 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
US4853336A (en) 1982-11-15 1989-08-01 Technicon Instruments Corporation Single channel continuous flow system
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
JPS62106000A (ja) 1985-10-30 1987-05-16 Fujitsu Ltd 生体高分子結晶自動作製装置
US5077017A (en) 1987-11-05 1991-12-31 Biotrack, Inc. Integrated serial dilution and mixing cartridge
US5185099A (en) 1988-04-20 1993-02-09 Institut National De Recherche Chimique Appliquee Visco-elastic, isotropic materials based on water, fluorinate sufactants and fluorinated oils, process for their preparation, and their use in various fields, such as optics, pharmacology and electrodynamics
US5026113A (en) 1988-09-09 1991-06-25 Sky-Top Sunroofs Ltd. Sliding and venting sunroof
US5237016A (en) 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5114208A (en) 1989-08-04 1992-05-19 Aisin Seiki Kabushiki Kaisha Sliding mechanism for sunroof
US6503707B1 (en) 1990-06-27 2003-01-07 The Blood Center Research Foundation, Inc. Method for genetic typing
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
WO1992019960A1 (en) 1991-05-09 1992-11-12 Nanophore, Inc. Methods for the electrophoretic separation of nucleic acids and other linear macromolecules in gel media with restrictive pore diameters
US5686315A (en) 1991-06-14 1997-11-11 Quidel Corporation Assay device for one step detection of analyte
US5251670A (en) 1991-06-25 1993-10-12 Bates Lyle D Flush valve
US5169942A (en) 1991-11-21 1992-12-08 General Electric Company Method for making 2-(18F)fluoro-2-deoxy-D-glucose
DE4139664A1 (de) 1991-12-02 1993-06-03 Diagen Inst Molekularbio Vorrichtung und verfahren zur isolierung und reinigung von nukleinsaeuren
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5264570A (en) 1992-08-05 1993-11-23 General Electric Company Method for making 2-[18 F]fluoro-2-deoxy-D-glucose
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
GB9301122D0 (en) 1993-01-21 1993-03-10 Scient Generics Ltd Method of analysis/separation
US5518892A (en) * 1994-02-23 1996-05-21 Idexx Laboratories, Inc. Apparatus and method for quantification of biological material in a liquid sample
US5986076A (en) 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
DE4420732A1 (de) 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
JP3220158B2 (ja) 1994-11-14 2001-10-22 トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア 分析対象物質の確定及び処理のためのメソ規模の試料前処理装置及びシステム
US5688651A (en) 1994-12-16 1997-11-18 Ramot University Authority For Applied Research And Development Ltd. Prevention of protein aggregation
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US20020022261A1 (en) 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US6146854A (en) 1995-08-31 2000-11-14 Sequenom, Inc. Filtration processes, kits and devices for isolating plasmids
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US5707850A (en) 1995-11-09 1998-01-13 Cole; Kenneth D. Concentration and size-fractionation of nucleic acids and viruses in porous media
US5772889A (en) 1995-11-13 1998-06-30 Transgenomic, Inc. System and method for performing nucleic acid separations using liquid chromatography
US5805947A (en) 1995-12-08 1998-09-08 Nikon Corporation Camera provided with a sliding cover
US5917184A (en) 1996-02-08 1999-06-29 Perseptive Biosystems Interface between liquid flow and mass spectrometer
AU706862B2 (en) * 1996-04-03 1999-06-24 Applied Biosystems, Llc Device and method for multiple analyte detection
EP0832436A1 (en) 1996-04-15 1998-04-01 Dade Behring Inc. Apparatus and method for analysis
JP3788519B2 (ja) 1996-06-28 2006-06-21 カリパー・ライフ・サイエンシズ・インコーポレーテッド 微小スケール流体装置の高処理能力スクリーニングアッセイシステム
JP3361530B2 (ja) 1996-06-28 2003-01-07 カリパー・テクノロジーズ・コープ． 電子ピペッタおよび電気泳動バイアスのための補償手段
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
WO1998002237A1 (en) 1996-07-15 1998-01-22 Kemgas Limited Production of powders
US5718509A (en) * 1996-10-03 1998-02-17 Instrumentation Technology Associates, Inc. Materials dispersion apparatus with relatively slidable blocks
US6140053A (en) 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
CA2276251A1 (en) 1996-11-20 1998-05-28 The Regents Of The University Of Michigan Microfabricated isothermal nucleic acid amplification devices and methods
US5725017A (en) 1997-01-27 1998-03-10 Medtronic, Inc. In-line pressure check valve for drug-delivery systems
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
DE19717085C2 (de) 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
US6558901B1 (en) 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
WO1998052691A1 (en) 1997-05-16 1998-11-26 Alberta Research Council Microfluidic system and methods of use
US20050070005A1 (en) 1997-06-16 2005-03-31 Martin Keller High throughput or capillary-based screening for a bioactivity or biomolecule
GB9715101D0 (en) 1997-07-18 1997-09-24 Environmental Sensors Ltd The production of microstructures for analysis of fluids
US6300138B1 (en) 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
US6426230B1 (en) 1997-08-01 2002-07-30 Qualigen, Inc. Disposable diagnostic device and method
US6111096A (en) 1997-10-31 2000-08-29 Bbi Bioseq, Inc. Nucleic acid isolation and purification
ATE218140T1 (de) 1997-12-06 2002-06-15 Dna Res Innovations Ltd Isolierung von nukleinsäuren
US6632653B1 (en) 1997-12-08 2003-10-14 Thomas W. Astle Continuous polymerase chain reaction apparatus with multiple temperature stations
CA2318881A1 (en) 1998-02-04 1999-08-12 Tina Garyantes Virtual wells for use in high throughput screening assays
KR20010082543A (ko) 1998-05-01 2001-08-30 추후제출 Ｄｎａ 재편성을 이용한 내병충성 유전자의 최적화 방법
US5997636A (en) 1998-05-01 1999-12-07 Instrumentation Technology Associates, Inc. Method and apparatus for growing crystals
GB2337261B (en) 1998-05-15 2002-09-18 Fsm Technologies Ltd Separation of nucleic acids
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
FR2782729B1 (fr) 1998-09-01 2002-10-25 Bio Merieux Carte de denombrement et de caracterisation de micro-organismes
US6804663B1 (en) 1998-09-21 2004-10-12 Microsoft Corporation Methods for optimizing the installation of a software product onto a target computer system
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
US20030069601A1 (en) 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
US7790865B1 (en) 1999-02-02 2010-09-07 Qiagen North American Holdings, Inc Eluting reagents, methods and kits for isolating DNA
CA2299119C (en) 1999-02-23 2013-02-05 Qiagen Gmbh A method of stabilizing and/or isolating nucleic acids
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
WO2000052446A1 (en) 1999-03-02 2000-09-08 Qualigen, Inc. Methods and apparatus for separation of biological fluids
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
WO2000053807A1 (en) 1999-03-11 2000-09-14 Whatman, Inc. Solid medium and process for the storage and rapid purification of nucleic acid
US6858439B1 (en) 1999-03-15 2005-02-22 Aviva Biosciences Compositions and methods for separation of moieties on chips
TW496775B (en) 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
US6436292B1 (en) 1999-04-02 2002-08-20 Symyx Technologies, Inc. Parallel high-performance liquid chromatography with post-separation treatment
US6451610B1 (en) 1999-04-14 2002-09-17 International Technidyne Corporation Method and apparatus for coagulation based assays
US7011940B1 (en) 1999-04-14 2006-03-14 Medical Discovery Partners Llc Quality control for cytochemical assays
JP2002542808A (ja) 1999-05-03 2002-12-17 ジェン−プローブ・インコーポレーテッド ポリヌクレオチドマトリックスに基づく微生物同定方法
EP1925678B1 (en) 1999-05-03 2009-07-22 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
US6821770B1 (en) 1999-05-03 2004-11-23 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
US6391624B1 (en) 1999-06-03 2002-05-21 Lockheed Martin Corporation Highly sensitive biological agent probe
DE19926181C1 (de) 1999-06-09 2000-12-14 Inst Mikrotechnik Mainz Gmbh Magazin für mikrostrukturierte Formteile und Verfahren zu dessen Herstellung
US6630006B2 (en) 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US7139592B2 (en) 1999-06-21 2006-11-21 Arraycomm Llc Null deepening for an adaptive antenna based communication station
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US7306672B2 (en) 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US6372895B1 (en) 2000-07-07 2002-04-16 3M Innovative Properties Company Fluorogenic compounds
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
GB2355717A (en) 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
CA2399398A1 (en) 2000-02-11 2001-08-16 Aclara Biosciences, Inc. Microfluid device with sample injector and method of use
US20020012971A1 (en) 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
CA2404008A1 (en) 2000-03-31 2001-10-11 Jurgen Sygusch Protein crystallization in microfluidic structures
US6638408B1 (en) 2000-04-03 2003-10-28 The Wistar Institute Method and device for separation of charged molecules by solution isoelectric focusing
US20020001856A1 (en) 2000-04-06 2002-01-03 Chow Andrea W. Methods and devices for achieving long incubation times in high-throughput systems
US6949575B2 (en) 2000-05-04 2005-09-27 Pfizer Inc. Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives
GB0011443D0 (en) 2000-05-13 2000-06-28 Dna Research Instr Limited Separation device
JP2004502926A (ja) 2000-05-24 2004-01-29 マイクロニックス、インコーポレーテッド 濃度勾配をもたらすマイクロ流体用装置
DE10030584A1 (de) 2000-06-21 2002-01-03 Gneuss Kunststofftechnik Gmbh Mehrweg-Drehschieber-Ventil zur Verteilung von hochmolekularen Polymer-Kunststoff-Schmelzen
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6548256B2 (en) 2000-07-14 2003-04-15 Eppendorf 5 Prime, Inc. DNA isolation method and kit
AU2001283069B2 (en) 2000-08-04 2006-04-27 Caliper Life Sciences, Inc. Control of operation conditions within fluidic systems
US20040005582A1 (en) 2000-08-10 2004-01-08 Nanobiodynamics, Incorporated Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
CA2422110A1 (en) 2000-09-18 2002-03-21 President And Fellows Of Harvard College Method and apparatus for gradient generation
AU2001296288A1 (en) 2000-09-21 2002-04-02 Dna Sciences, Inc. Sample injector system and method
US6808934B2 (en) 2000-09-25 2004-10-26 Picoliter Inc. High-throughput biomolecular crystallization and biomolecular crystal screening
WO2002030562A1 (en) 2000-10-10 2002-04-18 Aviva Biosciences Corporation An integrated biochip system for sample preparation and analysis
GB0030929D0 (en) 2000-12-19 2001-01-31 Inverness Medical Ltd Analyte measurement
US6770434B2 (en) 2000-12-29 2004-08-03 The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin Biological assay method
CN2482070Y (zh) 2001-01-02 2002-03-13 大连市临床检验中心 血液促凝球
US6875403B2 (en) * 2001-02-09 2005-04-05 Microchem Solutions Method and apparatus for reproducible sample injection on microfabricated devices
US20020110835A1 (en) 2001-02-13 2002-08-15 Rajan Kumar Microfluidic devices and methods
NL1017374C2 (nl) 2001-02-15 2002-08-16 Univ Delft Tech Inrichting voor het uitvoeren van een reactie, alsmede een werkwijze voor het uitvoeren van een reactie in de inrichting.
AU2002247248B2 (en) 2001-03-02 2007-07-05 University Of Pittsburgh Of The Commonwealth System Of Higher Education PCR method
EP1795263B2 (en) 2001-03-09 2017-08-23 Gen-Probe Incorporated Method for removing a fluid from a a vessel comprising a penetrable cap
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US20030064414A1 (en) 2001-03-30 2003-04-03 Benecky Michael J. Rapid assessment of coagulation activity in whole blood
US20040137458A1 (en) 2001-05-03 2004-07-15 Christian Archambault Molecular tag code for monitoring a product and process using same
US6797056B2 (en) 2001-06-08 2004-09-28 Syrrx, Inc. Microfluidic method employing delivery of plural different fluids to same lumen
US6994749B2 (en) 2001-06-08 2006-02-07 Syrrx, Inc. Microfluidic device for parallel delivery and mixing of fluids
US6567492B2 (en) 2001-06-11 2003-05-20 Eastern Isotopes, Inc. Process and apparatus for production of F-18 fluoride
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
WO2003000853A2 (en) 2001-06-20 2003-01-03 Caprion Pharmaceuticals Inc. Protein aggregation assays and uses thereof
US20030003962A1 (en) 2001-06-29 2003-01-02 Tan Vooi-Kia Automatic sliding machanism for portable electronic product, particularly for a sliding front cover of a mobile phone
US6702256B2 (en) 2001-07-17 2004-03-09 Agilent Technologies, Inc. Flow-switching microdevice
WO2003015890A1 (en) 2001-08-20 2003-02-27 President And Fellows Of Harvard College Fluidic arrays and method of using
CA2462914A1 (en) 2001-10-11 2003-04-17 Aviva Biosciences Corporation Methods, compositions, and automated systems for separating rare cells from fluid samples
US7297485B2 (en) 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
CA2464350A1 (en) 2001-10-19 2003-05-30 West Virginia University Research Corporation Microfluidic system for proteome analysis
NL1019378C2 (nl) 2001-11-16 2003-05-20 Univ Delft Tech Werkwijze voor het vullen van een putje in een substraat.
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US7867757B2 (en) 2001-12-28 2011-01-11 Norchip As Fluid manipulation in a microfabricated reaction chamber systems
IE20020619A1 (en) 2001-12-31 2003-07-23 Provost Fellows And Scholors O An assay assembly
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
FR2838066B1 (fr) 2002-04-09 2004-06-25 Genesystems Procede et automate d'extraction d'acides nucleiques a partir d'un melange complexe
CA2849556A1 (en) 2002-04-11 2003-10-23 Vu Truong-Le Preservation of bioactive materials by freeze dried foam
EP2282214B1 (en) 2002-05-09 2022-10-05 The University of Chicago Device and method for pressure-driven plug transport and reaction
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
US7122640B2 (en) 2002-06-10 2006-10-17 Phynexus, Inc. Open channel solid phase extraction systems and methods
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US20040005247A1 (en) 2002-07-03 2004-01-08 Nanostream, Inc. Microfluidic closed-end metering systems and methods
EP1380642B1 (en) 2002-07-10 2010-03-31 FUJIFILM Corporation A method for the separation and purification of nucleic acid
JP3983125B2 (ja) 2002-07-19 2007-09-26 富士フイルム株式会社 核酸の分離精製方法
JP3890360B2 (ja) 2002-07-19 2007-03-07 富士フイルム株式会社 核酸の分離精製方法
US7244961B2 (en) 2002-08-02 2007-07-17 Silicon Valley Scientific Integrated system with modular microfluidic components
AU2003284055A1 (en) 2002-10-09 2004-05-04 The Board Of Trustees Of The University Of Illinois Microfluidic systems and components
DK1558934T3 (da) 2002-10-31 2013-10-07 Chemometec As Fremgangsmåde til vurdering af partikler
US20050042639A1 (en) * 2002-12-20 2005-02-24 Caliper Life Sciences, Inc. Single molecule amplification and detection of DNA length
WO2004074818A2 (en) 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
CN101613660B (zh) * 2002-12-30 2013-05-15 加州大学评议会 检测和分析病原体的方法和设备
US7445926B2 (en) * 2002-12-30 2008-11-04 The Regents Of The University Of California Fluid control structures in microfluidic devices
WO2004075734A2 (en) 2003-02-25 2004-09-10 Inlight Solutions, Inc. DETERMINATION OF pH INCLUDING HEMOGLOBIN CORRECTION
JP4053444B2 (ja) 2003-03-07 2008-02-27 シャープ株式会社 携帯可能な多機能電子機器
US7713485B2 (en) 2003-03-19 2010-05-11 Industrial Technology Research Institute Microfluidics switch with moving planes
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
EP1473084B1 (en) 2003-03-31 2015-07-29 Canon Kabushiki Kaisha Biochemical reaction cartridge
FI118669B (fi) 2003-04-01 2008-01-31 Samsung Electro Mech Liukutyyppinen matkapuhelin ja liukumismenetelmä siihen
EP2266687A3 (en) 2003-04-10 2011-06-29 The President and Fellows of Harvard College Formation and control of fluidic species
US7262059B2 (en) 2003-05-06 2007-08-28 Thrombodyne, Inc. Systems and methods for measuring fluid properties
US8362219B2 (en) 2003-05-08 2013-01-29 Phynexus, Inc. Open channel solid phase extraction systems and methods
US6916113B2 (en) * 2003-05-16 2005-07-12 Agilent Technologies, Inc. Devices and methods for fluid mixing
WO2004104181A2 (en) 2003-05-19 2004-12-02 Brandeis University Nucleic acid processing methods, kits and devices
US7648835B2 (en) 2003-06-06 2010-01-19 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
DE50308515D1 (de) 2003-07-04 2007-12-13 November Ag Molekulare Medizin Verwendung eines einwegbehälters, mikrofluidische vorrichtung und verfahren zur bearbeitung von molekülen
DE10336849A1 (de) 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
BRPI0414004A (pt) 2003-08-27 2006-10-24 Harvard College controle eletrÈnico de espécies fluìdicas
JP2005083505A (ja) * 2003-09-09 2005-03-31 Olympus Corp スライド式バルブ装置
JP2005083510A (ja) * 2003-09-09 2005-03-31 Toshiba Corp バルブ装置、化学分析装置及び化学分析システム
US7003104B2 (en) 2003-10-13 2006-02-21 Hanbit Precision Co., Ltd. Apparatus for opening and closing cover of cellular phone
US7846333B2 (en) 2003-11-24 2010-12-07 Effendorf AG Porous media
SE526330C2 (sv) 2003-11-26 2005-08-23 Boule Medical Ab Förfarande och anordning för bestämning av en liten volym av ett flytnade prov
WO2005056186A1 (en) 2003-12-10 2005-06-23 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin A modular biochip assembly
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US7629165B2 (en) 2004-01-22 2009-12-08 Qualigen, Inc Diagnostic device and method
GB2416030B (en) 2004-01-28 2008-07-23 Norchip As A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
DE102004021780B4 (de) 2004-04-30 2008-10-02 Siemens Ag Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien
ES2553097T3 (es) 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
WO2005111243A2 (en) 2004-05-07 2005-11-24 Cepheid Multiplexed detection of biological agents
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
WO2006018044A1 (en) * 2004-08-18 2006-02-23 Agilent Technologies, Inc. Microfluidic assembly with coupled microfluidic devices
ATE541037T1 (de) 2004-08-25 2012-01-15 Fujifilm Corp Verfahren zur trennung und reinigung von nukleinsäure
JP4511596B2 (ja) 2004-09-15 2010-07-28 レイアード テクノロジーズ マップ カンパニー リミテッド 携帯電話の開閉に対する摺動機構
US7955504B1 (en) 2004-10-06 2011-06-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US20060183261A1 (en) 2005-02-15 2006-08-17 Dudenhoefer Christie L Method of forming a biological sensor
JP4829509B2 (ja) 2005-02-18 2011-12-07 シスメックス株式会社 遺伝子検査方法
JP2008535644A (ja) 2005-03-04 2008-09-04 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 多重エマルジョンの形成のための方法および装置
EP1861721B1 (en) 2005-03-10 2017-05-03 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes within samples
EP1899702A2 (de) 2005-04-09 2008-03-19 Boehringer Ingelheim microParts GmbH Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit
US20070014695A1 (en) 2005-04-26 2007-01-18 Applera Corporation Systems and Methods for Multiple Analyte Detection
DK1885880T3 (da) 2005-04-29 2010-11-08 Synthetic Genomics Inc Amplifikation og kloning af enkelte DNA-molekyler ved anvendelse af rolling circle-amplifikation
US7235216B2 (en) 2005-05-01 2007-06-26 Iba Molecular North America, Inc. Apparatus and method for producing radiopharmaceuticals
WO2006120221A1 (en) 2005-05-12 2006-11-16 Stmicroelectronics S.R.L. Microfluidic device with integrated micropump, in particular biochemical microreactor, and manufacturing method thereof
JP2008539787A (ja) 2005-05-18 2008-11-20 コーネル・リサーチ・ファンデーション・インコーポレイテッド 生物学的な障壁を有する薬物動態学ベース培養システム
RU2432205C2 (ru) 2005-06-23 2011-10-27 Биокартис С.А. Картридж, система и способ автоматизированной медицинской диагностики
JP2009501522A (ja) 2005-07-12 2009-01-22 コドン デバイシズ インコーポレイテッド 生体触媒工学のための組成物及び方法
EP1912667B1 (en) 2005-07-22 2012-08-29 Amgen Inc. Concentrated protein lyophilates, methods, and uses
EP1941035B1 (en) 2005-09-01 2017-11-22 Canon U.S. Life Sciences, Inc. Method and molecular diagnostic device for detection, analysis and identification of genomic dna
US7556776B2 (en) 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
US7329485B2 (en) 2005-10-12 2008-02-12 The Board Of Regents Of The University Of Oklahoma Methods for detecting compounds that interfere with protein aggregation utilizing an in vitro fluorescence-based assay
US8831887B2 (en) 2005-10-12 2014-09-09 The Research Foundation For The State University Of New York Absolute PCR quantification
US20070093894A1 (en) 2005-10-25 2007-04-26 Baylor College Of Medicine Incorporation of antimicrobial combinations onto devices to reduce infection
US20070134739A1 (en) 2005-12-12 2007-06-14 Gyros Patent Ab Microfluidic assays and microfluidic devices
WO2007070832A1 (en) 2005-12-13 2007-06-21 Great Basin Scientific Improved thin film biosensor and method and device for detection of analytes
WO2007081386A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use
US20070195127A1 (en) 2006-01-27 2007-08-23 President And Fellows Of Harvard College Fluidic droplet coalescence
EP1983889A4 (en) 2006-01-31 2009-09-16 Univ Chicago METHOD AND DEVICE FOR TESTING BLOODS
PL1981995T5 (pl) 2006-02-02 2019-10-31 Univ Leland Stanford Junior Nieinwazyjne genetyczne badania przesiewowe płodu metodą analizy cyfrowej
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
GB0604973D0 (en) 2006-03-11 2006-04-19 Central Science Lab Csl Of San Purification method and kit
WO2007106580A2 (en) 2006-03-15 2007-09-20 Micronics, Inc. Rapid magnetic flow assays
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8828661B2 (en) 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
US8900828B2 (en) 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
EP2481815B1 (en) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Microfluidic devices
WO2007146923A2 (en) 2006-06-12 2007-12-21 Great Basin Scientific Methods and materials for detecting frameshift mutations
WO2008002882A2 (en) 2006-06-26 2008-01-03 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
WO2008002267A1 (en) 2006-06-28 2008-01-03 Rgb Technologies Ab A sensor kit and a system for detecting an analyte in a test environment
US7465597B2 (en) 2006-06-29 2008-12-16 Home Diagnostics, Inc. Method of manufacturing a diagnostic test strip
US8187557B2 (en) 2006-07-13 2012-05-29 Cepheid Reagent reservoir system for analytical instruments
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
KR101422572B1 (ko) 2006-09-05 2014-07-30 삼성전자주식회사 핵산 검출을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템
US7375190B2 (en) 2006-09-19 2008-05-20 National Yang-Ming University Recombinant protein and method of screening for agents that modulate polypeptide aggregation
WO2008147382A1 (en) 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
US8101403B2 (en) 2006-10-04 2012-01-24 University Of Washington Method and device for rapid parallel microfluidic molecular affinity assays
CN101578520B (zh) 2006-10-18 2015-09-16 哈佛学院院长等 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法
US7709203B2 (en) 2006-10-20 2010-05-04 E.I. Du Pont De Nemours And Company Sequences diagnostic for shrimp pathogens
CN101558302B (zh) 2006-10-27 2013-11-06 蒙泰西托生物科学有限公司 用于改进的取样分析的便携设备
US8473216B2 (en) 2006-11-30 2013-06-25 Fluidigm Corporation Method and program for performing baseline correction of amplification curves in a PCR experiment
US7615351B2 (en) 2006-12-01 2009-11-10 Panomics, Inc. Two stage nucleic acid amplification using an amplification oligomer
US20100078077A1 (en) 2006-12-19 2010-04-01 Ismagilov Rustem F Spacers for Microfluidic Channels
US8338166B2 (en) 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US7851207B1 (en) 2007-02-07 2010-12-14 The United States Of America As Represented By The Secretary Of The Army Multiplex field device to detect and identify a variety of microbial agents simultaneously
JP2010531142A (ja) 2007-06-22 2010-09-24 サークル バイオロジクス、 エルエルシー． 液体濃縮装置、オートロガスな濃縮体液、およびそれらの使用方法
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
ES2604764T3 (es) 2007-07-17 2017-03-09 Somalogic, Inc. Análisis de muestras de ensayo
EP2017618A1 (en) 2007-07-20 2009-01-21 Koninklijke Philips Electronics N.V. Methods and systems for detecting
WO2009015390A2 (en) 2007-07-26 2009-01-29 University Of Chicago Co-incuating confined microbial communities
US20100227323A1 (en) 2007-07-30 2010-09-09 Cornell Research Foundation, Inc. Microchannel detection device and use thereof
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
WO2009033178A1 (en) 2007-09-07 2009-03-12 Fluidigm Corporation Copy number variation determination, methods and systems
US7736891B2 (en) 2007-09-11 2010-06-15 University Of Washington Microfluidic assay system with dispersion monitoring
JPWO2009054493A1 (ja) * 2007-10-26 2011-03-10 凸版印刷株式会社 反応チップおよびその製造方法
US8222048B2 (en) 2007-11-05 2012-07-17 Abbott Laboratories Automated analyzer for clinical laboratory
EP2225398A4 (en) 2007-11-28 2011-02-09 Great Basin Scient METHOD AND COMPOSITIONS FOR REINFORCING A DETECTABLE SIGNAL
DE102007059533A1 (de) 2007-12-06 2009-06-10 Thinxxs Microtechnology Ag Mikrofluidische Speichervorrichtung
US20090215050A1 (en) 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
GB0808557D0 (en) 2008-05-13 2008-06-18 3M Innovative Properties Co Sampling devices and methods of use
US8622987B2 (en) 2008-06-04 2014-01-07 The University Of Chicago Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
DE102008042581B4 (de) 2008-10-02 2012-02-02 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Mikrofluidische Extraktions- und Reaktionsvorrichtung
WO2010078420A2 (en) 2008-12-30 2010-07-08 Redhorse Fluidics Systems, devices, methods and kits for fluid handling
DE102009005874A1 (de) 2009-01-21 2010-07-22 Thinxxs Microtechnology Ag Ventil, insbesondere für ein Bauelement der Mikrofluidtechnik
DE102009009728A1 (de) 2009-02-19 2010-09-02 Thinxxs Microtechnology Ag Flusszelle mit integriertem Fluidspeicher
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
CN104722342B (zh) 2009-03-24 2017-01-11 芝加哥大学 滑动式芯片装置和方法
JP5840627B2 (ja) 2010-03-04 2016-01-06 ナショナル ユニヴァーシティー オブ シンガポール 細胞を検出および単離するためのマイクロ流体分取装置
CA2881200A1 (en) 2012-02-14 2013-08-22 Great Basin Scientific Methods of isothermal amplification using blocked primers
US20130331298A1 (en) 2012-06-06 2013-12-12 Great Basin Scientific Analyzer and disposable cartridge for molecular in vitro diagnostics
US9097710B2 (en) 2012-10-16 2015-08-04 The Methodist Hospital Research Institute Multiplexed volumetric bar chart chip for point of care biomarker and analyte quantitation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020125197A1 (en) * 2001-03-08 2002-09-12 Hager David C. Multi-well apparatus
US20040119070A1 (en) * 2002-08-02 2004-06-24 Roach David John Integrated microchip design
US20070026439A1 (en) * 2005-07-15 2007-02-01 Applera Corporation Fluid processing device and method
US20090021728A1 (en) * 2007-06-21 2009-01-22 Gen-Probe Incorporated Multi-Channel Optical Measurement Instrument

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