AU2006343808B2 - Inhibitors of VEGF receptor and HGF receptor signaling - Google Patents

Inhibitors of VEGF receptor and HGF receptor signaling Download PDF

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Publication number
AU2006343808B2
AU2006343808B2 AU2006343808A AU2006343808A AU2006343808B2 AU 2006343808 B2 AU2006343808 B2 AU 2006343808B2 AU 2006343808 A AU2006343808 A AU 2006343808A AU 2006343808 A AU2006343808 A AU 2006343808A AU 2006343808 B2 AU2006343808 B2 AU 2006343808B2
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AU
Australia
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group
alkyl
optionally substituted
yloxy
aryl
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AU2006343808A
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AU2006343808A1 (en
Inventor
Naomy Bernstein
Stephen William Claridge
Robert Deziel
Federic Gaudette
Marie Claude Granger
Ljubomir Isakovic
Michael Mannion
Franck Raeppel
Stephane Raeppel
Oscar Mario Saavedra
Arkadii Vaisburg
Amal Wahhab
Lijie Zhan
Nancy Zhou
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Mirati Therapeutics Inc
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Mirati Therapeutics Inc
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Publication of AU2006343808A1 publication Critical patent/AU2006343808A1/en
Assigned to METHYLGENE INC. reassignment METHYLGENE INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: METHYLGENE, INC.
Assigned to METHYLGENE INC. reassignment METHYLGENE INC. Request for Assignment Assignors: METHYLGENE INC.
Application granted granted Critical
Publication of AU2006343808B2 publication Critical patent/AU2006343808B2/en
Assigned to Mirati Therapeutics, Inc. reassignment Mirati Therapeutics, Inc. Request for Assignment Assignors: METHYLGENE INC.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2006343808A 2005-05-20 2006-05-19 Inhibitors of VEGF receptor and HGF receptor signaling Active AU2006343808B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US68303605P 2005-05-20 2005-05-20
US60/683,036 2005-05-20
US75490205P 2005-12-29 2005-12-29
US60/754,902 2005-12-29
US78505406P 2006-03-22 2006-03-22
US60/785,054 2006-03-22
PCT/IB2006/004306 WO2008041053A2 (en) 2005-05-20 2006-05-19 Inhibitors of vegf receptor and hgf receptor signaling

Publications (2)

Publication Number Publication Date
AU2006343808A1 AU2006343808A1 (en) 2008-04-10
AU2006343808B2 true AU2006343808B2 (en) 2012-03-29

Family

ID=39190471

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006343808A Active AU2006343808B2 (en) 2005-05-20 2006-05-19 Inhibitors of VEGF receptor and HGF receptor signaling

Country Status (13)

Country Link
US (2) US8093264B2 (enExample)
EP (1) EP1957498B1 (enExample)
JP (1) JP5148499B2 (enExample)
KR (1) KR101378716B1 (enExample)
CN (1) CN101796055B (enExample)
AU (1) AU2006343808B2 (enExample)
BR (1) BRPI0610322B8 (enExample)
CA (1) CA2611370C (enExample)
ES (1) ES2623221T3 (enExample)
IL (1) IL187484A (enExample)
MX (1) MX2007014616A (enExample)
NZ (1) NZ564283A (enExample)
WO (1) WO2008041053A2 (enExample)

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RU2008139599A (ru) * 2006-03-07 2010-04-20 Эррэй Биофарма Инк. (Us) Гетеробициклические производные пиразола и способы их применения
US20080064718A1 (en) * 2006-03-22 2008-03-13 Saavedra Oscar M Inhibitors of protein tyrosine kinase activity
EA200802118A1 (ru) 2006-04-07 2009-04-28 Девелоджен Ациенгезельшафт Обладающие ингибирующей активностью в отношении mnk1/mnk2 тиенопиримидины, предназначенные для применения в фармацевтических композициях
JP2009539878A (ja) * 2006-06-08 2009-11-19 アレイ バイオファーマ、インコーポレイテッド キノリン化合物および使用方法
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ES2593279T3 (es) 2007-08-29 2016-12-07 Methylgene Inc. Procesos e intermedios para preparar inhibidores de cinasa heterocíclicos condensados
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CN105777776B (zh) 2007-08-29 2021-06-08 梅特希尔基因公司 蛋白酪氨酸激酶活性的抑制剂
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UA100262C2 (uk) * 2008-03-05 2012-12-10 Метилген Інк. Інгібітори активності протеїнтирозинкінази
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US8293897B2 (en) 2008-10-14 2012-10-23 Ning Xi Compounds comprising a spiro-ring and methods of use
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WO2011082273A2 (en) * 2009-12-30 2011-07-07 Arqule, Inc. Substituted pyrrolo-aminopyrimidine compounds
UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
AR080328A1 (es) 2010-02-26 2012-03-28 Boehringer Ingelheim Int Tienopirimidinas que contienen un grupo alquilo sustituido inhibidoras de quinasas mnk1 y/o mnk2, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de trastornos metabolicos tales como diabetes y obesidad, y trastornos hiperproliferativos, entre otros
EA201201191A1 (ru) 2010-02-26 2013-04-30 Бёрингер Ингельхайм Интернациональ Гмбх 4-[циклоалкилокси(гетеро)ариламино]тиено[2,3-d]пиримидины, обладающие ингибирующей активностью по отношению к mnkl/mnk2, предназначенные для фармацевтических композиций
CN101863911A (zh) * 2010-04-13 2010-10-20 艾琪康医药科技（上海）有限公司 一种1-r1-3,4-脱氢-3或4-r6-哌啶的制备方法
EP2563794A4 (en) * 2010-04-16 2013-12-04 Methylgene Inc INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY AND ITS USE FOR THE TREATMENT OF EYE DISEASES
EP2594566A4 (en) 2010-07-16 2014-10-01 Kyowa Hakko Kirin Co Ltd AROMATIC HETEROCYCLIC NITROGEN CYCLE DERIVATIVE
US8664244B2 (en) 2010-09-12 2014-03-04 Advenchen Pharmaceuticals, LLC Compounds as c-Met kinase inhibitors
MY181439A (en) 2011-02-28 2020-12-22 Sunshine Lake Pharma Co Ltd Substituted quinoline compounds and methods of use
JP6218848B2 (ja) * 2012-11-20 2017-10-25 プロキナーゼ ゲゼルシャフト ミット ベシュレンクテル ハフツング プロテインキナーゼ阻害剤としてのチオエーテル誘導体
WO2015162515A1 (en) 2014-04-25 2015-10-29 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
CN105348213A (zh) * 2015-09-22 2016-02-24 武汉理工大学 β-氟烷基-β-氨基酸类化合物的制备方法
FR3041640B1 (fr) 2015-09-30 2019-05-17 Les Laboratoires Servier NOUVEAUX DERIVES DE PYRROLO[2,3-d]PYRIMIDINE, LEUR PROCEDE DE PREPRATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
US9630968B1 (en) 2015-12-23 2017-04-25 Arqule, Inc. Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
RU2019108280A (ru) 2016-08-24 2020-09-25 Аркьюл, Инк. Аминопирролопиримидиноновые соединения и способы их применения
CN108530464B (zh) * 2017-03-02 2020-10-27 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂
EP3897630B1 (en) 2018-12-21 2024-01-10 Celgene Corporation Thienopyridine inhibitors of ripk2
CN110423218A (zh) * 2019-08-09 2019-11-08 新乡双鹭药业有限公司 一种苹果酸卡博替尼合成中杂质的制备方法
CN113336768B (zh) 2020-02-18 2022-08-19 深圳海王医药科技研究院有限公司 一种多靶点酪氨酸激酶抑制剂
CN114957136A (zh) * 2021-02-24 2022-08-30 南京科默生物医药有限公司 一种用作vegfr抑制剂的抗肿瘤化合物及其用途
CN115215803B (zh) * 2022-09-19 2022-12-30 苏州美诺医药科技有限公司 一种4-卤代-1-(二氟甲基)-1h-咪唑的制备方法

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Also Published As

Publication number Publication date
KR101378716B1 (ko) 2014-04-10
WO2008041053A3 (en) 2009-12-23
US20070004675A1 (en) 2007-01-04
CN101796055A (zh) 2010-08-04
BRPI0610322A2 (pt) 2010-06-15
MX2007014616A (es) 2009-08-12
US20120083482A1 (en) 2012-04-05
JP2009504804A (ja) 2009-02-05
BRPI0610322B8 (pt) 2021-05-25
US8093264B2 (en) 2012-01-10
CN101796055B (zh) 2013-09-04
CA2611370C (en) 2014-11-25
BRPI0610322B1 (pt) 2020-12-01
WO2008041053A2 (en) 2008-04-10
EP1957498B1 (en) 2017-02-15
CA2611370A1 (en) 2006-11-20
ES2623221T3 (es) 2017-07-10
IL187484A0 (en) 2011-08-01
IL187484A (en) 2014-04-30
JP5148499B2 (ja) 2013-02-20
EP1957498A4 (en) 2010-10-27
AU2006343808A1 (en) 2008-04-10
EP1957498A2 (en) 2008-08-20
KR20080059112A (ko) 2008-06-26
NZ564283A (en) 2011-07-29
US8329726B2 (en) 2012-12-11

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