CA2611370C - Inhibitors of vegf receptor and hgf receptor signaling - Google Patents

Inhibitors of vegf receptor and hgf receptor signaling Download PDF

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Publication number
CA2611370C
CA2611370C CA2611370A CA2611370A CA2611370C CA 2611370 C CA2611370 C CA 2611370C CA 2611370 A CA2611370 A CA 2611370A CA 2611370 A CA2611370 A CA 2611370A CA 2611370 C CA2611370 C CA 2611370C
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CA
Canada
Prior art keywords
group
alkyl
optionally substituted
aryl
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2611370A
Other languages
English (en)
French (fr)
Other versions
CA2611370A1 (en
Inventor
Oscar Mario Saavedra
Stephen William Claridge
Lijie Zhan
Franck Raeppel
Arkadii Vaisburg
Stephane Raeppel
Robert Deziel
Michael Mannion
Nancy Zhou
Frederic Gaudette
Ljubomir Isakovic
Amal Wahhab
Marie-Claude Granger
Noemy Bernstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mirati Therapeutics Inc
Original Assignee
Methylgene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Methylgene Inc filed Critical Methylgene Inc
Publication of CA2611370A1 publication Critical patent/CA2611370A1/en
Application granted granted Critical
Publication of CA2611370C publication Critical patent/CA2611370C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2611370A 2005-05-20 2006-05-19 Inhibitors of vegf receptor and hgf receptor signaling Expired - Lifetime CA2611370C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US68303605P 2005-05-20 2005-05-20
US60/683,036 2005-05-20
US75490205P 2005-12-29 2005-12-29
US60/754,902 2005-12-29
US78505406P 2006-03-22 2006-03-22
US60/785,054 2006-03-22
PCT/IB2006/004306 WO2008041053A2 (en) 2005-05-20 2006-05-19 Inhibitors of vegf receptor and hgf receptor signaling

Publications (2)

Publication Number Publication Date
CA2611370A1 CA2611370A1 (en) 2006-11-20
CA2611370C true CA2611370C (en) 2014-11-25

Family

ID=39190471

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2611370A Expired - Lifetime CA2611370C (en) 2005-05-20 2006-05-19 Inhibitors of vegf receptor and hgf receptor signaling

Country Status (13)

Country Link
US (2) US8093264B2 (enExample)
EP (1) EP1957498B1 (enExample)
JP (1) JP5148499B2 (enExample)
KR (1) KR101378716B1 (enExample)
CN (1) CN101796055B (enExample)
AU (1) AU2006343808B2 (enExample)
BR (1) BRPI0610322B8 (enExample)
CA (1) CA2611370C (enExample)
ES (1) ES2623221T3 (enExample)
IL (1) IL187484A (enExample)
MX (1) MX2007014616A (enExample)
NZ (1) NZ564283A (enExample)
WO (1) WO2008041053A2 (enExample)

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CN108530464B (zh) * 2017-03-02 2020-10-27 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
CN110423218A (zh) * 2019-08-09 2019-11-08 新乡双鹭药业有限公司 一种苹果酸卡博替尼合成中杂质的制备方法
CN113336768B (zh) 2020-02-18 2022-08-19 深圳海王医药科技研究院有限公司 一种多靶点酪氨酸激酶抑制剂
CN114957136A (zh) * 2021-02-24 2022-08-30 南京科默生物医药有限公司 一种用作vegfr抑制剂的抗肿瘤化合物及其用途
CN115215803B (zh) * 2022-09-19 2022-12-30 苏州美诺医药科技有限公司 一种4-卤代-1-(二氟甲基)-1h-咪唑的制备方法
CN117902987A (zh) * 2024-01-22 2024-04-19 安庆双启医药科技有限公司 一种3-氟-5-碘苯胺的制备方法
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Also Published As

Publication number Publication date
BRPI0610322A2 (pt) 2010-06-15
JP5148499B2 (ja) 2013-02-20
KR20080059112A (ko) 2008-06-26
US8093264B2 (en) 2012-01-10
BRPI0610322B8 (pt) 2021-05-25
CN101796055A (zh) 2010-08-04
US8329726B2 (en) 2012-12-11
IL187484A0 (en) 2011-08-01
AU2006343808A1 (en) 2008-04-10
AU2006343808B2 (en) 2012-03-29
EP1957498B1 (en) 2017-02-15
IL187484A (en) 2014-04-30
WO2008041053A3 (en) 2009-12-23
MX2007014616A (es) 2009-08-12
US20120083482A1 (en) 2012-04-05
BRPI0610322B1 (pt) 2020-12-01
EP1957498A2 (en) 2008-08-20
ES2623221T3 (es) 2017-07-10
NZ564283A (en) 2011-07-29
KR101378716B1 (ko) 2014-04-10
WO2008041053A2 (en) 2008-04-10
CN101796055B (zh) 2013-09-04
EP1957498A4 (en) 2010-10-27
US20070004675A1 (en) 2007-01-04
CA2611370A1 (en) 2006-11-20
JP2009504804A (ja) 2009-02-05

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