MX2007014616A - Inhibidores de señalizacion del receptor del factor a de crecimiento endotelial vascular y del receptor del factor de crecimiento de hepatocitos. - Google Patents
Inhibidores de señalizacion del receptor del factor a de crecimiento endotelial vascular y del receptor del factor de crecimiento de hepatocitos.Info
- Publication number
- MX2007014616A MX2007014616A MX2007014616A MX2007014616A MX2007014616A MX 2007014616 A MX2007014616 A MX 2007014616A MX 2007014616 A MX2007014616 A MX 2007014616A MX 2007014616 A MX2007014616 A MX 2007014616A MX 2007014616 A MX2007014616 A MX 2007014616A
- Authority
- MX
- Mexico
- Prior art keywords
- receptor signaling
- receptor
- hgf
- inhibitors
- signaling
- Prior art date
Links
- 230000011664 signaling Effects 0.000 title abstract 5
- 108091008603 HGF receptors Proteins 0.000 title abstract 3
- 102000027430 HGF receptors Human genes 0.000 title abstract 3
- 108091008605 VEGF receptors Proteins 0.000 title abstract 3
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68303605P | 2005-05-20 | 2005-05-20 | |
| US75490205P | 2005-12-29 | 2005-12-29 | |
| US78505406P | 2006-03-22 | 2006-03-22 | |
| PCT/IB2006/004306 WO2008041053A2 (en) | 2005-05-20 | 2006-05-19 | Inhibitors of vegf receptor and hgf receptor signaling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007014616A true MX2007014616A (es) | 2009-08-12 |
Family
ID=39190471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007014616A MX2007014616A (es) | 2005-05-20 | 2006-05-19 | Inhibidores de señalizacion del receptor del factor a de crecimiento endotelial vascular y del receptor del factor de crecimiento de hepatocitos. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8093264B2 (enExample) |
| EP (1) | EP1957498B1 (enExample) |
| JP (1) | JP5148499B2 (enExample) |
| KR (1) | KR101378716B1 (enExample) |
| CN (1) | CN101796055B (enExample) |
| AU (1) | AU2006343808B2 (enExample) |
| BR (1) | BRPI0610322B8 (enExample) |
| CA (1) | CA2611370C (enExample) |
| ES (1) | ES2623221T3 (enExample) |
| IL (1) | IL187484A (enExample) |
| MX (1) | MX2007014616A (enExample) |
| NZ (1) | NZ564283A (enExample) |
| WO (1) | WO2008041053A2 (enExample) |
Families Citing this family (40)
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|---|---|---|---|---|
| US7276519B2 (en) * | 2002-11-25 | 2007-10-02 | Wyeth | Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors |
| WO2006010264A1 (en) * | 2004-07-30 | 2006-02-02 | Methylgene, Inc. | Inhibitors of vegf receptor and hgf receptor signaling |
| EP1904504B1 (en) * | 2005-05-20 | 2014-03-19 | MethylGene Inc. | Inhibitors of vegf receptor and hgf receptor signaling |
| AR056200A1 (es) * | 2005-09-27 | 2007-09-26 | Wyeth Corp | Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa |
| TW200806675A (en) * | 2006-01-30 | 2008-02-01 | Array Biopharma Inc | Heterobicyclic thiophene compounds and methods of use |
| MX2008011220A (es) * | 2006-03-07 | 2008-09-11 | Array Biopharma Inc | Compuestos de pirazol heterobiciclicos y metodos de uso. |
| WO2007107005A1 (en) * | 2006-03-22 | 2007-09-27 | Methylgene, Inc. | Inhibitors of protein tyrosine kinase activity |
| US8633201B2 (en) | 2006-04-07 | 2014-01-21 | Boehringer Ingelheim International Gmbh | Thienopyrimidines having Mnk1/Mnk2 inhibiting activity for pharmaceutical compositions |
| JP2009539878A (ja) * | 2006-06-08 | 2009-11-19 | アレイ バイオファーマ、インコーポレイテッド | キノリン化合物および使用方法 |
| EP1889847A1 (en) | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
| WO2009026720A1 (en) | 2007-08-29 | 2009-03-05 | Methylgene Inc. | Processes and intermediates for preparing fused heterocyclic kinase inhibitors |
| WO2009026701A1 (en) * | 2007-08-29 | 2009-03-05 | Methylgene Inc. | Sirtuin inhibitors |
| ES2635131T3 (es) * | 2007-08-29 | 2017-10-02 | Methylgene Inc. | Inhibidores de la actividad de la proteína tirosina cinasa |
| WO2009105776A1 (en) | 2008-02-21 | 2009-08-27 | Sequoia Pharmaceuticals, Inc. | Diamide inhibitors of cytochrome p450 |
| BRPI0923670A2 (pt) * | 2008-03-05 | 2013-07-30 | Methylgene Inc | inibidores da atividade de proteÍna tirosina quinase e seu uso, bem como composiÇço compreendendo os mesmos |
| EP2331551B1 (en) | 2008-08-26 | 2016-06-29 | Evotec International GmbH | Thienopyrimidines for pharmaceutical compositions |
| WO2010045095A1 (en) * | 2008-10-14 | 2010-04-22 | Ning Xi | Compounds and methods of use |
| CN102256493A (zh) * | 2008-10-29 | 2011-11-23 | 迪赛孚尔制药有限公司 | 表现出抗癌活性和抗增殖活性的环丙烷酰胺及其类似物 |
| CA2752421C (en) * | 2009-03-21 | 2013-08-06 | Ning Xi | Amino ester derivatives, salts thereof and methods of use |
| WO2011082273A2 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted pyrrolo-aminopyrimidine compounds |
| EP2539343B1 (en) | 2010-02-26 | 2015-12-30 | Evotec International GmbH | Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions |
| JP5575274B2 (ja) | 2010-02-26 | 2014-08-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 医薬組成物のためのmnkl/mnk2阻害活性を有する4−[シクロアルキルオキシ(ヘテロ)アリールアミノ]チエノ「2,3−d]ピリミジン |
| UY33241A (es) | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?. |
| CN101863911A (zh) * | 2010-04-13 | 2010-10-20 | 艾琪康医药科技(上海)有限公司 | 一种1-r1-3,4-脱氢-3或4-r6-哌啶的制备方法 |
| MY157319A (en) | 2010-04-16 | 2016-05-31 | Methylgene Inc | Inhibitors of protein tyrosine kinase activity |
| KR20130091331A (ko) | 2010-07-16 | 2013-08-16 | 교와 핫꼬 기린 가부시키가이샤 | 함질소 방향족 복소환 유도체 |
| US8664244B2 (en) | 2010-09-12 | 2014-03-04 | Advenchen Pharmaceuticals, LLC | Compounds as c-Met kinase inhibitors |
| WO2012118632A1 (en) | 2011-02-28 | 2012-09-07 | Ning Xi | Substituted quinoline compounds and methods of use |
| WO2014079545A1 (en) | 2012-11-20 | 2014-05-30 | Ktb Tumorforschungsgesellschaft Mbh | Thioether derivatives as protein kinase inhibitors |
| MD20160112A2 (ro) | 2014-04-25 | 2017-06-30 | Pfizer Inc. | Compuşi heteroaromatici şi utilizarea lor ca liganzi ai dopaminei D1 |
| CN105348213A (zh) * | 2015-09-22 | 2016-02-24 | 武汉理工大学 | β-氟烷基-β-氨基酸类化合物的制备方法 |
| FR3041640B1 (fr) | 2015-09-30 | 2019-05-17 | Les Laboratoires Servier | NOUVEAUX DERIVES DE PYRROLO[2,3-d]PYRIMIDINE, LEUR PROCEDE DE PREPRATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| BR112019003504A2 (pt) | 2016-08-24 | 2019-05-21 | Arqule, Inc. | compostos de amino-pirrolopirimidinona e métodos de uso dos mesmos |
| CN108530464B (zh) * | 2017-03-02 | 2020-10-27 | 深圳海王医药科技研究院有限公司 | 一种多靶点激酶抑制剂 |
| CN113874015B (zh) | 2018-12-21 | 2024-05-24 | 细胞基因公司 | Ripk2的噻吩并吡啶抑制剂 |
| CN110423218A (zh) * | 2019-08-09 | 2019-11-08 | 新乡双鹭药业有限公司 | 一种苹果酸卡博替尼合成中杂质的制备方法 |
| CN113336768B (zh) * | 2020-02-18 | 2022-08-19 | 深圳海王医药科技研究院有限公司 | 一种多靶点酪氨酸激酶抑制剂 |
| CN114957136A (zh) * | 2021-02-24 | 2022-08-30 | 南京科默生物医药有限公司 | 一种用作vegfr抑制剂的抗肿瘤化合物及其用途 |
| CN115215803B (zh) * | 2022-09-19 | 2022-12-30 | 苏州美诺医药科技有限公司 | 一种4-卤代-1-(二氟甲基)-1h-咪唑的制备方法 |
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| WO1995015373A2 (en) | 1993-11-30 | 1995-06-08 | Mcgill University | Inhibition of dna methyltransferase |
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| US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
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| WO2006010264A1 (en) * | 2004-07-30 | 2006-02-02 | Methylgene, Inc. | Inhibitors of vegf receptor and hgf receptor signaling |
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| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| TW200740820A (en) | 2005-07-05 | 2007-11-01 | Takeda Pharmaceuticals Co | Fused heterocyclic derivatives and use thereof |
| DE102005037499A1 (de) | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | Pyrazolderivate |
| CA2633010A1 (en) * | 2005-12-19 | 2007-06-28 | Methylgene Inc. | Histone deacetylase inhibitors for enhancing activity of antifungal agents |
| TW200806675A (en) | 2006-01-30 | 2008-02-01 | Array Biopharma Inc | Heterobicyclic thiophene compounds and methods of use |
| WO2007107005A1 (en) | 2006-03-22 | 2007-09-27 | Methylgene, Inc. | Inhibitors of protein tyrosine kinase activity |
-
2006
- 2006-05-19 BR BRPI0610322A patent/BRPI0610322B8/pt active IP Right Grant
- 2006-05-19 ES ES06851548.5T patent/ES2623221T3/es active Active
- 2006-05-19 CA CA2611370A patent/CA2611370C/en active Active
- 2006-05-19 CN CN2006800266085A patent/CN101796055B/zh active Active
- 2006-05-19 JP JP2008537239A patent/JP5148499B2/ja active Active
- 2006-05-19 MX MX2007014616A patent/MX2007014616A/es active IP Right Grant
- 2006-05-19 KR KR1020077029798A patent/KR101378716B1/ko active Active
- 2006-05-19 EP EP06851548.5A patent/EP1957498B1/en active Active
- 2006-05-19 NZ NZ564283A patent/NZ564283A/en unknown
- 2006-05-19 AU AU2006343808A patent/AU2006343808B2/en active Active
- 2006-05-19 US US11/438,133 patent/US8093264B2/en active Active
- 2006-05-19 WO PCT/IB2006/004306 patent/WO2008041053A2/en not_active Ceased
-
2007
- 2007-11-19 IL IL187484A patent/IL187484A/en active IP Right Grant
-
2011
- 2011-12-08 US US13/314,362 patent/US8329726B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0610322B1 (pt) | 2020-12-01 |
| EP1957498A4 (en) | 2010-10-27 |
| CA2611370A1 (en) | 2006-11-20 |
| AU2006343808A1 (en) | 2008-04-10 |
| CN101796055A (zh) | 2010-08-04 |
| US20120083482A1 (en) | 2012-04-05 |
| US8093264B2 (en) | 2012-01-10 |
| WO2008041053A3 (en) | 2009-12-23 |
| CN101796055B (zh) | 2013-09-04 |
| NZ564283A (en) | 2011-07-29 |
| ES2623221T3 (es) | 2017-07-10 |
| US20070004675A1 (en) | 2007-01-04 |
| EP1957498A2 (en) | 2008-08-20 |
| KR101378716B1 (ko) | 2014-04-10 |
| WO2008041053A2 (en) | 2008-04-10 |
| AU2006343808B2 (en) | 2012-03-29 |
| BRPI0610322A2 (pt) | 2010-06-15 |
| JP2009504804A (ja) | 2009-02-05 |
| EP1957498B1 (en) | 2017-02-15 |
| US8329726B2 (en) | 2012-12-11 |
| JP5148499B2 (ja) | 2013-02-20 |
| KR20080059112A (ko) | 2008-06-26 |
| IL187484A (en) | 2014-04-30 |
| BRPI0610322B8 (pt) | 2021-05-25 |
| IL187484A0 (en) | 2011-08-01 |
| CA2611370C (en) | 2014-11-25 |
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