NZ564283A - Inhibitors of VEGF receptor and HGF receptor signaling - Google Patents

Inhibitors of VEGF receptor and HGF receptor signaling

Info

Publication number
NZ564283A
NZ564283A NZ564283A NZ56428306A NZ564283A NZ 564283 A NZ564283 A NZ 564283A NZ 564283 A NZ564283 A NZ 564283A NZ 56428306 A NZ56428306 A NZ 56428306A NZ 564283 A NZ564283 A NZ 564283A
Authority
NZ
New Zealand
Prior art keywords
pyridin
group
imidazol
alkyl
fluoro
Prior art date
Application number
NZ564283A
Other languages
English (en)
Inventor
Stephane Raeppel
Robert Deziel
Michael Mannion
Nancy Zhou
Frederic Gaudette
Ljubomir Isakovic
Amal Wahhab
Marie-Claude Granger
Naomy Bernstein
Oscar Mario Saavedra
Stephen William Claridge
Lijie Zhan
Franck Raeppel
Arkadii Vaisburg
Original Assignee
Methylgene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Methylgene Inc filed Critical Methylgene Inc
Publication of NZ564283A publication Critical patent/NZ564283A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NZ564283A 2005-05-20 2006-05-19 Inhibitors of VEGF receptor and HGF receptor signaling NZ564283A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68303605P 2005-05-20 2005-05-20
US75490205P 2005-12-29 2005-12-29
US78505406P 2006-03-22 2006-03-22
PCT/IB2006/004306 WO2008041053A2 (en) 2005-05-20 2006-05-19 Inhibitors of vegf receptor and hgf receptor signaling

Publications (1)

Publication Number Publication Date
NZ564283A true NZ564283A (en) 2011-07-29

Family

ID=39190471

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ564283A NZ564283A (en) 2005-05-20 2006-05-19 Inhibitors of VEGF receptor and HGF receptor signaling

Country Status (13)

Country Link
US (2) US8093264B2 (enExample)
EP (1) EP1957498B1 (enExample)
JP (1) JP5148499B2 (enExample)
KR (1) KR101378716B1 (enExample)
CN (1) CN101796055B (enExample)
AU (1) AU2006343808B2 (enExample)
BR (1) BRPI0610322B8 (enExample)
CA (1) CA2611370C (enExample)
ES (1) ES2623221T3 (enExample)
IL (1) IL187484A (enExample)
MX (1) MX2007014616A (enExample)
NZ (1) NZ564283A (enExample)
WO (1) WO2008041053A2 (enExample)

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CN108530464B (zh) * 2017-03-02 2020-10-27 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂
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CN110423218A (zh) * 2019-08-09 2019-11-08 新乡双鹭药业有限公司 一种苹果酸卡博替尼合成中杂质的制备方法
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CN114957136A (zh) * 2021-02-24 2022-08-30 南京科默生物医药有限公司 一种用作vegfr抑制剂的抗肿瘤化合物及其用途
CN115215803B (zh) * 2022-09-19 2022-12-30 苏州美诺医药科技有限公司 一种4-卤代-1-(二氟甲基)-1h-咪唑的制备方法
CN117902987A (zh) * 2024-01-22 2024-04-19 安庆双启医药科技有限公司 一种3-氟-5-碘苯胺的制备方法
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Also Published As

Publication number Publication date
BRPI0610322A2 (pt) 2010-06-15
JP5148499B2 (ja) 2013-02-20
KR20080059112A (ko) 2008-06-26
US8093264B2 (en) 2012-01-10
BRPI0610322B8 (pt) 2021-05-25
CN101796055A (zh) 2010-08-04
US8329726B2 (en) 2012-12-11
IL187484A0 (en) 2011-08-01
AU2006343808A1 (en) 2008-04-10
AU2006343808B2 (en) 2012-03-29
EP1957498B1 (en) 2017-02-15
IL187484A (en) 2014-04-30
CA2611370C (en) 2014-11-25
WO2008041053A3 (en) 2009-12-23
MX2007014616A (es) 2009-08-12
US20120083482A1 (en) 2012-04-05
BRPI0610322B1 (pt) 2020-12-01
EP1957498A2 (en) 2008-08-20
ES2623221T3 (es) 2017-07-10
KR101378716B1 (ko) 2014-04-10
WO2008041053A2 (en) 2008-04-10
CN101796055B (zh) 2013-09-04
EP1957498A4 (en) 2010-10-27
US20070004675A1 (en) 2007-01-04
CA2611370A1 (en) 2006-11-20
JP2009504804A (ja) 2009-02-05

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