KR101378716B1 - Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제 - Google Patents

Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제 Download PDF

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Publication number
KR101378716B1
KR101378716B1 KR1020077029798A KR20077029798A KR101378716B1 KR 101378716 B1 KR101378716 B1 KR 101378716B1 KR 1020077029798 A KR1020077029798 A KR 1020077029798A KR 20077029798 A KR20077029798 A KR 20077029798A KR 101378716 B1 KR101378716 B1 KR 101378716B1
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alkyl
group
substituted
aryl
unsubstituted
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KR20080059112A (ko
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오스카 마리오 사베드라
스테펜 윌리엄 클라릿지
리지에 지한
프랭크 래펠
아카디 바이스버그
스테판 래펠
로버트 데지엘
미첼 맨니온
낸시 제트. 조우
프리데릭 가우데트
뤼보미어 이사코빅
아말 와하브
마리-끌로드 그랜저
노에미 베른스테인
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메틸진 인코포레이티드
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Publication of KR101378716B1 publication Critical patent/KR101378716B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020077029798A 2005-05-20 2006-05-19 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제 Expired - Lifetime KR101378716B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US68303605P 2005-05-20 2005-05-20
US60/683,036 2005-05-20
US75490205P 2005-12-29 2005-12-29
US60/754,902 2005-12-29
US78505406P 2006-03-22 2006-03-22
US60/785,054 2006-03-22
PCT/IB2006/004306 WO2008041053A2 (en) 2005-05-20 2006-05-19 Inhibitors of vegf receptor and hgf receptor signaling

Publications (2)

Publication Number Publication Date
KR20080059112A KR20080059112A (ko) 2008-06-26
KR101378716B1 true KR101378716B1 (ko) 2014-04-10

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KR1020077029798A Expired - Lifetime KR101378716B1 (ko) 2005-05-20 2006-05-19 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제

Country Status (13)

Country Link
US (2) US8093264B2 (enExample)
EP (1) EP1957498B1 (enExample)
JP (1) JP5148499B2 (enExample)
KR (1) KR101378716B1 (enExample)
CN (1) CN101796055B (enExample)
AU (1) AU2006343808B2 (enExample)
BR (1) BRPI0610322B8 (enExample)
CA (1) CA2611370C (enExample)
ES (1) ES2623221T3 (enExample)
IL (1) IL187484A (enExample)
MX (1) MX2007014616A (enExample)
NZ (1) NZ564283A (enExample)
WO (1) WO2008041053A2 (enExample)

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ES2562959T3 (es) 2010-02-26 2016-03-09 Evotec International Gmbh Tienopirimidinas que contienen un grupo alquilo sustituido para composiciones farmacéuticas
MX2012009735A (es) 2010-02-26 2012-09-12 Boehringer Ingelheim Int 4-[cicloalquiloxi (hetero) arilamino] tieno [2,3-d] pirimidinas que tienen actividad inhibitoria de mnk1/mnk2 para composiciones farmaceuticas.
UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
CN101863911A (zh) * 2010-04-13 2010-10-20 艾琪康医药科技（上海）有限公司 一种1-r1-3,4-脱氢-3或4-r6-哌啶的制备方法
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MX352844B (es) 2011-02-28 2017-12-11 Calitor Sciences Llc Compuestos de quinolina sustituidos y metodos de uso.
US9925193B2 (en) 2012-11-20 2018-03-27 Proqinase Gmbh Thioether derivatives as protein kinase inhibitors
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CN105348213A (zh) * 2015-09-22 2016-02-24 武汉理工大学 β-氟烷基-β-氨基酸类化合物的制备方法
FR3041640B1 (fr) 2015-09-30 2019-05-17 Les Laboratoires Servier NOUVEAUX DERIVES DE PYRROLO[2,3-d]PYRIMIDINE, LEUR PROCEDE DE PREPRATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
US9630968B1 (en) 2015-12-23 2017-04-25 Arqule, Inc. Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
AU2017315343A1 (en) 2016-08-24 2019-02-28 Arqule, Inc. Amino-pyrrolopyrimidinone compounds and methods of use thereof
CN108530464B (zh) * 2017-03-02 2020-10-27 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
CN110423218A (zh) * 2019-08-09 2019-11-08 新乡双鹭药业有限公司 一种苹果酸卡博替尼合成中杂质的制备方法
CN113336768B (zh) 2020-02-18 2022-08-19 深圳海王医药科技研究院有限公司 一种多靶点酪氨酸激酶抑制剂
CN114957136A (zh) * 2021-02-24 2022-08-30 南京科默生物医药有限公司 一种用作vegfr抑制剂的抗肿瘤化合物及其用途
CN115215803B (zh) * 2022-09-19 2022-12-30 苏州美诺医药科技有限公司 一种4-卤代-1-(二氟甲基)-1h-咪唑的制备方法
CN117902987A (zh) * 2024-01-22 2024-04-19 安庆双启医药科技有限公司 一种3-氟-5-碘苯胺的制备方法
WO2025239980A1 (en) * 2024-05-13 2025-11-20 University Of Virginia Patent Foundation Compounds for the inhibition of kifc3, methods of making the same, and pharmaceutical compositions comprising the same
US20260116871A1 (en) * 2024-10-24 2026-04-30 Fujian Haixi Pharmaceuticals Co., Ltd. Tyrosine Kinase Inhibitors and Uses Thereof

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Also Published As

Publication number Publication date
BRPI0610322A2 (pt) 2010-06-15
JP5148499B2 (ja) 2013-02-20
KR20080059112A (ko) 2008-06-26
US8093264B2 (en) 2012-01-10
BRPI0610322B8 (pt) 2021-05-25
CN101796055A (zh) 2010-08-04
US8329726B2 (en) 2012-12-11
IL187484A0 (en) 2011-08-01
AU2006343808A1 (en) 2008-04-10
AU2006343808B2 (en) 2012-03-29
EP1957498B1 (en) 2017-02-15
IL187484A (en) 2014-04-30
CA2611370C (en) 2014-11-25
WO2008041053A3 (en) 2009-12-23
MX2007014616A (es) 2009-08-12
US20120083482A1 (en) 2012-04-05
BRPI0610322B1 (pt) 2020-12-01
EP1957498A2 (en) 2008-08-20
ES2623221T3 (es) 2017-07-10
NZ564283A (en) 2011-07-29
WO2008041053A2 (en) 2008-04-10
CN101796055B (zh) 2013-09-04
EP1957498A4 (en) 2010-10-27
US20070004675A1 (en) 2007-01-04
CA2611370A1 (en) 2006-11-20
JP2009504804A (ja) 2009-02-05

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