UA100262C2 - Інгібітори активності протеїнтирозинкінази - Google Patents
Інгібітори активності протеїнтирозинкіназиInfo
- Publication number
- UA100262C2 UA100262C2 UAA201013462A UAA201013462A UA100262C2 UA 100262 C2 UA100262 C2 UA 100262C2 UA A201013462 A UAA201013462 A UA A201013462A UA A201013462 A UAA201013462 A UA A201013462A UA 100262 C2 UA100262 C2 UA 100262C2
- Authority
- UA
- Ukraine
- Prior art keywords
- tyrosine kinase
- kinase activity
- protein tyrosine
- inhibitors
- compounds
- Prior art date
Links
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title abstract 3
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 230000011664 signaling Effects 0.000 abstract 2
- 102000009465 Growth Factor Receptors Human genes 0.000 abstract 1
- 108010009202 Growth Factor Receptors Proteins 0.000 abstract 1
- 108091008605 VEGF receptors Proteins 0.000 abstract 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Цей винахід стосується сполук, які інгібують активність протеїнтирозинкіназ. Зокрема, винахід стосується сполук, які інгібують активність протеїнтирозинкіназ рецепторів факторів росту, що приводить до інгібування сигналізації рецепторів, наприклад інгібування сигналізації рецепторів VEGF. Винахід також пропонує сполуки, композиції та способи лікування хвороб та станів розростання клітин й офтальмологічних хвороб, розладів та станів.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3400508P | 2008-03-05 | 2008-03-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA100262C2 true UA100262C2 (uk) | 2012-12-10 |
Family
ID=41055503
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201013462A UA100262C2 (uk) | 2008-03-05 | 2009-02-27 | Інгібітори активності протеїнтирозинкінази |
UAA201011785A UA101362C2 (en) | 2008-03-05 | 2009-02-27 | Protein tyrosine kinase activity inhibitors |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201011785A UA101362C2 (en) | 2008-03-05 | 2009-02-27 | Protein tyrosine kinase activity inhibitors |
Country Status (19)
Country | Link |
---|---|
US (3) | US8729268B2 (uk) |
EP (2) | EP2332536A1 (uk) |
JP (2) | JP2011513339A (uk) |
KR (2) | KR20100137495A (uk) |
CN (2) | CN102015723B (uk) |
AR (2) | AR070539A1 (uk) |
AU (2) | AU2009221583B2 (uk) |
BR (2) | BRPI0908573A2 (uk) |
CA (2) | CA2717816A1 (uk) |
CO (1) | CO6290684A2 (uk) |
IL (2) | IL207946A0 (uk) |
MX (1) | MX2010009729A (uk) |
NZ (2) | NZ588355A (uk) |
RU (2) | RU2533827C2 (uk) |
SG (1) | SG182146A1 (uk) |
TW (2) | TW200940549A (uk) |
UA (2) | UA100262C2 (uk) |
WO (1) | WO2009109035A1 (uk) |
ZA (2) | ZA201005868B (uk) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG182146A1 (en) * | 2008-03-05 | 2012-07-30 | Methylgene Inc | Inhibitors of protein tyrosine kinase activity |
MX2012002591A (es) | 2009-09-03 | 2012-04-02 | Allergan Inc | Compuestos como moduladores de tirosina cinasas. |
US9340555B2 (en) | 2009-09-03 | 2016-05-17 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
MX2012012031A (es) * | 2010-04-16 | 2012-12-17 | Methylgene Inc | Inhibidores de la actividad de la proteina tirosina quinasa y uso de los mismos para tratar transtornos oftalmicos. |
TWI492949B (zh) * | 2010-06-09 | 2015-07-21 | Abbvie Bahamas Ltd | 結晶型激酶抑制劑 |
US8633317B2 (en) * | 2010-06-09 | 2014-01-21 | Abbvie Inc. | Crystalline salts of thieno[3,2-c]pyridine kinase inhibitors with improved cpy safety profile |
TWI482770B (zh) * | 2010-06-09 | 2015-05-01 | Abbvie Bahamas Ltd | 結晶型激酶抑制劑 |
EA201300283A1 (ru) * | 2010-08-27 | 2013-08-30 | Мерк Патент Гмбх | Производные фуропиридина |
CA2811479A1 (en) * | 2010-09-17 | 2012-03-22 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
BRPI1004176A2 (pt) * | 2010-10-25 | 2015-08-11 | Univ Rio De Janeiro | Compostos aril e/ou hetero aril uréias funcionalizados; processo de síntese desses composto; composição farmacêutica contendo tais compostos e usos |
WO2013044361A1 (en) * | 2011-09-30 | 2013-04-04 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
US20130096135A1 (en) * | 2011-09-30 | 2013-04-18 | Methylgene Inc. | Selected Inhibitors of Protein Tyrosine Kinase Activity |
WO2013044360A1 (en) * | 2011-09-30 | 2013-04-04 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
MX2017007629A (es) * | 2014-12-09 | 2018-05-17 | Abbvie Inc | Compuestos inhibidores de bcl-xl que tienen una baja permeabilidad en las celulas y conjugados de anticuerpo-farmaco que los incluyen. |
FR3037957B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
SG11202007198WA (en) | 2018-01-31 | 2020-08-28 | Deciphera Pharmaceuticals Llc | Combination therapy for the treatment of gastrointestinal stromal tumors |
TW202122082A (zh) | 2019-08-12 | 2021-06-16 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
BR112022002609A2 (pt) | 2019-08-12 | 2022-08-09 | Deciphera Pharmaceuticals Llc | Métodos de tratamento de tumores estromais gastrointestinais |
IL293866A (en) | 2019-12-30 | 2022-08-01 | Deciphera Pharmaceuticals Llc | Compositions of amorphous kinase inhibitors and methods of using them |
KR20220123058A (ko) | 2019-12-30 | 2022-09-05 | 데시페라 파마슈티칼스, 엘엘씨. | 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물 |
TW202342426A (zh) * | 2022-02-15 | 2023-11-01 | 大陸商百濟神州(蘇州)生物科技有限公司 | N-[(6-溴吡啶-3-基)甲基]-2-甲氧基乙烷-1-胺鹽及其製備方法 |
US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7000A (en) * | 1850-01-08 | Smut-machine | ||
US7019A (en) * | 1850-01-15 | Improvement in obstetrical supporters | ||
US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
WO1999024440A1 (en) | 1997-11-11 | 1999-05-20 | Pfizer Products Inc. | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
CA2333770A1 (en) | 1998-06-04 | 1999-12-09 | Abbott Laboratories | Cell adhesion-inhibiting antinflammatory compounds |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
WO2000075145A1 (en) | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
JP2003535867A (ja) | 2000-06-06 | 2003-12-02 | ファイザー プロダクツ インコーポレイテッド | 抗癌剤として有用なチオフェン誘導体 |
US20020004511A1 (en) | 2000-06-28 | 2002-01-10 | Luzzio Michael Joseph | Thiophene derivatives useful as anticancer agents |
EP1415987B1 (en) * | 2000-10-20 | 2007-02-28 | Eisai R&D Management Co., Ltd. | Nitrogenous aromatic ring compounds as anti cancer agents |
US6995171B2 (en) | 2001-06-21 | 2006-02-07 | Agouron Pharmaceuticals, Inc. | Bicyclic pyrimidine and pyrimidine derivatives useful as anticancer agents |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
CA2478050A1 (en) | 2002-03-01 | 2003-09-12 | Pfizer Inc. | Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents |
US20030199525A1 (en) | 2002-03-21 | 2003-10-23 | Hirst Gavin C. | Kinase inhibitors |
CL2003002287A1 (es) | 2002-11-25 | 2005-01-14 | Wyeth Corp | COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS |
US20050065171A1 (en) | 2003-06-25 | 2005-03-24 | Shakespeare William C. | Substituted purine derivatives |
MXPA06002296A (es) | 2003-08-29 | 2006-05-22 | Pfizer | Tienopiridina-fenilacetamidas y sus derivados utiles como nuevos agentes antiangiogenicos. |
US7581674B2 (en) | 2003-11-21 | 2009-09-01 | Charles Cohen | Financial transaction system and method |
CA2553433A1 (en) | 2004-01-23 | 2005-08-11 | Amgen Inc. | Quinoline quinazoline pyridine and pyrimidine compounds and their use in the treatment of inflammation angiogenesis and cancer |
US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
TW200538453A (en) | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
WO2005121125A1 (en) * | 2004-06-09 | 2005-12-22 | Pfizer Inc. | Ether-linked heteroaryl compounds |
US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
WO2006014325A2 (en) | 2004-07-02 | 2006-02-09 | Exelixis, Inc. | C-met modulators and method of use |
JP2008506714A (ja) | 2004-07-16 | 2008-03-06 | サネシス ファーマシューティカルズ, インコーポレイテッド | オーロラキナーゼインヒビターとして有用なチエノピリミジン |
RU2007107167A (ru) | 2004-07-30 | 2008-09-10 | Метилджин, Инк. (Ca) | Ингибиторы передачи сигнала рецептора vegf и рецептора hgf |
US7652009B2 (en) | 2004-11-30 | 2010-01-26 | Amgem Inc. | Substituted heterocycles and methods of use |
AU2006229343A1 (en) | 2005-03-28 | 2006-10-05 | Kirin Pharma Kabushiki Kaisha | Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency |
AU2006231646A1 (en) | 2005-04-06 | 2006-10-12 | Exelixis, Inc. | C-Met modulators and methods of use |
JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
ES2623221T3 (es) | 2005-05-20 | 2017-07-10 | Methylgene Inc | Inhibidores de la señalización del receptor de VEGF y del receptor de HGF |
KR101078968B1 (ko) | 2005-05-20 | 2011-11-01 | 메틸진 인코포레이티드 | Vegf 수용체 및 hgf 수용체 신호전달 억제제 |
TW200740820A (en) * | 2005-07-05 | 2007-11-01 | Takeda Pharmaceuticals Co | Fused heterocyclic derivatives and use thereof |
CA2636242A1 (en) * | 2006-01-30 | 2008-05-29 | Array Biopharma, Inc. | Heterobicyclic thiophene compounds and methods of use |
AR060061A1 (es) | 2006-03-22 | 2008-05-21 | Methylgene Inc | Inhibidores de la actividad de la proteina tirosina quinasa |
US7298968B1 (en) * | 2007-01-05 | 2007-11-20 | Rheem Manufacturing Company | Pumpless combination instantaneous/storage water heater system |
KR101556269B1 (ko) * | 2007-08-29 | 2015-09-30 | 메틸진 인코포레이티드 | 단백질 티로신 키나아제 활성의 억제제 |
SG182146A1 (en) * | 2008-03-05 | 2012-07-30 | Methylgene Inc | Inhibitors of protein tyrosine kinase activity |
MX2012012031A (es) * | 2010-04-16 | 2012-12-17 | Methylgene Inc | Inhibidores de la actividad de la proteina tirosina quinasa y uso de los mismos para tratar transtornos oftalmicos. |
-
2009
- 2009-02-27 SG SG2012040093A patent/SG182146A1/en unknown
- 2009-02-27 CN CN200980107358.1A patent/CN102015723B/zh not_active Expired - Fee Related
- 2009-02-27 CN CN201010549696.5A patent/CN102161663B/zh not_active Expired - Fee Related
- 2009-02-27 TW TW098106618A patent/TW200940549A/zh unknown
- 2009-02-27 KR KR1020107022142A patent/KR20100137495A/ko not_active Application Discontinuation
- 2009-02-27 RU RU2010140668/04A patent/RU2533827C2/ru not_active IP Right Cessation
- 2009-02-27 WO PCT/CA2009/000228 patent/WO2009109035A1/en active Application Filing
- 2009-02-27 AU AU2009221583A patent/AU2009221583B2/en not_active Ceased
- 2009-02-27 TW TW099142241A patent/TWI438205B/zh not_active IP Right Cessation
- 2009-02-27 NZ NZ588355A patent/NZ588355A/en not_active IP Right Cessation
- 2009-02-27 MX MX2010009729A patent/MX2010009729A/es not_active Application Discontinuation
- 2009-02-27 US US12/920,676 patent/US8729268B2/en not_active Expired - Fee Related
- 2009-02-27 CA CA2717816A patent/CA2717816A1/en not_active Abandoned
- 2009-02-27 NZ NZ589336A patent/NZ589336A/en not_active IP Right Cessation
- 2009-02-27 CA CA2763168A patent/CA2763168A1/en not_active Abandoned
- 2009-02-27 EP EP10015089A patent/EP2332536A1/en not_active Withdrawn
- 2009-02-27 KR KR1020107025059A patent/KR20100132068A/ko not_active Application Discontinuation
- 2009-02-27 AR ARP090100693A patent/AR070539A1/es unknown
- 2009-02-27 BR BRPI0908573-4A patent/BRPI0908573A2/pt not_active IP Right Cessation
- 2009-02-27 RU RU2010145459/04A patent/RU2498988C2/ru not_active IP Right Cessation
- 2009-02-27 JP JP2010548992A patent/JP2011513339A/ja active Pending
- 2009-02-27 BR BRPI0923670-8A patent/BRPI0923670A2/pt not_active IP Right Cessation
- 2009-02-27 UA UAA201013462A patent/UA100262C2/uk unknown
- 2009-02-27 EP EP09716596A patent/EP2262815A4/en not_active Withdrawn
- 2009-02-27 UA UAA201011785A patent/UA101362C2/ru unknown
-
2010
- 2010-08-17 ZA ZA2010/05868A patent/ZA201005868B/en unknown
- 2010-09-02 IL IL207946A patent/IL207946A0/en unknown
- 2010-10-01 CO CO10121775A patent/CO6290684A2/es active IP Right Grant
- 2010-10-21 IL IL208882A patent/IL208882A0/en unknown
- 2010-10-21 ZA ZA2010/07517A patent/ZA201007517B/en unknown
- 2010-11-26 AR ARP100104383A patent/AR079208A2/es unknown
- 2010-11-30 AU AU2010246540A patent/AU2010246540B2/en not_active Ceased
- 2010-12-09 US US12/964,289 patent/US8759522B2/en not_active Expired - Fee Related
-
2011
- 2011-01-21 JP JP2011010326A patent/JP5661485B2/ja not_active Expired - Fee Related
-
2014
- 2014-02-28 US US14/194,155 patent/US20140179632A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA100262C2 (uk) | Інгібітори активності протеїнтирозинкінази | |
WO2008035209A3 (en) | Quinoline and quinazoline derivatives as inhibitors of protein tyrosine kinase activity | |
MY157319A (en) | Inhibitors of protein tyrosine kinase activity | |
WO2007149427A3 (en) | Tyrosine kinase inhibitors | |
PH12020551208A1 (en) | Compounds for the treatment of kinase-dependent disorders | |
SI1896421T1 (sl) | Benzocikloheptapiridini kot inhibitorji receptorjev tirozin kinaze met | |
MX2007014616A (es) | Inhibidores de señalizacion del receptor del factor a de crecimiento endotelial vascular y del receptor del factor de crecimiento de hepatocitos. | |
WO2010005876A3 (en) | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors | |
TN2013000348A1 (en) | Compounds and compositions as trk inhibitors | |
MX2009008253A (es) | Derivados de 2-aminopiridina utiles como inhibidores de cinasa. | |
WO2012037155A3 (en) | Tyrosine kinase inhibitors | |
JOP20120246B1 (ar) | مركبات و تركيبات كمثبطات كيناز c-Kit | |
NO20090608L (no) | Tyrosinkinaseinhibitorer | |
MY165728A (en) | Selective glycosidase inhibitors and uses thereof | |
MY155621A (en) | Axl antibodies | |
MX339937B (es) | Compuestos y composiciones como inhibidores de la quinasa c-kit. | |
MA32393B1 (fr) | Composés et compositions servant d'inhibiteurs de kinases | |
JO3002B1 (ar) | مركبات و تركيبات كمثبطات كيناز بروتين | |
IL200793A0 (en) | Aminopyrimidines, compositions comprising the same and use thereof for inhibiting protein kinases | |
EP3715457A3 (en) | Modulation of prekallikrein (pkk) expression | |
GB2460597A (en) | N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors | |
MX2011008602A (es) | Metodos de tratamiento de condiciones relacionadas con el cabello. | |
WO2006086358A3 (en) | Mitotic kinesin inhibitors | |
TW200738638A (en) | Tyrosine kinase inhibitors | |
MX2010007669A (es) | Metodos para inhibir la angiogenesis utilizando antagonistas de egfl8. |