AU2005230684B2 - Process and reagents for oligonucleotide synthesis and purification - Google Patents

Process and reagents for oligonucleotide synthesis and purification Download PDF

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Publication number
AU2005230684B2
AU2005230684B2 AU2005230684A AU2005230684A AU2005230684B2 AU 2005230684 B2 AU2005230684 B2 AU 2005230684B2 AU 2005230684 A AU2005230684 A AU 2005230684A AU 2005230684 A AU2005230684 A AU 2005230684A AU 2005230684 B2 AU2005230684 B2 AU 2005230684B2
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AU
Australia
Prior art keywords
alkyl
oligonucleotide
aryl
rna
aralkyl
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AU2005230684A
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AU2005230684A1 (en
Inventor
Michael E. Jung
Muthiah Manoharan
Rajendra K. Pandey
Kallanthottathil G. Rajeev
Gang Wang
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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Assigned to ALNYLAM PHARMACEUTICALS, INC. reassignment ALNYLAM PHARMACEUTICALS, INC. Request for Assignment Assignors: ALNYLAM PHARMACEUTICALS
Priority to AU2011203074A priority Critical patent/AU2011203074B2/en
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Publication of AU2005230684B2 publication Critical patent/AU2005230684B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2005230684A 2004-04-05 2005-04-05 Process and reagents for oligonucleotide synthesis and purification Expired AU2005230684B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011203074A AU2011203074B2 (en) 2004-04-05 2011-06-23 Processes and reagents for oligonucleotide synthesis and purification

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55978204P 2004-04-05 2004-04-05
US60/559,782 2004-04-05
PCT/US2005/011490 WO2005097817A2 (en) 2004-04-05 2005-04-05 Process and reagents for oligonucleotide synthesis and purification

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2011203074A Division AU2011203074B2 (en) 2004-04-05 2011-06-23 Processes and reagents for oligonucleotide synthesis and purification

Publications (2)

Publication Number Publication Date
AU2005230684A1 AU2005230684A1 (en) 2005-10-20
AU2005230684B2 true AU2005230684B2 (en) 2011-10-06

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ID=35056873

Family Applications (1)

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AU2005230684A Expired AU2005230684B2 (en) 2004-04-05 2005-04-05 Process and reagents for oligonucleotide synthesis and purification

Country Status (6)

Country Link
US (4) US20050267300A1 (https=)
EP (2) EP1737878A2 (https=)
JP (4) JP2007531794A (https=)
AU (1) AU2005230684B2 (https=)
CA (1) CA2561741C (https=)
WO (1) WO2005097817A2 (https=)

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US8541569B2 (en) * 2008-09-06 2013-09-24 Chemgenes Corporation Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA
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CN102180875B (zh) * 2011-03-18 2013-01-16 浙江工业大学 一种三唑并吡啶衍生物的制备方法
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KR102213609B1 (ko) 2012-07-13 2021-02-08 웨이브 라이프 사이언시스 리미티드 키랄 제어
CN103657729B (zh) * 2012-09-20 2015-10-21 中国石油化工股份有限公司 烃油催化裂化硫转移助催化剂及其制备方法
JP6571663B2 (ja) * 2013-09-14 2019-09-04 ケムジーンズ コーポレーション 逆方向アプローチを使用した長いｒｎａの非常に効果的な合成
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
BR112016016400A2 (pt) 2014-01-16 2017-10-03 Wave Life Sciences Ltd Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos
WO2017035278A1 (en) 2015-08-24 2017-03-02 Halo-Bio Rnai Therapeutics, Inc. Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
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TWI809004B (zh) 2017-11-09 2023-07-21 美商Ionis製藥公司 用於降低snca表現之化合物及方法
SG11202006528XA (en) 2018-01-12 2020-08-28 Bristol Myers Squibb Co Antisense oligonucleotides targeting alpha-synuclein and uses thereof
CN120310791A (zh) 2018-01-12 2025-07-15 百时美施贵宝公司 靶向α-突触核蛋白的反义寡核苷酸及其用途
EP3950698A4 (en) * 2019-03-28 2023-01-25 Ajinomoto Co., Inc. METHOD OF PREPARING AN OLIGONUCLEOTIDE WITH PHOSPHOROTHIOATE SITE
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JP2022177332A (ja) * 2019-10-24 2022-12-01 日東電工株式会社 オリゴヌクレオチドを製造する方法
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KR20220087091A (ko) * 2020-12-17 2022-06-24 오토텔릭바이오 주식회사 고순도 안티센스 올리고뉴클레오타이드의 제조방법
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