EP2540734A2 - Process and reagents for oligonucleotide synthesis and purification - Google Patents

Process and reagents for oligonucleotide synthesis and purification Download PDF

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Publication number
EP2540734A2
EP2540734A2 EP12004337A EP12004337A EP2540734A2 EP 2540734 A2 EP2540734 A2 EP 2540734A2 EP 12004337 A EP12004337 A EP 12004337A EP 12004337 A EP12004337 A EP 12004337A EP 2540734 A2 EP2540734 A2 EP 2540734A2
Authority
EP
European Patent Office
Prior art keywords
alkyl
aryl
aralkyl
oligonucleotide
present invention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP12004337A
Other languages
German (de)
French (fr)
Other versions
EP2540734B1 (en
EP2540734A3 (en
Inventor
Muthiah Manoharan
Michael E. Jung
Kallanthottathil G. Rajeev
Rajendra K. Pandey
Gang Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alnylam Pharmaceuticals Inc
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US55978204P priority Critical
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Priority to EP05736465A priority patent/EP1737878A2/en
Publication of EP2540734A2 publication Critical patent/EP2540734A2/en
Publication of EP2540734A3 publication Critical patent/EP2540734A3/en
Application granted granted Critical
Publication of EP2540734B1 publication Critical patent/EP2540734B1/en
Application status is Active legal-status Critical
Anticipated expiration legal-status Critical

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