ATE221408T1 - Mikroreaktor für ein modulares system - Google Patents

Mikroreaktor für ein modulares system

Info

Publication number
ATE221408T1
ATE221408T1 AT95914943T AT95914943T ATE221408T1 AT E221408 T1 ATE221408 T1 AT E221408T1 AT 95914943 T AT95914943 T AT 95914943T AT 95914943 T AT95914943 T AT 95914943T AT E221408 T1 ATE221408 T1 AT E221408T1
Authority
AT
Austria
Prior art keywords
system components
reaction
reaction system
image
reactant
Prior art date
Application number
AT95914943T
Other languages
English (en)
Inventor
Allen J Bard
Original Assignee
Integrated Chemical Synthesize
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Integrated Chemical Synthesize filed Critical Integrated Chemical Synthesize
Application granted granted Critical
Publication of ATE221408T1 publication Critical patent/ATE221408T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38Diluting, dispersing or mixing samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6095Micromachined or nanomachined, e.g. micro- or nanosize
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00783Laminate assemblies, i.e. the reactor comprising a stack of plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00801Means to assemble
    • B01J2219/0081Plurality of modules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00822Metal
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00824Ceramic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00824Ceramic
    • B01J2219/00828Silicon wafers or plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00833Plastic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00835Comprising catalytically active material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00851Additional features
    • B01J2219/00858Aspects relating to the size of the reactor
    • B01J2219/00864Channel sizes in the nanometer range, e.g. nanoreactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00851Additional features
    • B01J2219/00867Microreactors placed in series, on the same or on different supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00851Additional features
    • B01J2219/00869Microreactors placed in parallel, on the same or on different supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00851Additional features
    • B01J2219/00871Modular assembly
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00873Heat exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00889Mixing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00905Separation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00925Irradiation
    • B01J2219/00932Sonic or ultrasonic vibrations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/028Modular arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04Exchange or ejection of cartridges, containers or reservoirs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0896Nanoscaled
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8881Modular construction, specially adapted therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178Special arrangements of analysers
    • G01N2035/00237Handling microquantities of analyte, e.g. microvalves, capillary networks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178Special arrangements of analysers
    • G01N2035/00326Analysers with modular structure
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00534Mixing by a special element, e.g. stirrer
    • G01N2035/00554Mixing by a special element, e.g. stirrer using ultrasound
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6034Construction of the column joining multiple columns
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6091Cartridges

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Vehicle Step Arrangements And Article Storage (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT95914943T 1994-04-01 1995-03-29 Mikroreaktor für ein modulares system ATE221408T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/221,931 US5580523A (en) 1994-04-01 1994-04-01 Integrated chemical synthesizers
PCT/US1995/003873 WO1995026796A1 (en) 1994-04-01 1995-03-29 Integrated chemical synthesizers

Publications (1)

Publication Number Publication Date
ATE221408T1 true ATE221408T1 (de) 2002-08-15

Family

ID=22830019

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02001172T ATE291227T1 (de) 1994-04-01 1995-03-29 Methoden zur benutzung eines modularen reaktionssystems im nanomassstab
AT95914943T ATE221408T1 (de) 1994-04-01 1995-03-29 Mikroreaktor für ein modulares system

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT02001172T ATE291227T1 (de) 1994-04-01 1995-03-29 Methoden zur benutzung eines modularen reaktionssystems im nanomassstab

Country Status (8)

Country Link
US (2) US5580523A (de)
EP (3) EP1203954B1 (de)
JP (1) JP3625477B2 (de)
AT (2) ATE291227T1 (de)
AU (1) AU708281B2 (de)
CA (1) CA2186896C (de)
DE (2) DE69534086T2 (de)
WO (1) WO1995026796A1 (de)

Families Citing this family (321)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US20050042149A1 (en) * 1994-04-01 2005-02-24 Integrated Chemical Synthesizers, Inc. Nanoscale chemical synthesis
US5985119A (en) * 1994-11-10 1999-11-16 Sarnoff Corporation Electrokinetic pumping
ATE277450T1 (de) * 1994-11-10 2004-10-15 Orchid Biosciences Inc Flüssigkeitsverteilungssystem
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5902551A (en) * 1995-01-13 1999-05-11 Semi-Gas Systems, Inc. Process gas docking station with point-of-use filter for receiving removable purifier cartridges
DE19507638C2 (de) * 1995-03-04 1997-09-25 Danfoss As Analysenvorrichtung
US6120665A (en) * 1995-06-07 2000-09-19 Chiang; William Yat Chung Electrokinetic pumping
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US20020068357A1 (en) * 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
DE59700294D1 (de) * 1996-01-23 1999-09-02 Novartis Ag Vorrichtung und verfahren zum synthetisieren von makromolekülen
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5964239A (en) * 1996-05-23 1999-10-12 Hewlett-Packard Company Housing assembly for micromachined fluid handling structure
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6494937B1 (en) 2001-09-27 2002-12-17 Idatech, Llc Hydrogen purification devices, components and fuel processing systems containing the same
US6783741B2 (en) 1996-10-30 2004-08-31 Idatech, Llc Fuel processing system
US6537352B2 (en) 1996-10-30 2003-03-25 Idatech, Llc Hydrogen purification membranes, components and fuel processing systems containing the same
US7195663B2 (en) 1996-10-30 2007-03-27 Idatech, Llc Hydrogen purification membranes, components and fuel processing systems containing the same
NO304355B1 (no) 1997-02-20 1998-12-07 Sinvent As Multi-autoklav for metodisk, automatisert syntese av zeolitter og andre forbindelser
US5961932A (en) * 1997-06-20 1999-10-05 Eastman Kodak Company Reaction chamber for an integrated micro-ceramic chemical plant
US6200536B1 (en) * 1997-06-26 2001-03-13 Battelle Memorial Institute Active microchannel heat exchanger
US6068684A (en) * 1997-09-11 2000-05-30 Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College Microstructure chromatograph with rectangular column
US7214298B2 (en) 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US6102068A (en) * 1997-09-23 2000-08-15 Hewlett-Packard Company Selector valve assembly
US5992820A (en) * 1997-11-19 1999-11-30 Sarnoff Corporation Flow control in microfluidics devices by controlled bubble formation
EP1054694A2 (de) 1998-02-13 2000-11-29 Selective Genetics, Inc. Gleichzeitige strömungsdurchmischung zur herstellung von zusammensetzungen, die gentherapievektoren enthalten
US6019897A (en) * 1998-08-20 2000-02-01 Dyax Corporation System for simultaneously pumping solvent for a plurality of chromatography columns
WO2000012994A1 (en) * 1998-08-31 2000-03-09 Genentech, Inc. Apparatus for rapid protein and polypeptide sequence analysis
US6086740A (en) * 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
WO2000048724A1 (fr) * 1999-02-18 2000-08-24 Toyo Kohan Co., Ltd. Microcircuit integre pour reaction chimique
US6749814B1 (en) * 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US7150994B2 (en) * 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
EP1106244A3 (de) * 1999-03-03 2001-11-21 Symyx Technologies, Inc. Mikrosysteme zur chemischen Verarbeitung und Steuerung von Prozessbedingungen in solchen Systemen
DE60017702T2 (de) * 1999-03-03 2006-04-06 Symyx Technologies, Inc., Santa Clara Chemische verfahrensmikrosysteme zur evaluierung heterogener katalysatoren und ihre verwendung
DE19917398C2 (de) * 1999-04-16 2002-06-20 Accoris Gmbh Modulares chemisches Mikrosystem
DE19917330B4 (de) * 1999-04-16 2004-08-26 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Mikroreaktormodul
FI111342B (fi) * 1999-05-24 2003-07-15 Pam Solutions Ltd Oy Syntetisaattorilaitteisto
US6485690B1 (en) 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
US6818185B1 (en) * 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
DE19928412C2 (de) 1999-06-22 2002-03-21 Agilent Technologies Inc Versorgungselement für einen Labor-Mikrochip
DE19928410C2 (de) * 1999-06-22 2002-11-28 Agilent Technologies Inc Gerätegehäuse mit einer Einrichtung zum Betrieb eines Labor-Mikrochips
US6210986B1 (en) 1999-09-23 2001-04-03 Sandia Corporation Microfluidic channel fabrication method
AU7869200A (en) * 1999-10-08 2001-04-23 Bio-Informatics Group, Inc. Biochip defining a channeled capillary array and associated methods
DE19954855C1 (de) * 1999-11-15 2001-04-05 Siemens Ag System zur automatisierten Behandlung von Fluiden, mit einanderreihbaren, austauschbaren Prozeßmodulen
DE19959249A1 (de) * 1999-12-08 2001-07-19 Inst Mikrotechnik Mainz Gmbh Modulares Mikroreaktionssystem
US7435392B2 (en) * 2000-02-03 2008-10-14 Acclavis, Llc Scalable continuous production system
US7056477B1 (en) 2000-02-03 2006-06-06 Cellular Process Chemistry, Inc. Modular chemical production system incorporating a microreactor
US7241423B2 (en) * 2000-02-03 2007-07-10 Cellular Process Chemistry, Inc. Enhancing fluid flow in a stacked plate microreactor
US6537506B1 (en) 2000-02-03 2003-03-25 Cellular Process Chemistry, Inc. Miniaturized reaction apparatus
WO2001067369A2 (en) * 2000-03-03 2001-09-13 California Institute Of Technology Combinatorial array for nucleic acid analysis
WO2001066245A2 (en) 2000-03-07 2001-09-13 Symyx Technologies, Inc. Parallel flow process optimization reactor
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US20010045061A1 (en) * 2000-03-13 2001-11-29 Ida Tech, L.L.C. Fuel processor and systems and devices containing the same
JP3847053B2 (ja) * 2000-03-15 2006-11-15 純 菊地 血液分析装置
WO2001087458A1 (en) * 2000-05-12 2001-11-22 University Of Cincinnati Magnetic bead-based arrays
AU2001259770A1 (en) * 2000-05-15 2001-11-26 Biomicro Systems, Inc. Air flow regulation in microfluidic circuits for pressure control and gaseous exchange
EP1286761A2 (de) * 2000-05-24 2003-03-05 Cellular Process Chemistry Inc. Modulares chemisches produktionssystem mit einem mikroreaktor
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US7062418B2 (en) 2000-06-27 2006-06-13 Fluidigm Corporation Computer aided design method and system for developing a microfluidic system
US20020012616A1 (en) * 2000-07-03 2002-01-31 Xiaochuan Zhou Fluidic methods and devices for parallel chemical reactions
US20030118486A1 (en) * 2000-07-03 2003-06-26 Xeotron Corporation Fluidic methods and devices for parallel chemical reactions
DE10032059A1 (de) * 2000-07-05 2002-01-17 Mir Chem Gmbh Vorrichtung zum Ausführen einer katalytischen Rohrreaktion
US7413714B1 (en) 2000-07-16 2008-08-19 Ymc Co. Ltd. Sequential reaction system
DE10036602A1 (de) * 2000-07-27 2002-02-14 Cpc Cellular Process Chemistry Mikroreaktor für Reaktionen zwischen Gasen und Flüssigkeiten
EP1315570A4 (de) * 2000-08-03 2006-12-13 Caliper Life Sciences Inc Verfahren und vorrichtungen für fluidförderung mit hohem durchsatz
CN1468227A (zh) * 2000-08-08 2004-01-14 ����-������ҩƷ��˾ 非咪唑芳氧基烷基胺
AU8112101A (en) * 2000-08-08 2002-02-18 Ortho Mcneil Pharm Inc Non-imidazole aryloxypiperidines
DE10041229A1 (de) * 2000-08-22 2002-03-07 Leica Microsystems Vorrichtung zur Behandlung von Objekten
US6821413B1 (en) * 2000-08-31 2004-11-23 Fluidphase Technologies, Inc. Method and apparatus for continuous separation and reaction using supercritical fluid
US6436720B1 (en) * 2000-09-15 2002-08-20 Cellular Process Chemistry, Inc. Residence time providing module/apparatus
KR20030038739A (ko) * 2000-09-22 2003-05-16 자이단호진 가와무라 리카가쿠 겐큐쇼 미소 케미컬 디바이스 및 그 유량 조절 방법
US6623860B2 (en) 2000-10-10 2003-09-23 Aclara Biosciences, Inc. Multilevel flow structures
WO2002030486A2 (en) 2000-10-13 2002-04-18 Fluidigm Corporation Microfluidic device based sample injection system for analytical devices
US6932943B1 (en) 2001-01-26 2005-08-23 Third Wave Technologies Nucleic acid synthesizers
US7435390B2 (en) * 2001-01-26 2008-10-14 Third Wave Technologies, Inc. Nucleic acid synthesizers
DE10106558C1 (de) * 2001-02-13 2002-11-07 Siemens Ag System zur automatisierten Behandlung von Fluiden, mit aneinanderreihbaren, austauschbaren Prozessmodulen
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
DE10106952C2 (de) * 2001-02-15 2003-01-16 Cognis Deutschland Gmbh Chip-Reaktor
DE10106953B4 (de) * 2001-02-15 2006-07-06 Cognis Ip Management Gmbh Mikroreaktoren
US6755074B2 (en) * 2001-02-27 2004-06-29 Isco, Inc. Liquid chromatographic method and system
US6904784B2 (en) 2001-02-27 2005-06-14 Teledyne Isco, Inc. Liquid chromatographic method and system
US20050196785A1 (en) * 2001-03-05 2005-09-08 California Institute Of Technology Combinational array for nucleic acid analysis
US7118917B2 (en) * 2001-03-07 2006-10-10 Symyx Technologies, Inc. Parallel flow reactor having improved thermal control
US6569227B2 (en) 2001-09-27 2003-05-27 Idatech, Llc Hydrogen purification devices, components and fuel processing systems containing the same
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US7192557B2 (en) 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US7270786B2 (en) 2001-03-28 2007-09-18 Handylab, Inc. Methods and systems for processing microfluidic samples of particle containing fluids
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US6960437B2 (en) 2001-04-06 2005-11-01 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
JP2004530044A (ja) * 2001-04-12 2004-09-30 アストラゼネカ アクチボラグ 微細工学的反応装置
US6863867B2 (en) * 2001-05-07 2005-03-08 Uop Llc Apparatus for mixing and reacting at least two fluids
US6805846B2 (en) * 2001-06-18 2004-10-19 Honda Giken Kogyo Kabushiki Kaisha Compact reactor capable of being charged with catalytic material for use in a hydrogen generation/fuel cell system
WO2003022417A2 (en) * 2001-06-27 2003-03-20 Nu Element, Inc. Modular micro-reactor architecture and method for fluid processing devices
US20030013046A1 (en) * 2001-06-29 2003-01-16 The Penn State Research Foundation, University Park, Pennsylvania Use of sacrificial layers in the manufacturing of chemical reactor structures and the application of such structures
GB0116384D0 (en) * 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
DE10134885B4 (de) * 2001-07-18 2004-02-05 Roche Diagnostics Gmbh Modulares Analysesystem
DE10143189A1 (de) * 2001-09-04 2003-03-20 Clariant Gmbh Verfahren und Vorrichtung zur prozeßbegleitenden Reinigung von Mikro-und Minireaktoren
WO2003027221A1 (en) * 2001-09-23 2003-04-03 Irm Llc Closed cell washer
GB2380528B (en) * 2001-10-05 2003-09-10 Minebea Co Ltd A bearing assembly and method of manufacturing a bearing assembly
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
GB0126281D0 (en) * 2001-11-01 2002-01-02 Astrazeneca Ab A chemical reactor
DE10155010A1 (de) * 2001-11-06 2003-05-15 Cpc Cellular Process Chemistry Mikroreaktorsystem
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
EP1463796B1 (de) 2001-11-30 2013-01-09 Fluidigm Corporation Mikrofluidische vorrichtung und verfahren zu ihrer verwendung
IE20020619A1 (en) * 2001-12-31 2003-07-23 Provost Fellows And Scholors O An assay assembly
US6924107B2 (en) 2002-01-28 2005-08-02 Bio-Informatics Group, Inc. Four dimensional biochip design for high throughput applications and methods of using the four dimensional biochip
DE20201753U1 (de) 2002-02-05 2002-04-11 Ehrfeld Mikrotechnik GmbH, 55234 Wendelsheim Modulares Mikroreaktorsystem
WO2003085379A2 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
EP2282214B1 (de) * 2002-05-09 2022-10-05 The University of Chicago Vorrichtung und Verfahren zum druckbetriebenen Transport durch Einstecken und Reaktion
US6970490B2 (en) * 2002-05-10 2005-11-29 The Trustees Of Princeton University Organic light emitting devices based on the formation of an electron-hole plasma
JP3605102B2 (ja) * 2002-07-18 2004-12-22 キヤノン株式会社 液体混合装置
AU2002318070A1 (en) * 2002-07-26 2004-02-16 Avantium International B.V. System for performing a chemical reaction on a plurality of different microreactors
HUP0202551A2 (hu) * 2002-08-01 2004-03-29 Comgenex, Inc. Kémiai, biokémiai és biológiai folyamatok miniatürizálására szolgáló hibrid lapka (chip) és eljárás annak alkalmazására
AU2003272223A1 (en) * 2002-08-19 2004-03-03 Bioprocessors Corporation Determination and/or control of reactor environmental conditions
DE10239597B4 (de) * 2002-08-28 2005-03-17 Fresenius Medical Care Deutschland Gmbh Einwegkassette
US6878271B2 (en) * 2002-09-09 2005-04-12 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US20040047767A1 (en) * 2002-09-11 2004-03-11 Richard Bergman Microfluidic channel for band broadening compensation
EP1400280A1 (de) * 2002-09-18 2004-03-24 Corning Incorporated Vorrichtung und Verfahren zum Betrieb eines Mikroreaktors bei hohem Druck
US7143785B2 (en) 2002-09-25 2006-12-05 California Institute Of Technology Microfluidic large scale integration
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
US7341609B2 (en) * 2002-10-03 2008-03-11 Genesis Fueltech, Inc. Reforming and hydrogen purification system
EP1415706B1 (de) 2002-10-29 2017-07-12 Corning Incorporated Beschichtete Mikrostruktur und deren Herstellungsverfahren
EP1415707A1 (de) * 2002-10-29 2004-05-06 Corning Incorporated Photokatalytischer Reaktor und Verfahren
CA2508475C (en) * 2002-12-04 2011-08-30 Spinx, Inc. Devices and methods for programmable microscale manipulation of fluids
WO2004052540A2 (en) * 2002-12-05 2004-06-24 Protasis Corporation Configurable microfluidic substrate assembly
US20040136873A1 (en) * 2003-01-09 2004-07-15 Argonaut Technologies, Inc. Modular reactor system
JP2004294319A (ja) * 2003-03-27 2004-10-21 Jsr Corp 流体プロセッサー
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7666361B2 (en) 2003-04-03 2010-02-23 Fluidigm Corporation Microfluidic devices and methods of using same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
WO2004092908A2 (en) * 2003-04-14 2004-10-28 Cellular Process Chemistry, Inc. System and method for determining optimal reaction parameters using continuously running process
US7011793B2 (en) * 2003-05-15 2006-03-14 Kionix, Inc. Reconfigurable modular microfluidic system and method of fabrication
GB2401804B (en) * 2003-05-19 2006-09-27 Phoenix Chemicals Ltd Reactor
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
DE10335068A1 (de) * 2003-07-31 2005-03-03 Dahlbeck, Rolf, Dr.-Ing. Mikroreaktormodul
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7744817B2 (en) 2003-08-11 2010-06-29 Sakura Finetek U.S.A., Inc. Manifold assembly
US7767152B2 (en) 2003-08-11 2010-08-03 Sakura Finetek U.S.A., Inc. Reagent container and slide reaction retaining tray, and method of operation
US7501283B2 (en) 2003-08-11 2009-03-10 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
DE10336849A1 (de) * 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
US9518899B2 (en) 2003-08-11 2016-12-13 Sakura Finetek U.S.A., Inc. Automated reagent dispensing system and method of operation
GB0320337D0 (en) * 2003-08-29 2003-10-01 Syrris Ltd A microfluidic system
DE10345029A1 (de) * 2003-09-25 2005-04-21 Microfluidic Chipshop Gmbh Vorrichtung zum Kontaktieren und Verbinden von mikrofluidischen Systemen mittels Steckern
DE10345028B4 (de) * 2003-09-25 2009-09-10 Microfluidic Chipshop Gmbh Vorrichtung zum Halten und Verbinden von mikrofluidischen Systemen
US20050084072A1 (en) * 2003-10-17 2005-04-21 Jmp Industries, Inc., An Ohio Corporation Collimator fabrication
US6994245B2 (en) * 2003-10-17 2006-02-07 James M. Pinchot Micro-reactor fabrication
US8066955B2 (en) * 2003-10-17 2011-11-29 James M. Pinchot Processing apparatus fabrication
US8030057B2 (en) 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
PT1776181E (pt) 2004-01-26 2014-01-02 Harvard College Sistema e método para o fornecimento de fluidos
WO2005069738A2 (en) * 2004-01-27 2005-08-04 Ramot At Tel Aviv University Ltd. Populations of cells and devices and systems including same
US20070281288A1 (en) * 2004-01-27 2007-12-06 Shimshon Belkin Method and System for Detecting Analytes
ATE462493T1 (de) * 2004-02-02 2010-04-15 Silicon Valley Scient Inc Integriertes system mit modularen mikrofluidischen komponenten
US7569127B1 (en) 2004-02-06 2009-08-04 University Of Central Florida Research Foundation, Inc. Interconnecting microfluidic package and fabrication method
US7666285B1 (en) * 2004-02-06 2010-02-23 University Of Central Florida Research Foundation, Inc. Portable water quality monitoring system
JP2007536504A (ja) * 2004-03-26 2007-12-13 インフェクシオ・リシェルシェ・インコーポレーテッド 取り外し可能マイクロ流体フローセル
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
EP2345739B8 (de) 2004-05-03 2016-12-07 Handylab, Inc. Mikrofluidische Vorrichtung zur Verarbeitung polynukleotidhaltiger Proben
DE102004022423A1 (de) * 2004-05-06 2005-12-15 Siemens Ag Mikrofluidiksystem
US7955504B1 (en) 2004-10-06 2011-06-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use
GB0422378D0 (en) * 2004-10-07 2004-11-10 Glaxo Group Ltd A method
CA2584372A1 (en) * 2004-11-04 2006-05-11 Bio-Rad Pasteur Stackable chromatography module and chromatography column comprising a stack of such modules
GB2421202B (en) * 2004-12-15 2009-12-09 Syrris Ltd Modular microfluidic system
US7795359B2 (en) 2005-03-04 2010-09-14 Novartis Ag Continuous process for production of polymeric materials
JP2006255522A (ja) * 2005-03-15 2006-09-28 Hitachi Ltd 物質の製造装置および製造方法
US20070031819A1 (en) * 2005-04-26 2007-02-08 University Of Washington Microfluidic systems for biological and molecular analysis and methods thereof
JP4757548B2 (ja) * 2005-06-24 2011-08-24 日本特殊陶業株式会社 マイクロチップ搭載装置
US20070298109A1 (en) * 2005-07-07 2007-12-27 The Trustees Of The University Of Pennsylvania Nano-scale devices
US7846489B2 (en) 2005-07-22 2010-12-07 State of Oregon acting by and though the State Board of Higher Education on behalf of Oregon State University Method and apparatus for chemical deposition
WO2007023862A1 (ja) 2005-08-26 2007-03-01 Nippon Shokubai Co., Ltd. 染料移行防止剤、洗濯用洗剤組成物
EP1938415B1 (de) 2005-09-16 2014-05-14 Dcns Sa Selbstregelndes eingangsmaterial-abliefersystem und wasserstofferzeugende brennstoffverarbeitungsbaugruppe damit
US7601302B2 (en) 2005-09-16 2009-10-13 Idatech, Llc Self-regulating feedstock delivery systems and hydrogen-generating fuel processing assemblies and fuel cell systems incorporating the same
DE102005045811A1 (de) 2005-09-27 2007-04-05 Siemens Ag Modulares Mikrofluidiksystem
FR2891911B1 (fr) * 2005-10-07 2008-04-25 Horiba Abx Sas Soc Par Actions "dispositif modulaire destine a l'analyse d'un fluide biologique, notamment sanguin"
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US8075852B2 (en) 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US8007267B2 (en) 2005-11-02 2011-08-30 Affymetrix, Inc. System and method for making lab card by embossing
JP4753367B2 (ja) * 2005-11-25 2011-08-24 日本電子株式会社 有機合成反応装置
US8679587B2 (en) * 2005-11-29 2014-03-25 State of Oregon acting by and through the State Board of Higher Education action on Behalf of Oregon State University Solution deposition of inorganic materials and electronic devices made comprising the inorganic materials
HU227638B1 (en) * 2005-12-23 2011-10-28 Thales Rt Flowing laboratorial ozonizating apparatus and method for ozonization reaction
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP2001990B1 (de) 2006-03-24 2016-06-29 Handylab, Inc. Integriertes system zur verarbeitung von mikrofluidischen proben und verwendungsverfahren
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
TW200738328A (en) 2006-03-31 2007-10-16 Lonza Ag Micro-reactor system assembly
US7972420B2 (en) 2006-05-22 2011-07-05 Idatech, Llc Hydrogen-processing assemblies and hydrogen-producing systems and fuel cell systems including the same
US7939051B2 (en) 2006-05-23 2011-05-10 Idatech, Llc Hydrogen-producing fuel processing assemblies, heating assemblies, and methods of operating the same
US8459509B2 (en) 2006-05-25 2013-06-11 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
US7641860B2 (en) 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
US7998418B1 (en) 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
DE102007023759A1 (de) * 2006-08-10 2008-02-14 Evonik Degussa Gmbh Anlage und Verfahren zur kontinuierlichen industriellen Herstellung von Fluoralkylchlorsilan
DE102007023762A1 (de) * 2006-08-10 2008-02-14 Evonik Degussa Gmbh Anlage und Verfahren zur kontinuierlichen industriellen Herstellung von 3-Glycidyloxypropylalkoxysilanen
DE102007023764A1 (de) * 2006-08-10 2008-02-14 Evonik Degussa Gmbh Anlage und Vorrichtung zur kontinuierlichen industriellen Herstellung von 3-Chlorpropylchlorsilanen
DE102007023756A1 (de) * 2006-08-10 2008-02-14 Evonik Degussa Gmbh Anlage und Verfahren zur kontinuierlichen industriellen Herstellung von Alkylalkoxysilanen
DE102007023757A1 (de) * 2006-08-10 2008-02-14 Evonik Degussa Gmbh Anlage und Verfahen zur kontinuierlichen industriellen Herstellung von Organosilanen
DE102007023760A1 (de) * 2006-08-10 2008-02-14 Evonik Degussa Gmbh Anlage, Reaktor und Verfahren zur kontinuierlichen industriellen Herstellung von 3-Methacryloxypropylalkoxysilanen
DE102007023763A1 (de) * 2006-08-10 2008-02-14 Evonik Degussa Gmbh Anlage, Reaktor und Verfahren zur kontinuierlichen industriellen Herstellung von Polyetheralkylalkoxysilanen
US7854902B2 (en) 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
JP4938596B2 (ja) * 2006-08-31 2012-05-23 京セラ株式会社 流路デバイス
US20080108122A1 (en) * 2006-09-01 2008-05-08 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Microchemical nanofactories
EP2067104A1 (de) * 2006-09-28 2009-06-10 Xeround Systems Ltd. Vorrichtung und verfahren für eine verteilte globale speicherdatenbank
US8592220B2 (en) * 2006-10-26 2013-11-26 Intermolecular, Inc. High pressure parallel fixed bed reactor and method
WO2008052758A1 (de) * 2006-10-31 2008-05-08 Bürkert Werke GmbH & Co. KG Modulares laborgerät zur analyse und synthese von flüssigkeiten und verfahren zur analyse und synthese von flüssigkeiten
DE102006053078A1 (de) * 2006-11-10 2008-05-15 Hte Ag The High Throughput Experimentation Company Vorrichtung und Verfahren zur kontinuierlichen Überführung und Analyse von Fluiden
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP2091647A2 (de) 2006-11-14 2009-08-26 Handylab, Inc. Mikrofluidisches system für parallele amplifikation und erkennung von polynukleotiden
JP4449997B2 (ja) * 2007-03-12 2010-04-14 株式会社日立製作所 マイクロリアクタシステム
US7797988B2 (en) 2007-03-23 2010-09-21 Advion Biosystems, Inc. Liquid chromatography-mass spectrometry
CN103495439B (zh) 2007-05-04 2015-09-16 欧普科诊断有限责任公司 流体连接器和微流体系统
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8324372B2 (en) 2007-07-13 2012-12-04 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
JP5125315B2 (ja) * 2007-08-24 2013-01-23 東京エレクトロン株式会社 クロマト検出装置
DE102007054043B4 (de) * 2007-11-13 2010-02-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Modulare mikrofluidische Funktionsplattform und deren Verwendung
US8262752B2 (en) 2007-12-17 2012-09-11 Idatech, Llc Systems and methods for reliable feedstock delivery at variable delivery rates
JP2009168650A (ja) * 2008-01-17 2009-07-30 Sekisui Chem Co Ltd カートリッジ式電気化学分析装置及び方法
US7919062B2 (en) * 2008-03-20 2011-04-05 Corning Incorporated Modular microfluidic system and method for building a modular microfludic system
US7745667B2 (en) * 2008-04-07 2010-06-29 Velocys Microchannel apparatus comprising structured walls, chemical processes, methods of making formaldehyde
US8222049B2 (en) * 2008-04-25 2012-07-17 Opko Diagnostics, Llc Flow control in microfluidic systems
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
DE102008041950A1 (de) 2008-09-10 2010-03-11 Evonik Degussa Gmbh System zur Bereitstellung einer universellen Infrastruktur für chemische Prozesse
DE102008047902A1 (de) 2008-09-19 2010-03-25 Albert-Ludwigs-Universität Freiburg Bausatz für Reaktoren und Reaktor
US20100081577A1 (en) * 2008-09-30 2010-04-01 Symyx Technologies, Inc. Reactor systems and methods
EP2350673B1 (de) * 2008-10-24 2022-05-11 Leica Biosystems Richmond, Inc. Modulares system für laborprotokolle und zugehörige verfahren
CH699853A1 (de) * 2008-11-13 2010-05-14 Tecan Trading Ag Messgerät und Verfahren zum Bestimmen von durch ein Laborsystem bereitgestellten Fluidparametern.
US8591829B2 (en) 2008-12-18 2013-11-26 Opko Diagnostics, Llc Reagent storage in microfluidic systems and related articles and methods
ES2812260T3 (es) 2009-02-02 2021-03-16 Opko Diagnostics Llc Estructuras para controlar la interacción de luz con dispositivos microfluídicos
US8573259B2 (en) * 2009-03-25 2013-11-05 The Regents Of The University Of Michigan Modular microfluidic assembly block and system including the same
US8236599B2 (en) 2009-04-09 2012-08-07 State of Oregon acting by and through the State Board of Higher Education Solution-based process for making inorganic materials
TW201114481A (en) * 2009-05-11 2011-05-01 Corning Inc Modular reactor and system
EP2251079A1 (de) * 2009-05-11 2010-11-17 Chemtrix B.V. Mikrofluidisches System und dessen Verwendung
DE202010000262U1 (de) 2009-05-12 2010-05-20 Lonza Ag Strömungsreaktor mit Mikrokanalsystem
CN102803948B (zh) * 2009-06-09 2015-11-25 通用电气健康护理生物科学股份公司 自动化流体处理系统
US8801922B2 (en) 2009-06-24 2014-08-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Dialysis system
US9333707B2 (en) 2009-10-05 2016-05-10 Boehringer Ingelheim Microparts Gmbh Joining method and joint for microfluidic components
US8567425B2 (en) 2009-11-24 2013-10-29 Opko Diagnostics, Llc Fluid mixing and delivery in microfluidic systems
US8753515B2 (en) 2009-12-05 2014-06-17 Home Dialysis Plus, Ltd. Dialysis system with ultrafiltration control
KR20160088958A (ko) 2010-02-23 2016-07-26 루미넥스 코포레이션 일체화된 샘플 제조, 반응 및 검출을 위한 장치 및 방법
US10830740B2 (en) 2010-03-31 2020-11-10 Cytiva Bioprocess R&D Ab Parallel separation system
MX2012012066A (es) 2010-04-16 2012-12-17 Opko Diagnostics Llc Control de retroalimentacion en sistemas microfluidicos.
US8580161B2 (en) 2010-05-04 2013-11-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Fluidic devices comprising photocontrollable units
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
US8501009B2 (en) 2010-06-07 2013-08-06 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Fluid purification system
WO2012092394A1 (en) 2010-12-29 2012-07-05 Cardinal Health 414, Llc Closed vial fill system for aseptic dispensing
US8752732B2 (en) 2011-02-01 2014-06-17 Sakura Finetek U.S.A., Inc. Fluid dispensing system
ES2617599T3 (es) 2011-04-15 2017-06-19 Becton, Dickinson And Company Termociclador microfluídico de exploración en tiempo real y métodos para termociclado sincronizado y detección óptica de exploración
EP2705130B1 (de) 2011-05-04 2016-07-06 Luminex Corporation Vorrichtung und verfahren für integrierte probenzubereitung, -reaktion und -erkennung
US20130020727A1 (en) 2011-07-15 2013-01-24 Cardinal Health 414, Llc. Modular cassette synthesis unit
US9417332B2 (en) 2011-07-15 2016-08-16 Cardinal Health 414, Llc Radiopharmaceutical CZT sensor and apparatus
US20130102772A1 (en) 2011-07-15 2013-04-25 Cardinal Health 414, Llc Systems, methods and devices for producing, manufacturing and control of radiopharmaceuticals-full
US9304518B2 (en) 2011-08-24 2016-04-05 Bio-Rad Laboratories, Inc. Modular automated chromatography system
US8932543B2 (en) 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
US8580568B2 (en) 2011-09-21 2013-11-12 Sakura Finetek U.S.A., Inc. Traceability for automated staining system
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
RU2622432C2 (ru) 2011-09-30 2017-06-15 Бектон, Дикинсон Энд Компани Унифицированная полоска для реактивов
GB201117064D0 (en) 2011-10-04 2011-11-16 Univ Brunel A modular flow reactor
JP2014533133A (ja) 2011-10-07 2014-12-11 ホーム・ダイアリシス・プラス・リミテッドHome DialysisPlus, Ltd. 透析システムのための熱交換流体の精製
US9138714B2 (en) 2011-10-31 2015-09-22 General Electric Company Microfluidic chip and a related method thereof
EP2773892B1 (de) 2011-11-04 2020-10-07 Handylab, Inc. Vorrichtung zur vorbereitung von polynukleotidproben
US9182886B2 (en) 2011-11-14 2015-11-10 Bio-Rad Laboratories Inc. Chromatography configuration interface
DE102012100344A1 (de) * 2012-01-17 2013-07-18 Karlsruher Institut für Technologie Mikroreaktor für katalytische Reaktionen
WO2013116769A1 (en) 2012-02-03 2013-08-08 Becton, Dickson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
EP2820411A4 (de) * 2012-03-01 2016-01-06 Services Petroliers Schlumberger Verfahren und vorrichtung zur bestimmung der asphaltenausbeute und des flockungspunktes von rohöl
BR112014021776B1 (pt) 2012-03-05 2022-08-09 Opko Diagnostics, Llc Sistema de ensaio e método para a determinação de uma probabilidade de um evento associado com o câncer da próstata
US9067189B2 (en) * 2012-03-30 2015-06-30 General Electric Company Microfluidic device and a related method thereof
AU2013204332B2 (en) 2012-04-16 2015-07-16 Commonwealth Scientific And Industrial Research Organisation Methods and systems for detecting an analyte or classifying a sample
US9211521B2 (en) * 2012-09-19 2015-12-15 Millifluidica, Llc Fluidic channel coated with metal catalysts and devices and methods relating thereto
CA2900708C (en) 2013-03-13 2021-06-15 Opko Diagnostics, Llc Mixing of fluids in fluidic systems
DE102013222283B3 (de) * 2013-11-04 2015-01-15 Robert Bosch Gmbh Vorrichtung und Verfahren zur Handhabung von Reagenzien
WO2015087354A2 (en) * 2013-12-12 2015-06-18 Council Of Scientific & Industrial Research A glass lined metal micro-reactor
ITTO20131057A1 (it) * 2013-12-20 2015-06-21 Consiglio Nazionale Ricerche Apparecchiatura per la rilevazione della presenza di un analita in un campione di sostanza, in particolare di prodotto alimentare
ES2864727T3 (es) 2014-04-29 2021-10-14 Outset Medical Inc Sistema y métodos de diálisis
KR102558427B1 (ko) * 2014-08-15 2023-07-24 메사추세츠 인스티튜트 오브 테크놀로지 활성 제약 성분을 포함한 화학적 생성물의 합성을 위한 시스템 및 방법
US9943819B2 (en) 2014-11-03 2018-04-17 Singh Instrument LLC Small-scale reactor having improved mixing
MX2017007576A (es) 2014-12-12 2018-03-09 Opko Diagnostics Llc Sistemas fluídicos que comprenden un canal de incubación, que incluye sistemas fluídicos formados por moldeo.
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
AU2016335374A1 (en) * 2015-10-09 2018-04-26 Sysmex Corporation Specimen treatment chip, specimen treatment device, and specimen treatment method
EP3387447A4 (de) 2015-12-11 2019-08-28 Opko Diagnostics, LLC Fluidische systeme mit inkubationsproben und/oder reagenzien
EP3408389B1 (de) 2016-01-29 2021-03-10 Purigen Biosystems, Inc. Isotachophorese zur reinigung von nukleinsäuren
US10476093B2 (en) 2016-04-15 2019-11-12 Chung-Hsin Electric & Machinery Mfg. Corp. Membrane modules for hydrogen separation and fuel processors and fuel cell systems including the same
US11185839B2 (en) 2016-05-02 2021-11-30 Massachusetts Institute Of Technology Reconfigurable multi-step chemical synthesis system and related components and methods
WO2017192286A1 (en) * 2016-05-02 2017-11-09 Purdue Research Foundation Systems and methods for producing a chemical product
WO2018035520A1 (en) 2016-08-19 2018-02-22 Outset Medical, Inc. Peritoneal dialysis system and methods
EP3538665B1 (de) 2016-11-14 2024-01-03 PPB Technology Pty Ltd Protease-sensormoleküle
EP3606660A4 (de) * 2017-04-06 2021-01-13 SRI International Inc. Modulare systeme zur durchführung von chemischen mehrschritt-reaktionen und verwendungsverfahren dafür
EP3404421B1 (de) * 2017-05-15 2024-09-25 Eppendorf SE Laborinstrument und einführbares netzwerkinstrument
CN106984066A (zh) * 2017-06-06 2017-07-28 利穗科技(苏州)有限公司 一种层析柱维护柱架
US11041150B2 (en) 2017-08-02 2021-06-22 Purigen Biosystems, Inc. Systems, devices, and methods for isotachophoresis
PL3665481T3 (pl) 2017-08-08 2024-02-05 PPB Technology Pty Ltd Czujniki węglowodanów
KR102294916B1 (ko) 2018-07-28 2021-08-27 한국과학기술원 모듈형 유체 칩 및 이를 포함하는 유체 유동 시스템
WO2020167391A1 (en) * 2019-02-11 2020-08-20 Exxonmobil Research And Engineering Company Processes and apparatus for the modular analysis of a fluid sample
DE102019003444A1 (de) * 2019-05-16 2020-11-19 Evorion Biotechnologies Gmbh Inkubationssystem
CN112834693A (zh) * 2019-11-22 2021-05-25 北方工业大学 一种多功能气体成分动态改变与动态检测装置
CN112834686A (zh) * 2019-11-22 2021-05-25 北方工业大学 一种多功能气体成分循环改变与循环检测装置
US11712655B2 (en) 2020-11-30 2023-08-01 H2 Powertech, Llc Membrane-based hydrogen purifiers
DE102021203636A1 (de) * 2021-04-13 2022-10-13 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Duo-Kartusche, mikrofluidische Analysevorrichtung, Verfahren zum Herstellen einer Duo-Kartusche und einer Analysevorrichtung und Verfahren zum Verwenden einer mikrofluidischen Analysevorrichtung
DE102021208823A1 (de) * 2021-08-12 2023-02-16 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung, Verfahren zum Herstellen einer mikrofluidischen Vorrichtung und Verfahren zum Betreiben einer mikrofluidischen Vorrichtung
DE102022102894A1 (de) 2022-02-08 2023-08-10 Institut für Energie- und Umwelttechnik e.V. (IUTA) Mikrofluidiksystem und Verfahren zum Herstellen eines solchen
US20240091733A1 (en) * 2022-09-02 2024-03-21 ODH IP Corp. System of modular kits to produce chemical targets of interest
WO2024190720A1 (ja) * 2023-03-10 2024-09-19 北森微流體研發股▲ふん▼有限公司 マイクロ流体モジュール、マイクロ流体システム、ナンバリングアップ方法、設計方法、及びメンテナンス方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2761882A (en) * 1955-04-04 1956-09-04 Nat Distillers Prod Corp Continuous sodium reduction process
US3557077A (en) * 1967-09-18 1971-01-19 Kay Brunfeldt Reactions system
US3531258A (en) * 1967-11-16 1970-09-29 Us Health Education & Welfare Apparatus for the automated synthesis of peptides
JPS4820995B1 (de) * 1968-07-08 1973-06-25
US3951741A (en) * 1973-07-10 1976-04-20 Peter Pfaender Process and apparatus for the synthesis of peptides by use of n-carboxyanhydrides
CA1089197A (en) * 1976-01-13 1980-11-11 Foster Wheeler Energy Corporation Modular system for reducing sulfur dioxide
US4160803A (en) * 1978-03-23 1979-07-10 Corning Glass Works Self packaged test kit
IT1113361B (it) * 1979-05-08 1986-01-20 Italfarmaco Spa Reattore a flusso ad enzimi immobilizzati su matrici solide a superficie piana
US4276048A (en) * 1979-06-14 1981-06-30 Dynatech Ag Miniature reaction container and a method and apparatus for introducing micro volumes of liquid to such a container
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
DE3016402A1 (de) * 1980-04-29 1981-11-05 GHT Gesellschaft für Hochtemperaturreaktor-Technik mbH, 5060 Bergisch Gladbach Hochtemperaturreaktor in modul-bauweise
US4704256A (en) * 1980-09-23 1987-11-03 California Institute Of Technology Apparatus for the sequential performance of chemical processes
US4362699A (en) * 1981-03-10 1982-12-07 Bio Research, Inc. Apparatus for high pressure peptide synthesis
US4638444A (en) * 1983-02-17 1987-01-20 Chemical Data Systems, Inc. Microprocessor-controlled back-pressure system for small volume chemical analysis applications
US4483964A (en) * 1983-06-20 1984-11-20 Chiron Corporation Reactor system and method for polynucleotide synthesis
US4668476A (en) * 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
EP0164206B1 (de) * 1984-05-02 1988-11-02 Brendan James Hamill Apparat für die chemische Synthese von Oligonucleotiden
GB8500294D0 (en) * 1985-01-07 1985-02-13 Martin W J Automatic chemistry machine
US4701304A (en) * 1985-04-19 1987-10-20 Applied Protein Technologies, Inc. Apparatus for automated synthesis of peptides
FR2582655B1 (fr) * 1985-06-03 1988-12-23 Centre Nat Rech Scient Multi-synthetiseur de peptides semi-automatique en phase solide
CA1289856C (en) * 1986-09-11 1991-10-01 Ei Mochida Chemical reaction apparatus
US5175209A (en) * 1987-01-06 1992-12-29 Baylor College Of Medicine Porous wafer for segmented synthesis of biopolymers
US4861866A (en) * 1987-01-21 1989-08-29 Eldex Laboratories, Inc. Continuous flow peptide synthesizer
US5037882A (en) * 1987-03-11 1991-08-06 Steel Samuel L Synthesis of oligonucleotide analogs
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US5132012A (en) * 1988-06-24 1992-07-21 Hitachi, Ltd. Liquid chromatograph
DE3902402C1 (de) * 1989-01-27 1990-06-13 Draegerwerk Ag, 2400 Luebeck, De
US5176881A (en) * 1989-08-11 1993-01-05 The University Of Tennessee Research Corporation Fiber optic-based regenerable biosensor
US5110431A (en) * 1990-02-28 1992-05-05 Applied Biosystems, Inc. On-capillary gap junction for fluorescence detection in capillary electrophoresis
GB2244135B (en) * 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
SE470347B (sv) * 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
EP0484278B1 (de) * 1990-11-01 1995-04-12 Ciba-Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse
AT394576B (de) * 1991-01-16 1992-05-11 Vogelbusch Gmbh Reaktor zur durchfuehrung biologischer reaktionen mittels biokatalysatoren
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
JPH06265447A (ja) * 1993-03-16 1994-09-22 Hitachi Ltd 微量反応装置およびこれを使用する微量成分測定装置
US5385712A (en) * 1993-12-07 1995-01-31 Sprunk; Darren K. Modular chemical reactor
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device

Also Published As

Publication number Publication date
CA2186896C (en) 2004-09-21
AU2200195A (en) 1995-10-23
EP1203954B1 (de) 2005-03-16
DE69534086T2 (de) 2006-04-13
JPH10501167A (ja) 1998-02-03
DE69527613T2 (de) 2003-04-10
JP3625477B2 (ja) 2005-03-02
ATE291227T1 (de) 2005-04-15
EP1203954A2 (de) 2002-05-08
US5580523A (en) 1996-12-03
EP0754084A4 (de) 1998-07-08
EP1203954A3 (de) 2003-02-12
CA2186896A1 (en) 1995-10-12
DE69534086D1 (de) 2005-04-21
US6828143B1 (en) 2004-12-07
DE69527613D1 (de) 2002-09-05
EP0754084A1 (de) 1997-01-22
AU708281B2 (en) 1999-07-29
EP1550866A1 (de) 2005-07-06
WO1995026796A1 (en) 1995-10-12
EP0754084B1 (de) 2002-07-31

Similar Documents

Publication Publication Date Title
DE69527613D1 (de) Mikroreaktor für ein modulares System
AU3498900A (en) Sequencing by incorporation
ATE138197T1 (de) Analyseelement und verfahren zu seiner herstellung
CA2238297A1 (en) Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate
DK0895806T3 (da) Fremgangsmåde til udførelse af endoterme reaktioner
DE68906984D1 (de) Apparat zur durchfuehrung von sich wiederholenden chemischen reaktionen.
DE69406726D1 (de) Vorrichtung für Gas-Flüssigkeit-Reaktionen
DE3483972D1 (de) Vollstaendiges element fuer biologische reaktion und verfahren zu dessen herstellung.
IS4711A (is) Tækjabúnaður fyrir aðskilnað efna og efnahvörf
DE68902034D1 (de) Reaktoren zur ausfuehrung chemischer reaktionen.
DE69814422D1 (de) 9-hydrazon- und 9-azynerythromycinderivate und verfahren zu deren herstellung
DE69818571D1 (de) Katalysatoren für chemische Umwandlungsreaktionen
DE59903250D1 (de) Röhrenreaktor für katalytische reaktionen
DE59809244D1 (de) Reaktor für chemische Umsetzungen
GB2293334A8 (en) Process for carrying out chemical equilibrium reactions
DE69805383D1 (de) Reaktor für chemische Drei-Phasen-Reaktionen
ID29144A (id) Proses untuk melakukan reaksi gas-cair dan reaktor aliran terus menerus yang bersesuaian untuk tujuan ini
DE69605331D1 (de) Temperaturregelverfahren für Reaktionen
DE3787436D1 (de) Verfahren und Apparat für die Ausführung von katalysierten chemischen Reaktionen und für die Katalyseforschung.
WO2002002224A3 (de) Vorrichtung zum ausführen einer katalytischen reaktion
IS4608A (is) Rafgreiningar- og hvötunarskiptiaðferð þar sem for-auðgun á sér stað með rafgreiningu
DE59410055D1 (de) Bindemittel auf basis fettchemischer reaktionsprodukte
Stoyan et al. Automation of layout design of modular engineering systems. II. CAD-Packing program system for computer-aided layout design
DE3770329D1 (de) Wirbelbett zur durchfuehrung von gas-feststoffreaktionen.
KR890701880A (ko) 발열적 화학반응방법

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee