ATE202109T1 - Kristallines ceftiofur (freie säure) - Google Patents

Kristallines ceftiofur (freie säure)

Info

Publication number
ATE202109T1
ATE202109T1 AT94910721T AT94910721T ATE202109T1 AT E202109 T1 ATE202109 T1 AT E202109T1 AT 94910721 T AT94910721 T AT 94910721T AT 94910721 T AT94910721 T AT 94910721T AT E202109 T1 ATE202109 T1 AT E202109T1
Authority
AT
Austria
Prior art keywords
pct
free acid
crystalline ceftiofur
date sep
ceftiofur
Prior art date
Application number
AT94910721T
Other languages
German (de)
English (en)
Inventor
Michael J Dunn
Michael S Bergren
Gregory E Hardee
Kenneth Paul Shephard
Robert S Chao
Jeffrey L Havens
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE202109T1 publication Critical patent/ATE202109T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT94910721T 1993-03-12 1994-03-07 Kristallines ceftiofur (freie säure) ATE202109T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3329193A 1993-03-12 1993-03-12
PCT/US1994/001862 WO1994020505A1 (en) 1993-03-12 1994-03-07 Crystalline ceftiofur free acid

Publications (1)

Publication Number Publication Date
ATE202109T1 true ATE202109T1 (de) 2001-06-15

Family

ID=21869579

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94910721T ATE202109T1 (de) 1993-03-12 1994-03-07 Kristallines ceftiofur (freie säure)

Country Status (31)

Country Link
US (1) US5721359A (ref)
EP (1) EP0690864B1 (ref)
JP (1) JP3852946B2 (ref)
KR (1) KR100296810B1 (ref)
CN (1) CN1055090C (ref)
AT (1) ATE202109T1 (ref)
AU (1) AU694419B2 (ref)
BR (1) BR1101034A (ref)
CA (1) CA2155322C (ref)
CZ (1) CZ289332B6 (ref)
DE (2) DE122005000055I2 (ref)
DK (1) DK0690864T3 (ref)
ES (1) ES2157254T3 (ref)
FI (1) FI120307B (ref)
FR (1) FR05C0045I2 (ref)
GR (1) GR3036514T3 (ref)
HU (1) HU222244B1 (ref)
IL (1) IL108910A (ref)
LU (1) LU91206I2 (ref)
LV (1) LV12889B (ref)
NL (1) NL300208I2 (ref)
NO (2) NO313199B1 (ref)
NZ (1) NZ263002A (ref)
PL (1) PL184611B1 (ref)
PT (1) PT690864E (ref)
RU (1) RU2136685C1 (ref)
SI (1) SI0690864T1 (ref)
SK (1) SK283674B6 (ref)
TW (1) TW267170B (ref)
WO (1) WO1994020505A1 (ref)
ZA (1) ZA941586B (ref)

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ES2313981T3 (es) * 2000-09-12 2009-03-16 PHARMACIA & UPJOHN COMPANY LLC Composicion farmaceutica que tiene excipiente modificado.
US7829100B2 (en) * 2000-09-12 2010-11-09 Teagarden Dirk L Pharmaceutical composition having modified carrier
KR100423895B1 (ko) * 2001-02-19 2004-03-24 주식회사 엘지생명과학 셉티오퍼 하이드로클로라이드의 현탁제 조성물
JP2005502628A (ja) * 2001-07-10 2005-01-27 ファルマシア・アンド・アップジョン・カンパニー 結晶性チアジンオキサゾリジノン
DK3168218T3 (en) * 2001-08-15 2019-01-14 Pharmacia & Upjohn Co Llc Crystalline comprising an L-malic acid salt of N- [2- (DIETHYLAMINO) ETHYL] -5 - [(5-FLUOR-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDE) METHYL] -2,4 -DIMETHYL-1H-PYRROL-3-CARBOXAMIDE FOR USE AS A MEDICINE
EP1485040B2 (en) † 2002-03-21 2019-12-11 Zoetis Services LLC Method of administering an injectable antibiotic to the ear of an animal
US20040022815A1 (en) * 2002-08-05 2004-02-05 Orchid Health Care Novel pharmaceutical composition of ceftiofur
KR20040015622A (ko) * 2002-08-13 2004-02-19 대한뉴팜(주) 세프티오푸르나트륨을 활성성분으로 함유하는 현탁주사액조성물
US20040115822A1 (en) * 2002-09-12 2004-06-17 Schapaugh Randal Lee Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition
US7659061B2 (en) * 2002-11-19 2010-02-09 Pharmacia & Upjohn Company Pharmaceutical compositions having a modified vehicle
US20040115837A1 (en) * 2002-11-27 2004-06-17 Schapaugh Randal Lee Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
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US20100125060A1 (en) * 2008-11-19 2010-05-20 Majid Razzak Formulations comprising ceftiofur and ketoprofen or ceftiofur and benzyl alcohol
CA2750565C (en) * 2009-01-30 2015-10-20 Glaxosmithkline Llc Crystalline n-{(1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
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CN103649097A (zh) * 2011-05-02 2014-03-19 佐蒂斯有限责任公司 用作抗菌剂的新型头孢菌素类
ES2725784T3 (es) 2011-07-20 2019-09-27 Univ Brigham Young Compuestos de ceragenina hidrófobos y dispositivos que incorporan al mismo
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CN102584855B (zh) * 2012-02-16 2014-06-25 青岛科技大学 一种改进的头孢噻呋的制备方法
US9533063B1 (en) 2012-03-01 2017-01-03 Brigham Young University Aerosols incorporating ceragenin compounds and methods of use thereof
EP2846634A2 (en) 2012-05-02 2015-03-18 Brigham Young University Ceragenin particulate materials and methods for making same
WO2014062960A1 (en) 2012-10-17 2014-04-24 Brigham Young University Treatment and prevention of mastitis
WO2014087972A1 (ja) * 2012-12-03 2014-06-12 株式会社カネカ 還元型補酵素ｑ10誘導体およびその製造方法
EP2941253B1 (en) 2013-01-07 2021-08-11 Brigham Young University Cationic steroid antimicrobial agents for use in treating cancer
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
CN110420211A (zh) 2013-03-15 2019-11-08 布莱阿姆青年大学 治疗炎症、自身免疫性疾病和疼痛的方法
US10568893B2 (en) 2013-03-15 2020-02-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
RU2546675C2 (ru) * 2013-04-11 2015-04-10 Федеральное казённое предприятие "Государственный научно-исследовательский институт химических продуктов" (ФКП "ГосНИИХП") Способ определения степени кристалличности составов на основе дифениламина
US9387215B2 (en) 2013-04-22 2016-07-12 Brigham Young University Animal feed including cationic cholesterol additive and related methods
CN108484469A (zh) * 2013-09-05 2018-09-04 田边三菱制药株式会社 新型结晶性芳烷基胺化合物及其制造方法
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
CA2844321C (en) 2014-02-27 2021-03-16 Brigham Young University Cationic steroidal antimicrobial compounds
US9867836B2 (en) 2014-03-13 2018-01-16 Brigham Young University Lavage and/or infusion using CSA compounds for increasing fertility in a mammal
US10220045B2 (en) 2014-03-13 2019-03-05 Brigham Young University Compositions and methods for forming stabilized compositions with reduced CSA agglomeration
US9931350B2 (en) 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
US9686966B2 (en) 2014-04-30 2017-06-27 Brigham Young University Methods and apparatus for cleaning or disinfecting a water delivery system
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10441595B2 (en) 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10227376B2 (en) 2014-08-22 2019-03-12 Brigham Young University Radiolabeled cationic steroid antimicrobials and diagnostic methods
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KR102331856B1 (ko) 2014-10-21 2021-11-29 다케다 야쿠힌 고교 가부시키가이샤 결정 형태의 5-클로로-n4-[2-(디메틸포스포릴)페닐]-n2-｛2-메톡시-4-[4-(4-메틸피페라진-1-일)피페리딘-1-일]피리미딘-2,4-디아민
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Also Published As

Publication number Publication date
FR05C0045I1 (ref) 2006-01-06
GR3036514T3 (en) 2001-12-31
DE122005000055I1 (de) 2006-02-23
CN1119016A (zh) 1996-03-20
SI0690864T1 (en) 2001-10-31
NL300208I2 (nl) 2006-05-01
LU91206I2 (fr) 2006-05-30
PL184611B1 (pl) 2002-11-29
RU2136685C1 (ru) 1999-09-10
FI954250L (fi) 1995-09-11
LV12889B (lv) 2002-12-20
SK111495A3 (en) 1995-12-06
NO2005025I2 (no) 2010-11-22
ES2157254T3 (es) 2001-08-16
EP0690864B1 (en) 2001-06-13
IL108910A0 (en) 1994-06-24
HU222244B1 (hu) 2003-05-28
DK0690864T3 (da) 2001-09-17
PT690864E (pt) 2001-11-30
CZ9502290A3 (cs) 2001-08-15
AU6351094A (en) 1994-09-26
TW267170B (ref) 1996-01-01
ZA941586B (en) 1995-09-07
BR1101034A (pt) 2002-04-30
FR05C0045I2 (ref) 2007-08-03
NO953564D0 (no) 1995-09-11
EP0690864A1 (en) 1996-01-10
DE122005000055I2 (de) 2008-06-05
HU9501960D0 (en) 1995-09-28
DE69427469D1 (en) 2001-07-19
CN1055090C (zh) 2000-08-02
JPH08507519A (ja) 1996-08-13
FI954250A0 (fi) 1995-09-11
NO953564L (no) 1995-11-07
NZ263002A (en) 1996-12-20
CA2155322C (en) 2000-02-29
US5721359A (en) 1998-02-24
PL310556A1 (en) 1995-12-27
KR100296810B1 (ko) 2001-10-24
NO313199B1 (no) 2002-08-26
AU694419B2 (en) 1998-07-23
IL108910A (en) 1999-10-28
SK283674B6 (sk) 2003-11-04
HUT73781A (en) 1996-09-30
FI120307B (fi) 2009-09-15
CA2155322A1 (en) 1994-09-15
CZ289332B6 (cs) 2002-01-16
WO1994020505A1 (en) 1994-09-15
NL300208I1 (nl) 2006-02-01
JP3852946B2 (ja) 2006-12-06
DE69427469T2 (de) 2001-10-31
NO2005025I1 (no) 2005-12-05

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