AR247878A1 - Procedimiento para preparar antagonistas receptores fibrinogenos - Google Patents

Procedimiento para preparar antagonistas receptores fibrinogenos

Info

Publication number
AR247878A1
AR247878A1 AR93324379A AR32437993A AR247878A1 AR 247878 A1 AR247878 A1 AR 247878A1 AR 93324379 A AR93324379 A AR 93324379A AR 32437993 A AR32437993 A AR 32437993A AR 247878 A1 AR247878 A1 AR 247878A1
Authority
AR
Argentina
Prior art keywords
formula
receptor antagonists
piridinyl
piperidinyl
submitted
Prior art date
Application number
AR93324379A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of AR247878A1 publication Critical patent/AR247878A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Abstract

PREPARACION DE COMPUESTOS DE FORMULA I, DONDE R1 ES 4-PIPERIDINILO O 4- PIRIDINILO, M ES UN ENTERO DE 2 O 6, R4 ES ARILO, ALQUILO O ARALQUILO DE ACUERDO CON LAS ETAPAS DEL PROCEDIMIENTO EN DONDE FORMULA A), TIROSINA O DERIVADOS DE TIROSINA (1-1) SE SOMETEN A SULFONILACION INTERMEDIADA POR BIS (TRIMETILSILIL) TRIFLUORACETAMIDA (BSTFA) UTILIZANDO R4SO2CI, EN ACETONITRILO, PARA OBTENER LA SULFONAMIDA (1-2); FORMULA B); R1 ES 4- PIRIDINILO, 4-PICOLINA METILADA (1-3) QUE SE HACE REACCIONAR CON NBULI, ANTES DE ENFRIAR CON UN ALQUILO DE CADENA RECTA TIENE BR EN UN EXTREMO Y CL EN EL OTROEXTREMO, PARA OBTENER FORMULA II, (1-2) SE AGREGA A (1-4) Y SE SOMETE A O-ALQUILACION FENOLICA EN HIDROXIDO ALCALINO, EN UN SOLVENTE APROTICO POLAR, Y CUANDO R1 ES 4-PIPERIDINILO, SE USA ADEMAS UN PRODUCTO DE HIDROGENACION SELECTIVO, EL PD/C EN ACIDO ACETICO.
AR93324379A 1992-02-28 1993-02-24 Procedimiento para preparar antagonistas receptores fibrinogenos AR247878A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/843,658 US5206373A (en) 1992-02-28 1992-02-28 Process for preparing fibrinogen receptor antagonists

Publications (1)

Publication Number Publication Date
AR247878A1 true AR247878A1 (es) 1995-04-28

Family

ID=25290632

Family Applications (1)

Application Number Title Priority Date Filing Date
AR93324379A AR247878A1 (es) 1992-02-28 1993-02-24 Procedimiento para preparar antagonistas receptores fibrinogenos

Country Status (25)

Country Link
US (1) US5206373A (es)
EP (2) EP0738714B1 (es)
JP (1) JP2674679B2 (es)
KR (1) KR100187779B1 (es)
CN (1) CN1050832C (es)
AR (1) AR247878A1 (es)
AT (1) ATE156118T1 (es)
AU (2) AU3732293A (es)
CA (1) CA2090509C (es)
CZ (1) CZ283485B6 (es)
DE (1) DE69312528T2 (es)
DK (1) DK0558139T3 (es)
ES (2) ES2156255T3 (es)
FI (1) FI106023B (es)
GR (2) GR3024965T3 (es)
HU (2) HU217959B (es)
LV (1) LV12824B (es)
MX (1) MX9301045A (es)
NZ (1) NZ249751A (es)
RO (1) RO116016B1 (es)
RU (2) RU2097377C1 (es)
SK (1) SK281250B6 (es)
TW (1) TW229206B (es)
WO (1) WO1993016995A1 (es)
YU (1) YU49077B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264813B1 (it) * 1993-07-28 1996-10-10 Oxon Italia Spa Procedimento per la preparazione di alcansolfonammidi
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5980951A (en) * 1996-04-10 1999-11-09 Merck & Co., Inc. Oral coated active drugs
EP0925063A4 (en) 1996-07-01 2000-12-27 Lilly Co Eli Blood-glucose-lowering and lipid-lowering compounds
GB9812088D0 (en) * 1998-06-05 1998-08-05 Celltech Therapeutics Ltd Chemical compounds
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
CN102452975A (zh) * 2010-11-01 2012-05-16 天津康鸿医药科技发展有限公司 盐酸替罗非班中间体合成方法
CN104447509B (zh) * 2013-09-18 2016-08-24 嘉实（湖南）医药科技有限公司 一种盐酸替罗非班的制备工艺
CN108440393A (zh) * 2018-03-20 2018-08-24 成都倍特药业有限公司 替罗非班物料杂质、杂质制备及物料中杂质检测方法
CN109608387A (zh) * 2019-01-02 2019-04-12 海门慧聚药业有限公司 盐酸替罗非班的制备
CN111100066B (zh) * 2019-11-29 2021-07-30 石药集团恩必普药业有限公司 一种盐酸替罗非班中间体及盐酸替罗非班的制备方法
CN112816282B (zh) * 2020-12-29 2022-04-12 江苏慧聚药业股份有限公司 一种盐酸替罗非班的有关物质及其制备和检测方法
CN115181058A (zh) * 2021-04-01 2022-10-14 武汉武药科技有限公司 组合物及其质量控制方法
CN114315697A (zh) * 2021-12-20 2022-04-12 河北国龙制药有限公司 一种盐酸替罗非班的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB756713A (en) * 1953-07-06 1956-09-05 Ciba Ltd Substituted piperidines and process of making them
GB772516A (en) * 1953-12-22 1957-04-17 Ciba Ltd Piperidines and process of making same
GB939019A (en) * 1959-01-19 1963-10-09 Aspro Nicholas Ltd Diphenyl methane derivatives and methods for the preparation thereof
IT1062206B (it) * 1974-02-01 1983-09-20 Rotta Research Lab S P A A S Derivati della tirosina attivi sulla muscolatura liscia
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
IL99537A (en) * 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical preparations containing them
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
HU9600658D0 (en) 1996-05-28
EP0558139A1 (en) 1993-09-01
SK102294A3 (en) 1995-04-12
WO1993016995A1 (en) 1993-09-02
ES2105069T3 (es) 1997-10-16
NZ249751A (en) 1996-06-25
GR3024965T3 (en) 1998-01-30
YU49077B (sh) 2003-08-29
HU226957B1 (en) 2010-03-29
RU2097377C1 (ru) 1997-11-27
CN1050832C (zh) 2000-03-29
RU94040166A (ru) 1996-07-10
TW229206B (es) 1994-09-01
KR100187779B1 (ko) 1999-06-01
DE69312528D1 (de) 1997-09-04
JPH069557A (ja) 1994-01-18
FI943933A0 (fi) 1994-08-26
ATE156118T1 (de) 1997-08-15
FI943933A (fi) 1994-10-04
HUT70537A (en) 1995-10-30
LV12824B (en) 2002-09-20
EP0738714A3 (en) 1996-11-20
ES2156255T3 (es) 2001-06-16
RU2114105C1 (ru) 1998-06-27
FI106023B (fi) 2000-11-15
EP0738714A2 (en) 1996-10-23
YU13193A (sh) 1997-07-31
JP2674679B2 (ja) 1997-11-12
AU657199B2 (en) 1995-03-02
GR3035827T3 (en) 2001-08-31
MX9301045A (es) 1993-09-01
US5206373A (en) 1993-04-27
CA2090509C (en) 1997-02-25
CA2090509A1 (en) 1993-08-29
AU3732293A (en) 1993-09-13
RO116016B1 (ro) 2000-09-29
DK0558139T3 (da) 1997-09-01
LV12824A (en) 2002-05-20
CN1076441A (zh) 1993-09-22
CZ203394A3 (en) 1995-10-18
EP0738714B1 (en) 2001-05-02
DE69312528T2 (de) 1998-02-19
EP0558139B1 (en) 1997-07-30
CZ283485B6 (cs) 1998-04-15
AU3383693A (en) 1993-09-02
SK281250B6 (sk) 2001-01-18
HU9402467D0 (en) 1994-10-28
KR950700252A (ko) 1995-01-16
HU217959B (hu) 2000-05-28

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