GB939019A - Diphenyl methane derivatives and methods for the preparation thereof - Google Patents

Diphenyl methane derivatives and methods for the preparation thereof

Info

Publication number
GB939019A
GB939019A GB191059A GB191059A GB939019A GB 939019 A GB939019 A GB 939019A GB 191059 A GB191059 A GB 191059A GB 191059 A GB191059 A GB 191059A GB 939019 A GB939019 A GB 939019A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
acid
addition salts
preparation
formaldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB191059A
Inventor
Richard William Temple
Leslie Frederick Wiggins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aspro Nicholas Ltd
Original Assignee
Aspro Nicholas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspro Nicholas Ltd filed Critical Aspro Nicholas Ltd
Priority to GB191059A priority Critical patent/GB939019A/en
Publication of GB939019A publication Critical patent/GB939019A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0939019/IV(a)/1> (wherein R1 is alkyl of at most 4 carbon atoms, R2 is hydrogen or methyl and R3 is hydrogen or alkyl of at most 4 carbon atoms) and pharmaceutically acceptable acid-addition salts thereof, and their preparation as acid-addition salts (1) by reducing acid-addition salts of compounds of the formula <FORM:0939019/IV(a)/2> to give products wherein R2 is hydrogen, which products may then be N-methylated by hydrogenation in ethanolic solution in the presence of Adams platinum catalyst and formaldehyde or by heating (as free bases or salts) in aqueous solution with formic acid and formaldehyde and, when R3 is hydrogen, sodium formate. The reduction may be effected with hydrogen in dry methanol or ethanol in presence of Adams platinum catalyst at 20 to 50 DEG C. and 1 to 10 atmospheres. Acid-addition salts, e.g. hydrochlorides, and free bases may be interconverted by conventional methods. Detailed examples are provided. The piperidine derivatives of the invention, which are stated to possess analgesic properties, may be made up into pharmaceutical compositions. A tablet containing ethyl 1,1-diphenyl - 2 - (21-piperidyl) - propionate hydrochloride is described. Specification 930,459 is referred to.
GB191059A 1959-01-19 1959-01-19 Diphenyl methane derivatives and methods for the preparation thereof Expired GB939019A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB191059A GB939019A (en) 1959-01-19 1959-01-19 Diphenyl methane derivatives and methods for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB191059A GB939019A (en) 1959-01-19 1959-01-19 Diphenyl methane derivatives and methods for the preparation thereof

Publications (1)

Publication Number Publication Date
GB939019A true GB939019A (en) 1963-10-09

Family

ID=9730176

Family Applications (1)

Application Number Title Priority Date Filing Date
GB191059A Expired GB939019A (en) 1959-01-19 1959-01-19 Diphenyl methane derivatives and methods for the preparation thereof

Country Status (1)

Country Link
GB (1) GB939019A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0738714A2 (en) * 1992-02-28 1996-10-23 MERCK &amp; CO. INC. Process for preparing new fibrinogen receptor antagonists

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0738714A2 (en) * 1992-02-28 1996-10-23 MERCK &amp; CO. INC. Process for preparing new fibrinogen receptor antagonists
EP0738714A3 (en) * 1992-02-28 1996-11-20 MERCK &amp; CO. INC. Process for preparing new fibrinogen receptor antagonists

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