YU49077B - Postupak za dobijanje antagonista fibrinogen receptora - Google Patents
Postupak za dobijanje antagonista fibrinogen receptoraInfo
- Publication number
- YU49077B YU49077B YU13193A YU13193A YU49077B YU 49077 B YU49077 B YU 49077B YU 13193 A YU13193 A YU 13193A YU 13193 A YU13193 A YU 13193A YU 49077 B YU49077 B YU 49077B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- formula
- compound
- receptor antagonists
- reacted
- give
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Postupak za dobijanje jedinjenja sledeće formule I: u kojoj je: R1 je piperidin m je ceo broj od dva do šest; i R4 je C1-10 alkil naznačen time, što se prema stupnjevima postupka a) sulfonuje tirozin ili derivati tirozina formule (1-1) b) u prisustvu bis(trimetilsili) trifluoroacetamida (BSTFA), upotrebljavajući R4SO2Cl, gde R4 ima značewe C1-10 alkil da bi se dobio odgovarajući sulfonamid formule (1-2) c) d) reaguje sa n-butil litijumom, pre gašenja sa Br(CH2)m-1 Cl da bi se dobilo jedinjenje formule (1-4) e) reaguje sulfonamid formule (1-2) dobijen pod a) f) sa u vodenom alkalnom hidroksidu u visoko polarnom aprotičnom rastvaraču. g) selektivno hidrogenizuje jedinjenje h) upotrebljavajući Pd/C u sirćetnoj kiselini, da bi se dobilo jedinjenje Prijava sadrži još 4 zavisna zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/843,658 US5206373A (en) | 1992-02-28 | 1992-02-28 | Process for preparing fibrinogen receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU13193A YU13193A (sh) | 1997-07-31 |
| YU49077B true YU49077B (sh) | 2003-08-29 |
Family
ID=25290632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU13193A YU49077B (sh) | 1992-02-28 | 1993-02-25 | Postupak za dobijanje antagonista fibrinogen receptora |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5206373A (sh) |
| EP (2) | EP0738714B1 (sh) |
| JP (1) | JP2674679B2 (sh) |
| KR (1) | KR100187779B1 (sh) |
| CN (1) | CN1050832C (sh) |
| AR (1) | AR247878A1 (sh) |
| AT (1) | ATE156118T1 (sh) |
| AU (2) | AU3732293A (sh) |
| CA (1) | CA2090509C (sh) |
| CZ (1) | CZ283485B6 (sh) |
| DE (1) | DE69312528T2 (sh) |
| DK (1) | DK0558139T3 (sh) |
| ES (2) | ES2105069T3 (sh) |
| FI (1) | FI106023B (sh) |
| GR (2) | GR3024965T3 (sh) |
| HU (2) | HU226957B1 (sh) |
| LV (1) | LV12824B (sh) |
| MX (1) | MX9301045A (sh) |
| NZ (1) | NZ249751A (sh) |
| RO (1) | RO116016B1 (sh) |
| RU (2) | RU2114105C1 (sh) |
| SK (1) | SK281250B6 (sh) |
| TW (1) | TW229206B (sh) |
| WO (1) | WO1993016995A1 (sh) |
| YU (1) | YU49077B (sh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1264813B1 (it) * | 1993-07-28 | 1996-10-10 | Oxon Italia Spa | Procedimento per la preparazione di alcansolfonammidi |
| US5780480A (en) * | 1996-02-28 | 1998-07-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| US5980951A (en) * | 1996-04-10 | 1999-11-09 | Merck & Co., Inc. | Oral coated active drugs |
| CA2259487A1 (en) | 1996-07-01 | 1998-01-08 | Margaret Mary Faul | Hypoglycemic and hypolipidemic compounds |
| GB9812088D0 (en) * | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
| CN1330636C (zh) * | 2005-09-26 | 2007-08-08 | 鲁南制药集团股份有限公司 | 盐酸替罗非班中间体的合成方法 |
| CN102452975A (zh) * | 2010-11-01 | 2012-05-16 | 天津康鸿医药科技发展有限公司 | 盐酸替罗非班中间体合成方法 |
| CN104447509B (zh) * | 2013-09-18 | 2016-08-24 | 嘉实（湖南）医药科技有限公司 | 一种盐酸替罗非班的制备工艺 |
| CN108440393A (zh) * | 2018-03-20 | 2018-08-24 | 成都倍特药业有限公司 | 替罗非班物料杂质、杂质制备及物料中杂质检测方法 |
| CN109608387A (zh) * | 2019-01-02 | 2019-04-12 | 海门慧聚药业有限公司 | 盐酸替罗非班的制备 |
| CN111100066B (zh) * | 2019-11-29 | 2021-07-30 | 石药集团恩必普药业有限公司 | 一种盐酸替罗非班中间体及盐酸替罗非班的制备方法 |
| CN112816282B (zh) * | 2020-12-29 | 2022-04-12 | 江苏慧聚药业股份有限公司 | 一种盐酸替罗非班的有关物质及其制备和检测方法 |
| CN115181058A (zh) * | 2021-04-01 | 2022-10-14 | 武汉武药科技有限公司 | 组合物及其质量控制方法 |
| CN114315697A (zh) * | 2021-12-20 | 2022-04-12 | 河北国龙制药有限公司 | 一种盐酸替罗非班的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB756713A (en) * | 1953-07-06 | 1956-09-05 | Ciba Ltd | Substituted piperidines and process of making them |
| GB772516A (en) * | 1953-12-22 | 1957-04-17 | Ciba Ltd | Piperidines and process of making same |
| GB939019A (en) * | 1959-01-19 | 1963-10-09 | Aspro Nicholas Ltd | Diphenyl methane derivatives and methods for the preparation thereof |
| IT1062206B (it) * | 1974-02-01 | 1983-09-20 | Rotta Research Lab S P A A S | Derivati della tirosina attivi sulla muscolatura liscia |
| DE2809377A1 (de) * | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
| CA2008116C (en) * | 1989-02-23 | 2001-11-20 | Thomas Weller | Glycine derivatives |
| IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
| NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
-
1992
- 1992-02-28 US US07/843,658 patent/US5206373A/en not_active Expired - Lifetime
-
1993
- 1993-02-20 TW TW082101202A patent/TW229206B/zh not_active IP Right Cessation
- 1993-02-20 ES ES93200486T patent/ES2105069T3/es not_active Expired - Lifetime
- 1993-02-20 EP EP96202049A patent/EP0738714B1/en not_active Expired - Lifetime
- 1993-02-20 EP EP93200486A patent/EP0558139B1/en not_active Expired - Lifetime
- 1993-02-20 ES ES96202049T patent/ES2156255T3/es not_active Expired - Lifetime
- 1993-02-20 DK DK93200486.4T patent/DK0558139T3/da active
- 1993-02-20 DE DE69312528T patent/DE69312528T2/de not_active Expired - Lifetime
- 1993-02-20 AT AT93200486T patent/ATE156118T1/de active
- 1993-02-23 RU RU96107890A patent/RU2114105C1/ru not_active IP Right Cessation
- 1993-02-23 NZ NZ249751A patent/NZ249751A/en not_active IP Right Cessation
- 1993-02-23 KR KR1019940702990A patent/KR100187779B1/ko not_active IP Right Cessation
- 1993-02-23 HU HU9402467A patent/HU226957B1/hu not_active IP Right Cessation
- 1993-02-23 WO PCT/US1993/001646 patent/WO1993016995A1/en active IP Right Grant
- 1993-02-23 HU HU9600658A patent/HU217959B/hu not_active IP Right Cessation
- 1993-02-23 RU RU9494040166A patent/RU2097377C1/ru not_active IP Right Cessation
- 1993-02-23 SK SK1022-94A patent/SK281250B6/sk not_active IP Right Cessation
- 1993-02-23 AU AU37322/93A patent/AU3732293A/en not_active Abandoned
- 1993-02-23 RO RO94-01433A patent/RO116016B1/ro unknown
- 1993-02-23 CZ CZ942033A patent/CZ283485B6/cs not_active IP Right Cessation
- 1993-02-24 AR AR93324379A patent/AR247878A1/es active
- 1993-02-25 YU YU13193A patent/YU49077B/sh unknown
- 1993-02-25 MX MX9301045A patent/MX9301045A/es not_active IP Right Cessation
- 1993-02-25 JP JP5036896A patent/JP2674679B2/ja not_active Expired - Lifetime
- 1993-02-26 AU AU33836/93A patent/AU657199B2/en not_active Ceased
- 1993-02-26 CA CA002090509A patent/CA2090509C/en not_active Expired - Lifetime
- 1993-02-27 CN CN93102136A patent/CN1050832C/zh not_active Expired - Fee Related
-
1994
- 1994-08-26 FI FI943933A patent/FI106023B/fi not_active IP Right Cessation
-
1997
- 1997-10-09 GR GR970402606T patent/GR3024965T3/el unknown
-
2001
- 2001-05-03 GR GR20010400122T patent/GR3035827T3/el unknown
-
2002
- 2002-03-15 LV LVP-02-41A patent/LV12824B/xx unknown
Also Published As
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