AR078793A1 - Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros - Google Patents
Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otrosInfo
- Publication number
- AR078793A1 AR078793A1 ARP100103942A ARP100103942A AR078793A1 AR 078793 A1 AR078793 A1 AR 078793A1 AR P100103942 A ARP100103942 A AR P100103942A AR P100103942 A ARP100103942 A AR P100103942A AR 078793 A1 AR078793 A1 AR 078793A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- heterocyclic ring
- alkylamino
- hydroxyalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25515909P | 2009-10-27 | 2009-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR078793A1 true AR078793A1 (es) | 2011-12-07 |
Family
ID=43383475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100103942A AR078793A1 (es) | 2009-10-27 | 2010-10-26 | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
Country Status (36)
Country | Link |
---|---|
US (5) | US8975254B2 (en.) |
EP (5) | EP3369732B1 (en.) |
JP (1) | JP5763083B2 (en.) |
KR (2) | KR101670299B1 (en.) |
CN (2) | CN105061313B (en.) |
AR (1) | AR078793A1 (en.) |
AU (1) | AU2010311299C1 (en.) |
BR (1) | BR112012008823B8 (en.) |
CA (1) | CA2777896C (en.) |
CL (1) | CL2012000772A1 (en.) |
CO (1) | CO6531494A2 (en.) |
CY (2) | CY2020010I1 (en.) |
DK (3) | DK2493858T3 (en.) |
EA (1) | EA021170B1 (en.) |
ES (3) | ES2877248T3 (en.) |
GE (1) | GEP20166472B (en.) |
HK (1) | HK1173442A1 (en.) |
HR (3) | HRP20140919T1 (en.) |
HU (2) | HUE055528T2 (en.) |
IL (2) | IL218586A (en.) |
LT (3) | LT3056485T (en.) |
LU (1) | LUC00154I2 (en.) |
MX (1) | MX2012004867A (en.) |
MY (1) | MY159924A (en.) |
NL (1) | NL301041I2 (en.) |
NO (1) | NO2020018I1 (en.) |
NZ (1) | NZ598747A (en.) |
PE (1) | PE20121058A1 (en.) |
PL (3) | PL2493858T3 (en.) |
PT (3) | PT3056485T (en.) |
RS (3) | RS53469B (en.) |
SI (3) | SI3369732T1 (en.) |
SM (1) | SMT201400138B (en.) |
UA (1) | UA109535C2 (en.) |
WO (1) | WO2011051540A1 (en.) |
ZA (1) | ZA201202655B (en.) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2603032T3 (es) * | 2010-07-15 | 2017-02-23 | Bayer Intellectual Property Gmbh | Compuestos de 3-piridil-heteroarilcarboxamida como pesticidas |
CN103492372B (zh) * | 2011-04-21 | 2015-09-30 | 奥赖恩公司 | 调节雄激素受体的甲酰胺类化合物 |
EP2574607A1 (en) * | 2011-09-06 | 2013-04-03 | F. Hoffmann-La Roche AG | PDE10 modulators |
CA2867174C (en) * | 2012-03-15 | 2020-06-23 | Signal Pharmaceuticals, Llc | Treatment of cancer with tor kinase inhibitors |
CN104302644A (zh) * | 2012-03-23 | 2015-01-21 | 日本农药株式会社 | 噻唑甲酰胺衍生物及其使用方法 |
SG11201408316SA (en) | 2012-06-15 | 2015-03-30 | Taisho Pharmaceutical Co Ltd | Branched chain alkyl heteroaromatic ring derivative |
WO2014031784A1 (en) | 2012-08-23 | 2014-02-27 | Alios Biopharma, Inc. | Compounds for the treatment of paramoxyvirus viral infections |
CN102952095A (zh) * | 2012-10-19 | 2013-03-06 | 盛世泰科生物医药技术(苏州)有限公司 | 一种2-羧酸乙酯-5-溴甲基噻唑的合成方法 |
AU2014308991B2 (en) * | 2013-08-21 | 2019-02-14 | Janssen Biopharma, Inc. | Antiviral compounds |
WO2015172196A1 (en) * | 2014-05-13 | 2015-11-19 | Monash University | Heterocyclic compounds and use of same |
KR20200052995A (ko) | 2015-01-20 | 2020-05-15 | 아비나스 오퍼레이션스, 인코포레이티드 | 안드로겐 수용체의 표적화된 분해를 위한 화합물 및 방법 |
US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
DK3250554T3 (da) * | 2015-01-30 | 2022-06-27 | Orion Corp | Carboxamidderivat og diastereomerer deraf i stabil, krystallinsk form |
MA41614A (fr) * | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
PE20171738A1 (es) | 2015-04-09 | 2017-12-04 | Orion Corp | Proceso para la preparacion de antagonistas del receptor androgeno e intermediarios de los mismos |
CA3024113A1 (en) * | 2015-05-18 | 2016-11-24 | Translational Drug Development, Llc | Heterocyclic compounds as kinase inhibitors |
CN107056755B (zh) * | 2015-12-07 | 2019-02-22 | 苏州信诺维医药科技有限公司 | 五元杂环酰胺类wnt通路抑制剂 |
CN107286094A (zh) * | 2016-04-12 | 2017-10-24 | 常州爱诺新睿医药技术有限公司 | 一种bay-1841788与药用辅料的固体分散体及其制备方法 |
DK3495352T3 (da) * | 2016-08-26 | 2021-05-03 | Crystal Pharmaceutical Suzhou Co Ltd | Krystalformer af en androgenreceptorantagonist, fremgangsmåde til fremstilling og anvendelse deraf |
DK3660004T3 (da) | 2016-10-11 | 2023-05-08 | Arvinas Operations Inc | Forbindelser og fremgangsmåder til målrettet degradering af androgenreceptor |
AU2018229817B2 (en) | 2017-03-07 | 2021-09-30 | Orion Corporation | Manufacture of a crystalline pharmaceutical product |
CA3068324A1 (en) | 2017-06-28 | 2019-01-03 | Bayer Consumer Care Ag | Combination of a pi3k-inhibitor with an androgen receptor antagonist |
US11236073B2 (en) | 2017-08-09 | 2022-02-01 | Hangzhou Solipharma Co., Ltd. | ODM-201 crystalline form, preparation method therefor, and pharmaceutical composition thereof |
CN107602471B (zh) * | 2017-09-22 | 2021-04-27 | 成都恒汇化成医药科技有限公司 | 一种达罗鲁胺的晶型制备方法 |
JP2021515040A (ja) * | 2018-02-27 | 2021-06-17 | サンド・アクチエンゲゼルシヤフト | ダロルタミドの結晶形態ii |
US20220062281A1 (en) * | 2018-08-13 | 2022-03-03 | National Centre For Biological Sciences-Tifr | Inhibitors to target hiv-1 nef-cd80/cd86 interactions for therapeutic intervention |
WO2020095183A1 (en) | 2018-11-05 | 2020-05-14 | Pfizer Inc. | Combination for treating cancer |
US20220160695A1 (en) | 2019-01-30 | 2022-05-26 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of metastatic castration-sensitive prostate cancer |
JP7241435B2 (ja) * | 2019-02-27 | 2023-03-17 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | 置換ピラゾール系化合物および該当化合物を含む組成物並びにその使用 |
CN114144168A (zh) | 2019-07-02 | 2022-03-04 | 奥赖恩公司 | 达鲁酰胺的药物组合物 |
CN110590668A (zh) * | 2019-07-17 | 2019-12-20 | 江苏君若医药有限公司 | N-[(1s)-2-[3-(3-氯-4-氰基苯基)-1h-吡唑-1-基]-1-甲基乙基]-5-(1-羟基乙基)- 1h-吡唑-3-甲酰胺的制备方法 |
MX2022001450A (es) | 2019-08-08 | 2022-04-20 | Laekna Ltd | Metodo de tratamiento del cancer. |
CN111116476A (zh) * | 2019-12-27 | 2020-05-08 | 武汉九州钰民医药科技有限公司 | 制备抗肿瘤药物多拉米胺的方法 |
CN115605470A (zh) | 2020-05-11 | 2023-01-13 | 奥赖恩公司(Fi) | 制备雄激素受体拮抗剂及其中间体的方法 |
KR20230057384A (ko) | 2020-08-13 | 2023-04-28 | 화이자 인코포레이티드 | 조합 요법 |
CN111978534B (zh) * | 2020-09-07 | 2022-05-31 | 陕西师范大学 | 一种含苯并咪唑液晶基元的侧链型液晶离聚物及其制备方法 |
BR112023018906A2 (pt) | 2021-03-24 | 2023-10-10 | Astellas Pharma Inc | Combinação de talazoparib e um antiandrógeno para o tratamento de câncer de próstata metastático sensível à castração com mutação no gene ddr |
CN113527208A (zh) * | 2021-08-31 | 2021-10-22 | 江西金丰药业有限公司 | 一步法制备2-氯-4-(1h-吡唑-3-基)苯甲腈的方法 |
CN113861115A (zh) * | 2021-09-10 | 2021-12-31 | 浙江师范大学 | 一种吡唑酰胺类衍生物及合成方法和应用 |
WO2023161458A1 (en) | 2022-02-28 | 2023-08-31 | Química Sintética, S.A. | Crystalline form of darolutamide |
WO2023194528A1 (en) | 2022-04-07 | 2023-10-12 | Astrazeneca Ab | Combination therapy for treating cancer |
WO2024074959A1 (en) | 2022-10-02 | 2024-04-11 | Pfizer Inc. | Combination of talazoparib and enzalutamide in the treatment of metastatic castration-resistant prostate cancer |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU88769I2 (fr) | 1982-07-23 | 1996-11-05 | Zeneca Ltd | Bicalutamide et ses sels et esters pharmaceutiquement acceptables (Casodex (R)) |
FR2656609B1 (fr) | 1989-12-28 | 1992-03-27 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
CZ244394A3 (en) | 1993-10-08 | 1995-06-14 | Shell Int Research | Herbicidal 1,2,4-oxadiazolecarboxylic acids amides, esters or halides |
FR2741342B1 (fr) | 1995-11-22 | 1998-02-06 | Roussel Uclaf | Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques |
WO2000017163A1 (fr) | 1998-09-22 | 2000-03-30 | Yamanouchi Pharmaceutical Co., Ltd. | Derives de cyanophenyle |
KR20040053210A (ko) | 2001-11-02 | 2004-06-23 | 화이자 프로덕츠 인크. | Pde9 억제제를 사용한 인슐린 저항 증후군 및 2형당뇨병의 치료 |
US20050101657A1 (en) | 2001-12-28 | 2005-05-12 | Takeda Chemical Industries Ltd. | Androgen receptor antagonists |
MXPA04005847A (es) * | 2001-12-28 | 2004-09-13 | Bayer Pharmaceuticals Corp | Compuestos derivados de 4-sulfuro/sulfoxido/sulfonil-1h-pirazolilo, para uso en enfermedades asociadas con el receptor 5-ht2c. |
CA2471880A1 (en) * | 2001-12-28 | 2003-07-17 | Bayer Pharmaceuticals Corporation | 1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor |
US20040180889A1 (en) | 2002-03-01 | 2004-09-16 | Pintex Pharmaceuticals, Inc. | Pin1-modulating compounds and methods of use thereof |
TW200406386A (en) * | 2002-06-07 | 2004-05-01 | Novartis Ag | Organic compounds |
PL374970A1 (en) * | 2002-08-02 | 2005-11-14 | Argenta Discovery Limited | Substituted thienyl-hydroxamic acids as histone deacetylase inhibitors |
DE10322108B4 (de) | 2003-05-09 | 2008-12-11 | Bayer Schering Pharma Aktiengesellschaft | Antiandrogene Pyrrolidine mit tumorhemmender Wirksamkeit |
US7271188B2 (en) | 2003-06-12 | 2007-09-18 | Chugai Seikayu Kabushiki Kaisha | Imidazolidine derivatives |
WO2005030704A1 (en) | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
CA2579886A1 (en) | 2004-09-09 | 2006-03-16 | Chugai Seiyaku Kabushiki Kaisha | Novel imidazolidine derivative and use thereof |
JP2008007405A (ja) * | 2004-12-07 | 2008-01-17 | Takeda Chem Ind Ltd | カルボキサミド誘導体 |
EP1710237A1 (en) * | 2005-04-08 | 2006-10-11 | Bayer CropScience S.A. | New heterocyclylethylbenzamide derivatives |
MX346924B (es) | 2005-05-13 | 2017-04-05 | Univ California | Compuestos de diarilhidantoina. |
US7709516B2 (en) | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
AR057656A1 (es) * | 2005-07-01 | 2007-12-12 | Ligand Pharm Inc | Compuestos moduladores de receptores de androgeno y metodods relacionados |
GB0518237D0 (en) * | 2005-09-07 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US8629147B2 (en) * | 2005-11-03 | 2014-01-14 | Chembridge Corporation | Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders |
TW200800997A (en) | 2006-03-22 | 2008-01-01 | Astrazeneca Ab | Chemical compounds |
JP5205274B2 (ja) | 2006-11-22 | 2013-06-05 | 日本農薬株式会社 | 新規なピラゾール誘導体、有害生物防除剤及びその使用方法 |
WO2008124000A2 (en) * | 2007-04-02 | 2008-10-16 | Ligand Pharmaceuticals Incorporated | Thiazole derivatives as androgen receptor modulator compounds |
US7968536B2 (en) * | 2007-06-29 | 2011-06-28 | Millennium Pharmaceuticals, Inc. | Heterocyclic compounds useful as RAF kinase inhibitors |
WO2009028543A1 (ja) | 2007-08-30 | 2009-03-05 | Takeda Pharmaceutical Company Limited | 置換ピラゾール誘導体 |
EP2220050A2 (en) | 2007-10-26 | 2010-08-25 | The Regents Of The University Of California | Diarylhydantoin compounds as androgen receptor modulators |
US20090270361A1 (en) | 2008-03-26 | 2009-10-29 | Takeda Pharmaceutical Company Limited | Substituted pyrazole derivatives and use thereof |
CA2725481A1 (en) * | 2008-06-18 | 2009-12-23 | Pfizer Limited | Nicotinamide derivatives |
-
2010
- 2010-10-26 AR ARP100103942A patent/AR078793A1/es active IP Right Grant
- 2010-10-27 RS RS20140420A patent/RS53469B/en unknown
- 2010-10-27 DK DK10781918.7T patent/DK2493858T3/da active
- 2010-10-27 RS RS20180913A patent/RS57592B1/sr unknown
- 2010-10-27 EP EP18163765.3A patent/EP3369732B1/en active Active
- 2010-10-27 ES ES18163765T patent/ES2877248T3/es active Active
- 2010-10-27 WO PCT/FI2010/000065 patent/WO2011051540A1/en active Application Filing
- 2010-10-27 EP EP16157716.8A patent/EP3056485B1/en active Active
- 2010-10-27 DK DK18163765.3T patent/DK3369732T3/da active
- 2010-10-27 PE PE2012000424A patent/PE20121058A1/es active IP Right Grant
- 2010-10-27 CN CN201510501603.4A patent/CN105061313B/zh active Active
- 2010-10-27 PT PT161577168T patent/PT3056485T/pt unknown
- 2010-10-27 NZ NZ598747A patent/NZ598747A/xx unknown
- 2010-10-27 MX MX2012004867A patent/MX2012004867A/es active IP Right Grant
- 2010-10-27 AU AU2010311299A patent/AU2010311299C1/en active Active
- 2010-10-27 BR BR112012008823A patent/BR112012008823B8/pt active IP Right Grant
- 2010-10-27 HU HUE18163765A patent/HUE055528T2/hu unknown
- 2010-10-27 EA EA201270597A patent/EA021170B1/ru active Protection Beyond IP Right Term
- 2010-10-27 KR KR1020167023703A patent/KR101670299B1/ko active IP Right Grant
- 2010-10-27 SI SI201032078T patent/SI3369732T1/sl unknown
- 2010-10-27 PT PT107819187T patent/PT2493858E/pt unknown
- 2010-10-27 EP EP14162075.7A patent/EP2754656A1/en not_active Withdrawn
- 2010-10-27 SI SI201031718T patent/SI3056485T1/en unknown
- 2010-10-27 PL PL10781918T patent/PL2493858T3/pl unknown
- 2010-10-27 DK DK16157716.8T patent/DK3056485T3/en active
- 2010-10-27 ES ES10781918.7T patent/ES2486263T3/es active Active
- 2010-10-27 ES ES16157716.8T patent/ES2678073T3/es active Active
- 2010-10-27 CN CN201080048340.1A patent/CN102596910B/zh active Active
- 2010-10-27 PL PL16157716T patent/PL3056485T3/pl unknown
- 2010-10-27 LT LTEP16157716.8T patent/LT3056485T/lt unknown
- 2010-10-27 SI SI201030739T patent/SI2493858T1/sl unknown
- 2010-10-27 PL PL18163765T patent/PL3369732T3/pl unknown
- 2010-10-27 JP JP2012535889A patent/JP5763083B2/ja active Active
- 2010-10-27 MY MYPI2012001441A patent/MY159924A/en unknown
- 2010-10-27 CA CA2777896A patent/CA2777896C/en active Active
- 2010-10-27 US US13/504,511 patent/US8975254B2/en active Active
- 2010-10-27 UA UAA201206302A patent/UA109535C2/ru unknown
- 2010-10-27 LT LTEP18163765.3T patent/LT3369732T/lt unknown
- 2010-10-27 EP EP10781918.7A patent/EP2493858B1/en active Active
- 2010-10-27 EP EP21169615.8A patent/EP3885340A1/en active Pending
- 2010-10-27 PT PT181637653T patent/PT3369732T/pt unknown
- 2010-10-27 RS RS20210903A patent/RS62123B1/sr unknown
- 2010-10-27 HU HUE16157716A patent/HUE039390T2/hu unknown
- 2010-10-27 KR KR1020127013214A patent/KR101654529B1/ko active IP Right Grant
- 2010-10-27 GE GEAP201012722A patent/GEP20166472B/en unknown
-
2012
- 2012-03-12 IL IL218586A patent/IL218586A/en active IP Right Grant
- 2012-03-28 CL CL2012000772A patent/CL2012000772A1/es unknown
- 2012-04-12 ZA ZA2012/02655A patent/ZA201202655B/en unknown
- 2012-04-27 CO CO12069611A patent/CO6531494A2/es active IP Right Grant
-
2013
- 2013-01-15 HK HK13100600.7A patent/HK1173442A1/zh unknown
-
2014
- 2014-09-23 SM SM201400138T patent/SMT201400138B/xx unknown
- 2014-09-26 HR HRP20140919AT patent/HRP20140919T1/hr unknown
-
2015
- 2015-01-16 US US14/598,973 patent/US9657003B2/en active Active
- 2015-03-30 IL IL238044A patent/IL238044A/en active IP Right Grant
-
2017
- 2017-04-13 US US15/486,995 patent/US10118933B2/en active Active
-
2018
- 2018-07-31 HR HRP20181229TT patent/HRP20181229T1/hr unknown
- 2018-09-25 US US16/140,716 patent/US10711013B2/en active Active
-
2020
- 2020-02-24 US US16/799,270 patent/US11046713B2/en active Active
- 2020-05-11 NL NL301041C patent/NL301041I2/nl unknown
- 2020-05-19 LU LU00154C patent/LUC00154I2/fr unknown
- 2020-06-05 CY CY2020010C patent/CY2020010I1/el unknown
- 2020-06-17 NO NO2020018C patent/NO2020018I1/no unknown
- 2020-06-26 LT LTPA2020514C patent/LTC2493858I2/lt unknown
-
2021
- 2021-07-22 HR HRP20211180TT patent/HRP20211180T1/hr unknown
- 2021-08-10 CY CY20211100717T patent/CY1124429T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR078793A1 (es) | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros | |
AR060050A1 (es) | Compuestos moduladores del receptor de s1p y uso de los mismos | |
CO2020006411A2 (es) | Inhibidores de endonucleasa cap-dependientes | |
PE20181304A1 (es) | Derivados de indol n-sustituidos como moduladores de los receptores de pge2 | |
AR056025A1 (es) | Compuestos de imidazol sustituidos como inhibidores de ksp | |
CR20160548A (es) | Nuevos Derivados de Pirazolo Pirimidina y su Uso como Inhibidores de MALT1 | |
AR035548A1 (es) | Compuestos organicos | |
AR067478A1 (es) | Compuestos derivados de morfolina pirimidina | |
AR050966A1 (es) | Derivados de bencimidazol utiles como moduladores selectivos de receptores de androgenos (sarms) | |
AR080688A1 (es) | Derivados de 2,3-dihidro-1h-inden-1-il-2,7-diazaspiro[3.5]nonano como agonistas o antagonistas inversos de grelina | |
AR088828A1 (es) | DERIVADOS DE CICLOHEXILAMINA QUE TIENEN ACTIVIDAD COMO AGONISTAS ADRENERGICOS b2 Y COMO ANTAGONISTAS MUSCARINICOS M3 | |
CO6251243A2 (es) | Nuevos inhibidores macrocíclicos de la replicación del virus de hepatitis c | |
AR081058A1 (es) | Derivados de arilmetoxi isoindolina, composiciones que los comprenden y su uso en el tratamiento del cancer. | |
AR088226A1 (es) | Derivados piperidinicos heterociclicos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades neurodegenerativas | |
AR072969A1 (es) | Derivados de ciclohexilamida, composiciones farmaceuticas y usos como antagonistas del receptor del factor de liberacion de corticotropina (crf - 1) | |
RU2009105496A (ru) | Аминоиндановое производное или его соль | |
AR070521A1 (es) | Derivados de 4h-pirido[4,3-d]-pirimidin-4-ona,inhibidores de quinasas,composiciones farmaceuticas que los contienen,uso de los mismos para el tratamiento de enfermedades con proliferacion celular o autoinmunes y metodo de preparacion de intermediarios de sintesis . | |
AR074426A1 (es) | Compuesto de n-(((1s,4s,6s)-3-(2-piridinilcarbonil)3-azabiciclo (4,1.0)hept-4-il) metil)-2-heteroarilamina, su uso para la prepracion de un medicamento para el tratamiento de una enfermedad que requiere un antagonista de un receptor de orexina humana y composicion farmaceutica que lo comprende | |
AR080467A1 (es) | Derivados tetrazolicos moduladores selectivos de receptores cb2, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del dolor y otras enfermedades | |
DOP2006000076A (es) | Derivados de ciclopentapiridina y tetrahidroquinolina | |
AR085615A1 (es) | Derivados de fluoropiridinona utiles como agentes antibacterianos y composiciones farmaceuticas que los contienen | |
ES2630079T3 (es) | Moduladores de la ruta del complemento y usos de los mismos | |
AR049711A1 (es) | Compuestos heterociclicos condensados como inhibidores de la aldosterona sintasa; composiciones farmaceuticas que los contienen y su uso en la preparacion de un medicamento para el tratamiento o prevencion de enfermedades relacionadas con el hiperaldosterismo y por una liberacion excesiva de cortiso | |
ES2530943T3 (es) | Derivados de la cromenona con actividad antitumoral | |
AR080032A1 (es) | Compuestos de pirazol como antagonistas de crth2 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |