AR054132A1 - Derivados de azolopiridin-2-ona como inhibidores de lipasas y fosfolipasas - Google Patents
Derivados de azolopiridin-2-ona como inhibidores de lipasas y fosfolipasasInfo
- Publication number
- AR054132A1 AR054132A1 ARP060102373A ARP060102373A AR054132A1 AR 054132 A1 AR054132 A1 AR 054132A1 AR P060102373 A ARP060102373 A AR P060102373A AR P060102373 A ARP060102373 A AR P060102373A AR 054132 A1 AR054132 A1 AR 054132A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkylene
- identically
- differently
- aryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Reivindicacion 1: Un compuesto de la formula (1), en la que: X de forma idéntica o diferente, es =C(-R)- o =N-, donde al menos uno y como máximo dos =C(-R-)- están reemplazados por =N-; Y es -O- o -S-; R de forma idéntica o diferente, es hidrogeno, halogeno, alquilo C1-6, alquiloxiC1-3-alquilenoC1-3, hidroxi, alquilC1-6-mercapto, amino, alquilC1-6-amino, di-alquilC2-12-amino, alquilC1-6-carbonilo, COOR3, trifluorometilo, alquilC1-6-sulfonilo, alquilC1-6-sulfinilo, aminosulfonilo, pentafluorosulfanilo, arilo C6-10, heteroarilo C5-12, CO-NR6R7, O-CO-NR6R7, O-CO-alquilenC1-6-CO-O-alquiloC1-6, O-CO-alquilenC1-6-CO-OH, O-CO-alquilenC1-6-CO-NR6R7 o alquiloxi C1-6 no sustituido o mono- o poli-F-sustituido; R1 es alquilo C4-16, alquilenC1-4-ariloC6-10, alquilenC1-4-heteroariloC5-12, alquilenC1-4-cicloalquiloC3-12, biciclo C8-14, donde los arilo, heteroarilo, cicloalquilo o biciclo pueden estar sustituidos una o más veces con halogeno, alquilo C1-6, alquiloxi C1-3, hidroxi, alquilC1-6-mercapto, amino, alquilC1-6-amino, di-alquilC2-12-amino, mono-alquilC1-6-aminocarbonilo, di-alquilC2-8-aminocarbonilo, alcoxiC1-6-carbonilo, alquilC1-6-carbonilo, ciano, trifluorometilo, trifluorometoxi, alquilC1-6-sulfonilo, aminosulfonilo; R2 es hidrogeno, alquilo C1-6; o R1 y R2 forman junto con el átomo de nitrogeno al que están unidos un sistema de anillos monocíclico, saturado o parcialmente insaturado, de 4 a 7 miembros o un sistema de anillos bicíclico saturado o parcialmente insaturado, de 8 a 14 miembros, cuyos miembros individuales del sistema de anillos pueden estar reemplazados por uno a tres átomos o grupos atomicos de la serie -CHR4-, -CR4R5-, -(C=R4)-, -NR6-, -C(=O)-, -O-, -S-, -SO-, -SO2-, con la condicion de que dos unidades de la serie -O-, -S-, -SO-, -SO2- no pueden ser adyacentes; R3 es hidrogeno, alquilo C1-6, bencilo; R4, R5 de forma idéntica o diferente, son alquilo C1-6, halogeno, trifluorometilo, COOR3, ciclopropilo, ciclopropileno; R6, R7 de forma idéntica o diferente, son hidrogeno, alquilo C1-6, arilo C6-10, heteroarilo C5-12, cicloalquilo C3-12, alquilenC1-4-ariloC6-10, alquilenC1-4-heteroariloC5-12, alquilenC1-4-cicloalquiloC4-12, biciclo C8-14; y las formas tautomeros de los compuestos y las sales fisiologicamente toleradas de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005026762A DE102005026762A1 (de) | 2005-06-09 | 2005-06-09 | Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054132A1 true AR054132A1 (es) | 2007-06-06 |
Family
ID=37076291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102373A AR054132A1 (es) | 2005-06-09 | 2006-06-07 | Derivados de azolopiridin-2-ona como inhibidores de lipasas y fosfolipasas |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7846943B2 (es) |
| EP (1) | EP1896485B1 (es) |
| JP (1) | JP2008542410A (es) |
| KR (1) | KR20080019215A (es) |
| CN (1) | CN101193896A (es) |
| AR (1) | AR054132A1 (es) |
| AT (1) | ATE468342T1 (es) |
| AU (1) | AU2006257022A1 (es) |
| BR (1) | BRPI0611688A2 (es) |
| CA (1) | CA2610325A1 (es) |
| CY (1) | CY1110213T1 (es) |
| DE (2) | DE102005026762A1 (es) |
| DK (1) | DK1896485T3 (es) |
| ES (1) | ES2346561T3 (es) |
| HR (1) | HRP20100409T1 (es) |
| IL (1) | IL187730A0 (es) |
| MA (1) | MA29481B1 (es) |
| MX (1) | MX2007015347A (es) |
| MY (1) | MY142792A (es) |
| NO (1) | NO20080133L (es) |
| NZ (1) | NZ564063A (es) |
| PL (1) | PL1896485T3 (es) |
| PT (1) | PT1896485E (es) |
| RS (1) | RS51268B (es) |
| RU (1) | RU2414473C2 (es) |
| SI (1) | SI1896485T1 (es) |
| TW (1) | TW200716653A (es) |
| UY (1) | UY29593A1 (es) |
| WO (1) | WO2006131231A1 (es) |
| ZA (1) | ZA200709501B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006014685A1 (de) * | 2006-03-28 | 2007-10-04 | Sanofi-Aventis | Imidazo-pyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholiphasen |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
| WO2010044441A1 (ja) | 2008-10-17 | 2010-04-22 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有する酢酸アミド誘導体 |
| AU2010319842A1 (en) * | 2009-10-29 | 2012-05-17 | Sirtris Pharmaceuticals, Inc. | Bicyclic pyridines and analogs as sirtuin modulators |
| JP5791150B2 (ja) | 2009-12-15 | 2015-10-07 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有するオキサジアゾール誘導体 |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| CN114560873B (zh) * | 2021-12-27 | 2023-02-28 | 浙江日出药业有限公司 | 一种3-氯甲基-6-氯-噁唑[4,5-b]吡啶-2(3H)酮的制备方法 |
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2005
- 2005-06-09 DE DE102005026762A patent/DE102005026762A1/de not_active Withdrawn
-
2006
- 2006-05-27 DE DE502006006986T patent/DE502006006986D1/de active Active
- 2006-05-27 ES ES06753937T patent/ES2346561T3/es active Active
- 2006-05-27 EP EP06753937A patent/EP1896485B1/de active Active
- 2006-05-27 AU AU2006257022A patent/AU2006257022A1/en not_active Abandoned
- 2006-05-27 RU RU2007145499/04A patent/RU2414473C2/ru not_active IP Right Cessation
- 2006-05-27 PT PT06753937T patent/PT1896485E/pt unknown
- 2006-05-27 SI SI200630748T patent/SI1896485T1/sl unknown
- 2006-05-27 RS RSP-2010/0270A patent/RS51268B/sr unknown
- 2006-05-27 BR BRPI0611688-4A patent/BRPI0611688A2/pt not_active IP Right Cessation
- 2006-05-27 JP JP2008515095A patent/JP2008542410A/ja not_active Abandoned
- 2006-05-27 PL PL06753937T patent/PL1896485T3/pl unknown
- 2006-05-27 AT AT06753937T patent/ATE468342T1/de active
- 2006-05-27 MX MX2007015347A patent/MX2007015347A/es active IP Right Grant
- 2006-05-27 DK DK06753937.9T patent/DK1896485T3/da active
- 2006-05-27 CA CA002610325A patent/CA2610325A1/en not_active Abandoned
- 2006-05-27 KR KR1020077028710A patent/KR20080019215A/ko not_active Application Discontinuation
- 2006-05-27 CN CNA2006800202416A patent/CN101193896A/zh active Pending
- 2006-05-27 WO PCT/EP2006/005095 patent/WO2006131231A1/de active Application Filing
- 2006-05-27 NZ NZ564063A patent/NZ564063A/en not_active IP Right Cessation
- 2006-06-07 TW TW095120135A patent/TW200716653A/zh unknown
- 2006-06-07 AR ARP060102373A patent/AR054132A1/es not_active Application Discontinuation
- 2006-06-07 MY MYPI20062625A patent/MY142792A/en unknown
- 2006-06-09 UY UY29593A patent/UY29593A1/es not_active Application Discontinuation
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2007
- 2007-11-05 ZA ZA200700950A patent/ZA200709501B/xx unknown
- 2007-11-22 MA MA30415A patent/MA29481B1/fr unknown
- 2007-11-28 IL IL187730A patent/IL187730A0/en unknown
- 2007-12-05 US US11/950,932 patent/US7846943B2/en not_active Expired - Fee Related
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2008
- 2008-01-08 NO NO20080133A patent/NO20080133L/no not_active Application Discontinuation
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2010
- 2010-07-20 CY CY20101100675T patent/CY1110213T1/el unknown
- 2010-07-23 HR HR20100409T patent/HRP20100409T1/hr unknown
- 2010-10-28 US US12/914,045 patent/US20110039883A1/en not_active Abandoned
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |