AR070469A1 - Derivados de naftiridina y composiciones farmaceuticas como inhibidores de quinasa con actividad sobre c- kit y pdgfr - Google Patents
Derivados de naftiridina y composiciones farmaceuticas como inhibidores de quinasa con actividad sobre c- kit y pdgfrInfo
- Publication number
- AR070469A1 AR070469A1 ARP090100626A ARP090100626A AR070469A1 AR 070469 A1 AR070469 A1 AR 070469A1 AR P090100626 A ARP090100626 A AR P090100626A AR P090100626 A ARP090100626 A AR P090100626A AR 070469 A1 AR070469 A1 AR 070469A1
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- Prior art keywords
- alkyl
- halo
- cycloalkyl
- substituted
- heterocycloalkyl
- Prior art date
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract
La presente proporciona una clase de compuestos, composiciones farmacéuticas que comprenden dichos compuestos y métodos para utilizar dichos compuestos para tratar o prevenir enfermedades o trastornos asociados con la actividad quinasa anormal o desregulada, particularmente enfermedades o trastornos que involucran la activacion anormal de quinasas c-kit, PDGFRalfa y PDGFRbeta. Reivindicacion 1: Un compuesto de la formula (1) en el cual R1 está seleccionado entre halo, alquilo C1-6, cicloalquilo C3-12, heterocicloalquilo C3-8, arilo C6-10 y heteroarilo C3-10; donde dicho alquilo C1-6 de R1 está sustituido en forma opcional con 1 a 3 radicales seleccionados en forma independiente entre halo, hidroxi, ciano, nitro, =N(OH), alcoxi C1-4 y benzoxi; donde dicho cicloalquilo, heterocicloalquilo, arilo o heteroarilo de R1 está sustituido en forma opcional con 1 a 3 radicales seleccionados en forma independiente entre halo, hidroxi, ciano, nitro, alquilo C1-6, alquilo C1-6 halo-sustituido, alquilo C1-6 hidroxi-sustituido, alcoxi C1-6, alcoxi C1-6 halo-sustituido, -X1NR3aR3b, -X1C(O)R3a, -X1C(O)OR3a, -X1OR3a, cicloalquilo C3-12, heterocicloalquilo C3-8, arilo C6-10 y heteroarilo C3-10; donde X1 está seleccionado entre un enlace y alquileno C1-4; donde R3a y R3b están seleccionados en forma independiente entre hidrogeno y alquilo C1-6; R2 se selecciona de metilo y etilo; A es un anillo insaturado de 5 miembros que contiene 2 o 3 heteroátomos o grupos seleccionados entre =N-, -NR4-, -O- y -S(O)0-2-; donde R4 está seleccionado entre hidrogeno, alquilo C1-4 y cicloalquilo C3-8; donde dicho alquilo C1-4 o cicloalquilo C3-8 de R4 puede tener un metileno reemplazado con un heteroátomo seleccionado entre O, S(O)0-2 y NR30; donde R30 está seleccionado entre H y alquilo C1-4; donde A puede estar opcionalmente sustituido por alquilo C1-2; o las sales aceptables para uso farmacéutico de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3091208P | 2008-02-22 | 2008-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR070469A1 true AR070469A1 (es) | 2010-04-07 |
Family
ID=40577860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090100626A AR070469A1 (es) | 2008-02-22 | 2009-02-24 | Derivados de naftiridina y composiciones farmaceuticas como inhibidores de quinasa con actividad sobre c- kit y pdgfr |
Country Status (17)
Country | Link |
---|---|
US (1) | US8278452B2 (es) |
EP (1) | EP2252612B1 (es) |
JP (1) | JP5230755B2 (es) |
KR (1) | KR101216323B1 (es) |
CN (1) | CN102083828B (es) |
AR (1) | AR070469A1 (es) |
AT (1) | ATE551342T1 (es) |
AU (1) | AU2009217356B2 (es) |
BR (1) | BRPI0908849A2 (es) |
CA (1) | CA2714700C (es) |
CL (1) | CL2009000400A1 (es) |
EA (1) | EA018551B1 (es) |
ES (1) | ES2383331T3 (es) |
MX (1) | MX2010009207A (es) |
PE (1) | PE20091492A1 (es) |
TW (1) | TW200940538A (es) |
WO (1) | WO2009105712A1 (es) |
Families Citing this family (43)
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WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
KR102012398B1 (ko) | 2009-11-05 | 2019-08-20 | 리젠 파마슈티컬스 소시에떼 아노님 | 신규한 벤조피란 키나제 조절제 |
TWI510487B (zh) | 2010-04-21 | 2015-12-01 | Plexxikon Inc | 用於激酶調節的化合物和方法及其適應症 |
EP2680846A4 (en) * | 2011-03-01 | 2014-08-06 | Npharmakon Llc | USE OF N- (4-METHOXYPHENYL) -1-PHENYL-1H-PYRAZOL-3-AMINE AND COMPOUNDS ASSOCIATED THEREWITH |
CN107337659A (zh) | 2011-05-04 | 2017-11-10 | 理森制药股份公司 | 作为蛋白激酶调节剂的新颖化合物 |
EP2758411A2 (en) * | 2011-09-19 | 2014-07-30 | Gencia Corporation | Modified creatine compounds |
PL2794627T3 (pl) | 2011-12-22 | 2019-04-30 | Alios Biopharma Inc | Podstawione nukleozydy, nukleotydy i ich analogi |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
UY34824A (es) | 2012-05-25 | 2013-11-29 | Janssen R & D Ireland | Nucleósidos de espirooxetano de uracilo |
MX2014015024A (es) * | 2012-06-07 | 2015-07-06 | Deciphera Pharmaceuticals Llc | Dihidronaftiridinas y compuestos relacionados útiles como inhibidores de cinasas para el tratamiento de enfermedades proliferativas. |
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
SI2870157T1 (en) | 2012-07-04 | 2018-02-28 | Rhizen Pharmaceuticals S.A. | SELECTIVE PI3K-DELTA INHIBITORS |
KR102327888B1 (ko) | 2012-12-21 | 2021-11-17 | 얀센 바이오파마, 인코퍼레이트. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체 |
ES2788848T3 (es) | 2013-09-06 | 2020-10-23 | Aurigene Discovery Tech Ltd | Derivados de 1,2,4-oxadiazol como inmunomoduladores |
CN104458675A (zh) * | 2013-09-12 | 2015-03-25 | 中国药科大学 | 一种筛选干细胞因子受体激酶抑制剂高通量筛选方法 |
CN104458674A (zh) * | 2013-09-12 | 2015-03-25 | 中国药科大学 | 一种筛选血管内皮生长因子1激酶抑制剂高通量筛选方法 |
SG10201804835VA (en) | 2013-10-11 | 2018-07-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
EA034708B1 (ru) | 2015-03-10 | 2020-03-10 | Ауриджен Дискавери Текнолоджис Лимитед | 1,2,4-оксадиазольные и тиадиазольные соединения в качестве иммуномодуляторов |
CA2979161A1 (en) * | 2015-03-10 | 2016-09-15 | Aurigene Discovery Technologies Limited | 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
CA3010890C (en) * | 2016-01-11 | 2023-09-26 | Merck Patent Gmbh | Quinolin-2-one derivatives |
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WO2008051757A1 (en) * | 2006-10-20 | 2008-05-02 | Irm Llc | Compositions and methods for modulating c-kit and pdgfr receptors |
EP2152688A1 (en) | 2007-05-04 | 2010-02-17 | Irm Llc | Compounds and compositions as c-kit and pdgfr kinase inhibitors |
KR101122481B1 (ko) | 2007-05-04 | 2012-02-29 | 아이알엠 엘엘씨 | C-kit 및 pdgfr 키나제 억제제로서의 피리미딘 유도체 및 조성물 |
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2009
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CN102083828A (zh) | 2011-06-01 |
US8278452B2 (en) | 2012-10-02 |
JP2011513231A (ja) | 2011-04-28 |
BRPI0908849A2 (pt) | 2015-08-25 |
EA018551B1 (ru) | 2013-08-30 |
AU2009217356B2 (en) | 2012-05-03 |
CA2714700C (en) | 2013-07-30 |
US20110183997A1 (en) | 2011-07-28 |
CA2714700A1 (en) | 2009-08-27 |
JP5230755B2 (ja) | 2013-07-10 |
MX2010009207A (es) | 2011-03-03 |
AU2009217356A1 (en) | 2009-08-27 |
KR20100115379A (ko) | 2010-10-27 |
KR101216323B1 (ko) | 2012-12-27 |
EP2252612B1 (en) | 2012-03-28 |
CL2009000400A1 (es) | 2010-09-10 |
ES2383331T3 (es) | 2012-06-20 |
CN102083828B (zh) | 2013-11-13 |
ATE551342T1 (de) | 2012-04-15 |
WO2009105712A1 (en) | 2009-08-27 |
PE20091492A1 (es) | 2009-10-22 |
EA201001331A1 (ru) | 2011-04-29 |
TW200940538A (en) | 2009-10-01 |
EP2252612A1 (en) | 2010-11-24 |
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