AR060158A1 - Derivados de azolopiridin-3-ona como inhibidores de lipasas y fosfolipasas - Google Patents

Derivados de azolopiridin-3-ona como inhibidores de lipasas y fosfolipasas

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Publication number
AR060158A1
AR060158A1 ARP070101271A ARP070101271A AR060158A1 AR 060158 A1 AR060158 A1 AR 060158A1 AR P070101271 A ARP070101271 A AR P070101271A AR P070101271 A ARP070101271 A AR P070101271A AR 060158 A1 AR060158 A1 AR 060158A1
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Argentina
Prior art keywords
alkylene
alkyl
aryl
alkylamino
cycloalkyl
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ARP070101271A
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English (en)
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Sanofi Aventis Deutschland
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Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of AR060158A1 publication Critical patent/AR060158A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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Abstract

Reivindicacion 1: Un compuesto de formula (1) en la que: X es, de forma idéntica o diferente, =C(-R)- o =N-, donde al menos uno y como mucho dos X son =N-; Y es NR6 o O; R es, de forma idéntica o diferente, hidrogeno, halogeno, alquilo C1-6, haloalquilo C1-3, alquiloxi C1-3-alquileno C1-3, arilo, heterociclo, hidroxi, alquiloxi C1-6, haloalquiloxi C1-3, ariloxi, ciano, nitro o -S(O)p-alquilo C1-6, donde p = 0, 1 o 2, aminosulfonilo, pentafluorosulfanilo, amino, alquilamino C1-6, di- alquilamino C2-12, -CO-alquilo C1-6, -COOR3, -CO-NR4R5, -O-CO-NR4R5, -O-CO-alquileno C1-6-CO-O-alquilo C1-6, -O-CO-alquileno C1-6-CO-OH o -O-CO-alquileno C1-6-CO-NR4R5; R1 es alquilo C5-16, alquileno C1-4-arilo, alquileno C1-4-heterociclo, alquileno C1-4-cicloalquilo C3-12 o biciclo C8-14, donde arilo, heterociclo, cicloalquilo o biciclo pueden estar sustituidos una o más veces preferiblemente con halogeno, alquilo C1-6, alquiloxi C1-3, hidroxi, alquil C1-6mercapto, amino, alquilamino C1-6, di- alquilamino C2-12, mono-alquilaminocarbonilo C1-6, di-alquilaminocarbonilo C2-8, alcoxicarbonilo C1-6, alquilcarbonilo C1-6, ciano, nitro, trifluorometilo, trifluorometiloxi, pentafluorosulfanilo, alquilsulfonilo C1-6 o aminosulfonilo; R2 es hidrogeno; R3 es hidrogeno, alquilo C1-6 o bencilo; R4, R5 son, de forma idéntica o diferente, hidrogeno, alquilo C1-6, arilo, cicloalquilo C3-12, alquileno C1-4-arilo o alquileno C1-4-cicloalquil C3-12; R6 es hidrogeno, alquilo C1-10, alquileno C1- 4-CN, alquileno C1-4-arilo, alquileno C1-4-heterociclo, alquileno C1-4-cicloalquilo C3-12, biciclo C8-14, donde arilo, heterociclo, cicloalquilo o biciclo pueden estar sustituidos una o más veces preferiblemente con halogeno, alquilo C1-6, alquiloxi C1-6, hidroxi, alquil C1-6mercapto, amino, alquilamino C1-6, di-alquilamino C2-12, mono-alquilaminocarbonilo C1-6, di-alquilaminocarbonilo C2-8, alcoxicarbonilo C1-6, alquilcarbonilo C1-6, ciano, trifluorometilo, trifluorometiloxi, nitroalquilsulfonilo C1-6 o aminosulfonilo; las formas tautoméricas del compuesto y las sales fisiologicamente toleradas del mismo.
ARP070101271A 2006-03-28 2007-03-27 Derivados de azolopiridin-3-ona como inhibidores de lipasas y fosfolipasas AR060158A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006014688A DE102006014688A1 (de) 2006-03-28 2006-03-28 Azolopyridin-3-on-derivate als Inhibitoren von Lipasen und Phospholipasen

Publications (1)

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AR060158A1 true AR060158A1 (es) 2008-05-28

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ID=38190768

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ARP070101271A AR060158A1 (es) 2006-03-28 2007-03-27 Derivados de azolopiridin-3-ona como inhibidores de lipasas y fosfolipasas

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US (1) US8148395B2 (es)
EP (1) EP2001879B1 (es)
JP (1) JP2009531357A (es)
KR (1) KR20080104032A (es)
CN (1) CN101415706A (es)
AR (1) AR060158A1 (es)
AU (1) AU2007229709A1 (es)
BR (1) BRPI0709217A2 (es)
CA (1) CA2647425A1 (es)
DE (1) DE102006014688A1 (es)
MA (1) MA30291B1 (es)
MX (1) MX2008012127A (es)
NO (1) NO20084418L (es)
RU (1) RU2008142535A (es)
TW (1) TW200813049A (es)
WO (1) WO2007110216A1 (es)
ZA (1) ZA200807135B (es)

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