AR057554A1 - Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas - Google Patents
Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasasInfo
- Publication number
- AR057554A1 AR057554A1 ARP060104521A ARP060104521A AR057554A1 AR 057554 A1 AR057554 A1 AR 057554A1 AR P060104521 A ARP060104521 A AR P060104521A AR P060104521 A ARP060104521 A AR P060104521A AR 057554 A1 AR057554 A1 AR 057554A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heteroaryl
- cycloalkyl
- amino
- nr6r7
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Composiciones farmacéuticas que los contienen, método de preparacion y usos para prevenir o tratar trastornos del metabolismo de ácidos grasos y trastornos de utilizacion de la glucosa. Reivindicacion 1: Un compuesto de formula (1) en la cual W es - (C=O)-, -SO-, -SO2-; R1 es alquilo C5-16, cicloalquilo C5-12, X-arilo, X-heteroarilo, X-cicloalquilo C5-12 o biciclo C8-14, donde arilo, heteroarilo, cicloalquilo o biciclo pueden estar sustituidos una o varias veces preferentemente con halogeno, alquilo C1-6, alquil C1-6-oxi, hidroxi, alquil C1-6-mercapto, amino, alquil C1-6-amino, di-alquil C2-12-amino, mono-alquil C1-6-aminocarbonilo, di-alquil C2-8-aminocarbonilo, alcoxi C1-6-carbonilo, alquil C1-6-carbonilo, ciano, nitro, trifluorometilo, trifluorometoxi, alquil C1-6-sulfonilo, aminosulfonilo, y pueden estar monosustituidos con Y-arilo, Y-heteroarilo, Y-cicloalquilo C3-12, en donde arilo, heteroarilo o cicloalquilo pueden estar mono- a trisustituidos preferentemente con halogeno, alquilo C1-6, alquil C1-6-oxi, hidroxi, alquil C1-6-mercapto, amino, alquil C1-6-amino, di-alquil C2-12-amino, mono-alquil C1-6-aminocarbonilo, di-alquil C2-8-aminocarbonilo, alcoxi C1-6-carbonilo, alquil C1-6-carbonilo, ciano, nitro, trifluorometilo, trifluorometoxi, alquil C1-6-sulfonilo, aminosulfonilo; X es alquileno C1-3 que puede estar sustituido una o varias veces con halogeno, alquilo C1-3, hidroxi o trifluorometilo; Y un enlace, alquileno C1-3, -O-, NH-; R2, R3, R4, R5 son, de forma idéntica o diferente, H, halogeno, alquilo C1-6, haloalquilo C1-3, alquil C1-3-oxi-alquileno C1-3, hidroxi, fenoxi, NR6R7, ciano, nitro, COOR6, CO-NR6R7, -S-R6, -SO-R6, -SO2-R6, aminosulfonilo, pentafluorosulfanilo, arilo, heteroarilo, O-heteroarilo, cicloalquilo C3-12, CO-R6, CO-NR6R7, O-CO-NR6R7, O-CO-alquilen C1-6-CO-O-alquilo C1-6, O-CO-alquilen C1-6-CO-OH, O-CO-alquilen C1-6-CO-NR6R7 o alquil C1-6-oxi no sustituido o mono- o poli-F-sustituido; R6, R7 son, de forma idéntica o diferente, H, alquilo C1-6, bencilo, las formas tautoméricas de los compuestos y sus sales fisiologicamente toleradas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005049953A DE102005049953A1 (de) | 2005-10-19 | 2005-10-19 | Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057554A1 true AR057554A1 (es) | 2007-12-05 |
Family
ID=37667178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104521A AR057554A1 (es) | 2005-10-19 | 2006-10-17 | Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7897625B2 (es) |
| EP (1) | EP1940807B1 (es) |
| JP (1) | JP2009512650A (es) |
| KR (1) | KR20080063474A (es) |
| CN (1) | CN101291918A (es) |
| AR (1) | AR057554A1 (es) |
| AU (1) | AU2006303552A1 (es) |
| BR (1) | BRPI0617613A2 (es) |
| CA (1) | CA2625722A1 (es) |
| CR (1) | CR9850A (es) |
| DE (1) | DE102005049953A1 (es) |
| DO (1) | DOP2006000226A (es) |
| EC (1) | ECSP088377A (es) |
| GT (1) | GT200600463A (es) |
| HN (1) | HN2006035238A (es) |
| IL (1) | IL190714A0 (es) |
| MA (1) | MA29858B1 (es) |
| NO (1) | NO20081942L (es) |
| NZ (1) | NZ567573A (es) |
| PE (1) | PE20070724A1 (es) |
| RU (1) | RU2430096C2 (es) |
| TN (1) | TNSN08177A1 (es) |
| TW (1) | TW200730513A (es) |
| UY (1) | UY29872A1 (es) |
| WO (1) | WO2007045393A1 (es) |
| ZA (1) | ZA200802370B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2069326B1 (en) * | 2006-10-04 | 2015-03-18 | Merck Sharp & Dohme Corp. | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
| WO2010044441A1 (ja) | 2008-10-17 | 2010-04-22 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有する酢酸アミド誘導体 |
| RU2553451C2 (ru) * | 2008-12-24 | 2015-06-20 | Биал-Портела Энд Ка, С.А. | Фармацевтические соединения |
| EP2470527A4 (en) * | 2009-08-20 | 2013-02-27 | Merck Sharp & Dohme | BENZOTRIAZOLE D ETHER DERIVATIVES |
| RU2012127701A (ru) | 2009-12-15 | 2014-01-27 | Шионоги энд Ко. Лтд. | Производное оксадиазола, обладающее ингибирующей активностью в отношении эндотелиальной липазы |
| WO2011140296A1 (en) * | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| JP2013537917A (ja) * | 2010-09-27 | 2013-10-07 | ヤンセン ファーマシューティカ エヌ．ベー． | 内皮リパーゼ阻害剤として有用なα−ケトアミド誘導体 |
| HUE042032T2 (hu) | 2013-02-25 | 2019-06-28 | Aurigene Discovery Tech Ltd | Triszubsztituált benzotriazol-származékok, melyek dihidro-orotát-oxigenáz-inhibitor hatásúak |
| RU2563254C2 (ru) * | 2013-07-08 | 2015-09-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина |
| RU2553987C1 (ru) * | 2013-12-26 | 2015-06-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) | N-адамантилбензотриазолы, проявляющие активность против вируса гриппа а, и способ их получения |
| CN104292172B (zh) * | 2014-09-12 | 2016-08-17 | 浙江理工大学 | 一种苯并三氮唑类衍生物及其制备方法 |
| US20180369206A1 (en) | 2017-04-24 | 2018-12-27 | Aurigene Discovery Technologies Limited | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors |
| TWI818954B (zh) | 2018-02-20 | 2023-10-21 | 法商施維雅藥廠 | 三取代之苯并三唑衍生物的使用方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1035188A (en) * | 1974-08-15 | 1978-07-25 | Eastman Kodak Company | Blocked development restrainers |
| US4273860A (en) * | 1977-12-28 | 1981-06-16 | Eastman Kodak Company | Inhibition of image formation utilizing cobalt(III) complexes |
| CA1124716A (en) | 1978-10-20 | 1982-06-01 | Michael J. Simons | Blocked benzotriazole compounds as development restrainer precursors |
| JPS6239573A (ja) * | 1985-08-13 | 1987-02-20 | Sumitomo Chem Co Ltd | シクロアルケニルアミド誘導体、その製造法およびそれを有効成分とする土壌病害防除剤 |
| US6440648B1 (en) * | 2000-06-13 | 2002-08-27 | Eastman Kodak Company | Color photographic element having improved contrast and compatibility with both dry and conventional processing |
| US6372421B1 (en) * | 2000-06-13 | 2002-04-16 | Eastman Kodak Company | Photothermographic imaging element having improved contrast and methods of image formation |
| EP1385845B1 (en) | 2001-05-05 | 2008-01-09 | Smithkline Beecham Plc | N-aroyl cyclic amines |
| MXPA04005790A (es) | 2001-12-14 | 2004-09-13 | Novo Nordisk As | Compuestos y usos de los mismos para reducir la actividad de la lipasa sensible a la hormona. |
| DE10247680B4 (de) * | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| US20060211755A1 (en) * | 2003-03-31 | 2006-09-21 | Eli Lilly And Company Patent Division | 3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors |
-
2005
- 2005-10-19 DE DE102005049953A patent/DE102005049953A1/de not_active Ceased
-
2006
- 2006-10-12 KR KR1020087009298A patent/KR20080063474A/ko not_active Application Discontinuation
- 2006-10-12 RU RU2008119460/04A patent/RU2430096C2/ru not_active IP Right Cessation
- 2006-10-12 BR BRPI0617613-5A patent/BRPI0617613A2/pt not_active IP Right Cessation
- 2006-10-12 NZ NZ567573A patent/NZ567573A/en not_active IP Right Cessation
- 2006-10-12 EP EP06806216.5A patent/EP1940807B1/de active Active
- 2006-10-12 JP JP2008535942A patent/JP2009512650A/ja not_active Abandoned
- 2006-10-12 CA CA002625722A patent/CA2625722A1/en not_active Abandoned
- 2006-10-12 CN CNA2006800384397A patent/CN101291918A/zh active Pending
- 2006-10-12 WO PCT/EP2006/009857 patent/WO2007045393A1/de active Application Filing
- 2006-10-12 AU AU2006303552A patent/AU2006303552A1/en not_active Abandoned
- 2006-10-17 TW TW095138145A patent/TW200730513A/zh unknown
- 2006-10-17 GT GT200600463A patent/GT200600463A/es unknown
- 2006-10-17 DO DO2006000226A patent/DOP2006000226A/es unknown
- 2006-10-17 PE PE2006001257A patent/PE20070724A1/es not_active Application Discontinuation
- 2006-10-17 AR ARP060104521A patent/AR057554A1/es unknown
- 2006-10-18 UY UY29872A patent/UY29872A1/es not_active Application Discontinuation
- 2006-10-18 HN HN2006035238A patent/HN2006035238A/es unknown
-
2008
- 2008-03-13 ZA ZA200802370A patent/ZA200802370B/xx unknown
- 2008-03-28 CR CR9850A patent/CR9850A/es not_active Application Discontinuation
- 2008-04-08 MA MA30825A patent/MA29858B1/fr unknown
- 2008-04-08 IL IL190714A patent/IL190714A0/en unknown
- 2008-04-09 US US12/099,924 patent/US7897625B2/en not_active Expired - Fee Related
- 2008-04-17 EC EC2008008377A patent/ECSP088377A/es unknown
- 2008-04-18 TN TNP2008000177A patent/TNSN08177A1/en unknown
- 2008-04-23 NO NO20081942A patent/NO20081942L/no not_active Application Discontinuation
-
2011
- 2011-01-20 US US13/009,951 patent/US20110118321A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006303552A1 (en) | 2007-04-26 |
| IL190714A0 (en) | 2008-11-03 |
| NO20081942L (no) | 2008-04-23 |
| MA29858B1 (fr) | 2008-10-03 |
| US7897625B2 (en) | 2011-03-01 |
| TNSN08177A1 (en) | 2009-10-30 |
| CN101291918A (zh) | 2008-10-22 |
| KR20080063474A (ko) | 2008-07-04 |
| US20080287503A1 (en) | 2008-11-20 |
| HN2006035238A (es) | 2010-05-24 |
| NZ567573A (en) | 2010-06-25 |
| CA2625722A1 (en) | 2007-04-26 |
| TW200730513A (en) | 2007-08-16 |
| UY29872A1 (es) | 2007-05-31 |
| PE20070724A1 (es) | 2007-08-07 |
| EP1940807A1 (de) | 2008-07-09 |
| RU2008119460A (ru) | 2009-11-27 |
| CR9850A (es) | 2008-06-18 |
| JP2009512650A (ja) | 2009-03-26 |
| US20110118321A1 (en) | 2011-05-19 |
| ZA200802370B (en) | 2008-12-31 |
| BRPI0617613A2 (pt) | 2011-08-02 |
| RU2430096C2 (ru) | 2011-09-27 |
| DOP2006000226A (es) | 2007-05-15 |
| ECSP088377A (es) | 2008-05-30 |
| GT200600463A (es) | 2007-05-21 |
| WO2007045393A1 (de) | 2007-04-26 |
| EP1940807B1 (de) | 2015-06-17 |
| DE102005049953A1 (de) | 2007-04-26 |
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