UY29872A1 - Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas - Google Patents

Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas

Info

Publication number
UY29872A1
UY29872A1 UY29872A UY29872A UY29872A1 UY 29872 A1 UY29872 A1 UY 29872A1 UY 29872 A UY29872 A UY 29872A UY 29872 A UY29872 A UY 29872A UY 29872 A1 UY29872 A1 UY 29872A1
Authority
UY
Uruguay
Prior art keywords
derivatives
carbamoilbenzotriazol
phospholipases
lipases
inhibitors
Prior art date
Application number
UY29872A
Other languages
English (en)
Inventor
Dr Gunter Muller
Dr Gerhard Zoller
Dr Norbert Tennagels
Dr Stefan Petry
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of UY29872A1 publication Critical patent/UY29872A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Se divulgan derivados de benzotriazol de la fórmula I con los significados indicados en la descripción, sus sales de uso farmacéutico y su uso como sustancias medicinales.
UY29872A 2005-10-19 2006-10-18 Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas UY29872A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005049953A DE102005049953A1 (de) 2005-10-19 2005-10-19 Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen

Publications (1)

Publication Number Publication Date
UY29872A1 true UY29872A1 (es) 2007-05-31

Family

ID=37667178

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29872A UY29872A1 (es) 2005-10-19 2006-10-18 Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas

Country Status (26)

Country Link
US (2) US7897625B2 (es)
EP (1) EP1940807B1 (es)
JP (1) JP2009512650A (es)
KR (1) KR20080063474A (es)
CN (1) CN101291918A (es)
AR (1) AR057554A1 (es)
AU (1) AU2006303552A1 (es)
BR (1) BRPI0617613A2 (es)
CA (1) CA2625722A1 (es)
CR (1) CR9850A (es)
DE (1) DE102005049953A1 (es)
DO (1) DOP2006000226A (es)
EC (1) ECSP088377A (es)
GT (1) GT200600463A (es)
HN (1) HN2006035238A (es)
IL (1) IL190714A0 (es)
MA (1) MA29858B1 (es)
NO (1) NO20081942L (es)
NZ (1) NZ567573A (es)
PE (1) PE20070724A1 (es)
RU (1) RU2430096C2 (es)
TN (1) TNSN08177A1 (es)
TW (1) TW200730513A (es)
UY (1) UY29872A1 (es)
WO (1) WO2007045393A1 (es)
ZA (1) ZA200802370B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2069326B1 (en) * 2006-10-04 2015-03-18 Merck Sharp & Dohme Corp. Bicyclic and tricyclic derivatives as thrombin receptor antagonists
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
US8957219B2 (en) 2008-10-17 2015-02-17 Shionogi & Co., Ltd. Acetic acid amide derivative having inhibitory activity on endothelial lipase
AU2009330821B2 (en) * 2008-12-24 2015-06-11 Bial - Portela & Ca, S.A. Pharmaceutical compounds
EP2470527A4 (en) * 2009-08-20 2013-02-27 Merck Sharp & Dohme BENZOTRIAZOLE D ETHER DERIVATIVES
RU2012127701A (ru) 2009-12-15 2014-01-27 Шионоги энд Ко. Лтд. Производное оксадиазола, обладающее ингибирующей активностью в отношении эндотелиальной липазы
US8450350B2 (en) * 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
WO2012047580A1 (en) * 2010-09-27 2012-04-12 Janssen Pharmaceutica Nv Alpha-ketoamide derivatives useful endothelial lipase inhibitors
RS57962B1 (sr) 2013-02-25 2019-01-31 Aurigene Discovery Tech Ltd Derivati trisupstituisanog benzotriazola kao inhibitori dihidroorotat oksigenaze
RU2563254C2 (ru) * 2013-07-08 2015-09-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина
RU2553987C1 (ru) * 2013-12-26 2015-06-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) N-адамантилбензотриазолы, проявляющие активность против вируса гриппа а, и способ их получения
CN104292172B (zh) * 2014-09-12 2016-08-17 浙江理工大学 一种苯并三氮唑类衍生物及其制备方法
MA48459B1 (fr) * 2017-04-24 2021-09-30 Aurigene Discovery Tech Ltd Méthodes d'utilisation de dérivés de benzotriazole trisubstitués en tant qu'inhibiteurs de dihydroorotate oxygénase
US20180369206A1 (en) 2017-04-24 2018-12-27 Aurigene Discovery Technologies Limited Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
JP7434185B2 (ja) 2018-02-20 2024-02-20 レ ラボラトワール セルヴィエ 三置換ベンゾトリアゾール誘導体の使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1035188A (en) * 1974-08-15 1978-07-25 Eastman Kodak Company Blocked development restrainers
US4273860A (en) * 1977-12-28 1981-06-16 Eastman Kodak Company Inhibition of image formation utilizing cobalt(III) complexes
CA1124716A (en) 1978-10-20 1982-06-01 Michael J. Simons Blocked benzotriazole compounds as development restrainer precursors
JPS6239573A (ja) * 1985-08-13 1987-02-20 Sumitomo Chem Co Ltd シクロアルケニルアミド誘導体、その製造法およびそれを有効成分とする土壌病害防除剤
US6372421B1 (en) * 2000-06-13 2002-04-16 Eastman Kodak Company Photothermographic imaging element having improved contrast and methods of image formation
US6440648B1 (en) * 2000-06-13 2002-08-27 Eastman Kodak Company Color photographic element having improved contrast and compatibility with both dry and conventional processing
US7432270B2 (en) 2001-05-05 2008-10-07 Smithkline Beecham P.L.C. N-aroyl cyclic amines
AU2002351731A1 (en) 2001-12-14 2003-06-30 Novo Nordisk A/S Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
DE10247680B4 (de) * 2002-10-12 2005-09-01 Aventis Pharma Deutschland Gmbh Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase
WO2004093872A1 (en) * 2003-03-31 2004-11-04 Eli Lilly And Company 3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors

Also Published As

Publication number Publication date
DOP2006000226A (es) 2007-05-15
IL190714A0 (en) 2008-11-03
EP1940807B1 (de) 2015-06-17
TNSN08177A1 (en) 2009-10-30
TW200730513A (en) 2007-08-16
WO2007045393A1 (de) 2007-04-26
US7897625B2 (en) 2011-03-01
NZ567573A (en) 2010-06-25
CN101291918A (zh) 2008-10-22
DE102005049953A1 (de) 2007-04-26
BRPI0617613A2 (pt) 2011-08-02
CR9850A (es) 2008-06-18
CA2625722A1 (en) 2007-04-26
PE20070724A1 (es) 2007-08-07
AR057554A1 (es) 2007-12-05
ECSP088377A (es) 2008-05-30
ZA200802370B (en) 2008-12-31
EP1940807A1 (de) 2008-07-09
JP2009512650A (ja) 2009-03-26
US20080287503A1 (en) 2008-11-20
RU2430096C2 (ru) 2011-09-27
MA29858B1 (fr) 2008-10-03
AU2006303552A1 (en) 2007-04-26
HN2006035238A (es) 2010-05-24
NO20081942L (no) 2008-04-23
RU2008119460A (ru) 2009-11-27
US20110118321A1 (en) 2011-05-19
KR20080063474A (ko) 2008-07-04
GT200600463A (es) 2007-05-21

Similar Documents

Publication Publication Date Title
UY29872A1 (es) Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas
UY29853A1 (es) Derivados de diacilindazol como inhibidores de lipasas y fosfolipasas-
UY29878A1 (es) Derivados de triazolopiridina en calidad de inhibidores de lipasas y fosfolipasas
UY31001A1 (es) Derivados de imidazolidinacarboxamida como inhibidores de lipasas y fosfolipasas
TW200722421A (en) Azole derivatives as inhibitors of lipases and phospholipases
ECSP077271A (es) Derivados de pirimidina
ECSP078013A (es) Inhibidores heterocíclicos de mek y métodos de uso de ellos
ECSP077259A (es) Derivados de pirimidina
ECSP10010246A (es) Inhibidores de beta-lactamasa
UY32649A (es) "sales de 4-(dimetilamino)butil 2-(4-((2-amino-4-metil-6-(pentilamino)pirimidin-5-il)metil)fenil)acetato"
ATE471324T1 (de) Triazolophthalazine
CR8385A (es) Pirimidinas sustituidas con sulfoximina como inhibidores de cdk y/o vegf, su preparacion y sus usos como medicamento
ECSP10010664A (es) Derivados de urea heterocíclicos para el tratamiento de infecciones bacterianas
CY1110213T1 (el) Παραγωγα αζολοπυριδιν-2-ονης ως αναστολεις λιπασων και φωσφολιπασων
UY29594A1 (es) Derivados de benzotiazol-2-ona como inhibidores de lipasas y fosfolipasas
AR063027A1 (es) Derivados de sulfonamida
TW200716577A (en) Benzooxazol-2-one derivatives as inhibitors of lipases and phospholipases
UY31000A1 (es) Oxoisoxazoles como inhibidores de lipasas y fosfolipasas
PA8795401A1 (es) Asociacion entre un antiaterotrombotico y un inhibidor de la enzima de conversion de la angiotensina
UY29595A1 (es) Derivados de benzooxazol-2-ona como inhibidores de lipasas y de fosfolipasas
UY29489A1 (es) Derivados de azol en calidad de inhibidores de lipasas y fosfolipasas
UY30242A1 (es) Derivados de azolopiridin-3-ona como inhibidores de lipasas y fosfolipasas
UY30982A1 (es) Nuevos derivados de pirimidina, procesos de preparacion, composiciones farmacéuticas conteniéndolos y aplicaciones.
UY30243A1 (es) Derivados de imidazopiridin-2-ona como inhibidores de lipasas y fosfolipasas

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20130123