ECSP088377A - Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas - Google Patents
Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasasInfo
- Publication number
- ECSP088377A ECSP088377A EC2008008377A ECSP088377A ECSP088377A EC SP088377 A ECSP088377 A EC SP088377A EC 2008008377 A EC2008008377 A EC 2008008377A EC SP088377 A ECSP088377 A EC SP088377A EC SP088377 A ECSP088377 A EC SP088377A
- Authority
- EC
- Ecuador
- Prior art keywords
- derivatives
- carbamoilbenzotriazol
- phospholipases
- lipases
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La invención se refiere a derivados de benzotriazol de la fórmula general (I) con los significados indicados en la descripción, a sus sales de uso farmacéutico y a su uso como medicamentos. (I)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005049953A DE102005049953A1 (de) | 2005-10-19 | 2005-10-19 | Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP088377A true ECSP088377A (es) | 2008-05-30 |
Family
ID=37667178
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2008008377A ECSP088377A (es) | 2005-10-19 | 2008-04-17 | Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas |
Country Status (26)
Country | Link |
---|---|
US (2) | US7897625B2 (es) |
EP (1) | EP1940807B1 (es) |
JP (1) | JP2009512650A (es) |
KR (1) | KR20080063474A (es) |
CN (1) | CN101291918A (es) |
AR (1) | AR057554A1 (es) |
AU (1) | AU2006303552A1 (es) |
BR (1) | BRPI0617613A2 (es) |
CA (1) | CA2625722A1 (es) |
CR (1) | CR9850A (es) |
DE (1) | DE102005049953A1 (es) |
DO (1) | DOP2006000226A (es) |
EC (1) | ECSP088377A (es) |
GT (1) | GT200600463A (es) |
HN (1) | HN2006035238A (es) |
IL (1) | IL190714A0 (es) |
MA (1) | MA29858B1 (es) |
NO (1) | NO20081942L (es) |
NZ (1) | NZ567573A (es) |
PE (1) | PE20070724A1 (es) |
RU (1) | RU2430096C2 (es) |
TN (1) | TNSN08177A1 (es) |
TW (1) | TW200730513A (es) |
UY (1) | UY29872A1 (es) |
WO (1) | WO2007045393A1 (es) |
ZA (1) | ZA200802370B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010505842A (ja) * | 2006-10-04 | 2010-02-25 | シェーリング コーポレイション | トロンビン受容体拮抗薬としての二環式誘導体および三環式誘導体 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
US8957219B2 (en) | 2008-10-17 | 2015-02-17 | Shionogi & Co., Ltd. | Acetic acid amide derivative having inhibitory activity on endothelial lipase |
RU2553451C2 (ru) * | 2008-12-24 | 2015-06-20 | Биал-Портела Энд Ка, С.А. | Фармацевтические соединения |
EP2470527A4 (en) * | 2009-08-20 | 2013-02-27 | Merck Sharp & Dohme | BENZOTRIAZOLE D ETHER DERIVATIVES |
CN102753545A (zh) | 2009-12-15 | 2012-10-24 | 盐野义制药株式会社 | 具有血管内皮脂酶抑制活性的噁二唑衍生物 |
US8450350B2 (en) * | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
JP2013537917A (ja) * | 2010-09-27 | 2013-10-07 | ヤンセン ファーマシューティカ エヌ.ベー. | 内皮リパーゼ阻害剤として有用なα−ケトアミド誘導体 |
WO2014128669A2 (en) | 2013-02-25 | 2014-08-28 | Aurigene Discovery Technologies Limited | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
RU2563254C2 (ru) * | 2013-07-08 | 2015-09-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина |
RU2553987C1 (ru) * | 2013-12-26 | 2015-06-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) | N-адамантилбензотриазолы, проявляющие активность против вируса гриппа а, и способ их получения |
CN104292172B (zh) * | 2014-09-12 | 2016-08-17 | 浙江理工大学 | 一种苯并三氮唑类衍生物及其制备方法 |
US20180369206A1 (en) | 2017-04-24 | 2018-12-27 | Aurigene Discovery Technologies Limited | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors |
RS62519B1 (sr) * | 2017-04-24 | 2021-11-30 | Aurigene Discovery Tech Ltd | Metode upotrebe trisupstituisanih derivata benzotriazola kao inhibitora dihidroorotat oksigenaze |
BR112020016929A8 (pt) | 2018-02-20 | 2022-06-28 | Agios Pharmaceuticals Inc | Métodos de uso para derivados de benzotriazol trissubstituídos |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1035188A (en) * | 1974-08-15 | 1978-07-25 | Eastman Kodak Company | Blocked development restrainers |
US4273860A (en) * | 1977-12-28 | 1981-06-16 | Eastman Kodak Company | Inhibition of image formation utilizing cobalt(III) complexes |
CA1126999A (en) | 1978-10-20 | 1982-07-06 | Michael J. Simons | Use of azole compounds with a n,n disubstituted carbamoyl group on a ring nitrogen as development restrainer precursors in photographic elements |
JPS6239573A (ja) * | 1985-08-13 | 1987-02-20 | Sumitomo Chem Co Ltd | シクロアルケニルアミド誘導体、その製造法およびそれを有効成分とする土壌病害防除剤 |
US6372421B1 (en) * | 2000-06-13 | 2002-04-16 | Eastman Kodak Company | Photothermographic imaging element having improved contrast and methods of image formation |
US6440648B1 (en) * | 2000-06-13 | 2002-08-27 | Eastman Kodak Company | Color photographic element having improved contrast and compatibility with both dry and conventional processing |
IL158463A0 (en) | 2001-05-05 | 2004-05-12 | Smithkline Beecham Plc | N-aroyl cyclic amines |
IL162270A0 (en) | 2001-12-14 | 2005-11-20 | Novo Nordisk As | Compounds and uses thereof for decreasing activityof hormone-sensitive lipase |
DE10247680B4 (de) * | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
DE602004023062D1 (en) * | 2003-03-31 | 2009-10-22 | Lilly Co Eli | 3-oxo-1,3-dihydro-indazol-2-carbonsäureamid derivate als phospholipase inhibitoren |
-
2005
- 2005-10-19 DE DE102005049953A patent/DE102005049953A1/de not_active Ceased
-
2006
- 2006-10-12 BR BRPI0617613-5A patent/BRPI0617613A2/pt not_active IP Right Cessation
- 2006-10-12 CN CNA2006800384397A patent/CN101291918A/zh active Pending
- 2006-10-12 KR KR1020087009298A patent/KR20080063474A/ko not_active Application Discontinuation
- 2006-10-12 CA CA002625722A patent/CA2625722A1/en not_active Abandoned
- 2006-10-12 EP EP06806216.5A patent/EP1940807B1/de active Active
- 2006-10-12 WO PCT/EP2006/009857 patent/WO2007045393A1/de active Application Filing
- 2006-10-12 NZ NZ567573A patent/NZ567573A/en not_active IP Right Cessation
- 2006-10-12 JP JP2008535942A patent/JP2009512650A/ja not_active Abandoned
- 2006-10-12 AU AU2006303552A patent/AU2006303552A1/en not_active Abandoned
- 2006-10-12 RU RU2008119460/04A patent/RU2430096C2/ru not_active IP Right Cessation
- 2006-10-17 GT GT200600463A patent/GT200600463A/es unknown
- 2006-10-17 DO DO2006000226A patent/DOP2006000226A/es unknown
- 2006-10-17 PE PE2006001257A patent/PE20070724A1/es not_active Application Discontinuation
- 2006-10-17 AR ARP060104521A patent/AR057554A1/es unknown
- 2006-10-17 TW TW095138145A patent/TW200730513A/zh unknown
- 2006-10-18 UY UY29872A patent/UY29872A1/es not_active Application Discontinuation
- 2006-10-18 HN HN2006035238A patent/HN2006035238A/es unknown
-
2008
- 2008-03-13 ZA ZA200802370A patent/ZA200802370B/xx unknown
- 2008-03-28 CR CR9850A patent/CR9850A/es not_active Application Discontinuation
- 2008-04-08 IL IL190714A patent/IL190714A0/en unknown
- 2008-04-08 MA MA30825A patent/MA29858B1/fr unknown
- 2008-04-09 US US12/099,924 patent/US7897625B2/en not_active Expired - Fee Related
- 2008-04-17 EC EC2008008377A patent/ECSP088377A/es unknown
- 2008-04-18 TN TNP2008000177A patent/TNSN08177A1/en unknown
- 2008-04-23 NO NO20081942A patent/NO20081942L/no not_active Application Discontinuation
-
2011
- 2011-01-20 US US13/009,951 patent/US20110118321A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2625722A1 (en) | 2007-04-26 |
TNSN08177A1 (en) | 2009-10-30 |
DE102005049953A1 (de) | 2007-04-26 |
RU2008119460A (ru) | 2009-11-27 |
MA29858B1 (fr) | 2008-10-03 |
RU2430096C2 (ru) | 2011-09-27 |
CR9850A (es) | 2008-06-18 |
EP1940807B1 (de) | 2015-06-17 |
JP2009512650A (ja) | 2009-03-26 |
EP1940807A1 (de) | 2008-07-09 |
DOP2006000226A (es) | 2007-05-15 |
BRPI0617613A2 (pt) | 2011-08-02 |
HN2006035238A (es) | 2010-05-24 |
NZ567573A (en) | 2010-06-25 |
GT200600463A (es) | 2007-05-21 |
AU2006303552A1 (en) | 2007-04-26 |
UY29872A1 (es) | 2007-05-31 |
IL190714A0 (en) | 2008-11-03 |
NO20081942L (no) | 2008-04-23 |
US20080287503A1 (en) | 2008-11-20 |
US20110118321A1 (en) | 2011-05-19 |
WO2007045393A1 (de) | 2007-04-26 |
TW200730513A (en) | 2007-08-16 |
US7897625B2 (en) | 2011-03-01 |
PE20070724A1 (es) | 2007-08-07 |
CN101291918A (zh) | 2008-10-22 |
ZA200802370B (en) | 2008-12-31 |
AR057554A1 (es) | 2007-12-05 |
KR20080063474A (ko) | 2008-07-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP088377A (es) | Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas | |
UY29853A1 (es) | Derivados de diacilindazol como inhibidores de lipasas y fosfolipasas- | |
CR9851A (es) | Derivados de triazolopiridina en calidad de inhibidores de lipasas y fosfolipasas | |
UY30498A1 (es) | Nueva clase de compuestos de benzimidazolilo, sus sales, composiciones farmacéuticas conteniéndolos y aplicaciones | |
UY31001A1 (es) | Derivados de imidazolidinacarboxamida como inhibidores de lipasas y fosfolipasas | |
ECSP077271A (es) | Derivados de pirimidina | |
ECSP077259A (es) | Derivados de pirimidina | |
CR11518A (es) | Compuestos de carbamoilo como inhibidores de dgat1 190 | |
ECSP10010246A (es) | Inhibidores de beta-lactamasa | |
PA8791801A1 (es) | Compuestos de pirazol | |
ECSP12012174A (es) | Derivados de n-(imidazopirimidin-7-il)-heteroarilamida y su uso como inhibidores de pde10a | |
EA200870217A1 (ru) | 4-арил-2-аминопиримидины или 4-арил-2-аминоалкилпиримидины в качестве модуляторов jak-2 и содержащие их фармацевтические композиции | |
TW200722421A (en) | Azole derivatives as inhibitors of lipases and phospholipases | |
CR10963A (es) | Compuestos de 2-amino pirimidina | |
CY1110213T1 (el) | Παραγωγα αζολοπυριδιν-2-ονης ως αναστολεις λιπασων και φωσφολιπασων | |
AR063027A1 (es) | Derivados de sulfonamida | |
UY29594A1 (es) | Derivados de benzotiazol-2-ona como inhibidores de lipasas y fosfolipasas | |
UY31000A1 (es) | Oxoisoxazoles como inhibidores de lipasas y fosfolipasas | |
UY32165A (es) | Compuestos de triazol y de imidazol, su uso, así como productos que los contienen | |
SG162766A1 (en) | Benzooxazole-2-on derivatives as lipase and phospholipase inhibitors | |
UY32166A (es) | Compuestos de triazol y de imidazol, su uso, así como productos que los contienen | |
PA8795401A1 (es) | Asociacion entre un antiaterotrombotico y un inhibidor de la enzima de conversion de la angiotensina | |
UY30235A1 (es) | Inhibidores de la adenilato ciclasa soluble | |
UY29595A1 (es) | Derivados de benzooxazol-2-ona como inhibidores de lipasas y de fosfolipasas | |
DOP2007000060A (es) | Inhibidores de la adenilato ciclasa soluble |