AR019630A1 - Agentes multiaglutinantes que modulan receptores ppar gama y rxr - Google Patents

Agentes multiaglutinantes que modulan receptores ppar gama y rxr

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Publication number
AR019630A1
AR019630A1 ARP990102706A ARP990102706A AR019630A1 AR 019630 A1 AR019630 A1 AR 019630A1 AR P990102706 A ARP990102706 A AR P990102706A AR P990102706 A ARP990102706 A AR P990102706A AR 019630 A1 AR019630 A1 AR 019630A1
Authority
AR
Argentina
Prior art keywords
range
receptor
ppar
agents
rxr
Prior art date
Application number
ARP990102706A
Other languages
English (en)
Original Assignee
Advanced Medicine Inc
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Publication date
Application filed by Advanced Medicine Inc filed Critical Advanced Medicine Inc
Publication of AR019630A1 publication Critical patent/AR019630A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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Abstract

Se revelan compuestos multiaglutinantes novedosos (agentes) que se aglutinan a los receptores PPAR gama. Los compuestos de la presente invencion comprendenuna pluralidad de ligandos y cada uno de ellos se aglutinan a tales receptores, modulando asís us procedimientos biologicos y/o funciones. Los ligandos soncapaces de aglutinarse o bien al receptor PPAR gama o a un receptor RXR, siempre y cuando por lo menos un ligando de los compuestos multiaglutinantes seaglutina a un receptor PPAR gama.Cada uno de los ligandos se sujeta covalentemente a un enlace o enlaces que podrán ser los mismos o diferentes paraproporcionar el compuesto multiaglutinante. Se selecciona el enlace de tal modo que el compuesto multiaglutinante así construídodemuestra aumentada modulacionde los procedimientos biologicos mediados por el receptor PPAR gama.
ARP990102706A 1998-06-08 1999-06-08 Agentes multiaglutinantes que modulan receptores ppar gama y rxr AR019630A1 (es)

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US8846698P 1998-06-08 1998-06-08
US9293898P 1998-07-15 1998-07-15

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ARP990102702A AR019628A1 (es) 1998-06-08 1999-06-08 Metodo para identificar nuevos agentes multimericos que modulan receptores.
ARP990102699A AR031973A1 (es) 1998-06-08 1999-06-08 Agonistas de los receptores beta2-adrenergicos, una composicion farmaceutica, y uso de dichos agonistas para la manufactura de un medicamento
ARP990102697A AR030142A1 (es) 1998-06-08 1999-06-08 Agonistas de los receptores beta2-adrenergicos, una composicion farmaceutica, uso de dichos agonistas para la manufactura de un medicamento, un metodo para la identificacion de compuestos con ligandos multimericos que poseen propiedades de multiple ligamiento, una biblioteca de compuestos con ligand
ARP990102706A AR019630A1 (es) 1998-06-08 1999-06-08 Agentes multiaglutinantes que modulan receptores ppar gama y rxr
ARP990102698A AR031364A1 (es) 1998-06-08 1999-06-08 Agonistas del receptor adrenergico beta-2, una composicion farmaceutica, uso de dichos agonistas para la manufactura de un medicamento, un metodo para identificar compuestos de ligando multimerico que poseen propiedades de enlace multimerico, y un centro de compuestos de ligando multimerico que pose

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ARP990102699A AR031973A1 (es) 1998-06-08 1999-06-08 Agonistas de los receptores beta2-adrenergicos, una composicion farmaceutica, y uso de dichos agonistas para la manufactura de un medicamento
ARP990102697A AR030142A1 (es) 1998-06-08 1999-06-08 Agonistas de los receptores beta2-adrenergicos, una composicion farmaceutica, uso de dichos agonistas para la manufactura de un medicamento, un metodo para la identificacion de compuestos con ligandos multimericos que poseen propiedades de multiple ligamiento, una biblioteca de compuestos con ligand

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