AR019628A1 - Metodo para identificar nuevos agentes multimericos que modulan receptores. - Google Patents

Metodo para identificar nuevos agentes multimericos que modulan receptores.

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Publication number
AR019628A1
AR019628A1 ARP990102702A ARP990102702A AR019628A1 AR 019628 A1 AR019628 A1 AR 019628A1 AR P990102702 A ARP990102702 A AR P990102702A AR P990102702 A ARP990102702 A AR P990102702A AR 019628 A1 AR019628 A1 AR 019628A1
Authority
AR
Argentina
Prior art keywords
compounds
receptors
identifying new
agents
ligands
Prior art date
Application number
ARP990102702A
Other languages
English (en)
Original Assignee
Advanced Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine Inc filed Critical Advanced Medicine Inc
Publication of AR019628A1 publication Critical patent/AR019628A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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Abstract

Se han descubierto nuevos compuestos (agentes) de multiple enlace que se enlazan con receptores celulares. Los compuestos de esta invencion comprenden unapluralidad de ligandos cada uno de los cuales puede enlazarse a dichos receptores celulares modulando con ello los procesos/funciones biologicas de losmismos. Cada uno de los ligandos está covalentemente unido a un ligante o ligantes, que pueden ser los mismos o diferentes, para proporcionar el compuesto demultiple enlace. El ligante se selecciona de tal manera que el compuesto de multiple enlace así construído demuestra un aumento de modulacion o ruptura de losprocesos/funciones biologicos de la célula. También se ha descubierto un método para identificar estos nuevos compuestos de multiple enlace que se enlazan conreceptores celulares y un método para generar una mezcla de estos nuevos compuestos de multiple enlace.
ARP990102702A 1998-06-08 1999-06-08 Metodo para identificar nuevos agentes multimericos que modulan receptores. AR019628A1 (es)

Applications Claiming Priority (2)

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US8846698P 1998-06-08 1998-06-08
US9293898P 1998-07-15 1998-07-15

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AR019628A1 true AR019628A1 (es) 2002-02-27

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ID=26778693

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ARP990102699A AR031973A1 (es) 1998-06-08 1999-06-08 Agonistas de los receptores beta2-adrenergicos, una composicion farmaceutica, y uso de dichos agonistas para la manufactura de un medicamento
ARP990102697A AR030142A1 (es) 1998-06-08 1999-06-08 Agonistas de los receptores beta2-adrenergicos, una composicion farmaceutica, uso de dichos agonistas para la manufactura de un medicamento, un metodo para la identificacion de compuestos con ligandos multimericos que poseen propiedades de multiple ligamiento, una biblioteca de compuestos con ligand
ARP990102698A AR031364A1 (es) 1998-06-08 1999-06-08 Agonistas del receptor adrenergico beta-2, una composicion farmaceutica, uso de dichos agonistas para la manufactura de un medicamento, un metodo para identificar compuestos de ligando multimerico que poseen propiedades de enlace multimerico, y un centro de compuestos de ligando multimerico que pose
ARP990102702A AR019628A1 (es) 1998-06-08 1999-06-08 Metodo para identificar nuevos agentes multimericos que modulan receptores.
ARP990102706A AR019630A1 (es) 1998-06-08 1999-06-08 Agentes multiaglutinantes que modulan receptores ppar gama y rxr

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ARP990102699A AR031973A1 (es) 1998-06-08 1999-06-08 Agonistas de los receptores beta2-adrenergicos, una composicion farmaceutica, y uso de dichos agonistas para la manufactura de un medicamento
ARP990102697A AR030142A1 (es) 1998-06-08 1999-06-08 Agonistas de los receptores beta2-adrenergicos, una composicion farmaceutica, uso de dichos agonistas para la manufactura de un medicamento, un metodo para la identificacion de compuestos con ligandos multimericos que poseen propiedades de multiple ligamiento, una biblioteca de compuestos con ligand
ARP990102698A AR031364A1 (es) 1998-06-08 1999-06-08 Agonistas del receptor adrenergico beta-2, una composicion farmaceutica, uso de dichos agonistas para la manufactura de un medicamento, un metodo para identificar compuestos de ligando multimerico que poseen propiedades de enlace multimerico, y un centro de compuestos de ligando multimerico que pose

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