ATE407136T1 - Verfahren und system zur trennung und aufreinigung wenigstens eines narkotischen alkaloids unter anwendung von präparativer umkehrphasenchromatographie - Google Patents
Verfahren und system zur trennung und aufreinigung wenigstens eines narkotischen alkaloids unter anwendung von präparativer umkehrphasenchromatographieInfo
- Publication number
- ATE407136T1 ATE407136T1 AT03743676T AT03743676T ATE407136T1 AT E407136 T1 ATE407136 T1 AT E407136T1 AT 03743676 T AT03743676 T AT 03743676T AT 03743676 T AT03743676 T AT 03743676T AT E407136 T1 ATE407136 T1 AT E407136T1
- Authority
- AT
- Austria
- Prior art keywords
- narcotic
- alkaloid
- purification
- separation
- narcotic alkaloid
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28078—Pore diameter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
- B01J20/28004—Sorbent size or size distribution, e.g. particle size
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
- B01J20/283—Porous sorbents based on silica
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
- B01J20/285—Porous sorbents based on polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
- B01J20/287—Non-polar phases; Reversed phases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36032102P | 2002-02-28 | 2002-02-28 | |
US43459702P | 2002-12-16 | 2002-12-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE407136T1 true ATE407136T1 (de) | 2008-09-15 |
Family
ID=27791639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03743676T ATE407136T1 (de) | 2002-02-28 | 2003-02-18 | Verfahren und system zur trennung und aufreinigung wenigstens eines narkotischen alkaloids unter anwendung von präparativer umkehrphasenchromatographie |
Country Status (12)
Country | Link |
---|---|
US (1) | US7671203B2 (de) |
EP (1) | EP1487838B1 (de) |
JP (1) | JP2005522460A (de) |
CN (1) | CN1639166A (de) |
AT (1) | ATE407136T1 (de) |
AU (1) | AU2003216279B2 (de) |
CA (1) | CA2477739A1 (de) |
DE (1) | DE60323345D1 (de) |
ES (1) | ES2312798T3 (de) |
IL (2) | IL163759A0 (de) |
MX (1) | MXPA04008213A (de) |
WO (1) | WO2003074526A2 (de) |
Families Citing this family (30)
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KR101198346B1 (ko) * | 2003-04-08 | 2012-11-06 | 노보 노르디스크 에이/에스 | 크로마토그래피 고정상의 재생 |
EP1682505B1 (de) * | 2003-10-29 | 2008-12-24 | Mallinckrodt Inc. | Grosstechnisches verfahren zur abtrennung und aufreinigung von fentanyl durch präparative umkehrphasenchromatographie |
JP2008501797A (ja) | 2004-06-08 | 2008-01-24 | マリンクロッド・インコーポレイテッド | アヘンからのアルカロイド類の抽出 |
WO2006052456A1 (en) * | 2004-10-27 | 2006-05-18 | Mallinckrodt Inc. | Method for separation and purification of hydrocodone by preparative chromatography |
EP1899351A1 (de) * | 2005-06-09 | 2008-03-19 | Mallinckrodt, Inc. | Verfahren zur abtrennung und aufreinigung von naltrexon durch präparative chromatographie |
IT1396543B1 (it) * | 2008-07-16 | 2012-12-14 | Farmabios Spa | Processo per la purificazione di bloccanti neuromuscolari |
US8492547B2 (en) * | 2009-07-09 | 2013-07-23 | Mallinckrodt Llc | Method for the enrichment of buprenorphine using chromatographic techniques |
US10151759B2 (en) * | 2011-02-10 | 2018-12-11 | Hoffmann-La Roche Inc. | Method for the purification of a glycan and/or a glycoconjugate by chromatography using a stationary phase comprising cotton |
TWI414340B (zh) | 2011-05-04 | 2013-11-11 | Ind Tech Res Inst | 高壓萃取設備及其萃取方法 |
WO2013169537A1 (en) * | 2012-05-08 | 2013-11-14 | Dow Corning Corporation | Purification of chlorosilanes using chromatography |
CN103505909B (zh) * | 2012-06-21 | 2018-02-13 | 通用电气健康护理生物科学股份公司 | 层析柱框架和对层析柱进行维护和填充的方法 |
KR102196230B1 (ko) | 2012-09-17 | 2020-12-29 | 더블유.알. 그레이스 앤드 캄파니-콘. | 크로마토그래피 매질 및 장치 |
EP2970320B1 (de) | 2013-03-15 | 2020-10-28 | Johnson Matthey Public Limited Company | Morphinsulfatmethanolsolvat, verfahren zur herstellung davon sowie zugehörige zusammensetzungen und verfahren zur behandlung von schmerzen |
US9700813B2 (en) | 2013-05-06 | 2017-07-11 | Tomas Hudlicky | Methods and apparatus for time-pulsed chromatography |
CN104415573B (zh) * | 2013-09-10 | 2017-03-22 | 中国科学院大连化学物理研究所 | 一种延胡索提取物中叔胺碱和季铵碱的分类制备方法 |
WO2015088427A1 (en) * | 2013-12-09 | 2015-06-18 | Ge Healthcare Bio-Sciences Ab | Piston and process column |
ES2929099T3 (es) | 2014-05-02 | 2022-11-24 | Grace W R & Co | Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado |
US10422776B2 (en) * | 2014-05-09 | 2019-09-24 | Waters Technologies Corporation | Methods for preparing liquid mixtures |
CN105777766B (zh) * | 2014-12-15 | 2017-11-24 | 北大方正集团有限公司 | Delta‑7溴甲纳曲酮的制备方法 |
JP2018517559A (ja) | 2015-06-05 | 2018-07-05 | ダブリュー・アール・グレース・アンド・カンパニー−コーンW R Grace & Co−Conn | 吸着性バイオプロセス清澄化剤並びにその製造及び使用方法 |
EP3468685A4 (de) * | 2016-06-10 | 2020-02-12 | Repligen Corporation | Chromatographiesäulenverpackungsmediumwiedergewinnung |
CN106621461B (zh) * | 2016-12-13 | 2018-10-02 | 北京科技大学 | 一种基于层析原理的高效分离装置 |
CN110256505B (zh) * | 2019-06-13 | 2020-09-18 | 中国农业科学院饲料研究所 | 长裂苦苣菜生物碱初级分离物及其分离方法和应用 |
CN110698488B (zh) * | 2019-09-20 | 2022-05-13 | 甘肃省药物碱厂 | 一种从罂粟壳中提取分离吗啡的方法 |
CN111157638A (zh) * | 2019-12-31 | 2020-05-15 | 济南康和医药科技有限公司 | 一种检测维生素c中草酸含量的方法 |
IL299452A (en) | 2020-06-17 | 2023-02-01 | Psilo Scientific Ltd | Extraction and composition of psychoactive alkaloids with controlled dephosphorylation |
CA3113240C (en) | 2020-12-28 | 2023-09-05 | Psilo Scientific Ltd. | Transmucosal psychoactive alkaloid composition and preparation thereof |
CN113075326B (zh) * | 2021-03-31 | 2024-03-15 | 周迎春 | 一种利用液质联用-内标法快速测定罂粟壳生物碱的方法 |
US20220395767A1 (en) * | 2021-06-15 | 2022-12-15 | Perkinelmer Health Sciences, Inc. | Enhancing lcms analyte signals |
CN113274764B (zh) * | 2021-06-18 | 2022-04-05 | 中触媒新材料股份有限公司 | 一种液相吸附分离系统及其控温工艺方法 |
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-
2003
- 2003-02-18 JP JP2003572994A patent/JP2005522460A/ja not_active Withdrawn
- 2003-02-18 MX MXPA04008213A patent/MXPA04008213A/es active IP Right Grant
- 2003-02-18 DE DE60323345T patent/DE60323345D1/de not_active Expired - Fee Related
- 2003-02-18 CA CA002477739A patent/CA2477739A1/en not_active Abandoned
- 2003-02-18 ES ES03743676T patent/ES2312798T3/es not_active Expired - Lifetime
- 2003-02-18 CN CN03804869.8A patent/CN1639166A/zh active Pending
- 2003-02-18 EP EP03743676A patent/EP1487838B1/de not_active Expired - Lifetime
- 2003-02-18 WO PCT/US2003/004498 patent/WO2003074526A2/en active Application Filing
- 2003-02-18 IL IL16375903A patent/IL163759A0/xx unknown
- 2003-02-18 AU AU2003216279A patent/AU2003216279B2/en not_active Ceased
- 2003-02-18 AT AT03743676T patent/ATE407136T1/de not_active IP Right Cessation
- 2003-02-18 US US10/501,353 patent/US7671203B2/en not_active Expired - Fee Related
-
2004
- 2004-08-26 IL IL163759A patent/IL163759A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL163759A0 (en) | 2005-12-18 |
EP1487838A2 (de) | 2004-12-22 |
CN1639166A (zh) | 2005-07-13 |
DE60323345D1 (de) | 2008-10-16 |
WO2003074526A3 (en) | 2003-12-04 |
IL163759A (en) | 2010-02-17 |
AU2003216279B2 (en) | 2009-11-12 |
JP2005522460A (ja) | 2005-07-28 |
ES2312798T3 (es) | 2009-03-01 |
MXPA04008213A (es) | 2005-05-16 |
WO2003074526A2 (en) | 2003-09-12 |
US7671203B2 (en) | 2010-03-02 |
AU2003216279A1 (en) | 2003-09-16 |
CA2477739A1 (en) | 2003-09-12 |
EP1487838B1 (de) | 2008-09-03 |
US20050182257A1 (en) | 2005-08-18 |
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