KR930702252A - 광학분할에 있어서의 광학이성체와 용매의 회수방법, 용매의 순환사용방법 및 광학이성체의 재이용방법 - Google Patents

광학분할에 있어서의 광학이성체와 용매의 회수방법, 용매의 순환사용방법 및 광학이성체의 재이용방법

Info

Publication number
KR930702252A
KR930702252A KR1019930701126A KR930701126A KR930702252A KR 930702252 A KR930702252 A KR 930702252A KR 1019930701126 A KR1019930701126 A KR 1019930701126A KR 930701126 A KR930701126 A KR 930701126A KR 930702252 A KR930702252 A KR 930702252A
Authority
KR
South Korea
Prior art keywords
optical
solvent
optical isomer
liquid
recovering
Prior art date
Application number
KR1019930701126A
Other languages
English (en)
Other versions
KR960009561B1 (en
Inventor
마사까즈 네가와
후미히꼬 쇼오지
Original Assignee
고지마 아끼로오
다이셀 가가꾸 고오교오 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16591429&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR930702252(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 고지마 아끼로오, 다이셀 가가꾸 고오교오 가부시끼가이샤 filed Critical 고지마 아끼로오
Publication of KR930702252A publication Critical patent/KR930702252A/ko
Application granted granted Critical
Publication of KR960009561B1 publication Critical patent/KR960009561B1/ko

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterized by the components to be separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3833—Chiral chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

용매순환통로중에 배치되고, 내부에 광학분할용 충전제를 수용하여 이루어지는 충전상에, 탈리액 도입구, 충전제에 흡착용이한 광학이성체를 함유하는 엑스트랙트 발출구, 광학이성체 혼합물 함유액 도입구, 및 충전제에 흡착곤란한 광학이성체를 함유하는 라피네이트 발출구를 이 순서로 설치하고, 이들을 충전상내의 유체의 유통방향으로 축차 이동하는 의사이동상 방식을 이용하고, 얻어지는 엑스트랙트 및/또는 라피네이트에서 용매와 광학이성체를 회수하고, 회수한 용매를 용매순환통로에 반환하고, 혹은 용매를 회수하지 않을 경우는 엑스트랙트 또는 라피네이트를 가열함으로써 소망하지 않는 광학이성체를 라세미체로 하고, 얻어지는 라세미체 함유의 용매액을 의사이동상 방식에 의한 광학이성체의 분리에 재사용하는 것을 특징으로 하는 용매와 광학이성체의 회수, 재이용방법.

Description

광학분할에 있어서의 광학이성체와 용매의 회수방법, 용매의 순환사용방법 및 광학이성체의 재이용방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 방법을 실시하는 한 예의 장치를 예시하는 설명도이다. 제2도는 본 발명의 방법을 실시하는 다른 장치를 예시하는 설명도이다.

Claims (8)

  1. 내부에 광학분할용 충전제를 수용하고, 또한 전단과 후단이 유체통로에서 결합되어 무단상으로 되어 있어 액체가 한 방향으로 순환하고 있는 충전상에 광학이성체 혼합물 함유액 및 탈리액을 도입하고, 동시에 충전상에서 분리된 한 쪽의 광학이성체를 함유하는 액과 다른 쪽의 광학이성체를 함유하는 액을 발출하는 것으로 이루어지고, 충전상에는 탈리액 도입구, 흡착되기 쉬운 광학이성체를 함유하는 액(엑스트랙트)의 발출구, 광학이성체 혼합물 함유액 도입구, 흡착되기 어려운 광학이성체를 함유하는 액(라피네이트)의 발출구를 액체의 흐름방향에 따라 이 순서로 배치하고, 또한 이들을 상내의 유체흐름방향으로 그것들의 위치를 간헐적으로 축차 이동하는 것에 의해 이루어지는 의사이동상 방식을 이용하여 얻어지는 상기 엑스트랙트 및/또는 라피네이트에서 용매와 광학이성체를 회수하는 것을 특징으로 하는 광학분할에 있어서의 광학이성체와 용매의 회수방법.
  2. 제1항에 있어서, 상기 광학분할용 충전제의 입경이 1~100㎛인 것을 특징으로 하는 광학분할에 있어서의 광학이성체와 용매의 회수방법.
  3. 제1항에 있어서, 상기 제1항 기재의 의사이동상 방식을 이용하여 얻어지는 엑스트랙트 및/또는 라피네이트에서 증발기 및/또는 증류기에 의해 용매를 분리하는 것을 특징으로 하는 광학분할에 있어서의 광학이성체와 용매의 회수방법.
  4. 제3항에 있어서, 상기 증발기 및/또는 증류기가 감압계인 것을 특징으로 하는 광학분할에 있어서의 광학이성체와 용매의 회수방법.
  5. 상기 제1항 기재의 방법에 의해 회수된 용매를 제1항에 있어서의 유체통로 중으로 반환하는 것을 특징으로 하는 용매의 순환사용방법.
  6. 제5항에 있어서, 회수된 상기 용매의 순도가 98% 이상인 것을 특징으로 하는 용매의 순환사용방법.
  7. 상기 제1항 기재의 엑스트랙트 또는 라피네이트 중의 대장체인 광학이성체를 라세미화하고, 얻어진 광학이성체 혼합물 함유액을 광학이성체 혼합물 함유액 도입구로 반환하는 것을 특징으로 하는 광학이성체의 재이용 방법.
  8. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR93701126A 1991-08-22 1993-04-15 Recovery of optical isomer and solvent in optical resolution, reuse of solvent by recycling, and reuse of optical isomer KR960009561B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3210565A JP3010816B2 (ja) 1991-08-22 1991-08-22 光学分割における光学異性体と溶媒との回収方法、溶媒の循環使用方法、および光学異性体の再利用方法
JP91-210565 1991-08-22
PCT/JP1992/001024 WO1993004022A1 (en) 1991-08-22 1992-08-10 Recovery of optical isomer and solvent in optical resolution, reuse of solvent by recycling, and reuse of optical isomer

Publications (2)

Publication Number Publication Date
KR930702252A true KR930702252A (ko) 1993-09-08
KR960009561B1 KR960009561B1 (en) 1996-07-20

Family

ID=16591429

Family Applications (1)

Application Number Title Priority Date Filing Date
KR93701126A KR960009561B1 (en) 1991-08-22 1993-04-15 Recovery of optical isomer and solvent in optical resolution, reuse of solvent by recycling, and reuse of optical isomer

Country Status (6)

Country Link
US (2) US5434298A (ko)
EP (2) EP0563388B2 (ko)
JP (1) JP3010816B2 (ko)
KR (1) KR960009561B1 (ko)
DE (2) DE69233679T2 (ko)
WO (1) WO1993004022A1 (ko)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770088A (en) * 1992-06-30 1998-06-23 Daicel Chemical Industries, Ltd. Simulated moving bed chromatographic separation process
ATE217859T1 (de) * 1994-02-25 2002-06-15 Daicel Chem Verfahren zur herstellung von optisch aktiven mevalonolactonen
JPH07285889A (ja) * 1994-04-20 1995-10-31 Daicel Chem Ind Ltd 光学異性体の分離方法
JPH08176133A (ja) * 1994-12-26 1996-07-09 Takeda Chem Ind Ltd Ｌ−アスコルビン酸の精製法
US5626762A (en) * 1995-02-13 1997-05-06 Uop Separations by simulated moving bed chromatography operating at low K' values using weakly interating adsorbents as the stationary phase
US5518625A (en) * 1995-02-13 1996-05-21 Uop Chiral separations by simulated moving bed chromatography operating at low k' values
US5645729A (en) * 1995-02-13 1997-07-08 Uop Separations by simulated moving bed chromatography operating at low k' values using weakly interacting adsorbents as the stationary phase
IL115941A (en) * 1995-11-09 1998-10-30 Weizmann Kiryat Membrane Prod Multi-stage membrane system and process
FR2754731B1 (fr) * 1996-10-18 1999-07-02 Novasep Sa Perfectionnement aux procedes d'enrichissement d'isomeres optiques par lit mobile simule
JPH1190106A (ja) * 1997-09-26 1999-04-06 Daicel Chem Ind Ltd 擬似移動床式クロマト分離装置
EP1070076A4 (en) * 1998-03-16 2002-05-29 Chiral Technologies Inc CHIRAL SEPARATION OF PYRIMIDINES
ES2211080T3 (es) * 1998-05-01 2004-07-01 Pfizer Products Inc. Procedimiento para la produccion de sertralina tetralona enantiomericamente pura u opticamente enriquecida usando cromatografia continua.
US6107492A (en) * 1998-05-08 2000-08-22 Ucb, S.A. Process for the preparation of levetiracetam
JP3453516B2 (ja) * 1998-05-29 2003-10-06 オルガノ株式会社 クロマト分離方法
DE19858892A1 (de) * 1998-12-19 2000-06-21 Merck Patent Gmbh Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße
DE19962543A1 (de) * 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
DK2682397T3 (da) 2000-07-21 2017-06-19 Gilead Sciences Inc Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
JPWO2002030853A1 (ja) 2000-10-13 2004-02-19 ダイセル化学工業株式会社 光学異性体分離用充填剤及びそれを用いた光学異性体の分離方法
JP4873207B2 (ja) * 2001-02-26 2012-02-08 東レ・ファインケミカル株式会社 光学活性カルボン酸クロリドの精製方法
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
FR2836396B1 (fr) * 2002-02-22 2004-06-18 Novasep Procede et dispositif de chromatographie avec recuperation de solvant
JP2004003935A (ja) * 2002-04-12 2004-01-08 Daicel Chem Ind Ltd 擬似移動床式クロマトグラフィー用光学異性体分離用充填剤
FR2846252B1 (fr) * 2002-10-29 2005-07-01 Novasep Procede et dispositif de chromatographie integrant une etape de concentration
US20060128955A1 (en) * 2003-05-09 2006-06-15 Vela Pharmaceuticals, Inc. Method of isolating (R)-tofisopam
GB0325055D0 (en) * 2003-10-27 2003-12-03 Smithkline Beecham Corp New process
DE102004025000A1 (de) 2004-05-21 2005-12-08 Bayer Technology Services Gmbh Verfahren zur Herstellung von chemischen und pharmazeutischen Produkten mit integrierter Mehrsäulen-Chromatographie
US20080096939A1 (en) * 2004-07-03 2008-04-24 Andreas Keil Process For Preparation Of Pramipexole By Chiral Chromatography
ATE497964T1 (de) 2004-12-20 2011-02-15 Sk Holdings Co Ltd Verfahren zur trennung von optisch reinen thiophenverbindungen unter anwendung von simulierter bewegtbettchromatographie
FR2889077B1 (fr) * 2005-07-26 2007-10-12 Novasep Soc Par Actions Simpli Procede et dispositif de separation chromatographique de fractions d'un melange
JP2007085829A (ja) * 2005-09-21 2007-04-05 Daicel Chem Ind Ltd 近赤外分光分析装置を校正するための装置及び方法
HU226863B1 (en) * 2005-12-09 2009-12-28 Chinoin Gyogyszer Es Vegyeszet Process for separation of optical isomers of "corey-lactone" by liquid chromatography
KR100741752B1 (ko) * 2005-12-26 2007-07-23 삼성토탈 주식회사 단일 흡착 챔버를 사용하여 공급물을 전처리하는 유사 이동층 흡착 분리 방법 및 그에 사용되는 장치
WO2008088830A2 (en) * 2007-01-16 2008-07-24 Evolved Nanomaterial Sciences, Inc. Chiral separating agents with active support
US7618539B2 (en) 2008-03-31 2009-11-17 Ampac Fine Chemicals Llc Simulated moving bed chromatography for strongly retained compounds
WO2013156630A1 (en) 2012-04-20 2013-10-24 Alphaptose Gmbh S-enantiomer of a tri-substituted glycerol compound
EP2801604B1 (en) 2013-05-07 2017-04-12 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
CN104387237B (zh) * 2014-01-22 2016-01-27 江苏汉邦科技有限公司 模拟移动床色谱拆分4-氯二苯甲醇对映体的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985589A (en) * 1957-05-22 1961-05-23 Universal Oil Prod Co Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets
JPS5820283B2 (ja) * 1976-12-18 1983-04-22 田辺製薬株式会社 ラセミ有機化合物の連続的光学分割方法
GB8429121D0 (en) * 1984-11-17 1984-12-27 Laporte Industries Ltd Zeolites
FR2593409B1 (fr) * 1986-01-30 1990-08-24 Centre Nat Rech Scient Procede de separation des constituants d'un melange comprenant au moins deux composes connus pour etre difficiles a separer et faisant appel au phenomene d'adsorption
JPS62210053A (ja) * 1986-03-07 1987-09-16 Agency Of Ind Science & Technol 光学異性体分離用充填剤
JP2925753B2 (ja) * 1990-02-23 1999-07-28 ダイセル化学工業株式会社 光学異性体の分離方法
US5220053A (en) * 1992-01-24 1993-06-15 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids

Also Published As

Publication number Publication date
KR960009561B1 (en) 1996-07-20
DE69223037T2 (de) 1998-02-26
EP0563388A4 (en) 1994-07-06
DE69233679D1 (de) 2007-03-29
EP0719749A3 (en) 1996-07-17
DE69223037T3 (de) 2001-08-02
DE69223037D1 (de) 1997-12-11
JPH06239767A (ja) 1994-08-30
EP0719749B1 (en) 2007-02-14
EP0563388B2 (en) 2001-04-04
EP0719749A2 (en) 1996-07-03
US5434298A (en) 1995-07-18
US5434299A (en) 1995-07-18
EP0563388B1 (en) 1997-11-05
JP3010816B2 (ja) 2000-02-21
EP0563388A1 (en) 1993-10-06
WO1993004022A1 (en) 1993-03-04
DE69233679T2 (de) 2007-06-14

Similar Documents

Publication Publication Date Title
KR930702252A (ko) 광학분할에 있어서의 광학이성체와 용매의 회수방법, 용매의 순환사용방법 및 광학이성체의 재이용방법
JP2925753B2 (ja) 光学異性体の分離方法
MY107040A (en) Continuous process and apparatus for the chromatographic separation of a mixture of at least three constituents into three effluents purified by means of two solvents
MY106861A (en) Process and apparatus for continuous chromatographic separation of a mixture of at least three constituents.
EP0122539A3 (en) Process for separating ethanol from a solution containing ethanol
DE69401506D1 (de) Verfahren zur chromatografischer fraktionierung von fettsäuren und ihre derivaten
DE69434893D1 (de) Trennung von gelösten stoffen in gasförmigen lösungsmitteln
ATE407136T1 (de) Verfahren und system zur trennung und aufreinigung wenigstens eines narkotischen alkaloids unter anwendung von präparativer umkehrphasenchromatographie
Stepan et al. Some conditions for use of macroreticular resins in the quantitative analysis of organic pollutants in water
DE69510780T2 (de) Verfahren zur trennung eines materials von einer mischung durch verdrängungschromatographie
DE60016222D1 (de) Verfahren zur trennung von ätherischen ölen aus ätherischen ölen enthalendem material
Di Muccio et al. Solid-matrix partition for separation of organochlorine pesticide residues from fatty materials
ATE95160T1 (de) Verfahren zur gewinnung von milchsaeure aus loesungen, die sie enthalten.
NO314788B1 (no) Framgangsmåte for utvinning av en eller flere forbindelser fra en blanding
CA2336140A1 (en) Liquid-phase adsorption process for removing and concentrating heteroatom compounds in hydrocarbons
Hill et al. Frontal chromatographic techniques in preparative chromatography
KR960000276A (ko) 의사(擬似) 이동상 크로마토분리법
JP2547595B2 (ja) カロチンの精製方法
JPS6219759A (ja) 疎水性の充填剤を使用するカラムクロマトグラフイ−の溶離液の循環使用方法
KR950002817A (ko) 액체 혼합물의 성분 분리방법
Brannegan et al. Supercritical fluid extraction of ethoxyquin from a beef matrix
EP0105066B1 (en) Process for the separation of fatty acids using a solid bed of adsorbent
Wu et al. A Simple Novel Method for the Analysis of Lubricating Oil Additives by the Use of Sep‐Pak Cartridges
Lewis The use of porous glass beads in the separation and purification of ruthenium complexes with large organic ligands
JPS57207507A (en) Separation by adsorption

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20120629

Year of fee payment: 17

EXPY Expiration of term