ATE497964T1 - Verfahren zur trennung von optisch reinen thiophenverbindungen unter anwendung von simulierter bewegtbettchromatographie - Google Patents
Verfahren zur trennung von optisch reinen thiophenverbindungen unter anwendung von simulierter bewegtbettchromatographieInfo
- Publication number
- ATE497964T1 ATE497964T1 AT04808489T AT04808489T ATE497964T1 AT E497964 T1 ATE497964 T1 AT E497964T1 AT 04808489 T AT04808489 T AT 04808489T AT 04808489 T AT04808489 T AT 04808489T AT E497964 T1 ATE497964 T1 AT E497964T1
- Authority
- AT
- Austria
- Prior art keywords
- moving bed
- simulated moving
- thiophene
- optically active
- optically pure
- Prior art date
Links
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical class C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title abstract 11
- 238000000034 method Methods 0.000 title abstract 5
- 238000004587 chromatography analysis Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 229930192474 thiophene Natural products 0.000 abstract 5
- 238000000926 separation method Methods 0.000 abstract 2
- 238000001179 sorption measurement Methods 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical compound CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 abstract 1
- 229960003933 dorzolamide Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2004/003358 WO2006068333A1 (en) | 2004-12-20 | 2004-12-20 | Method for separating of optically pure thiophene compounds using simulated moving bed chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE497964T1 true ATE497964T1 (de) | 2011-02-15 |
Family
ID=36601901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04808489T ATE497964T1 (de) | 2004-12-20 | 2004-12-20 | Verfahren zur trennung von optisch reinen thiophenverbindungen unter anwendung von simulierter bewegtbettchromatographie |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7767832B2 (de) |
| EP (1) | EP1828198B1 (de) |
| AT (1) | ATE497964T1 (de) |
| DE (1) | DE602004031387D1 (de) |
| WO (1) | WO2006068333A1 (de) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4797413A (en) | 1986-05-14 | 1989-01-10 | Merck & Co., Inc. | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use |
| US4863922A (en) | 1984-12-12 | 1989-09-05 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use |
| US4968815A (en) * | 1990-04-16 | 1990-11-06 | Merck & Co., Inc. | Synthesis of (S)-3-(thien-2-ylthio)butyric acid analogs |
| US4968814A (en) * | 1990-04-18 | 1990-11-06 | Merck & Co., Inc. | (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof |
| US5157129A (en) | 1990-04-18 | 1992-10-20 | Merck & Co., Inc. | Enantiospecific synthesis of s-(+)-5,6-dihydro-4-(r-amino)-4h-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide |
| JP3010816B2 (ja) | 1991-08-22 | 2000-02-21 | ダイセル化学工業株式会社 | 光学分割における光学異性体と溶媒との回収方法、溶媒の循環使用方法、および光学異性体の再利用方法 |
| US5498752A (en) * | 1991-08-22 | 1996-03-12 | Daicel Chemical Industries, Ltd. | Process for recovering optical isomers and solvent, process for using solvent by circulation and process for reusing optical isomers in optical resolution |
| US5760249A (en) * | 1995-08-29 | 1998-06-02 | Merck & Co., Inc. | Synthesis of hydroxysulfone and related compounds |
-
2004
- 2004-12-20 AT AT04808489T patent/ATE497964T1/de not_active IP Right Cessation
- 2004-12-20 US US11/721,366 patent/US7767832B2/en not_active Expired - Fee Related
- 2004-12-20 WO PCT/KR2004/003358 patent/WO2006068333A1/en active Application Filing
- 2004-12-20 EP EP04808489A patent/EP1828198B1/de not_active Not-in-force
- 2004-12-20 DE DE602004031387T patent/DE602004031387D1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US7767832B2 (en) | 2010-08-03 |
| EP1828198A1 (de) | 2007-09-05 |
| EP1828198B1 (de) | 2011-02-09 |
| WO2006068333A1 (en) | 2006-06-29 |
| EP1828198A4 (de) | 2008-12-03 |
| US20090234140A1 (en) | 2009-09-17 |
| DE602004031387D1 (de) | 2011-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |