CY1108121T1 - Διαδικασια παρασκευης ζ-φλουπεντιξολης - Google Patents

Διαδικασια παρασκευης ζ-φλουπεντιξολης

Info

Publication number
CY1108121T1
CY1108121T1 CY20081100599T CY081100599T CY1108121T1 CY 1108121 T1 CY1108121 T1 CY 1108121T1 CY 20081100599 T CY20081100599 T CY 20081100599T CY 081100599 T CY081100599 T CY 081100599T CY 1108121 T1 CY1108121 T1 CY 1108121T1
Authority
CY
Cyprus
Prior art keywords
flupentixol
preparation procedure
preparation
isomers
separation
Prior art date
Application number
CY20081100599T
Other languages
English (en)
Inventor
Flavio Villani
Antonio Nardi
Annibale Salvi
Stefano Maiorana
Original Assignee
Laboratorio Chimico Internazionale S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Chimico Internazionale S.P.A. filed Critical Laboratorio Chimico Internazionale S.P.A.
Publication of CY1108121T1 publication Critical patent/CY1108121T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C07D335/20—Thioxanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε μια διαδικασία παρασκευής ισομερών φλουπεντιξόλης, ειδικότερα σε μια διαδικασία παρασκευής Ζ-φλουπεντιξόλης και τους δεκανοϊκούς εστέρες και νέα συνθετικά ενδιάμεσα της.
CY20081100599T 2003-10-17 2008-06-06 Διαδικασια παρασκευης ζ-φλουπεντιξολης CY1108121T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002024A ITMI20032024A1 (it) 2003-10-17 2003-10-17 Procedimento per la preparazione dello z-flupentixol
EP04769498A EP1673365B1 (en) 2003-10-17 2004-09-29 Process for the preparation of z-flupentixol

Publications (1)

Publication Number Publication Date
CY1108121T1 true CY1108121T1 (el) 2014-02-12

Family

ID=34452249

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100599T CY1108121T1 (el) 2003-10-17 2008-06-06 Διαδικασια παρασκευης ζ-φλουπεντιξολης

Country Status (12)

Country Link
EP (1) EP1673365B1 (el)
CN (1) CN1867558B (el)
AT (1) ATE388949T1 (el)
CA (1) CA2536667C (el)
CY (1) CY1108121T1 (el)
DE (1) DE602004012430T2 (el)
DK (1) DK1673365T3 (el)
ES (1) ES2302032T3 (el)
IT (1) ITMI20032024A1 (el)
PL (1) PL1673365T3 (el)
PT (1) PT1673365E (el)
WO (1) WO2005037820A1 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102002034B (zh) * 2009-08-28 2012-11-28 江苏恩华药业股份有限公司 盐酸氟哌噻吨异构体的分离方法
CN101912397B (zh) * 2010-04-30 2013-03-27 H.隆德贝克有限公司 氟哌噻吨组合物
CN102786511B (zh) * 2011-05-18 2014-10-15 重庆圣华曦药业股份有限公司 一种制备盐酸氟哌噻吨中间体的改进方法
CN103450151B (zh) * 2013-02-04 2014-07-30 四川海思科制药有限公司 一种氟哌噻吨化合物的制备方法
CN105348256B (zh) * 2015-11-16 2018-01-30 成都倍特药业有限公司 一种药用级盐酸氟哌噻吨的制备方法
CN107382962B (zh) * 2016-05-16 2020-11-03 江苏同禾药业有限公司 一种2-三氟甲基-9-烯丙基-9-噻吨醇的制备方法
CN107987053B (zh) * 2017-12-08 2023-04-14 植恩生物技术股份有限公司 一种高纯度z型盐酸氟哌噻吨的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1210890B (de) * 1960-03-07 1966-02-17 Smith & Kline & French Lab Verfahren zur Herstellung von Trifluormethyl-xanthen- oder thioxanthenderivaten
US3282930A (en) * 1962-08-17 1966-11-01 Smith Kline French Lab Hydroxyalkylenepiperazine derivatives and analogs thereof
US3681346A (en) * 1969-06-20 1972-08-01 Kefalas As {60 -isomer of the decanoic acid ester of 10-{8 3,-(4-hydroxyethyl-1-piperazinyl)propylidene{9 -2-trifluoro-methyl thiaxanthene, acid addition salts thereof, method of use and compositions

Also Published As

Publication number Publication date
ES2302032T3 (es) 2008-07-01
PL1673365T3 (pl) 2008-08-29
CA2536667A1 (en) 2005-04-28
ITMI20032024A1 (it) 2005-04-18
WO2005037820A1 (en) 2005-04-28
DE602004012430D1 (de) 2008-04-24
ATE388949T1 (de) 2008-03-15
DK1673365T3 (da) 2008-06-30
CN1867558B (zh) 2013-02-06
PT1673365E (pt) 2008-05-20
EP1673365A1 (en) 2006-06-28
CN1867558A (zh) 2006-11-22
CA2536667C (en) 2012-01-10
EP1673365B1 (en) 2008-03-12
DE602004012430T2 (de) 2009-03-05

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