DK1673365T3 - Fremgangsmåde til fremstillingen af Z-flupentixol - Google Patents
Fremgangsmåde til fremstillingen af Z-flupentixolInfo
- Publication number
- DK1673365T3 DK1673365T3 DK04769498T DK04769498T DK1673365T3 DK 1673365 T3 DK1673365 T3 DK 1673365T3 DK 04769498 T DK04769498 T DK 04769498T DK 04769498 T DK04769498 T DK 04769498T DK 1673365 T3 DK1673365 T3 DK 1673365T3
- Authority
- DK
- Denmark
- Prior art keywords
- flupentixol
- preparation
- isomers
- separation
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
- C07D335/12—Thioxanthenes
- C07D335/20—Thioxanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002024A ITMI20032024A1 (it) | 2003-10-17 | 2003-10-17 | Procedimento per la preparazione dello z-flupentixol |
| PCT/IB2004/003155 WO2005037820A1 (en) | 2003-10-17 | 2004-09-29 | Process for the preparation of z-flupentixol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1673365T3 true DK1673365T3 (da) | 2008-06-30 |
Family
ID=34452249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04769498T DK1673365T3 (da) | 2003-10-17 | 2004-09-29 | Fremgangsmåde til fremstillingen af Z-flupentixol |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1673365B1 (da) |
| CN (1) | CN1867558B (da) |
| AT (1) | ATE388949T1 (da) |
| CA (1) | CA2536667C (da) |
| CY (1) | CY1108121T1 (da) |
| DE (1) | DE602004012430T2 (da) |
| DK (1) | DK1673365T3 (da) |
| ES (1) | ES2302032T3 (da) |
| IT (1) | ITMI20032024A1 (da) |
| PL (1) | PL1673365T3 (da) |
| PT (1) | PT1673365E (da) |
| WO (1) | WO2005037820A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102002034B (zh) * | 2009-08-28 | 2012-11-28 | 江苏恩华药业股份有限公司 | 盐酸氟哌噻吨异构体的分离方法 |
| CN101912397B (zh) * | 2010-04-30 | 2013-03-27 | H.隆德贝克有限公司 | 氟哌噻吨组合物 |
| CN102786511B (zh) * | 2011-05-18 | 2014-10-15 | 重庆圣华曦药业股份有限公司 | 一种制备盐酸氟哌噻吨中间体的改进方法 |
| CN103450151B (zh) * | 2013-02-04 | 2014-07-30 | 四川海思科制药有限公司 | 一种氟哌噻吨化合物的制备方法 |
| CN105348256B (zh) * | 2015-11-16 | 2018-01-30 | 成都倍特药业有限公司 | 一种药用级盐酸氟哌噻吨的制备方法 |
| CN107382962B (zh) * | 2016-05-16 | 2020-11-03 | 江苏同禾药业有限公司 | 一种2-三氟甲基-9-烯丙基-9-噻吨醇的制备方法 |
| CN107987053B (zh) * | 2017-12-08 | 2023-04-14 | 植恩生物技术股份有限公司 | 一种高纯度z型盐酸氟哌噻吨的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1210890B (de) * | 1960-03-07 | 1966-02-17 | Smith & Kline & French Lab | Verfahren zur Herstellung von Trifluormethyl-xanthen- oder thioxanthenderivaten |
| US3282930A (en) * | 1962-08-17 | 1966-11-01 | Smith Kline French Lab | Hydroxyalkylenepiperazine derivatives and analogs thereof |
| US3681346A (en) * | 1969-06-20 | 1972-08-01 | Kefalas As | {60 -isomer of the decanoic acid ester of 10-{8 3,-(4-hydroxyethyl-1-piperazinyl)propylidene{9 -2-trifluoro-methyl thiaxanthene, acid addition salts thereof, method of use and compositions |
-
2003
- 2003-10-17 IT IT002024A patent/ITMI20032024A1/it unknown
-
2004
- 2004-09-29 EP EP04769498A patent/EP1673365B1/en active Active
- 2004-09-29 CA CA2536667A patent/CA2536667C/en not_active Expired - Fee Related
- 2004-09-29 DE DE602004012430T patent/DE602004012430T2/de active Active
- 2004-09-29 PT PT04769498T patent/PT1673365E/pt unknown
- 2004-09-29 AT AT04769498T patent/ATE388949T1/de active
- 2004-09-29 DK DK04769498T patent/DK1673365T3/da active
- 2004-09-29 PL PL04769498T patent/PL1673365T3/pl unknown
- 2004-09-29 CN CN2004800304514A patent/CN1867558B/zh active Active
- 2004-09-29 ES ES04769498T patent/ES2302032T3/es active Active
- 2004-09-29 WO PCT/IB2004/003155 patent/WO2005037820A1/en active IP Right Grant
-
2008
- 2008-06-06 CY CY20081100599T patent/CY1108121T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2536667A1 (en) | 2005-04-28 |
| WO2005037820A1 (en) | 2005-04-28 |
| CA2536667C (en) | 2012-01-10 |
| DE602004012430T2 (de) | 2009-03-05 |
| ATE388949T1 (de) | 2008-03-15 |
| CY1108121T1 (el) | 2014-02-12 |
| EP1673365A1 (en) | 2006-06-28 |
| ES2302032T3 (es) | 2008-07-01 |
| PT1673365E (pt) | 2008-05-20 |
| EP1673365B1 (en) | 2008-03-12 |
| PL1673365T3 (pl) | 2008-08-29 |
| ITMI20032024A1 (it) | 2005-04-18 |
| DE602004012430D1 (de) | 2008-04-24 |
| CN1867558A (zh) | 2006-11-22 |
| CN1867558B (zh) | 2013-02-06 |
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