MXPA05005103A - Compuesto de feromona dauer novedoso farmacologicamente activo para controlar envejecimiento y tension y metodo para aislar y caracterizar el mismo. - Google Patents

Compuesto de feromona dauer novedoso farmacologicamente activo para controlar envejecimiento y tension y metodo para aislar y caracterizar el mismo.

Info

Publication number
MXPA05005103A
MXPA05005103A MXPA05005103A MXPA05005103A MXPA05005103A MX PA05005103 A MXPA05005103 A MX PA05005103A MX PA05005103 A MXPA05005103 A MX PA05005103A MX PA05005103 A MXPA05005103 A MX PA05005103A MX PA05005103 A MXPA05005103 A MX PA05005103A
Authority
MX
Mexico
Prior art keywords
stress
isolating
pheromone compound
characterizing
extract
Prior art date
Application number
MXPA05005103A
Other languages
English (en)
Inventor
Ki Paik Young
Original Assignee
Kdr Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kdr Biotech Co Ltd filed Critical Kdr Biotech Co Ltd
Publication of MXPA05005103A publication Critical patent/MXPA05005103A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invencion describe un metodo para aislar y purificar en forma efectiva un compuesto de feromona dauer fisiologicamente activo que tiene la siguiente formula estructural I relacionada a envejecimiento y tension de C. elegans, y determinacion de la estructura de este material. Primero, se prepara extracto de etanol al concentrar en forma completa un medio liquido con metanol despues de cultivar C. elegans en un medio liquido basal S, y luego esta fraccion de etanol ademas se extrae con etilacetato. Despues se retiran impurezas del extracto de etil acetato por una columna de adsorcion de gel de silice y un extracto de feromona se aisla y purifica por procedimientos cromatograficos en columna de amina, utilizando diversos solventes como eluyente. Finalmente, un compuesto de feromona que tiene la formula estructural I se aisla y caracteriza completamente por HPLC con exclusion de tamano.
MXPA05005103A 2002-11-14 2003-10-07 Compuesto de feromona dauer novedoso farmacologicamente activo para controlar envejecimiento y tension y metodo para aislar y caracterizar el mismo. MXPA05005103A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020020070591A KR100700884B1 (ko) 2002-11-14 2002-11-14 약학적으로 유용한 노화 및 스트레스 조절용 신규 페로몬 화합물 및 그 분리정제방법
PCT/KR2003/002059 WO2004043944A1 (en) 2002-11-14 2003-10-07 Pharmacologically active novel dauer pheromone compound for controlling aging and stress and method for isolating and characterizing the same

Publications (1)

Publication Number Publication Date
MXPA05005103A true MXPA05005103A (es) 2005-09-30

Family

ID=36147023

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05005103A MXPA05005103A (es) 2002-11-14 2003-10-07 Compuesto de feromona dauer novedoso farmacologicamente activo para controlar envejecimiento y tension y metodo para aislar y caracterizar el mismo.

Country Status (13)

Country Link
US (1) US7119213B2 (es)
EP (1) EP1603894B1 (es)
JP (1) JP2006506420A (es)
KR (1) KR100700884B1 (es)
CN (1) CN1323078C (es)
AT (1) ATE404549T1 (es)
AU (1) AU2003265002A1 (es)
BR (1) BR0315265A (es)
CA (1) CA2462181A1 (es)
DE (1) DE60322969D1 (es)
MX (1) MXPA05005103A (es)
RU (1) RU2303596C2 (es)
WO (1) WO2004043944A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100556335B1 (ko) 2004-02-05 2006-03-03 정만길 6알-(3,6-디데옥시-엘-아라비노-헥소피라노실옥시)헵타노익산, 그 제조방법 및 그를 포함하는 장기휴면 유발효과
WO2013022985A2 (en) * 2011-08-08 2013-02-14 Boyce Thompson Institute For Plant Research Small molecule compounds for the control of nematodes
EP3563682A1 (en) 2011-08-08 2019-11-06 California Institute of Technology The utility of nematode small molecules
KR101384330B1 (ko) * 2012-01-17 2014-04-14 연세대학교 산학협력단 다우몬을 유효성분으로 함유하는 항염증용 약학적 조성물
WO2018039593A1 (en) 2016-08-25 2018-03-01 California Institute Of Technology Ascaroside treatment of eosinophilic esophagitis
EP3969460A4 (en) 2019-05-17 2023-03-08 California Institute Of Technology ASCAROSIDE DERIVATIVES AND METHODS OF USE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3227030B2 (ja) * 1993-06-10 2001-11-12 日東電工株式会社 生理活性δ−ラクトンの合成方法
JP4750232B2 (ja) 1998-01-21 2011-08-17 フィドゥラン ストレス、不安および攻撃性を低減するブタ鎮静フェロモン

Also Published As

Publication number Publication date
DE60322969D1 (de) 2008-09-25
US7119213B2 (en) 2006-10-10
RU2303596C2 (ru) 2007-07-27
AU2003265002A1 (en) 2004-06-03
BR0315265A (pt) 2005-08-23
ATE404549T1 (de) 2008-08-15
CN1323078C (zh) 2007-06-27
RU2005118102A (ru) 2006-01-20
EP1603894B1 (en) 2008-08-13
EP1603894A1 (en) 2005-12-14
JP2006506420A (ja) 2006-02-23
KR20040042338A (ko) 2004-05-20
CN1692107A (zh) 2005-11-02
KR100700884B1 (ko) 2007-03-29
US20050075389A1 (en) 2005-04-07
EP1603894A4 (en) 2006-09-27
WO2004043944A1 (en) 2004-05-27
CA2462181A1 (en) 2004-05-14

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