GB806691A - New alkaloids - Google Patents
New alkaloidsInfo
- Publication number
- GB806691A GB806691A GB1588255A GB1588255A GB806691A GB 806691 A GB806691 A GB 806691A GB 1588255 A GB1588255 A GB 1588255A GB 1588255 A GB1588255 A GB 1588255A GB 806691 A GB806691 A GB 806691A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ammonia
- alkaloids
- alkaloid
- benzene
- alkali
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930013930 alkaloid Natural products 0.000 title abstract 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 229910021529 ammonia Inorganic materials 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 2
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000011941 Tilia x europaea Nutrition 0.000 abstract 1
- 241001246889 Voacanga Species 0.000 abstract 1
- 240000004627 Voacanga thouarsii Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- TXHIDIHEXDFONW-UHFFFAOYSA-N benzene;propan-2-one Chemical compound CC(C)=O.C1=CC=CC=C1 TXHIDIHEXDFONW-UHFFFAOYSA-N 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 150000003840 hydrochlorides Chemical class 0.000 abstract 1
- 238000011221 initial treatment Methods 0.000 abstract 1
- 239000004571 lime Substances 0.000 abstract 1
- 239000000395 magnesium oxide Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises the cardiotonic product which is an alkaloid or mixture of alkaloids extracted from Voacanga africana or V. obtusa. The plant is subjected to treatment with alkali (e.g. ammonia, magnesia, lime or ammoniacal alcohol), the solution treated with an organic solvent (such as ether, benzene or a chlorinated derivative), the organic phase further extracted with a concentrated acid such as sulphuric or acetic and the alkaloid(s) finally precipitated with an alkali, e.g. ammonia or sodium carbonate. When alcohol-ammonia is used for the initial treatment the extract may be evaporated to dryness in vacuo before addition of the organic solvent. The mixture of alkaloids may be separated by chromatography on neutral alumina, the first product having M.P. 134-135 DEG C. and the second (eluted with benzene-acetone) having M.P. 225-230 DEG C. They may be converted into salts such as hydrochlorides or sulphates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1588255A GB806691A (en) | 1955-06-02 | 1955-06-02 | New alkaloids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1588255A GB806691A (en) | 1955-06-02 | 1955-06-02 | New alkaloids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB806691A true GB806691A (en) | 1958-12-31 |
Family
ID=10067232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1588255A Expired GB806691A (en) | 1955-06-02 | 1955-06-02 | New alkaloids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB806691A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003216279B2 (en) * | 2002-02-28 | 2009-11-12 | Mallinckrodt Inc. | Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography |
-
1955
- 1955-06-02 GB GB1588255A patent/GB806691A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003216279B2 (en) * | 2002-02-28 | 2009-11-12 | Mallinckrodt Inc. | Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography |
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