GB933657A - Process for the preparation of aescin isomers - Google Patents

Process for the preparation of aescin isomers

Info

Publication number
GB933657A
GB933657A GB2153861A GB2153861A GB933657A GB 933657 A GB933657 A GB 933657A GB 2153861 A GB2153861 A GB 2153861A GB 2153861 A GB2153861 A GB 2153861A GB 933657 A GB933657 A GB 933657A
Authority
GB
United Kingdom
Prior art keywords
aescin
isomers
preparation
free acid
acid form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2153861A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Publication of GB933657A publication Critical patent/GB933657A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention comprises a - and b -aescin, m-pts 225-7 DEG C. and 222-3 DEG C. respectively, and a process for their preparation by converting natural horse chestnut aescin (prepared by the method of Specification 929,816) into the free acid form, preferably by means of an ion exchanger, maintaining a solution of the aescin in its free acid form at 50-90 DEG C. until precipitation of the b -aescin is complete, separating the dissolved a -aescin and precipitated b -aescin fractions. The isomers are then isolated by drying in vacuo, if desired with use of drying agents, at temperatures below 100 DEG C. Detailed examples illustrate the isolation procedure. The isomers possess the same qualitative haemolytic effect as natural aescin, but the haemolytic indices are 1:20,000 and 1:40,000 for a - and b -aescin respectively.
GB2153861A 1960-06-14 1961-06-14 Process for the preparation of aescin isomers Expired GB933657A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEC21671A DE1125117B (en) 1960-06-14 1960-06-14 Process for the production of two AEscin isomers from extracts of the horse chestnut

Publications (1)

Publication Number Publication Date
GB933657A true GB933657A (en) 1963-08-08

Family

ID=7017049

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2153861A Expired GB933657A (en) 1960-06-14 1961-06-14 Process for the preparation of aescin isomers

Country Status (5)

Country Link
BE (1) BE604947A (en)
CH (1) CH411235A (en)
DE (1) DE1125117B (en)
GB (1) GB933657A (en)
LU (1) LU40248A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH686556A5 (en) * 1994-07-14 1996-04-30 Flachsmann Ag Emil Process for the preparation of pesticide-poor concentrates of active ingredient from plants.

Also Published As

Publication number Publication date
LU40248A1 (en) 1961-08-12
CH411235A (en) 1966-04-15
BE604947A (en) 1961-12-13
DE1125117B (en) 1962-03-08

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