IL163759A0 - Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography - Google Patents

Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography

Info

Publication number
IL163759A0
IL163759A0 IL16375903A IL16375903A IL163759A0 IL 163759 A0 IL163759 A0 IL 163759A0 IL 16375903 A IL16375903 A IL 16375903A IL 16375903 A IL16375903 A IL 16375903A IL 163759 A0 IL163759 A0 IL 163759A0
Authority
IL
Israel
Prior art keywords
narcotic
alkaloid
purification
separation
narcotic alkaloid
Prior art date
Application number
IL16375903A
Other languages
English (en)
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of IL163759A0 publication Critical patent/IL163759A0/xx

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/283—Porous sorbents based on silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/287—Non-polar phases; Reversed phases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
IL16375903A 2002-02-28 2003-02-18 Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography IL163759A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36032102P 2002-02-28 2002-02-28
US43459702P 2002-12-16 2002-12-16
PCT/US2003/004498 WO2003074526A2 (en) 2002-02-28 2003-02-18 Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography

Publications (1)

Publication Number Publication Date
IL163759A0 true IL163759A0 (en) 2005-12-18

Family

ID=27791639

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16375903A IL163759A0 (en) 2002-02-28 2003-02-18 Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography
IL163759A IL163759A (en) 2002-02-28 2004-08-26 Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL163759A IL163759A (en) 2002-02-28 2004-08-26 Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography

Country Status (12)

Country Link
US (1) US7671203B2 (xx)
EP (1) EP1487838B1 (xx)
JP (1) JP2005522460A (xx)
CN (1) CN1639166A (xx)
AT (1) ATE407136T1 (xx)
AU (1) AU2003216279B2 (xx)
CA (1) CA2477739A1 (xx)
DE (1) DE60323345D1 (xx)
ES (1) ES2312798T3 (xx)
IL (2) IL163759A0 (xx)
MX (1) MXPA04008213A (xx)
WO (1) WO2003074526A2 (xx)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1771080B (zh) * 2003-04-08 2010-12-15 诺沃挪第克公司 包括至少一个色谱处理步骤的生产治疗用多肽或其前体的方法
CA2544195A1 (en) * 2003-10-29 2005-05-19 Enrico A. Antonini Industrial method for separation and purification of fentanyl by reverse phase preparative chromatography
MXPA06014107A (es) 2004-06-08 2007-03-07 Mallinckrodt Inc Extraccion de alcaloides del opio.
ATE461199T1 (de) 2004-10-27 2010-04-15 Mallinckrodt Inc Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie
WO2006135650A1 (en) * 2005-06-09 2006-12-21 Mallinckrodt Inc. Method for separation and purification of naltrexone by preparative chromatography
US8541647B2 (en) 2008-05-29 2013-09-24 Tasmania Alkaloids Pty, Ltd. Papaver somniferum with high concentration of codeine
IT1396543B1 (it) * 2008-07-16 2012-12-14 Farmabios Spa Processo per la purificazione di bloccanti neuromuscolari
WO2011005452A1 (en) * 2009-07-09 2011-01-13 Mallinckrodt Inc. Method for the enrichment of buprenorphine using chromatographic techniques
EP2673065B1 (en) * 2011-02-10 2015-12-09 Academisch Ziekenhuis Leiden Acting Under The Name Leiden University Medical Center Method for the purification of a glycan and/or a glycoconjugate by chromatography using a stationary phase comprising cotton
TWI414340B (zh) 2011-05-04 2013-11-11 Ind Tech Res Inst 高壓萃取設備及其萃取方法
JP2015518956A (ja) * 2012-05-08 2015-07-06 ダウ コーニング コーポレーションＤｏｗ Ｃｏｒｎｉｎｇ Ｃｏｒｐｏｒａｔｉｏｎ クロマトグラフィーを用いるクロロシランの精製
CN103505909B (zh) * 2012-06-21 2018-02-13 通用电气健康护理生物科学股份公司 层析柱框架和对层析柱进行维护和填充的方法
RU2015114330A (ru) 2012-09-17 2016-11-10 У.Р. Грейс Энд Ко.-Конн. Хроматографические среды и устройства
EP2970320B1 (en) 2013-03-15 2020-10-28 Johnson Matthey Public Limited Company Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain
CA2851112A1 (en) 2013-05-06 2014-11-06 Tomas Hudlicky Methods and apparatus for time-pulsed chromatography
CN104415573B (zh) * 2013-09-10 2017-03-22 中国科学院大连化学物理研究所 一种延胡索提取物中叔胺碱和季铵碱的分类制备方法
US10571441B2 (en) * 2013-12-09 2020-02-25 Ge Healthcare Bio-Sciences Ab Piston and process column
EP3137209B1 (en) 2014-05-02 2022-10-05 W.R. Grace & CO. - CONN. Functionalized support material and methods of making and using functionalized support material
US10422776B2 (en) * 2014-05-09 2019-09-24 Waters Technologies Corporation Methods for preparing liquid mixtures
CN105777766B (zh) * 2014-12-15 2017-11-24 北大方正集团有限公司 Delta‑7溴甲纳曲酮的制备方法
PL3302784T3 (pl) 2015-06-05 2022-01-17 W.R. Grace & Co.-Conn. Adsorbentowe środki klarujące do bioprzetwarzania oraz sposoby ich wytwarzania i stosowania
CN109689177B (zh) * 2016-06-10 2021-11-02 瑞普利金公司 层析柱填充介质回收法
CN106621461B (zh) * 2016-12-13 2018-10-02 北京科技大学 一种基于层析原理的高效分离装置
CN110256505B (zh) * 2019-06-13 2020-09-18 中国农业科学院饲料研究所 长裂苦苣菜生物碱初级分离物及其分离方法和应用
CN110698488B (zh) * 2019-09-20 2022-05-13 甘肃省药物碱厂 一种从罂粟壳中提取分离吗啡的方法
CN111157638A (zh) * 2019-12-31 2020-05-15 济南康和医药科技有限公司 一种检测维生素c中草酸含量的方法
IL298561A (en) 2020-06-17 2023-01-01 Psilo Scientific Ltd Methanol-based extraction of psychoactive compounds from a mushroom
CA3113240C (en) 2020-12-28 2023-09-05 Psilo Scientific Ltd. Transmucosal psychoactive alkaloid composition and preparation thereof
CN113075326B (zh) * 2021-03-31 2024-03-15 周迎春 一种利用液质联用-内标法快速测定罂粟壳生物碱的方法
US20220395767A1 (en) * 2021-06-15 2022-12-15 Perkinelmer Health Sciences, Inc. Enhancing lcms analyte signals
CN113274764B (zh) * 2021-06-18 2022-04-05 中触媒新材料股份有限公司 一种液相吸附分离系统及其控温工艺方法

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB773467A (en) 1954-08-16 1957-04-24 Merck & Co Inc Morphine alkaloids
GB786138A (en) * 1955-02-04 1957-11-13 Sandoz Ltd New ergot alkaloid derivatives and process of making same
GB806691A (en) * 1955-06-02 1958-12-31 Sorelux S A New alkaloids
GB806692A (en) * 1955-06-30 1958-12-31 Sorelux S A New alkaloids
GB865687A (en) * 1957-06-21 1961-04-19 Geigy Ag J R New alkaloid, voacamidine from voacanga africana and a process for its isolation
GB890614A (en) 1957-08-16 1962-03-07 Oletta S A A novel alkaloid
FR2105140B1 (xx) * 1970-09-30 1974-06-21 Forschag
IT1118225B (it) 1977-08-12 1986-02-24 Simes Procedimento per l'ottenimento di steroidi poliossidrilati,lisergolo ed alcaloidi ergolici
US4189583A (en) 1978-04-26 1980-02-19 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis of 4A-aryl-decahydroisoquinolines
FR2460955A1 (fr) 1979-07-10 1981-01-30 Fabre Sa Pierre Procede de preparation de l'ergotamine et des alcaloides du groupe ergotoxine
US4277604A (en) 1980-01-25 1981-07-07 The United States Of America As Represented By The Department Of Health And Human Services Facile synthesis of codeine precursors from thebaine
US4514569A (en) 1982-01-28 1985-04-30 Hendrickson James B Synthesis of 1-substituted isoquinolines
BE901141A (fr) 1983-12-02 1985-05-28 Groupe Ind De Realisations Et Perfectionnements aux appareils de chromatographie.
US4798792A (en) 1985-09-09 1989-01-17 E. I. Du Pont De Nemours And Company Bacterial hydroxylation of codeine
US4769452A (en) 1986-02-07 1988-09-06 Vipont Laboratories, Inc. Production of purity benzo-c-phenanthridine alkaloid salts
US4749787A (en) * 1986-10-23 1988-06-07 Harbor Branch Oceanographic Institution, Inc. Process of isolating vinblastine from the plant catharanthis roseus
DE3679327D1 (de) 1986-11-25 1991-06-20 Council Scient Ind Res Verfahren zur herstellung von codein aus morphin.
US4831133A (en) 1987-05-01 1989-05-16 Allelix, Inc. Extraction of alkaloids of Catharanthus roseus tissue
US5196351A (en) 1987-09-30 1993-03-23 Beckman Instruments, Inc. Bidentate conjugate and method of use thereof
US5534620A (en) 1987-09-30 1996-07-09 Beckman Instruments, Inc. Method of heterogenous purification using a bidentate conjugate
CH675685A5 (xx) 1988-06-24 1990-10-31 Flachsmann Ag Emil
US4956429A (en) 1989-03-01 1990-09-11 Penick Corporation Method of making a coca leaf flavor extract
US5133981A (en) 1989-11-17 1992-07-28 Atrix Laboratories, Inc. Purification of benzophenanthridine alkaloids extracts from alkaloid extracts
US5039804A (en) 1989-12-13 1991-08-13 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
DE4002784C1 (xx) 1990-01-31 1991-04-18 B.A.T. Cigarettenfabriken Gmbh, 2000 Hamburg, De
DE4016760A1 (de) 1990-05-25 1991-11-28 Merck Patent Gmbh Chromatographieanlagen
GB2248029A (en) 1990-09-19 1992-03-25 Amicon Ltd Chromatography system.
US5230802A (en) 1991-05-15 1993-07-27 Philip Morris Incorporated Extraction process using a novel organic acid as a liquid ion exchanger
GB9213524D0 (en) 1992-06-25 1992-08-12 Macfarlan Smith Ltd Biocatalysis in the synthesis of analgesic and antitussive compounds
US5352789A (en) 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5527913A (en) 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
CZ281174B6 (cs) 1993-08-13 1996-07-17 Galena, A.S. Způsob přípravy 3,14ß-dihydroxy-17-normorfinanu
AT400950B (de) 1994-02-04 1996-04-25 Immodal Pharmaka Gmbh Verfahren zur technischen herstellung definierter isomerengemische aus verbindungen mit spirozyklischen - aminocarboxyl- und/oder spirozyklischen - aminocarbonyl-systemen
GB9406423D0 (en) 1994-03-31 1994-05-25 Ici Plc Solvent extraction process
US5578725A (en) 1995-01-30 1996-11-26 Regents Of The University Of Minnesota Delta opioid receptor antagonists
AU678929B2 (en) 1995-03-06 1997-06-12 Frutarom Schweiz Ag A process for the removal of undesired lipophilic contaminations and/or residues, which are contained in beverages or in vegetable preparations
DE19535762A1 (de) 1995-09-26 1997-03-27 Basf Ag Verfahren zur Racematspaltung
US6054584A (en) 1996-11-19 2000-04-25 The Board Of Regents Of The University And Community College System Of Neveda Process for extracting and purifying morphine from opium
US5981750A (en) 1995-11-21 1999-11-09 The Board Of Regents Of The University And Community College System Of Nevada Solid-phase synthesis of codeine from morphine
DE69729828T2 (de) 1996-02-29 2005-07-14 Varian, Inc., Palo Alto Zusammenschiebbare vorrichtung zur kompression von packungsmaterial in flüssigkeitschromatographiekolonnen und verfahren zu ihrer benutzung
US5667675A (en) 1996-02-29 1997-09-16 Varian Associate, Inc. Collapsible apparatus for compressing packing material in liquid chromatography columns and methods of use
US5908927A (en) * 1996-05-22 1999-06-01 High Standard Products Corporation Synthesis of deuterated opiate glucuronides
US6067749A (en) 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
GB9713703D0 (en) 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
DE19743176A1 (de) 1997-09-30 1999-04-01 Knoell Hans Forschung Ev Verfahren zur Auftrennung komplexer Substanzgemische mittels Festphasenextraktion zur Anwendung in der Wirkstoffsuche und für analytische Zwecke
US6265542B1 (en) 1997-10-24 2001-07-24 Genentech, Inc. Purification of molecules
US6057161A (en) * 1997-10-27 2000-05-02 Varian, Inc. Method for determination of drugs of abuse in biological samples
AUPP132198A0 (en) 1998-01-14 1998-02-05 Tasmanian Alkaloids Pty Ltd Improved production of reticuline
GB9805516D0 (en) 1998-03-17 1998-05-13 Johnson Matthey Plc Preparation of opiates
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
US6054585A (en) 1998-12-23 2000-04-25 Sabinsa Corporation Process for making high purity piperine for nutritional use
US6166211A (en) * 1999-03-19 2000-12-26 Endo Pharmaceuticals, Inc. Sequential benzylic oxidations of the naloxone ring system
AUPP946399A0 (en) 1999-03-26 1999-04-22 Johnson & Johnson Research Pty. Limited Codeinone reductase from alkaloid poppy
US6262265B1 (en) * 1999-06-18 2001-07-17 Microgenics Corporation Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay
US6218541B1 (en) 1999-06-28 2001-04-17 Cba, International, Inc. Method for extracting bisbenzylisoquinolines
US6395915B1 (en) 1999-09-10 2002-05-28 Technikrom, Inc. Method for producing purified tocotrienols and tocopherols using liquid chromatography
US6500840B2 (en) 2000-08-21 2002-12-31 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease

Also Published As

Publication number Publication date
EP1487838A2 (en) 2004-12-22
CA2477739A1 (en) 2003-09-12
WO2003074526A2 (en) 2003-09-12
US7671203B2 (en) 2010-03-02
CN1639166A (zh) 2005-07-13
WO2003074526A3 (en) 2003-12-04
ATE407136T1 (de) 2008-09-15
US20050182257A1 (en) 2005-08-18
EP1487838B1 (en) 2008-09-03
AU2003216279B2 (en) 2009-11-12
JP2005522460A (ja) 2005-07-28
ES2312798T3 (es) 2009-03-01
DE60323345D1 (de) 2008-10-16
MXPA04008213A (es) 2005-05-16
AU2003216279A1 (en) 2003-09-16
IL163759A (en) 2010-02-17

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