AU2001237736A1 - Method and apparatus for preparing taxol using supercritical fluid from source materials - Google Patents

Method and apparatus for preparing taxol using supercritical fluid from source materials

Info

Publication number
AU2001237736A1
AU2001237736A1 AU2001237736A AU3773601A AU2001237736A1 AU 2001237736 A1 AU2001237736 A1 AU 2001237736A1 AU 2001237736 A AU2001237736 A AU 2001237736A AU 3773601 A AU3773601 A AU 3773601A AU 2001237736 A1 AU2001237736 A1 AU 2001237736A1
Authority
AU
Australia
Prior art keywords
supercritical fluid
source materials
preparing taxol
taxol
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001237736A
Inventor
Young Hae Choi
Joo Hee Han
Jin Woong Kim
Min Jeong Noh
Ki Pung Yoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanwha Chemical Corp
Original Assignee
Hanwha Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanwha Chemical Corp filed Critical Hanwha Chemical Corp
Publication of AU2001237736A1 publication Critical patent/AU2001237736A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods for isolating taxol and derivatives thereof with high purity are described. The methods include a supercritical fluid and a cosolvent extraction step, a liquid-liquid separation step, and a column chromatography step. An apparatus for isolating Taxol and derivatives thereof that allows the method steps to be performed online also is described.
AU2001237736A 2000-02-25 2001-02-24 Method and apparatus for preparing taxol using supercritical fluid from source materials Abandoned AU2001237736A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR009255 2000-02-25
KR1020000009255A KR100666652B1 (en) 2000-02-25 2000-02-25 Method for preparing taxol using supercritical fluid from plant
PCT/KR2001/000282 WO2001062753A1 (en) 2000-02-25 2001-02-24 Method and apparatus for preparing taxol using supercritical fluid from source materials

Publications (1)

Publication Number Publication Date
AU2001237736A1 true AU2001237736A1 (en) 2001-09-03

Family

ID=19649887

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001237736A Abandoned AU2001237736A1 (en) 2000-02-25 2001-02-24 Method and apparatus for preparing taxol using supercritical fluid from source materials

Country Status (8)

Country Link
US (1) US6503396B2 (en)
EP (1) EP1261596B1 (en)
KR (1) KR100666652B1 (en)
CN (1) CN1205197C (en)
AT (1) ATE359280T1 (en)
AU (1) AU2001237736A1 (en)
DE (1) DE60127820T2 (en)
WO (1) WO2001062753A1 (en)

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US6648609B2 (en) * 2002-04-05 2003-11-18 Berger Instruments, Inc. Pump as a pressure source for supercritical fluid chromatography involving pressure regulators and a precision orifice
KR100508518B1 (en) * 2002-11-13 2005-08-17 한미약품 주식회사 Method for the preparation of paclitaxel solid dispersion by using the supercritical fluid process and paclitaxel solid dispersion prepared thereby
WO2005087338A1 (en) * 2004-03-16 2005-09-22 UNIVERSITé LAVAL Process for extraction of diterpenes and triterpenes from biomaterial
US7169307B2 (en) * 2004-09-02 2007-01-30 Jian Liu Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
US20060074254A1 (en) * 2004-09-30 2006-04-06 Zisheng Zhang Process for extracting taxanes
EP1792542A1 (en) * 2005-12-02 2007-06-06 SCF Technologies A/S A method for producing a prepared food product having a reduced content of species
WO2007092827A2 (en) * 2006-02-08 2007-08-16 Waters Investments Limited Improved separation method
EP1818328A1 (en) * 2006-02-10 2007-08-15 6570763 Canada Inc. Chromatographic method for the isolation and purification of taxane derivatives
JP5060791B2 (en) * 2007-01-26 2012-10-31 独立行政法人森林総合研究所 Method for drying wood, method for penetrating chemicals into wood and drying apparatus
US9163618B2 (en) 2008-06-24 2015-10-20 Agilent Technologies, Inc. Automated conversion between SFC and HPLC
US8215922B2 (en) 2008-06-24 2012-07-10 Aurora Sfc Systems, Inc. Compressible fluid pumping system for dynamically compensating compressible fluids over large pressure ranges
US8419936B2 (en) * 2010-03-23 2013-04-16 Agilent Technologies, Inc. Low noise back pressure regulator for supercritical fluid chromatography
US8293111B2 (en) * 2010-05-17 2012-10-23 Uti Limited Partnership Apparatus, system, and method for chromatography using a water stationary phase
EP2616155B1 (en) * 2010-09-15 2015-08-12 BASF Plant Science Company GmbH Extraction device and method for extracting ingredients from a biological sample
WO2012071385A1 (en) 2010-11-23 2012-05-31 Lexington Pharmaceutical Laboratories, Llc Low temperature chlorination of carbohydrates
CN102649776A (en) * 2011-02-25 2012-08-29 苏州宝泽堂医药科技有限公司 Method for preparing lappaconitine
MX342969B (en) 2011-10-14 2016-10-20 Lexington Pharmaceuticals Laboratories Llc Chlorination of carbohydrates and carbohydrate derivatives.
CN103030673B (en) * 2012-12-31 2015-07-22 浙江大学宁波理工学院 Method for extracting myricetin-3-O-rutinose from taxus mairei leaves
US9745269B2 (en) 2013-03-15 2017-08-29 Cba Pharma, Inc. Supercritical fluid extraction of bis-benzyl isoquinolines
CN104059034A (en) * 2014-06-06 2014-09-24 庞作仁 Production system and process for nontoxically extracting taxol through ultrasonic wave countercurrent extraction
US10857482B1 (en) * 2016-12-07 2020-12-08 Rien Havens Botanical super heated processing equipment
CN110305079A (en) * 2019-06-12 2019-10-08 苏州岚云医药科技有限公司 A kind of anticancer drug supercritical fluid extraction method of purification
US12023601B2 (en) * 2019-09-09 2024-07-02 Alden Botanica LLC Carbon dioxide extraction processes, devices, methods, and systems
US20220315859A1 (en) * 2019-09-13 2022-10-06 Dalrada Health Products Plant oil extraction device
CN112979594B (en) * 2021-02-26 2021-12-14 南通科鑫超临界设备有限公司 Supercritical extraction process of andrographolide
CN113896695B (en) * 2021-05-26 2023-12-01 四川杉宝生物科技有限公司 Method for simultaneously extracting cephalomannine and taxol from Taxus media
CN113831306A (en) * 2021-09-30 2021-12-24 王强 Supercritical CO2Method for extracting paclitaxel by fluid extraction

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US4683063A (en) * 1985-05-08 1987-07-28 Vitamins, Inc. Method for carrying out extractions in subterranean well
US4898673A (en) * 1987-07-11 1990-02-06 Vitamins, Inc. Dynamic supercritical fluid extraction system
US5019504A (en) 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5380916A (en) 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
JP3222466B2 (en) * 1991-04-19 2001-10-29 ザ・ユニバーシティ・オブ・ミシシッピー Methods and compositions for isolating taxanes
CA2072400C (en) * 1991-07-05 2003-08-19 Jayaprakash B. Nair Supercritical extraction of taxanes
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
KR0133947B1 (en) 1992-09-15 1998-04-22 윤종용 Voice channel changer
US5854064A (en) * 1996-07-31 1998-12-29 Aphios Corporation Methods for fractionation of biologically-derived materials
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
KR0132275B1 (en) * 1994-04-14 1998-04-17 한동근 Method and apparatus for extracting and purifying taxol by counter current-type super critical fluid extraction
KR100278917B1 (en) 1994-11-21 2001-01-15 김영환 Method for manufacturing contact mask of semiconductor device
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
KR100208656B1 (en) * 1996-11-19 1999-07-15 변상요 Apparatus for manufacturing taxol by online continuous process of extraction and purification using supercritical fluid
CN1099899C (en) 1997-12-31 2003-01-29 孙传经 Commercial scale supercritical carbon dioxide prepn. chromatography and use thereof
US6136989A (en) * 1998-12-30 2000-10-24 Phytogen Life Sciences, Incorporated Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US6291241B1 (en) * 1999-03-29 2001-09-18 Trevor Percival Castor Methods for making Hypericum fractions and St. John's Wort products

Also Published As

Publication number Publication date
US20020000410A1 (en) 2002-01-03
CN1406235A (en) 2003-03-26
KR20010084323A (en) 2001-09-06
KR100666652B1 (en) 2007-01-09
EP1261596B1 (en) 2007-04-11
EP1261596A4 (en) 2004-06-30
US6503396B2 (en) 2003-01-07
CN1205197C (en) 2005-06-08
WO2001062753A1 (en) 2001-08-30
ATE359280T1 (en) 2007-05-15
DE60127820T2 (en) 2007-12-27
EP1261596A1 (en) 2002-12-04
DE60127820D1 (en) 2007-05-24

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