DE60022280D1 - Verfahren zu Herstellung von gereinigte Tocotrienolen und Tocopherolen mit Hilfe von Flüssigechromatographie - Google Patents

Verfahren zu Herstellung von gereinigte Tocotrienolen und Tocopherolen mit Hilfe von Flüssigechromatographie

Info

Publication number
DE60022280D1
DE60022280D1 DE60022280T DE60022280T DE60022280D1 DE 60022280 D1 DE60022280 D1 DE 60022280D1 DE 60022280 T DE60022280 T DE 60022280T DE 60022280 T DE60022280 T DE 60022280T DE 60022280 D1 DE60022280 D1 DE 60022280D1
Authority
DE
Germany
Prior art keywords
tocopherols
tocotrienols
liquid chromatography
preparation
chromatography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60022280T
Other languages
English (en)
Other versions
DE60022280T2 (de
Inventor
Louis Bellafiore
Kevin Henretta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hygeia Industries Inc
Original Assignee
Technikrom Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technikrom Inc filed Critical Technikrom Inc
Publication of DE60022280D1 publication Critical patent/DE60022280D1/de
Application granted granted Critical
Publication of DE60022280T2 publication Critical patent/DE60022280T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60022280T 1999-09-10 2000-09-11 Verfahren zu Herstellung von gereinigte Tocotrienolen und Tocopherolen mit Hilfe von Flüssigechromatographie Expired - Lifetime DE60022280T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15330899P 1999-09-10 1999-09-10
US153308P 1999-09-10

Publications (2)

Publication Number Publication Date
DE60022280D1 true DE60022280D1 (de) 2005-10-06
DE60022280T2 DE60022280T2 (de) 2006-06-22

Family

ID=22546645

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60022280T Expired - Lifetime DE60022280T2 (de) 1999-09-10 2000-09-11 Verfahren zu Herstellung von gereinigte Tocotrienolen und Tocopherolen mit Hilfe von Flüssigechromatographie

Country Status (5)

Country Link
US (1) US6395915B1 (de)
EP (1) EP1083174B1 (de)
JP (1) JP2001122869A (de)
AT (1) ATE303375T1 (de)
DE (1) DE60022280T2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY127451A (en) * 1999-11-04 2006-12-29 Malaysian Palm Oil Board A method of chromatographic isolation for vitamin e isomers
JP2002153702A (ja) * 2000-11-21 2002-05-28 Japan Organo Co Ltd トコトリエノ−ルのクロマト分取法
WO2003037884A2 (en) 2001-09-19 2003-05-08 Archer-Daniels-Midland Company Process for separation of tocopherols
DE60323345D1 (de) 2002-02-28 2008-10-16 Mallinckrodt Inc Verfahren und system zur trennung und aufreinigung wenigstens eines narkotischen alkaloids unter anwendung von präparativer umkehrphasenchromatographie
NO319618B1 (no) * 2002-07-05 2005-09-05 Norsk Hydro As Fiskefôr som inneholder tokotrienol for a forbedre stabiliteten og pigmentfordelingen i fiskefilet og bearbeidede fiskeprodukter.
US7072742B1 (en) 2003-10-17 2006-07-04 Technikrom, Inc. Accurate blending module and method
US8271139B2 (en) * 2003-10-17 2012-09-18 Asahi Kasei Bioprocess, Inc. Multi-stage accurate blending system and method
US7515994B2 (en) * 2003-10-17 2009-04-07 Technikrom, Inc. Accurate blending module and method
EP1714695B9 (de) * 2005-04-18 2010-09-22 Asahi Kasei Bioprocess, Inc. Automatisierte Syntheseeinrichtung und Verfahren
PL1888059T3 (pl) 2005-06-01 2015-06-30 Bioelectron Tech Corp Środki terapeutyczne aktywne wobec układów redoks do leczenia chorób mitochondrialnych i innych zaburzeń oraz modulacja biomarkerów energetycznych
US20070021497A1 (en) * 2005-07-11 2007-01-25 The Fruitful Yield Vitamin e compositions
JP5374162B2 (ja) 2006-02-22 2013-12-25 エジソン ファーマシューティカルズ， インコーポレイテッド ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節
MX2011002318A (es) 2008-09-10 2011-05-10 Edison Pharmaceuticals Inc Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox.
PT2963006T (pt) 2008-10-28 2018-12-14 Bioelectron Tech Corp Composição contendo alfa-tocotrienol quinona e seus intermediários
EP2424495B1 (de) 2009-04-28 2018-01-17 Bioelectron Technology Corporation Behandlung von erblicher leber-optikus-neuropathie und dominanter optikus-neuropathie mit tocotrienol-chinonen
JP2012531411A (ja) 2009-06-25 2012-12-10 アンペア ライフ サイエンシーズ，インコーポレイテッド トコトリエノールまたはトコトリエノール濃縮抽出物を用いた広汎性発達障害の処置
WO2013013078A1 (en) 2011-07-19 2013-01-24 Edison Pharmeceuticals, Inc. Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
US9039898B2 (en) 2011-11-15 2015-05-26 Engineering Research Associates, Inc. Method for separating components in natural oil
US8937191B2 (en) * 2012-12-20 2015-01-20 Orochem Technologies, Inc. Recovery of highly pure alpha-tocotrienol from crude palm oil extract
JP2016530333A (ja) * 2013-09-13 2016-09-29 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー 放射線の影響から防護するため及び放射線の影響を緩和するための組成物の調製及び使用
US9512098B1 (en) 2014-02-03 2016-12-06 Board Of Trustees Of The University Of Arkansas Process of producing purified gamma- and delta-tocotrienols from tocol-rich oils or distillates
CN104262315A (zh) * 2014-09-05 2015-01-07 宁波大红鹰生物工程股份有限公司 一种生育三烯酚的分离提纯方法
US20160324914A1 (en) 2015-05-05 2016-11-10 Tocol Pharmaceuticals, Llc Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation
WO2017039673A1 (en) * 2015-09-03 2017-03-09 Hygeia Industries, Inc. Improved method for preparative and commercial scale reverse phase liquid chromatography
CN106632210B (zh) * 2015-11-03 2019-05-03 浙江医药股份有限公司新昌制药厂 从母育酚中分离纯化制备高纯度生育三烯酚的方法
WO2017106786A1 (en) 2015-12-16 2017-06-22 Bioelectron Technology Corporation Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
CA3008849A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
CA3039158C (fr) 2016-10-21 2023-09-26 Novasep Process Utilisation de gaz comprime pour le deplacement d'eluant applique a la chromatographie
CN113884605B (zh) * 2021-10-14 2023-06-16 安徽科技学院 一种土壤酚类物质用分级式高效分离纯化方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4122094A (en) 1976-06-09 1978-10-24 Lever Brothers Company Separation of the isomers of tocopherol by liquid/solid chromatography
GB2113503B (en) * 1981-12-30 1985-05-09 Plessey Co Plc Electro-acoustic transducers
JPH029875A (ja) 1988-03-16 1990-01-12 Bio Ind Kyokai トコフェロール及びトコトリエノールの製造方法
US5157132A (en) 1990-05-18 1992-10-20 Carotech Associates Integrated process for recovery of carotenoids and tocotrienols from oil
BR9106474A (pt) 1990-05-23 1993-05-18 Lipogenics Inc Processos para recuperacao de compostos tocotrienois,tocolerois e semelhantes a tocotrienol
BR9907278A (pt) 1998-01-29 2000-10-24 Eastman Chem Co Processos para separar um tocotrienol de uma primeira mistura de tocol, e, composição
US6706898B2 (en) 1998-01-29 2004-03-16 Archer-Daniels-Midland Company Methods for separating a tocopherol from a tocopherol-containing mixture

Also Published As

Publication number Publication date
ATE303375T1 (de) 2005-09-15
JP2001122869A (ja) 2001-05-08
EP1083174B1 (de) 2005-08-31
US6395915B1 (en) 2002-05-28
EP1083174A1 (de) 2001-03-14
DE60022280T2 (de) 2006-06-22

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HYGEIA INDUSTRIES, INC.,, EVANSTON, III, US