PT920447E - Processo para a purificacao de ciclosporinas - Google Patents
Processo para a purificacao de ciclosporinasInfo
- Publication number
- PT920447E PT920447E PT98913969T PT98913969T PT920447E PT 920447 E PT920447 E PT 920447E PT 98913969 T PT98913969 T PT 98913969T PT 98913969 T PT98913969 T PT 98913969T PT 920447 E PT920447 E PT 920447E
- Authority
- PT
- Portugal
- Prior art keywords
- silica gel
- column filled
- cyclosporins
- purification
- cyclosporin
- Prior art date
Links
- 229930182912 cyclosporin Natural products 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 108010036941 Cyclosporins Proteins 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 2
- 229930105110 Cyclosporin A Natural products 0.000 abstract 2
- 108010036949 Cyclosporine Proteins 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 229960001265 ciclosporin Drugs 0.000 abstract 2
- 239000000741 silica gel Substances 0.000 abstract 2
- 229910002027 silica gel Inorganic materials 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Saccharide Compounds (AREA)
- Silicon Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9700645A HU223054B1 (hu) | 1997-03-25 | 1997-03-25 | Tisztítási eljárás nagytisztaságú ciklosporin A előállítására |
Publications (1)
Publication Number | Publication Date |
---|---|
PT920447E true PT920447E (pt) | 2002-11-29 |
Family
ID=89994909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT98913969T PT920447E (pt) | 1997-03-25 | 1998-03-23 | Processo para a purificacao de ciclosporinas |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0920447B1 (pt) |
JP (1) | JP2000511939A (pt) |
AT (1) | ATE223434T1 (pt) |
AU (1) | AU737260B2 (pt) |
BG (1) | BG64215B1 (pt) |
CA (1) | CA2255062C (pt) |
CZ (1) | CZ293687B6 (pt) |
DE (1) | DE69807635T2 (pt) |
DK (1) | DK0920447T3 (pt) |
ES (1) | ES2180159T3 (pt) |
HK (1) | HK1020740A1 (pt) |
HU (1) | HU223054B1 (pt) |
IL (1) | IL126871A0 (pt) |
NO (1) | NO322211B1 (pt) |
NZ (1) | NZ332718A (pt) |
PL (1) | PL194252B1 (pt) |
PT (1) | PT920447E (pt) |
RU (1) | RU2182577C2 (pt) |
SK (1) | SK283672B6 (pt) |
UA (1) | UA58511C2 (pt) |
WO (1) | WO1998042734A1 (pt) |
YU (1) | YU49468B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2151450A1 (de) * | 2008-07-29 | 2010-02-10 | Sandoz AG | Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden |
DE102009037551A1 (de) * | 2009-08-17 | 2011-02-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Cyclosporinderivate |
HUP1500502A2 (en) * | 2015-10-26 | 2017-04-28 | Rotachrom Tech Kft | Process for the purification of cyclosporin-a |
CN114653350A (zh) * | 2022-02-25 | 2022-06-24 | 江苏九阳生物制药有限公司 | 一种环孢素a层析硅胶的再生方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU213553B (en) * | 1992-05-25 | 1997-07-28 | Biogal Gyogyszergyar | Process for isolating of cyclosporin-a |
FI92334C (fi) * | 1992-12-30 | 1994-10-25 | Leiras Oy | Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta |
KR100304324B1 (ko) * | 1994-10-13 | 2001-11-22 | 김용규 | 사이클로스포린a의제조방법 |
-
1997
- 1997-03-25 HU HU9700645A patent/HU223054B1/hu not_active IP Right Cessation
-
1998
- 1998-03-23 PL PL98330142A patent/PL194252B1/pl not_active IP Right Cessation
- 1998-03-23 AT AT98913969T patent/ATE223434T1/de not_active IP Right Cessation
- 1998-03-23 ES ES98913969T patent/ES2180159T3/es not_active Expired - Lifetime
- 1998-03-23 AU AU68482/98A patent/AU737260B2/en not_active Ceased
- 1998-03-23 CA CA002255062A patent/CA2255062C/en not_active Expired - Fee Related
- 1998-03-23 NZ NZ332718A patent/NZ332718A/xx unknown
- 1998-03-23 PT PT98913969T patent/PT920447E/pt unknown
- 1998-03-23 SK SK1618-98A patent/SK283672B6/sk unknown
- 1998-03-23 WO PCT/HU1998/000029 patent/WO1998042734A1/en active IP Right Grant
- 1998-03-23 IL IL12687198A patent/IL126871A0/xx unknown
- 1998-03-23 DE DE69807635T patent/DE69807635T2/de not_active Expired - Fee Related
- 1998-03-23 RU RU98123499/04A patent/RU2182577C2/ru active
- 1998-03-23 JP JP10545312A patent/JP2000511939A/ja not_active Ceased
- 1998-03-23 DK DK98913969T patent/DK0920447T3/da active
- 1998-03-23 UA UA98116251A patent/UA58511C2/uk unknown
- 1998-03-23 EP EP98913969A patent/EP0920447B1/en not_active Expired - Lifetime
- 1998-03-23 YU YU53598A patent/YU49468B/sh unknown
- 1998-03-23 CZ CZ19983814A patent/CZ293687B6/cs not_active IP Right Cessation
- 1998-11-10 BG BG102911A patent/BG64215B1/bg unknown
- 1998-11-24 NO NO19985483A patent/NO322211B1/no not_active IP Right Cessation
-
1999
- 1999-12-09 HK HK99105786A patent/HK1020740A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69807635D1 (de) | 2002-10-10 |
AU6848298A (en) | 1998-10-20 |
YU49468B (sh) | 2006-05-25 |
ES2180159T3 (es) | 2003-02-01 |
HK1020740A1 (en) | 2000-05-19 |
HUP9700645A3 (en) | 2001-11-28 |
RU2182577C2 (ru) | 2002-05-20 |
YU53598A (en) | 1999-11-22 |
EP0920447A1 (en) | 1999-06-09 |
BG64215B1 (bg) | 2004-05-31 |
CA2255062C (en) | 2008-06-17 |
HUP9700645A2 (hu) | 1999-06-28 |
CZ381498A3 (cs) | 1999-02-17 |
CZ293687B6 (cs) | 2004-07-14 |
WO1998042734A1 (en) | 1998-10-01 |
ATE223434T1 (de) | 2002-09-15 |
JP2000511939A (ja) | 2000-09-12 |
EP0920447B1 (en) | 2002-09-04 |
NO985483L (no) | 1998-11-24 |
HU223054B1 (hu) | 2004-03-01 |
HU9700645D0 (en) | 1997-05-28 |
DE69807635T2 (de) | 2003-08-07 |
NZ332718A (en) | 2000-04-28 |
DK0920447T3 (da) | 2002-12-16 |
NO985483D0 (no) | 1998-11-24 |
CA2255062A1 (en) | 1998-10-01 |
PL330142A1 (en) | 1999-04-26 |
SK283672B6 (sk) | 2003-11-04 |
AU737260B2 (en) | 2001-08-16 |
NO322211B1 (no) | 2006-08-28 |
PL194252B1 (pl) | 2007-05-31 |
BG102911A (en) | 1999-09-30 |
SK161898A3 (en) | 1999-05-07 |
IL126871A0 (en) | 1999-09-22 |
UA58511C2 (uk) | 2003-08-15 |
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