ES2180159T3 - Procedimiento de purificacion de la ciclosporina a. - Google Patents

Procedimiento de purificacion de la ciclosporina a.

Info

Publication number
ES2180159T3
ES2180159T3 ES98913969T ES98913969T ES2180159T3 ES 2180159 T3 ES2180159 T3 ES 2180159T3 ES 98913969 T ES98913969 T ES 98913969T ES 98913969 T ES98913969 T ES 98913969T ES 2180159 T3 ES2180159 T3 ES 2180159T3
Authority
ES
Spain
Prior art keywords
cyclosporine
purification procedure
gel
filled
column
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98913969T
Other languages
English (en)
Inventor
Vilmos Keri
Arvai Edit Nagyne
Lajos Deak
Gyorgyne Mako
Istvanne Miskolczy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Application granted granted Critical
Publication of ES2180159T3 publication Critical patent/ES2180159T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Saccharide Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Silicon Compounds (AREA)

Abstract

EL OBJETO DE LA INVENCION ES UN PROCEDIMIENTO PARA LA PREPARACION CROMATOGRAFICA DE LA CICLOSPORINA A, A PARTIR DE UN PRODUCTO CRUDO QUE CONTIENE COMPLEJO DE CICLOSPORINA, POR EL USO DE UNA COLUMNA RELLENA CON GEL DE SILICE Y LA APLICACION DE UNA CROMATOGRAFIA DE ETAPAS MULTIPLES, CON UNA COLUMNA RELLENA CON GEL DE SILICE EN FASE NORMAL Y UNA MEZCLA DE DISOLVENTE QUE CONTIENE TOLUENO COMO PRINCIPAL COMPONENTE.
ES98913969T 1997-03-25 1998-03-23 Procedimiento de purificacion de la ciclosporina a. Expired - Lifetime ES2180159T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9700645A HU223054B1 (hu) 1997-03-25 1997-03-25 Tisztítási eljárás nagytisztaságú ciklosporin A előállítására

Publications (1)

Publication Number Publication Date
ES2180159T3 true ES2180159T3 (es) 2003-02-01

Family

ID=89994909

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98913969T Expired - Lifetime ES2180159T3 (es) 1997-03-25 1998-03-23 Procedimiento de purificacion de la ciclosporina a.

Country Status (22)

Country Link
EP (1) EP0920447B1 (es)
JP (1) JP2000511939A (es)
AT (1) ATE223434T1 (es)
AU (1) AU737260B2 (es)
BG (1) BG64215B1 (es)
CA (1) CA2255062C (es)
CZ (1) CZ293687B6 (es)
DE (1) DE69807635T2 (es)
DK (1) DK0920447T3 (es)
ES (1) ES2180159T3 (es)
HK (1) HK1020740A1 (es)
HU (1) HU223054B1 (es)
IL (1) IL126871A0 (es)
NO (1) NO322211B1 (es)
NZ (1) NZ332718A (es)
PL (1) PL194252B1 (es)
PT (1) PT920447E (es)
RU (1) RU2182577C2 (es)
SK (1) SK283672B6 (es)
UA (1) UA58511C2 (es)
WO (1) WO1998042734A1 (es)
YU (1) YU49468B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2151450A1 (de) * 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
DE102009037551A1 (de) 2009-08-17 2011-02-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Cyclosporinderivate
HUP1500502A2 (en) 2015-10-26 2017-04-28 Rotachrom Tech Kft Process for the purification of cyclosporin-a
CN114653350A (zh) * 2022-02-25 2022-06-24 江苏九阳生物制药有限公司 一种环孢素a层析硅胶的再生方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU213553B (en) * 1992-05-25 1997-07-28 Biogal Gyogyszergyar Process for isolating of cyclosporin-a
FI92334C (fi) * 1992-12-30 1994-10-25 Leiras Oy Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta
KR100304324B1 (ko) * 1994-10-13 2001-11-22 김용규 사이클로스포린a의제조방법

Also Published As

Publication number Publication date
AU737260B2 (en) 2001-08-16
HK1020740A1 (en) 2000-05-19
YU49468B (sh) 2006-05-25
YU53598A (en) 1999-11-22
CA2255062C (en) 2008-06-17
PT920447E (pt) 2002-11-29
NO985483D0 (no) 1998-11-24
CA2255062A1 (en) 1998-10-01
HUP9700645A3 (en) 2001-11-28
WO1998042734A1 (en) 1998-10-01
EP0920447B1 (en) 2002-09-04
BG64215B1 (bg) 2004-05-31
CZ293687B6 (cs) 2004-07-14
SK283672B6 (sk) 2003-11-04
BG102911A (en) 1999-09-30
AU6848298A (en) 1998-10-20
HU9700645D0 (en) 1997-05-28
UA58511C2 (uk) 2003-08-15
NO985483L (no) 1998-11-24
DK0920447T3 (da) 2002-12-16
DE69807635T2 (de) 2003-08-07
NZ332718A (en) 2000-04-28
RU2182577C2 (ru) 2002-05-20
CZ381498A3 (cs) 1999-02-17
HU223054B1 (hu) 2004-03-01
ATE223434T1 (de) 2002-09-15
IL126871A0 (en) 1999-09-22
SK161898A3 (en) 1999-05-07
HUP9700645A2 (hu) 1999-06-28
EP0920447A1 (en) 1999-06-09
DE69807635D1 (de) 2002-10-10
JP2000511939A (ja) 2000-09-12
PL330142A1 (en) 1999-04-26
NO322211B1 (no) 2006-08-28
PL194252B1 (pl) 2007-05-31

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