YU49468B - Postupak za prečišćavanje ciklosporina - Google Patents
Postupak za prečišćavanje ciklosporinaInfo
- Publication number
- YU49468B YU49468B YU53598A YU53598A YU49468B YU 49468 B YU49468 B YU 49468B YU 53598 A YU53598 A YU 53598A YU 53598 A YU53598 A YU 53598A YU 49468 B YU49468 B YU 49468B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- cyclosporin
- purification
- chromatography
- cyclosproin
- silica gel
- Prior art date
Links
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
- 108010036949 Cyclosporine Proteins 0.000 title abstract 2
- 229960001265 ciclosporin Drugs 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 229930182912 cyclosporin Natural products 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Saccharide Compounds (AREA)
- Silicon Compounds (AREA)
Abstract
Postupak prečišćavanja za dobijanje ciklosporina A u veoma čistom obliku iz ciklosproinskog kompleksa koji sadrži sirovi proizvod sa hromatografskom metodom na silika gel koloni, naznačen time, što se koristi višestepena hromatografija sa smešom rastvarača koja sadrži toluen kao glavnu komponentu. Prijava sadrži još 2 nezavisna patentna zahteva i 10 zavisnih patentnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9700645A HU223054B1 (hu) | 1997-03-25 | 1997-03-25 | Tisztítási eljárás nagytisztaságú ciklosporin A előállítására |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU53598A YU53598A (sh) | 1999-11-22 |
| YU49468B true YU49468B (sh) | 2006-05-25 |
Family
ID=89994909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU53598A YU49468B (sh) | 1997-03-25 | 1998-03-23 | Postupak za prečišćavanje ciklosporina |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0920447B1 (sh) |
| JP (1) | JP2000511939A (sh) |
| AT (1) | ATE223434T1 (sh) |
| AU (1) | AU737260B2 (sh) |
| BG (1) | BG64215B1 (sh) |
| CA (1) | CA2255062C (sh) |
| CZ (1) | CZ293687B6 (sh) |
| DE (1) | DE69807635T2 (sh) |
| DK (1) | DK0920447T3 (sh) |
| ES (1) | ES2180159T3 (sh) |
| HK (1) | HK1020740A1 (sh) |
| HU (1) | HU223054B1 (sh) |
| IL (1) | IL126871A0 (sh) |
| NO (1) | NO322211B1 (sh) |
| NZ (1) | NZ332718A (sh) |
| PL (1) | PL194252B1 (sh) |
| PT (1) | PT920447E (sh) |
| RU (1) | RU2182577C2 (sh) |
| SK (1) | SK283672B6 (sh) |
| UA (1) | UA58511C2 (sh) |
| WO (1) | WO1998042734A1 (sh) |
| YU (1) | YU49468B (sh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2151450A1 (de) * | 2008-07-29 | 2010-02-10 | Sandoz AG | Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden |
| DE102009037551A1 (de) * | 2009-08-17 | 2011-02-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Cyclosporinderivate |
| HUP1500502A2 (en) | 2015-10-26 | 2017-04-28 | Rotachrom Tech Kft | Process for the purification of cyclosporin-a |
| CN114653350A (zh) * | 2022-02-25 | 2022-06-24 | 江苏九阳生物制药有限公司 | 一种环孢素a层析硅胶的再生方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU213553B (en) * | 1992-05-25 | 1997-07-28 | Biogal Gyogyszergyar | Process for isolating of cyclosporin-a |
| FI92334C (fi) * | 1992-12-30 | 1994-10-25 | Leiras Oy | Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta |
| KR100304324B1 (ko) * | 1994-10-13 | 2001-11-22 | 김용규 | 사이클로스포린a의제조방법 |
-
1997
- 1997-03-25 HU HU9700645A patent/HU223054B1/hu not_active IP Right Cessation
-
1998
- 1998-03-23 SK SK1618-98A patent/SK283672B6/sk unknown
- 1998-03-23 YU YU53598A patent/YU49468B/sh unknown
- 1998-03-23 AT AT98913969T patent/ATE223434T1/de not_active IP Right Cessation
- 1998-03-23 JP JP10545312A patent/JP2000511939A/ja not_active Ceased
- 1998-03-23 PT PT98913969T patent/PT920447E/pt unknown
- 1998-03-23 ES ES98913969T patent/ES2180159T3/es not_active Expired - Lifetime
- 1998-03-23 CZ CZ19983814A patent/CZ293687B6/cs not_active IP Right Cessation
- 1998-03-23 RU RU98123499/04A patent/RU2182577C2/ru active
- 1998-03-23 WO PCT/HU1998/000029 patent/WO1998042734A1/en active IP Right Grant
- 1998-03-23 NZ NZ332718A patent/NZ332718A/xx unknown
- 1998-03-23 DK DK98913969T patent/DK0920447T3/da active
- 1998-03-23 PL PL98330142A patent/PL194252B1/pl not_active IP Right Cessation
- 1998-03-23 EP EP98913969A patent/EP0920447B1/en not_active Expired - Lifetime
- 1998-03-23 DE DE69807635T patent/DE69807635T2/de not_active Expired - Fee Related
- 1998-03-23 IL IL12687198A patent/IL126871A0/xx unknown
- 1998-03-23 AU AU68482/98A patent/AU737260B2/en not_active Ceased
- 1998-03-23 UA UA98116251A patent/UA58511C2/uk unknown
- 1998-03-23 CA CA002255062A patent/CA2255062C/en not_active Expired - Fee Related
- 1998-11-10 BG BG102911A patent/BG64215B1/bg unknown
- 1998-11-24 NO NO19985483A patent/NO322211B1/no not_active IP Right Cessation
-
1999
- 1999-12-09 HK HK99105786A patent/HK1020740A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BG102911A (en) | 1999-09-30 |
| ATE223434T1 (de) | 2002-09-15 |
| CZ293687B6 (cs) | 2004-07-14 |
| PT920447E (pt) | 2002-11-29 |
| CA2255062C (en) | 2008-06-17 |
| HU223054B1 (hu) | 2004-03-01 |
| HU9700645D0 (en) | 1997-05-28 |
| ES2180159T3 (es) | 2003-02-01 |
| EP0920447B1 (en) | 2002-09-04 |
| CA2255062A1 (en) | 1998-10-01 |
| EP0920447A1 (en) | 1999-06-09 |
| NO985483D0 (no) | 1998-11-24 |
| NO322211B1 (no) | 2006-08-28 |
| PL194252B1 (pl) | 2007-05-31 |
| HK1020740A1 (en) | 2000-05-19 |
| SK161898A3 (en) | 1999-05-07 |
| PL330142A1 (en) | 1999-04-26 |
| NZ332718A (en) | 2000-04-28 |
| UA58511C2 (uk) | 2003-08-15 |
| WO1998042734A1 (en) | 1998-10-01 |
| RU2182577C2 (ru) | 2002-05-20 |
| AU737260B2 (en) | 2001-08-16 |
| SK283672B6 (sk) | 2003-11-04 |
| DE69807635T2 (de) | 2003-08-07 |
| BG64215B1 (bg) | 2004-05-31 |
| DE69807635D1 (de) | 2002-10-10 |
| IL126871A0 (en) | 1999-09-22 |
| YU53598A (sh) | 1999-11-22 |
| JP2000511939A (ja) | 2000-09-12 |
| DK0920447T3 (da) | 2002-12-16 |
| NO985483L (no) | 1998-11-24 |
| HUP9700645A3 (en) | 2001-11-28 |
| HUP9700645A2 (hu) | 1999-06-28 |
| AU6848298A (en) | 1998-10-20 |
| CZ381498A3 (cs) | 1999-02-17 |
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