ATE490258T1 - Anwendung von zentrifugaler verteilungschromatographie zur aufreinigung von galanthamine - Google Patents
Anwendung von zentrifugaler verteilungschromatographie zur aufreinigung von galanthamineInfo
- Publication number
- ATE490258T1 ATE490258T1 AT05824656T AT05824656T ATE490258T1 AT E490258 T1 ATE490258 T1 AT E490258T1 AT 05824656 T AT05824656 T AT 05824656T AT 05824656 T AT05824656 T AT 05824656T AT E490258 T1 ATE490258 T1 AT E490258T1
- Authority
- AT
- Austria
- Prior art keywords
- galanthamine
- phase
- purification
- derivatives
- application
- Prior art date
Links
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title abstract 8
- HPOIPOPJGBKXIR-UHFFFAOYSA-N 3,6-dimethoxy-10-methyl-galantham-1-ene Natural products O1C(C(=CC=2)OC)=C3C=2CN(C)CCC23C1CC(OC)C=C2 HPOIPOPJGBKXIR-UHFFFAOYSA-N 0.000 title abstract 4
- LPCKPBWOSNVCEL-UHFFFAOYSA-N Chlidanthine Natural products O1C(C(=CC=2)O)=C3C=2CN(C)CCC23C1CC(OC)C=C2 LPCKPBWOSNVCEL-UHFFFAOYSA-N 0.000 title abstract 4
- 229960003980 galantamine Drugs 0.000 title abstract 4
- BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 title abstract 4
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 title abstract 4
- IYVSXSLYJLAZAT-NOLJZWGESA-N lycoramine Natural products CN1CC[C@@]23CC[C@H](O)C[C@@H]2Oc4cccc(C1)c34 IYVSXSLYJLAZAT-NOLJZWGESA-N 0.000 title abstract 4
- 238000004587 chromatography analysis Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 239000012071 phase Substances 0.000 abstract 3
- 230000005526 G1 to G0 transition Effects 0.000 abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000012074 organic phase Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 238000006073 displacement reaction Methods 0.000 abstract 1
- 238000004810 partition chromatography Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds or centrifugal chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0413425A FR2879599B1 (fr) | 2004-12-16 | 2004-12-16 | Utilisation de la chromatographie de partage centrifuge pour la purification de la galanthamine |
| PCT/FR2005/003046 WO2006064105A1 (fr) | 2004-12-16 | 2005-12-06 | Utilisation de la chromatographie de partage centrifuge pour la purification de la galanthamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE490258T1 true ATE490258T1 (de) | 2010-12-15 |
Family
ID=34951811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05824656T ATE490258T1 (de) | 2004-12-16 | 2005-12-06 | Anwendung von zentrifugaler verteilungschromatographie zur aufreinigung von galanthamine |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090216012A1 (de) |
| EP (1) | EP1824857B1 (de) |
| AT (1) | ATE490258T1 (de) |
| DE (1) | DE602005025155D1 (de) |
| FR (1) | FR2879599B1 (de) |
| WO (1) | WO2006064105A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010029554A1 (en) | 2008-09-11 | 2010-03-18 | I.B.R. Israeli Biotechnology Research Ltd. | Leucojum bulb extracts and use thereof |
| DE102009040381A1 (de) | 2009-09-07 | 2011-03-17 | Kallimopoulos, Thomas, Dr. | Verfahren zur Isolierung von Alkaloiden aus Pflanzen |
| US9918921B2 (en) | 2013-12-19 | 2018-03-20 | The Procter & Gamble Company | Methods for shaping fibrous material and treatment compositions therefor |
| US9877559B2 (en) | 2013-12-19 | 2018-01-30 | The Procter & Gamble Comany | Methods for shaping fibrous material and treatment compositions therefor |
| BG67337B1 (bg) | 2018-05-23 | 2021-06-15 | Софарма Ад | Метод за получаване на пречистен галантамин хидробромид |
| CN113376281B (zh) * | 2021-06-10 | 2023-02-07 | 上海市农业科学院 | 一种同时检测石蒜属植物生物碱合成途径中14种代谢物的方法 |
| FR3146813A1 (fr) | 2023-03-24 | 2024-09-27 | Gilson Purification | Procédés de séparation et de purification d'un composé organique contenu dans une matière d'origine naturelle |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2028802A (en) * | 1934-12-06 | 1936-01-28 | Standard Sanitary Mfg Co | Sink structure |
| US6407229B1 (en) * | 1994-10-21 | 2002-06-18 | Sanochemia Pharmazeutika Ag | Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine |
| DE19509663A1 (de) * | 1995-03-17 | 1996-09-19 | Lohmann Therapie Syst Lts | Verfahren zur Isolierung von Galanthamin |
| GB9610887D0 (en) * | 1996-05-24 | 1996-07-31 | N H S Trust | Process |
| FR2791578B1 (fr) * | 1999-03-31 | 2001-06-08 | S E A B Societes D Etudes Et D | Dispositif ameliore de chromatographie de partage centrifuge a cellules |
| CN1261434C (zh) * | 2003-07-28 | 2006-06-28 | 浙江一新制药股份有限公司 | 从石蒜粗提物中分离高纯度加兰他敏的方法 |
-
2004
- 2004-12-16 FR FR0413425A patent/FR2879599B1/fr not_active Expired - Fee Related
-
2005
- 2005-12-06 AT AT05824656T patent/ATE490258T1/de not_active IP Right Cessation
- 2005-12-06 DE DE602005025155T patent/DE602005025155D1/de not_active Expired - Lifetime
- 2005-12-06 US US11/722,004 patent/US20090216012A1/en not_active Abandoned
- 2005-12-06 WO PCT/FR2005/003046 patent/WO2006064105A1/fr not_active Ceased
- 2005-12-06 EP EP05824656A patent/EP1824857B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2879599A1 (fr) | 2006-06-23 |
| DE602005025155D1 (de) | 2011-01-13 |
| FR2879599B1 (fr) | 2007-03-23 |
| EP1824857A1 (de) | 2007-08-29 |
| WO2006064105A1 (fr) | 2006-06-22 |
| US20090216012A1 (en) | 2009-08-27 |
| EP1824857B1 (de) | 2010-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |